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Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
GBIO Generation Bio	$0.41 -22.1%	$0.38	$0.30 ▼ $3.65	$34.95M	2.59	483,972 shs	4.57 million shs
HRMY Harmony Biosciences	$35.20 -3.4%	$33.84	$26.47 ▼ $41.61	$2.09B	0.83	635,644 shs	701,636 shs
MDGL Madrigal Pharmaceuticals	$334.13 -4.2%	$291.89	$200.63 ▼ $377.46	$7.74B	-1.05	361,550 shs	326,009 shs
RVNC Revance Therapeutics	$3.65	$3.65	$2.76 ▼ $6.65	$381.02M	0.9	3.74 million shs	N/A
STOK Stoke Therapeutics	$13.22 +7.0%	$10.97	$5.35 ▼ $16.15	$674.27M	1.14	678,585 shs	1.55 million shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
GBIO Generation Bio	-22.08%	+5.15%	+12.86%	+4.18%	-86.63%
HRMY Harmony Biosciences	-3.38%	+3.53%	+8.37%	+23.68%	+6.41%
MDGL Madrigal Pharmaceuticals	-4.19%	+5.92%	+18.18%	+10.76%	+24.03%
RVNC Revance Therapeutics	0.00%	0.00%	0.00%	0.00%	-7.83%
STOK Stoke Therapeutics	+7.04%	+11.47%	+14.26%	+71.91%	-3.36%

Compare MarketRank™

Company	Overall Score	Analyst's Opinion	Short Interest Score	ESG Score	News and Social Media Sentiment	Company Ownership	Earnings & Valuation
GBIO Generation Bio	3.5963 of 5 stars	3.5	5.0	0.0	0.8	3.3	1.3
HRMY Harmony Biosciences	4.8347 of 5 stars	4.5	1.0	0.0	3.9	3.3	4.4
MDGL Madrigal Pharmaceuticals	4.3419 of 5 stars	3.4	1.0	4.6	2.5	4.2	0.6
RVNC Revance Therapeutics	2.7381 of 5 stars	3.1	0.0	4.7	0.0	1.7	0.6
STOK Stoke Therapeutics	4.2454 of 5 stars	3.6	1.0	4.8	3.1	0.8	1.3

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
GBIO Generation Bio	3.00	Buy	$8.00	1,868.99% Upside
HRMY Harmony Biosciences	3.00	Buy	$51.33	45.83% Upside
MDGL Madrigal Pharmaceuticals	2.89	Moderate Buy	$420.63	25.89% Upside
RVNC Revance Therapeutics	2.13	Hold	$8.45	131.51% Upside
STOK Stoke Therapeutics	3.29	Buy	$25.80	95.16% Upside

Current Analyst Ratings Breakdown

Latest RVNC, MDGL, HRMY, GBIO, and STOK Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
7/18/2025	GBIO Generation Bio	Wedbush Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Outperform	$5.00 ➝ $7.00
7/18/2025	STOK Stoke Therapeutics	Jefferies Financial Group Subscribe to MarketBeat All Access for the recommendation accuracy rating	Initiated Coverage	Buy	$30.00
7/10/2025	HRMY Harmony Biosciences	Deutsche Bank Aktiengesellschaft Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$54.00 ➝ $55.00
7/10/2025	HRMY Harmony Biosciences	The Goldman Sachs Group Subscribe to MarketBeat All Access for the recommendation accuracy rating	Upgrade	Hold	$33.00
7/1/2025	STOK Stoke Therapeutics	Needham & Company LLC Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$22.00
6/2/2025	HRMY Harmony Biosciences	Oppenheimer Subscribe to MarketBeat All Access for the recommendation accuracy rating	Initiated Coverage	Outperform	$61.00
5/15/2025	HRMY Harmony Biosciences	Mizuho Subscribe to MarketBeat All Access for the recommendation accuracy rating	Boost Price Target	Outperform ➝ Outperform	$44.00 ➝ $48.00
5/14/2025	STOK Stoke Therapeutics	Cantor Fitzgerald Subscribe to MarketBeat All Access for the recommendation accuracy rating	Upgrade	Strong-Buy
5/14/2025	STOK Stoke Therapeutics	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Lower Price Target	Buy ➝ Buy	$47.00 ➝ $35.00
5/13/2025	HRMY Harmony Biosciences	Cantor Fitzgerald Subscribe to MarketBeat All Access for the recommendation accuracy rating	Upgrade	Strong-Buy
5/8/2025	GBIO Generation Bio	Needham & Company LLC Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$8.00 ➝ $8.00

(Data available from 7/19/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
GBIO Generation Bio	$19.89M	1.37	N/A	N/A	$1.29 per share	0.31
HRMY Harmony Biosciences	$714.73M	2.83	$2.85 per share	12.36	$11.56 per share	3.04
MDGL Madrigal Pharmaceuticals	$317.38M	23.37	N/A	N/A	$34.59 per share	9.66
RVNC Revance Therapeutics	$234.04M	1.63	N/A	N/A	($1.73) per share	-2.11
STOK Stoke Therapeutics	$36.56M	19.74	N/A	N/A	$4.32 per share	3.06

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
GBIO Generation Bio	-$131.67M	-$1.08	N/A	N/A	N/A	-292.92%	-75.84%	-30.40%	8/6/2025 (Estimated)
HRMY Harmony Biosciences	$145.49M	$2.62	13.44	11.32	0.50	20.53%	24.32%	15.92%	8/5/2025 (Estimated)
MDGL Madrigal Pharmaceuticals	-$465.89M	-$18.05	N/A	N/A	N/A	-123.38%	-50.54%	-37.19%	8/6/2025 (Estimated)
RVNC Revance Therapeutics	-$323.99M	-$1.93	N/A	N/A	N/A	-74.67%	N/A	-37.22%	8/6/2025 (Estimated)
STOK Stoke Therapeutics	-$88.98M	$0.79	16.73	N/A	N/A	26.33%	19.08%	15.72%	8/6/2025 (Estimated)

Latest RVNC, MDGL, HRMY, GBIO, and STOK Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
8/6/2025	Q2 2025	GBIO Generation Bio	-$0.28	N/A	N/A	N/A	$2.51 million	N/A
8/6/2025	Q2 2025	MDGL Madrigal Pharmaceuticals	-$3.64	N/A	N/A	N/A	$158.94 million	N/A
8/6/2025	Q2 2025	STOK Stoke Therapeutics	-$0.0905	N/A	N/A	N/A	$31.51 million	N/A
8/5/2025	Q2 2025	HRMY Harmony Biosciences	$0.78	N/A	N/A	N/A	$204.37 million	N/A
5/7/2025	Q1 2025	GBIO Generation Bio	-$0.25	-$0.22	+$0.03	-$0.22	$1.70 million	$8.72 million
5/6/2025	Q1 2025	HRMY Harmony Biosciences	$0.59	$0.78	+$0.19	$0.78	$184.26 million	$184.73 million
5/1/2025	Q1 2025	MDGL Madrigal Pharmaceuticals	-$3.62	-$3.32	+$0.30	-$3.32	$112.79 million	$137.25 million

Compare Dividends

Company	Annual Payout	Dividend Yield	3-Year Dividend Growth	Payout Ratio	Years of Consecutive Growth
GBIO Generation Bio	N/A	N/A	N/A	N/A	N/A
HRMY Harmony Biosciences	N/A	N/A	N/A	N/A	N/A
MDGL Madrigal Pharmaceuticals	N/A	N/A	N/A	N/A	N/A
RVNC Revance Therapeutics	N/A	N/A	N/A	N/A	N/A
STOK Stoke Therapeutics	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
GBIO Generation Bio	N/A	8.43	8.43
HRMY Harmony Biosciences	0.22	3.67	3.63
MDGL Madrigal Pharmaceuticals	0.17	5.91	5.58
RVNC Revance Therapeutics	N/A	4.12	3.05
STOK Stoke Therapeutics	N/A	8.41	8.41

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
GBIO Generation Bio	95.22%
HRMY Harmony Biosciences	86.23%
MDGL Madrigal Pharmaceuticals	98.50%
RVNC Revance Therapeutics	97.70%
STOK Stoke Therapeutics	N/A

Insider Ownership

Company	Insider Ownership
GBIO Generation Bio	21.80%
HRMY Harmony Biosciences	23.60%
MDGL Madrigal Pharmaceuticals	21.50%
RVNC Revance Therapeutics	5.10%
STOK Stoke Therapeutics	9.50%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
GBIO Generation Bio	150	67.04 million	52.42 million	Optionable
HRMY Harmony Biosciences	200	57.42 million	43.87 million	Optionable
MDGL Madrigal Pharmaceuticals	90	22.20 million	17.43 million	Optionable
RVNC Revance Therapeutics	500	104.39 million	99.07 million	Optionable
STOK Stoke Therapeutics	100	54.60 million	49.41 million	Optionable

RVNC, MDGL, HRMY, GBIO, and STOK Headlines

Recent News About These Companies

Jefferies Initiates Coverage of Stoke Therapeutics (STOK) with Buy Recommendation

July 19 at 2:19 AM | msn.com

Jefferies starts Stoke at Buy, sees $1 bln+ opportunity in rare epilepsy drug

July 19 at 2:19 AM | finance.yahoo.com

Stoke Therapeutics (NASDAQ:STOK) Shares Gap Up - What's Next?

July 18 at 12:03 PM | marketbeat.com

Stoke Therapeutics (NASDAQ:STOK) Now Covered by Analysts at Jefferies Financial Group

July 18 at 9:31 AM | marketbeat.com

Epilepsy Pipeline Appears Robust With 75+ Key Pharma Companies Actively Working in the Therapeutics Segment | DelveInsight

July 15, 2025 | theglobeandmail.com

Stoke Therapeutics (NASDAQ:STOK) investors are sitting on a loss of 58% if they invested five years ago

July 15, 2025 | finance.yahoo.com

The charming Stoke-on-Trent four-bed family home that's 'ready to be lived in'

July 13, 2025 | msn.com

New Royal Stoke technology cuts hospital stays by over a day

July 13, 2025 | msn.com

Stoke City Boss Delighted To Finally Get Signing Over The Line

July 13, 2025 | therealefl.co.ukT

Grit bin raiders and double parking hinders work to keep Stoke-on-Trent moving in winter

July 13, 2025 | msn.com

Five of the best beer gardens around Stoke-on-Trent to enjoy in the sun

July 13, 2025 | msn.com

Man City prospect told to gain notoriety at Stoke City

July 13, 2025 | msn.com

Case builds for Biogen, Stoke's Dravet syndrome drug

July 11, 2025 | pharmaphorum.comP

Lille rival Aston Villa in race for Stoke’s Sol Sidibé

July 10, 2025 | sports.yahoo.com

Aston Villa want Stoke City midfielder Sol Sidibe

July 10, 2025 | sports.yahoo.com

Stoke City vs Shrewsbury LIVE Score Updates: Match Canceled

July 10, 2025 | vavel.comV

Council still against Stoke-on-Trent 'merger' as devolution decision gets nearer

July 10, 2025 | msn.com

Live updates after 'accident' on Stoke-on-Trent road

July 10, 2025 | stokesentinel.co.ukS

Stoke City close in on fourth summer signing

July 10, 2025 | msn.com

Biogen and Stoke Therapeutics Announce Presentation of Data from Studies of Zorevunersen, an Investigational Medicine for Dravet syndrome, at the 16th European Paediatric Neurology Society (EPNS) Congress

July 10, 2025 | globenewswire.com

Stoke Therapeutics and Biogen Announce Presentation of Data from Studies of Zorevunersen, an Investigational Medicine for Dravet syndrome, at the 16th European Paediatric Neurology Society (EPNS) Congress

July 10, 2025 | businesswire.com

New MarketBeat Followers Over Time

Media Sentiment Over Time

RVNC, MDGL, HRMY, GBIO, and STOK Company Descriptions

Generation Bio NASDAQ:GBIO

$0.41 -0.12 (-22.08%)

Closing price 07/18/2025 04:00 PM Eastern

Extended Trading

$0.42 +0.01 (+2.14%)

As of 07/18/2025 07:59 PM Eastern

Generation Bio Co. develops non-viral genetic medicines for the treatment of rare and prevalent diseases. The company develops cell-targeted lipid nanoparticle (ctLNP) platform, a modular delivery system for nucleic acids to avoid off-target clearance by the liver and spleen that enables ctLNPs to persist in systemic circulation, which allows for highly selective and potent ligand-driven targeting to specific tissues and cell types; and novel immune-quiet DNA (iqDNA) to enable long-lasting high levels of gene expression from non-integrating episomes and avoids innate immune sensors that have long prevented DNA from use in non-viral systems. It uses its platform for developing a portfolio of programs for treating cancer, autoimmune, hematologic disorders, prioritizing sickle cell, beta-thalassemia, and hemophilia A diseases, as well as for other tissues and cell types, including retina, skeletal muscle, and central nervous system. The company was formerly known as Torus Therapeutics, Inc. and changed its name to Generation Bio Co. in November 2017. Generation Bio Co. was incorporated in 2016 and is headquartered in Cambridge, Massachusetts.

Harmony Biosciences NASDAQ:HRMY

$35.20 -1.23 (-3.38%)

Closing price 07/18/2025 04:00 PM Eastern

Extended Trading

$35.48 +0.28 (+0.80%)

As of 07/18/2025 07:10 PM Eastern

Harmony Biosciences Holdings, Inc., a commercial-stage pharmaceutical company, focuses on developing and commercializing therapies for patients with rare and other neurological diseases in the United States. The company offers WAKIX (pitolisant), a molecule with a novel mechanism of action for the treatment of excessive daytime sleepiness in adult patients with narcolepsy. It also offers HBS-102, a melanin-concentrating hormone receptor 1 for MCH neurons. The company was formerly known as Harmony Biosciences II, Inc. and changed its name to Harmony Biosciences Holdings, Inc. in February 2020. Harmony Biosciences Holdings, Inc. was incorporated in 2017 and is headquartered in Plymouth Meeting, Pennsylvania.

Madrigal Pharmaceuticals NASDAQ:MDGL

$334.13 -14.60 (-4.19%)

Closing price 07/18/2025 04:00 PM Eastern

Extended Trading

$332.00 -2.13 (-0.64%)

As of 07/18/2025 05:38 PM Eastern

Madrigal Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on the development of therapeutics for the treatment of non-alcoholic steatohepatitis (NASH) in the United States. Its lead product candidate is resmetirom, a liver-directed thyroid hormone receptor beta agonist, which is in Phase 3 clinical trials for treating NASH. The company is headquartered in West Conshohocken, Pennsylvania.

Revance Therapeutics NASDAQ:RVNC

Revance Therapeutics, Inc., a biotechnology company, engages in the development, manufacture, and commercialization of neuromodulators for various aesthetic and therapeutic indications in the United States and internationally. The company's lead drug candidate is DAXXIFY (DaxibotulinumtoxinA-lanm) for injection for the treatment of glabellar lines and cervical dystonia; has completed phase II clinical trials to treat upper facial lines, moderate or severe dynamic forehead lines, and moderate or severe lateral canthal lines; and has completed Phase II clinical trials for the treatment of adult upper limb spasticity and plantar fasciitis. It is also developing OnabotulinumtoxinA, a biosimilar to BOTOX that is in preclinical stage. The company also offers Resilient Hyaluronic Acid (RHA) dermal filler for the correction of moderate to severe dynamic facial wrinkles; and RHA Redensity, a dermal filler for the treatment of moderate to severe dynamic perioral rhytids. It has a collaboration and license agreement with Viatris Inc. to develop, manufacture, and commercialize onabotulinumtoxinA. The company was formerly known as Essentia Biosystems, Inc. and changed its name to Revance Therapeutics, Inc. in April 2005. Revance Therapeutics, Inc. was incorporated in 1999 and is headquartered in Nashville, Tennessee.

Stoke Therapeutics NASDAQ:STOK

$13.22 +0.87 (+7.04%)

Closing price 07/18/2025 04:00 PM Eastern

Extended Trading

$13.54 +0.32 (+2.46%)

As of 07/18/2025 06:43 PM Eastern

Stoke Therapeutics, Inc., an early-stage biopharmaceutical company, develops medicines to treat the underlying causes of severe genetic diseases in the United States. The company utilizes its proprietary targeted augmentation of nuclear gene output to develop antisense oligonucleotides to selectively restore protein levels. Its lead clinical candidate is STK-002, which is in preclinical stage for the treatment of autosomal dominant optic atrophy. The company also develops STK-001, which is in phase I/II clinical trial to treat Dravet syndrome; and programs focused on multiple targets, including haploinsufficiency diseases of the central nervous system and eye. The company has a license and collaboration agreement with Acadia Pharmaceuticals Inc. for the discovery, development, and commercialization of novel RNA-based medicines for the treatment of severe and rare genetic neurodevelopmental diseases of the central nervous system. The company was formerly known as ASOthera Pharmaceuticals, Inc. and changed its name to Stoke Therapeutics, Inc. in May 2016. Stoke Therapeutics, Inc. was incorporated in 2014 and is headquartered in Bedford, Massachusetts.

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Comparative Price Performance Over Time