S&P 500   4,967.23
DOW   37,986.40
QQQ   414.65
How major US stock indexes fared Friday, 4/19/2024
Stock market today: Tumbling tech stocks drag Wall Street to the finish line of another losing week
American Express profits jump 34%, helped by jump in new customers, higher spending
American Express, Fifth Third rise; Netflix, PPG Industries fall, Friday, 4/19/2024
Intuitive Surgical Stock Can Trend Much Higher This Year 
3 Magnificent Seven Stocks Outperforming the Rest
Bargain Hunting: 3 Stocks With RSIs That Scream Oversold
S&P 500   4,967.23
DOW   37,986.40
QQQ   414.65
How major US stock indexes fared Friday, 4/19/2024
Stock market today: Tumbling tech stocks drag Wall Street to the finish line of another losing week
American Express profits jump 34%, helped by jump in new customers, higher spending
American Express, Fifth Third rise; Netflix, PPG Industries fall, Friday, 4/19/2024
Intuitive Surgical Stock Can Trend Much Higher This Year 
3 Magnificent Seven Stocks Outperforming the Rest
Bargain Hunting: 3 Stocks With RSIs That Scream Oversold
S&P 500   4,967.23
DOW   37,986.40
QQQ   414.65
How major US stock indexes fared Friday, 4/19/2024
Stock market today: Tumbling tech stocks drag Wall Street to the finish line of another losing week
American Express profits jump 34%, helped by jump in new customers, higher spending
American Express, Fifth Third rise; Netflix, PPG Industries fall, Friday, 4/19/2024
Intuitive Surgical Stock Can Trend Much Higher This Year 
3 Magnificent Seven Stocks Outperforming the Rest
Bargain Hunting: 3 Stocks With RSIs That Scream Oversold
S&P 500   4,967.23
DOW   37,986.40
QQQ   414.65
How major US stock indexes fared Friday, 4/19/2024
Stock market today: Tumbling tech stocks drag Wall Street to the finish line of another losing week
American Express profits jump 34%, helped by jump in new customers, higher spending
American Express, Fifth Third rise; Netflix, PPG Industries fall, Friday, 4/19/2024
Intuitive Surgical Stock Can Trend Much Higher This Year 
3 Magnificent Seven Stocks Outperforming the Rest
Bargain Hunting: 3 Stocks With RSIs That Scream Oversold

Compare Stocks

Comparative Price Performance Over Time

Compare Stocks - Price & Volume

CompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's Volume
China Biologic Products Holdings, Inc. stock logo
CBPO
China Biologic Products
$119.99
+1.7%
$119.23
$99.74
$120.05
$4.72B0.47148,695 shs24,016 shs
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
$55.05
-2.0%
$73.26
$37.55
$91.10
$4.67B1.761.85 million shs1.77 million shs
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
$38.64
+2.2%
$39.56
$29.85
$45.00
$4.91B1.251.27 million shs1.26 million shs
Novavax, Inc. stock logo
NVAX
Novavax
$3.97
+2.1%
$4.70
$3.53
$11.36
$555.61M1.597.67 million shs2.91 million shs
Spark Therapeutics Inc stock logo
ONCE
Spark Therapeutics
$0.18
$113.43
$34.53
$114.20
$6.94M2.05891,560 shsN/A
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Price Performance

Company1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year Performance
China Biologic Products Holdings, Inc. stock logo
CBPO
China Biologic Products
0.00%0.00%0.00%0.00%0.00%
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
+1.08%-10.73%-21.96%-9.40%+5.01%
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
-0.55%-3.84%-7.35%+10.72%+7.51%
Novavax, Inc. stock logo
NVAX
Novavax
0.00%-9.53%-21.26%-3.95%-56.58%
Spark Therapeutics Inc stock logo
ONCE
Spark Therapeutics
0.00%0.00%0.00%0.00%-99.84%

MarketRank™

CompanyOverall ScoreAnalyst's OpinionShort Interest ScoreDividend StrengthESG ScoreNews and Social Media SentimentCompany OwnershipEarnings & Valuation
China Biologic Products Holdings, Inc. stock logo
CBPO
China Biologic Products
N/AN/AN/AN/AN/AN/AN/AN/A
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
2.4376 of 5 stars
4.21.00.00.02.02.50.6
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
4.936 of 5 stars
3.42.00.04.43.12.54.4
Novavax, Inc. stock logo
NVAX
Novavax
3.841 of 5 stars
3.33.00.04.72.20.80.6
Spark Therapeutics Inc stock logo
ONCE
Spark Therapeutics
N/AN/AN/AN/AN/AN/AN/AN/A

Analyst Ratings

CompanyConsensus Rating ScoreConsensus RatingConsensus Price Target% Upside from Current Price
China Biologic Products Holdings, Inc. stock logo
CBPO
China Biologic Products
N/AN/AN/AN/A
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
2.38
Hold$76.2938.58% Upside
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
2.86
Moderate Buy$53.2937.90% Upside
Novavax, Inc. stock logo
NVAX
Novavax
2.67
Moderate Buy$17.00328.21% Upside
Spark Therapeutics Inc stock logo
ONCE
Spark Therapeutics
N/AN/AN/AN/A

Current Analyst Ratings

Latest ONCE, CBPO, NVAX, HALO, and CRSP Analyst Ratings

DateCompanyBrokerageActionRatingPrice TargetDetails
4/18/2024
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
Citigroup
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Boost Price TargetBuy ➝ Buy$88.00 ➝ $89.00
4/17/2024
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
HC Wainwright
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Reiterated RatingBuy ➝ Buy$50.00
4/16/2024
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
Benchmark
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Reiterated RatingBuy ➝ Buy$50.00
4/11/2024
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
Needham & Company LLC
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Reiterated RatingBuy ➝ Buy$90.00
3/6/2024
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
Mizuho
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Boost Price TargetBuy ➝ Buy$82.00 ➝ $99.00
3/1/2024
Novavax, Inc. stock logo
NVAX
Novavax
HC Wainwright
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Lower Price TargetBuy ➝ Buy$35.00 ➝ $19.00
2/29/2024
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
TD Cowen
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Initiated CoverageOutperform$54.00
2/26/2024
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
Morgan Stanley
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Boost Price TargetUnderweight ➝ Underweight$46.00 ➝ $48.00
2/22/2024
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
Royal Bank of Canada
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Boost Price TargetSector Perform ➝ Sector Perform$57.00 ➝ $66.00
2/22/2024
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
Wells Fargo & Company
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Boost Price TargetEqual Weight ➝ Equal Weight$55.00 ➝ $70.00
2/22/2024
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
Barclays
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Boost Price TargetEqual Weight ➝ Equal Weight$61.00 ➝ $80.00
(Data available from 4/19/2021 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Sales & Book Value

CompanyAnnual RevenuePrice/SalesCashflowPrice/CashBook ValuePrice/Book
China Biologic Products Holdings, Inc. stock logo
CBPO
China Biologic Products
$503.70M9.38$5.01 per share23.93$45.09 per share2.66
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
$371.21M12.59N/AN/A$23.70 per share2.32
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
$829.25M5.92$3.23 per share11.96$0.63 per share61.33
Novavax, Inc. stock logo
NVAX
Novavax
$556.38M1.00N/AN/A($6.04) per share-0.66
Spark Therapeutics Inc stock logo
ONCE
Spark Therapeutics
$64.72M0.11N/AN/A$13.15 per share0.01

Profitability & Earnings

CompanyNet IncomeEPSTrailing P/E RatioForward P/E RatioP/E GrowthNet MarginsReturn on Equity (ROE)Return on Assets (ROA)Next Earnings Date
China Biologic Products Holdings, Inc. stock logo
CBPO
China Biologic Products
$138.81M$4.2833.5227.90N/A27.43%8.32%7.64%N/A
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
-$153.61M-$1.96N/AN/AN/AN/A-8.09%-6.73%5/13/2024 (Estimated)
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
$281.59M$2.1118.319.070.4433.96%248.20%19.13%5/14/2024 (Estimated)
Novavax, Inc. stock logo
NVAX
Novavax
-$545.06M-$5.53N/AN/AN/A-55.41%N/A-32.63%5/14/2024 (Estimated)
Spark Therapeutics Inc stock logo
ONCE
Spark Therapeutics
-$78.82M-$2.11N/AN/AN/A-358.41%-59.10%-33.13%N/A

Latest ONCE, CBPO, NVAX, HALO, and CRSP Earnings

DateQuarterCompanyConsensus EstimateReported EPSBeat/MissGap EPSRevenue EstimateActual RevenueDetails
2/28/2024Q4 2023
Novavax, Inc. stock logo
NVAX
Novavax
-$0.49-$1.44-$0.95-$1.44$310.96 million$291.34 million      
2/21/2024Q4 2023
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
$0.15$1.10+$0.95$1.10$148.72 million$201.20 million
2/20/2024Q4 2023
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
$0.77$0.75-$0.02$0.85$235.25 million$230.04 million

Dividends

CompanyAnnual PayoutDividend Yield3-Year Dividend GrowthPayout RatioYears of Consecutive Growth
China Biologic Products Holdings, Inc. stock logo
CBPO
China Biologic Products
N/AN/AN/AN/AN/A
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
N/AN/AN/AN/AN/A
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
N/AN/AN/AN/AN/A
Novavax, Inc. stock logo
NVAX
Novavax
N/AN/AN/AN/AN/A
Spark Therapeutics Inc stock logo
ONCE
Spark Therapeutics
N/AN/AN/AN/AN/A

Debt

CompanyDebt-to-Equity RatioCurrent RatioQuick Ratio
China Biologic Products Holdings, Inc. stock logo
CBPO
China Biologic Products
N/A
12.01
10.13
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
N/A
17.54
17.54
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
17.89
6.64
5.50
Novavax, Inc. stock logo
NVAX
Novavax
N/A
0.70
0.67
Spark Therapeutics Inc stock logo
ONCE
Spark Therapeutics
0.35
4.67
4.35

Ownership

Institutional Ownership

CompanyInstitutional Ownership
China Biologic Products Holdings, Inc. stock logo
CBPO
China Biologic Products
34.77%
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
69.20%
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
97.79%
Novavax, Inc. stock logo
NVAX
Novavax
53.04%
Spark Therapeutics Inc stock logo
ONCE
Spark Therapeutics
88.37%

Miscellaneous

CompanyEmployeesShares OutstandingFree FloatOptionable
China Biologic Products Holdings, Inc. stock logo
CBPO
China Biologic Products
2,26939.36 millionN/AOptionable
CRISPR Therapeutics AG stock logo
CRSP
CRISPR Therapeutics
47384.88 million81.40 millionOptionable
Halozyme Therapeutics, Inc. stock logo
HALO
Halozyme Therapeutics
373127.05 million124.01 millionOptionable
Novavax, Inc. stock logo
NVAX
Novavax
1,543139.95 million138.69 millionOptionable
Spark Therapeutics Inc stock logo
ONCE
Spark Therapeutics
36838.52 millionN/ANo Data

ONCE, CBPO, NVAX, HALO, and CRSP Headlines

SourceHeadline
Cancer vaccine startup launches with $54 million, Spark veteran as CEOCancer vaccine startup launches with $54 million, Spark veteran as CEO
statnews.com - April 18 at 3:07 PM
Spring season sparks renewed emphasis on bicycle safetySpring season sparks renewed emphasis on bicycle safety
wkow.com - April 17 at 1:48 AM
Total eclipse sparks ‘once-in-a-lifetime’ parties across blackout zone: ‘All everyone is talking about’Total eclipse sparks ‘once-in-a-lifetime’ parties across blackout zone: ‘All everyone is talking about’
msn.com - April 7 at 2:37 PM
Local sewing group is forming to help local recreation centerLocal sewing group is forming to help local recreation center
dothaneagle.com - April 4 at 9:35 AM
Project Spark: win $20,000 worth of funding for a short filmProject Spark: win $20,000 worth of funding for a short film
provideocoalition.com - March 28 at 1:41 PM
Sharon Osbourne takes another swipe at X Factor as she admits shes very much against rebootSharon Osbourne takes another swipe at X Factor as she admits she's 'very much against' reboot
mirror.co.uk - March 27 at 4:13 PM
Lenmeldy Sparks Controversy as Worlds Most Expensive Medicine, Debating the $4.25 Million Price TagLenmeldy Sparks Controversy as World's Most Expensive Medicine, Debating the $4.25 Million Price Tag
techtimes.com - March 22 at 11:36 PM
Aries Season Is Here, and Its Time to Start FreshAries Season Is Here, and It's Time to Start Fresh
sg.finance.yahoo.com - March 16 at 1:43 PM
ful. Health Introduces Innovative Solution to Help Group Health Plans Right-Size Healthcare Spendingful. Health Introduces Innovative Solution to Help Group Health Plans Right-Size Healthcare Spending
finance.yahoo.com - March 14 at 7:33 PM
Protein discovery sparks treatment hope for aggressive cancerProtein discovery sparks treatment hope for aggressive cancer
sciencedaily.com - March 14 at 2:25 PM
Fred L. Goldenberg: Drug prices out of controlFred L. Goldenberg: Drug prices out of control
finance.yahoo.com - March 13 at 3:57 PM
Man attacked, suspects flee on busy Viger Avenue in MontrealMan attacked, suspects flee on busy Viger Avenue in Montreal
montreal.ctvnews.ca - March 12 at 1:27 PM
Ben Kirshner’s Plan to Transform How Pennsylvania Does BusinessBen Kirshner’s Plan to Transform How Pennsylvania Does Business
phillymag.com - March 11 at 1:53 AM
San Diego 19-year-old tries ketamine for eating disorderSan Diego 19-year-old tries ketamine for eating disorder
sandiegoreader.com - March 7 at 2:56 AM
Omega Park inaugurates the Makwa Foundation for the Conservation and Protection of Endangered SpeciesOmega Park inaugurates the Makwa Foundation for the Conservation and Protection of Endangered Species
finance.yahoo.com - March 5 at 7:55 AM
Viking Therapeutics weight loss drug showed faster results in clinical trials than Ozempic or Wegovy. Heres how it works.Viking Therapeutics' weight loss drug showed faster results in clinical trials than Ozempic or Wegovy. Here's how it works.
ca.news.yahoo.com - February 28 at 2:13 PM
Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter 2023 Financial ResultsPliant Therapeutics Provides Corporate Update and Reports Fourth Quarter 2023 Financial Results
markets.businessinsider.com - February 27 at 7:39 PM
Big Money Is Taking Over MDMA-Assisted TherapyBig Money Is Taking Over MDMA-Assisted Therapy
msn.com - February 24 at 2:00 PM
PCM Trials Acquires EmVenio Research to Create the Most Patient-Centric Model for Hybrid and Decentralized Clinical TrialsPCM Trials Acquires EmVenio Research to Create the Most Patient-Centric Model for Hybrid and Decentralized Clinical Trials
finance.yahoo.com - February 23 at 1:30 PM
10 Minor Unsolved Mysteries In The Legend of Zelda With Major Implications10 Minor Unsolved Mysteries In The Legend of Zelda With Major Implications
msn.com - February 22 at 8:57 PM
How to get Resplendent Sparks in Diablo 4How to get Resplendent Sparks in Diablo 4
pcgamer.com - February 14 at 1:37 PM
The So-Called Worst Star Trek: Voyager Episode Is A Lot Better Than You ThinkThe So-Called Worst Star Trek: Voyager Episode Is A Lot Better Than You Think
denofgeek.com - February 12 at 10:27 AM
Mitochondrial misfire sparks inflammationMitochondrial misfire sparks inflammation
msn.com - February 8 at 2:37 PM
Eli Lilly Fatty Liver Drug Posts Promising Early Data, But Field Is Still CompetitiveEli Lilly Fatty Liver Drug Posts Promising Early Data, But Field Is Still Competitive
medcitynews.com - February 6 at 10:17 PM

New MarketBeat Followers Over Time

Media Sentiment Over Time

Top Headlines

All Headlines

Company Descriptions

China Biologic Products logo

China Biologic Products

NASDAQ:CBPO
China Biologic Products Holdings, Inc. engages in the research, development, manufacture, and sale of human plasma-based biopharmaceutical products to hospitals and inoculation centers in the People's Republic of China. It offers human albumin for treating shock caused by blood loss trauma or burn; raised intracranial pressure caused by hydrocephalus or trauma; oedema or ascites caused by hepatocirrhosis and nephropathy; and neonatal hyperbilirubinemia, as well as for the prevention and treatment of low-density-lipoproteinemia. The company also provides human immunoglobulin and IVIG for original and secondary immunoglobulin deficiency, auto-immune deficiency, and immunoglobulin G secondary deficiency; human hepatitis B immunoglobulin for the prevention of measles and contagious hepatitis; human rabies immunoglobulin primarily for passive immunity from bites or claws by rabies or other infected animals; and human tetanus immunoglobulin for the prevention and therapy of tetanus. In addition, it offers placenta polypeptide for the treatment of cell immunity deficiency diseases, viral infection, and leucopenia, as well as assists in postoperative healing; factor VIII for treating coagulopathies; human fibrinogen; and human prothrombin complex concentrate for treating congenital and acquired clotting factor II, VII, IX, X deficiency, as well as excessive anticoagulant, vitamin K deficiency, etc. Further, the company is developing Human fibrinogen for the treatment for lack of fibrinogen and increase human fibrinogen concentration; and artificial dura and spinal dura mater products for use in brain and spinal surgeries. The company sells its products directly, as well as through distributors. The company was formerly known as China Biologic Products, Inc. and changed its name to China Biologic Products Holdings, Inc. in July 2017. China Biologic Products Holdings, Inc. is headquartered in Beijing, the People's Republic of China.
CRISPR Therapeutics logo

CRISPR Therapeutics

NASDAQ:CRSP
CRISPR Therapeutics is a gene-editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene-editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic collaborations with companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, Massachusetts, and business offices in San Francisco, California and London, United Kingdom. For more information, please visit www.crisprtx.com.
Halozyme Therapeutics logo

Halozyme Therapeutics

NASDAQ:HALO
Halozyme Therapeutics, Inc., a biopharma technology platform company, researches, develops, and commercializes proprietary enzymes and devices in the United States, Switzerland, Belgium, Japan, and internationally. The company's products are based on the patented recombinant human hyaluronidase enzyme (rHuPH20) that enables delivery of injectable biologics, such as monoclonal antibodies and other therapeutic molecules, as well as small molecules and fluids. It offers Hylenex recombinant, a formulation of rHuPH20 to facilitate subcutaneous (SC) fluid administration for achieving hydration to enhance the dispersion and absorption of other injected drugs in SC urography and to enhance resorption of radiopaque agents; rilpivirine, cabotegravir, and N6LS BNAB for the treatment of HIV; ocrelizumab for multiple sclerosis; XYOSTED, an injection for SC administration of testosterone replacement therapy; and ATRS-1902, a proprietary drug device combination product. The company also provides Herceptin (trastuzumab), Herceptin Hylecta, and Phesgo to treat breast cancer; Mabthera SC for the treatment of chronic lymphocytic leukemia; HYQVIA to treat primary immunodeficiency disorders; and DARZALEX for patients with amyloidosis, smoldering myeloma, and multiple myeloma. In addition, it offers Epinephrine Injection to treat allergic reactions; nivolumab+relatlimab and ANTI-TIM3 for the treatment of solid tumors; ARGX-117 for multifocal motor neuropathy; atezolizumab; nivolumab; afgartigimod; teriparatide injections; and OTREXUP, a SC methotrexate injection for adults with severe active rheumatoid arthritis and severe recalcitrant psoriasis, as well as children with active polyarticular juvenile idiopathic arthritis. Further, the company provides ATRS-1902 for adrenal crisis rescue; ARGX-113; and ARGX-117 to treat severe autoimmune diseases in multifocal motor neuropathy. Halozyme Therapeutics, Inc. was founded in 1998 and is headquartered in San Diego, California.
Novavax logo

Novavax

NASDAQ:NVAX
Novavax, Inc., a biotechnology company, that promotes improved health by discovering, developing, and commercializing vaccines to protect against serious infectious diseases. It offers vaccine platform that combines a recombinant protein approach, nanoparticle technology, and its patented Matrix-M adjuvant to enhance the immune response. It focuses on urgent health challenges, which is evaluating vaccines for COVID-19, influenza, and COVID-19 influenza combination. The company is commercializing a COVID-19 vaccine, NVX-CoV2373 under the brand names of Nuvaxovid, Covovax, and Novavax COVID-19 Vaccine, adjuvanted for adult and adolescent populations as a primary series and for both homologous and heterologous booster indications. It is also developing R21/Matrix-M adjuvant malaria vaccine. Novavax, Inc. was incorporated in 1987 and is headquartered in Gaithersburg, Maryland.
Spark Therapeutics logo

Spark Therapeutics

NASDAQ:ONCE
Spark Therapeutics, Inc. focuses on the development of gene therapy products for patients suffering from debilitating genetic diseases. Its products include LUXTURNA (voretigene neparvovec) for the treatment of patients with confirmed biallelic RPE65 mutation-associated retinal dystrophy and viable retinal cells. The company's gene therapy product candidates comprise SPK-8011 and SPK-8016 for hemophilia; SPK-7001 for choroideremia; and SPK-9001 for hemophilia B. It is also developing other liver-directed gene therapies, including SPK-3006 for Pompe disease; and neurodegenerative disease product candidates to address Huntington's disease and others, as well as TPP1 deficiency, which is a form of Batten disease. The company's preclinical programs targets inherited retinal diseases, including Stargardt's disease. The company has collaboration agreement with Pfizer, Inc. for the development and commercialization of SPK-FIX product candidates in its gene therapy program for the treatment of hemophilia B. It also has licensing and commercialization agreement with Novartis to develop and commercialize voretigene neparvovec outside the United States. Spark Therapeutics, Inc. was founded in 2013 and is headquartered in Philadelphia, Pennsylvania.