S&P 500   4,967.23
DOW   37,986.40
QQQ   414.65
How major US stock indexes fared Friday, 4/19/2024
Stock market today: Tumbling tech stocks drag Wall Street to the finish line of another losing week
American Express profits jump 34%, helped by jump in new customers, higher spending
American Express, Fifth Third rise; Netflix, PPG Industries fall, Friday, 4/19/2024
Intuitive Surgical Stock Can Trend Much Higher This Year 
3 Magnificent Seven Stocks Outperforming the Rest
Bargain Hunting: 3 Stocks With RSIs That Scream Oversold
S&P 500   4,967.23
DOW   37,986.40
QQQ   414.65
How major US stock indexes fared Friday, 4/19/2024
Stock market today: Tumbling tech stocks drag Wall Street to the finish line of another losing week
American Express profits jump 34%, helped by jump in new customers, higher spending
American Express, Fifth Third rise; Netflix, PPG Industries fall, Friday, 4/19/2024
Intuitive Surgical Stock Can Trend Much Higher This Year 
3 Magnificent Seven Stocks Outperforming the Rest
Bargain Hunting: 3 Stocks With RSIs That Scream Oversold
S&P 500   4,967.23
DOW   37,986.40
QQQ   414.65
How major US stock indexes fared Friday, 4/19/2024
Stock market today: Tumbling tech stocks drag Wall Street to the finish line of another losing week
American Express profits jump 34%, helped by jump in new customers, higher spending
American Express, Fifth Third rise; Netflix, PPG Industries fall, Friday, 4/19/2024
Intuitive Surgical Stock Can Trend Much Higher This Year 
3 Magnificent Seven Stocks Outperforming the Rest
Bargain Hunting: 3 Stocks With RSIs That Scream Oversold
S&P 500   4,967.23
DOW   37,986.40
QQQ   414.65
How major US stock indexes fared Friday, 4/19/2024
Stock market today: Tumbling tech stocks drag Wall Street to the finish line of another losing week
American Express profits jump 34%, helped by jump in new customers, higher spending
American Express, Fifth Third rise; Netflix, PPG Industries fall, Friday, 4/19/2024
Intuitive Surgical Stock Can Trend Much Higher This Year 
3 Magnificent Seven Stocks Outperforming the Rest
Bargain Hunting: 3 Stocks With RSIs That Scream Oversold

Compare Stocks

Comparative Price Performance Over Time

Compare Stocks - Price & Volume

CompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's Volume
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
$8.69
+1.0%
$9.29
$5.57
$11.46
$3.18B0.852.79 million shs2.90 million shs
Grifols, S.A. stock logo
GRFS
Grifols
$6.28
-4.0%
$7.13
$5.30
$12.15
$4.32B0.562.97 million shs1.24 million shs
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
$109.94
+0.6%
$120.08
$106.61
$146.70
$6.93B0.59615,330 shs756,641 shs
Mirati Therapeutics, Inc. stock logo
MRTX
Mirati Therapeutics
$58.70
$58.82
$27.30
$64.41
$4.12B0.772.76 million shsN/A
United Therapeutics Co. stock logo
UTHR
United Therapeutics
$237.93
+0.4%
$231.71
$204.44
$261.54
$11.20B0.52434,215 shs395,447 shs
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Price Performance

Company1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year Performance
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
-0.58%-3.96%-9.70%+5.71%+14.34%
Grifols, S.A. stock logo
GRFS
Grifols
-0.61%-1.65%+7.92%-3.25%-13.03%
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
+2.03%-3.72%-12.58%-6.24%-24.69%
Mirati Therapeutics, Inc. stock logo
MRTX
Mirati Therapeutics
0.00%0.00%0.00%-0.17%+38.12%
United Therapeutics Co. stock logo
UTHR
United Therapeutics
+0.69%-0.13%-1.03%+8.76%+4.52%

MarketRank™

CompanyOverall ScoreAnalyst's OpinionShort Interest ScoreDividend StrengthESG ScoreNews and Social Media SentimentCompany OwnershipEarnings & Valuation
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
3.9487 of 5 stars
3.23.00.04.03.11.70.6
Grifols, S.A. stock logo
GRFS
Grifols
3.625 of 5 stars
2.85.00.80.01.80.03.8
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
4.8392 of 5 stars
4.41.00.04.02.63.32.5
Mirati Therapeutics, Inc. stock logo
MRTX
Mirati Therapeutics
0.1622 of 5 stars
1.10.00.04.70.00.00.6
United Therapeutics Co. stock logo
UTHR
United Therapeutics
4.4126 of 5 stars
3.50.00.04.63.33.31.9

Analyst Ratings

CompanyConsensus Rating ScoreConsensus RatingConsensus Price Target% Upside from Current Price
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
2.33
Hold$13.0049.60% Upside
Grifols, S.A. stock logo
GRFS
Grifols
1.67
Reduce$10.5067.20% Upside
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
2.85
Moderate Buy$195.0877.45% Upside
Mirati Therapeutics, Inc. stock logo
MRTX
Mirati Therapeutics
2.21
Hold$60.002.21% Upside
United Therapeutics Co. stock logo
UTHR
United Therapeutics
2.90
Moderate Buy$292.6723.01% Upside

Current Analyst Ratings

Latest UTHR, BHC, JAZZ, MRTX, and GRFS Analyst Ratings

DateCompanyBrokerageActionRatingPrice TargetDetails
4/12/2024
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
Royal Bank of Canada
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Reiterated RatingSector Perform ➝ Sector Perform$12.00
4/10/2024
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
Cantor Fitzgerald
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Reiterated RatingOverweight ➝ Overweight$180.00
4/5/2024
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
Royal Bank of Canada
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Boost Price TargetSector Perform ➝ Sector Perform$9.00 ➝ $12.00
3/22/2024
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
JPMorgan Chase & Co.
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Boost Price TargetOverweight ➝ Overweight$170.00 ➝ $190.00
3/22/2024
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
Cantor Fitzgerald
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Reiterated RatingOverweight ➝ Overweight$180.00
3/20/2024
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
Truist Financial
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Reiterated RatingBuy ➝ Buy$200.00
3/20/2024
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
Needham & Company LLC
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Reiterated RatingBuy ➝ Buy$220.00
3/20/2024
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
Piper Sandler
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Boost Price TargetOverweight ➝ Overweight$171.00 ➝ $188.00
3/15/2024
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
Stifel Nicolaus
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Boost Price TargetBuy ➝ Buy$225.00 ➝ $230.00
3/14/2024
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
HC Wainwright
Subscribe to MarketBeat All Access for the recommendation accuracy rating
Lower Price TargetBuy ➝ Buy$204.00 ➝ $200.00
3/12/2024
Grifols, S.A. stock logo
GRFS
Grifols
Deutsche Bank Aktiengesellschaft
Subscribe to MarketBeat All Access for the recommendation accuracy rating
DowngradeHold ➝ Sell
(Data available from 4/19/2021 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Sales & Book Value

CompanyAnnual RevenuePrice/SalesCashflowPrice/CashBook ValuePrice/Book
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
$8.76B0.36$7.24 per share1.20($0.23) per share-37.78
Grifols, S.A. stock logo
GRFS
Grifols
$6.59B0.66$0.75 per share8.34$12.61 per share0.50
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
$3.83B1.81$28.56 per share3.85$59.36 per share1.85
Mirati Therapeutics, Inc. stock logo
MRTX
Mirati Therapeutics
$12.44M331.01N/AN/A$17.31 per share3.39
United Therapeutics Co. stock logo
UTHR
United Therapeutics
$2.33B4.81$22.34 per share10.65$127.35 per share1.87

Profitability & Earnings

CompanyNet IncomeEPSTrailing P/E RatioForward P/E RatioP/E GrowthNet MarginsReturn on Equity (ROE)Return on Assets (ROA)Next Earnings Date
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
-$592M-$1.62N/A2.14N/A-6.76%5,147.48%4.84%5/2/2024 (Estimated)
Grifols, S.A. stock logo
GRFS
Grifols
$131.34MN/A0.004.620.261.84%1.73%0.66%N/A
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
$414.83M$6.1217.965.901.4810.82%31.27%9.81%5/1/2024 (Confirmed)
Mirati Therapeutics, Inc. stock logo
MRTX
Mirati Therapeutics
-$740.87M-$12.22N/AN/AN/A-1,900.65%-82.15%-67.82%N/A
United Therapeutics Co. stock logo
UTHR
United Therapeutics
$984.80M$19.8411.999.70N/A42.31%17.72%14.47%5/1/2024 (Estimated)

Latest UTHR, BHC, JAZZ, MRTX, and GRFS Earnings

DateQuarterCompanyConsensus EstimateReported EPSBeat/MissGap EPSRevenue EstimateActual RevenueDetails
5/1/2024N/A
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
$3.55N/A-$3.55N/AN/AN/A  
2/28/2024Q4 2023
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
$4.44$4.40-$0.04$7.38$1.01 billion$1.01 billion    
2/22/2024Q4 2023
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
$1.01$1.15+$0.14$2.41$2.29 billion$2.41 billion    
2/21/202412/31/2023
United Therapeutics Co. stock logo
UTHR
United Therapeutics
$4.28$4.36+$0.08$4.36$575.01 million$614.70 million      

Dividends

CompanyAnnual PayoutDividend Yield3-Year Dividend GrowthPayout RatioYears of Consecutive Growth
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
N/AN/AN/AN/AN/A
Grifols, S.A. stock logo
GRFS
Grifols
$0.365.73%N/AN/AN/A
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
N/AN/AN/AN/AN/A
Mirati Therapeutics, Inc. stock logo
MRTX
Mirati Therapeutics
N/AN/AN/AN/AN/A
United Therapeutics Co. stock logo
UTHR
United Therapeutics
N/AN/AN/AN/AN/A

Debt

CompanyDebt-to-Equity RatioCurrent RatioQuick Ratio
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
N/A
1.30
0.94
Grifols, S.A. stock logo
GRFS
Grifols
1.24
2.83
1.32
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
1.37
2.24
1.85
Mirati Therapeutics, Inc. stock logo
MRTX
Mirati Therapeutics
N/A
7.54
7.40
United Therapeutics Co. stock logo
UTHR
United Therapeutics
0.05
4.41
4.28

Ownership

Institutional Ownership

CompanyInstitutional Ownership
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
78.65%
Grifols, S.A. stock logo
GRFS
Grifols
N/A
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
89.14%
Mirati Therapeutics, Inc. stock logo
MRTX
Mirati Therapeutics
N/A
United Therapeutics Co. stock logo
UTHR
United Therapeutics
94.08%

Miscellaneous

CompanyEmployeesShares OutstandingFree FloatOptionable
Bausch Health Companies Inc. stock logo
BHC
Bausch Health Companies
20,270365.41 million335.74 millionOptionable
Grifols, S.A. stock logo
GRFS
Grifols
26,314687.56 millionN/AOptionable
Jazz Pharmaceuticals plc stock logo
JAZZ
Jazz Pharmaceuticals
2,80063.00 million60.23 millionOptionable
Mirati Therapeutics, Inc. stock logo
MRTX
Mirati Therapeutics
58770.15 million67.86 millionOptionable
United Therapeutics Co. stock logo
UTHR
United Therapeutics
1,16847.06 million41.18 millionOptionable

UTHR, BHC, JAZZ, MRTX, and GRFS Headlines

SourceHeadline
United Therapeutics Co. (NASDAQ:UTHR) CEO Martine A. Rothblatt Sells 3,600 SharesUnited Therapeutics Co. (NASDAQ:UTHR) CEO Martine A. Rothblatt Sells 3,600 Shares
marketbeat.com - April 19 at 6:44 PM
Leerink Partnrs Comments on United Therapeutics Co.s FY2024 Earnings (NASDAQ:UTHR)Leerink Partnrs Comments on United Therapeutics Co.'s FY2024 Earnings (NASDAQ:UTHR)
marketbeat.com - April 19 at 8:50 AM
Martine A. Rothblatt Sells 3,600 Shares of United Therapeutics Co. (NASDAQ:UTHR) StockMartine A. Rothblatt Sells 3,600 Shares of United Therapeutics Co. (NASDAQ:UTHR) Stock
americanbankingnews.com - April 19 at 4:34 AM
United Therapeutics: Strategic Expansion and Competitive Edge Reinforce Outperform RatingUnited Therapeutics: Strategic Expansion and Competitive Edge Reinforce Outperform Rating
markets.businessinsider.com - April 18 at 8:23 AM
United Therapeutics Co. (NASDAQ:UTHR) CEO Sells $835,380.00 in StockUnited Therapeutics Co. (NASDAQ:UTHR) CEO Sells $835,380.00 in Stock
insidertrades.com - April 18 at 6:16 AM
United Therapeutics Co. (NASDAQ:UTHR) to Post Q1 2024 Earnings of $5.93 Per Share, Leerink Partnrs ForecastsUnited Therapeutics Co. (NASDAQ:UTHR) to Post Q1 2024 Earnings of $5.93 Per Share, Leerink Partnrs Forecasts
americanbankingnews.com - April 18 at 5:48 AM
Insider Selling: United Therapeutics Co. (NASDAQ:UTHR) CEO Sells 3,600 Shares of StockInsider Selling: United Therapeutics Co. (NASDAQ:UTHR) CEO Sells 3,600 Shares of Stock
marketbeat.com - April 17 at 6:38 PM
United Therapeutics CEO Martine Rothblatt sells shares worth over $1.7 millionUnited Therapeutics CEO Martine Rothblatt sells shares worth over $1.7 million
investing.com - April 16 at 11:57 PM
United Therapeutics to Feature Clinical Data Across its Commercial and Development Portfolio at the American Thoracic Society 2024 International ConferenceUnited Therapeutics to Feature Clinical Data Across its Commercial and Development Portfolio at the American Thoracic Society 2024 International Conference
finance.yahoo.com - April 16 at 8:55 AM
Louisiana State Employees Retirement System Makes New $2.90 Million Investment in United Therapeutics Co. (NASDAQ:UTHR)Louisiana State Employees Retirement System Makes New $2.90 Million Investment in United Therapeutics Co. (NASDAQ:UTHR)
marketbeat.com - April 16 at 6:51 AM
United Therapeutics Co. (NASDAQ:UTHR) CEO Sells $847,512.00 in StockUnited Therapeutics Co. (NASDAQ:UTHR) CEO Sells $847,512.00 in Stock
insidertrades.com - April 16 at 4:19 AM
Martine A. Rothblatt Sells 13,800 Shares of United Therapeutics Co. (NASDAQ:UTHR) StockMartine A. Rothblatt Sells 13,800 Shares of United Therapeutics Co. (NASDAQ:UTHR) Stock
insidertrades.com - April 13 at 4:54 AM
United Therapeutics (NASDAQ:UTHR) Stock Rating Lowered by StockNews.comUnited Therapeutics (NASDAQ:UTHR) Stock Rating Lowered by StockNews.com
americanbankingnews.com - April 13 at 1:38 AM
Innovation in Healthcare: HTEC’s Q1 2024 Index RebalanceInnovation in Healthcare: HTEC’s Q1 2024 Index Rebalance
finance.yahoo.com - April 12 at 3:30 PM
United Therapeutics Co. (NASDAQ:UTHR) Shares Sold by Allspring Global Investments Holdings LLCUnited Therapeutics Co. (NASDAQ:UTHR) Shares Sold by Allspring Global Investments Holdings LLC
marketbeat.com - April 12 at 6:18 AM
United Therapeutics (NASDAQ:UTHR) Downgraded by StockNews.com to "Buy"United Therapeutics (NASDAQ:UTHR) Downgraded by StockNews.com to "Buy"
marketbeat.com - April 11 at 11:12 PM
United Therapeutics Co. (NASDAQ:UTHR) CEO Martine A. Rothblatt Sells 13,800 SharesUnited Therapeutics Co. (NASDAQ:UTHR) CEO Martine A. Rothblatt Sells 13,800 Shares
marketbeat.com - April 11 at 6:34 PM
United Therapeutics chairperson & CEO sells $4.73m in stockUnited Therapeutics chairperson & CEO sells $4.73m in stock
investing.com - April 11 at 1:41 PM
United Therapeutics Co. (NASDAQ:UTHR) Short Interest UpdateUnited Therapeutics Co. (NASDAQ:UTHR) Short Interest Update
americanbankingnews.com - April 11 at 3:36 AM
United Therapeutics Co. (NASDAQ:UTHR) CEO Martine A. Rothblatt Sells 5,060 Shares of StockUnited Therapeutics Co. (NASDAQ:UTHR) CEO Martine A. Rothblatt Sells 5,060 Shares of Stock
americanbankingnews.com - April 10 at 4:54 AM
Insider Selling: United Therapeutics Co. (NASDAQ:UTHR) CEO Sells 5,060 Shares of StockInsider Selling: United Therapeutics Co. (NASDAQ:UTHR) CEO Sells 5,060 Shares of Stock
insidertrades.com - April 10 at 4:53 AM
United Therapeutics Co. (NASDAQ:UTHR) CEO Sells $1,201,851.20 in StockUnited Therapeutics Co. (NASDAQ:UTHR) CEO Sells $1,201,851.20 in Stock
marketbeat.com - April 9 at 6:30 PM
United Therapeutics Co. (NASDAQ:UTHR) Shares Sold by TobamUnited Therapeutics Co. (NASDAQ:UTHR) Shares Sold by Tobam
marketbeat.com - April 9 at 11:47 AM
DekaBank Deutsche Girozentrale Boosts Holdings in United Therapeutics Co. (NASDAQ:UTHR)DekaBank Deutsche Girozentrale Boosts Holdings in United Therapeutics Co. (NASDAQ:UTHR)
marketbeat.com - April 8 at 7:13 AM

New MarketBeat Followers Over Time

Media Sentiment Over Time

Company Descriptions

Bausch Health Companies logo

Bausch Health Companies

NYSE:BHC
Bausch Health Companies Inc. operates as a diversified specialty pharmaceutical and medical device company in the United States and internationally. It develops, manufactures, and markets a range of products primarily in gastroenterology, hepatology, neurology, dermatology, international pharmaceuticals, over-the-counter (OTC) products, aesthetic medical devices, and eye health. The company operates through five segments: Salix, International, Solta Medical, Diversified, and Bausch + Lomb. The Salix segment provides gastroenterology products in the United States. The International segment sells aesthetic medical devices, branded pharmaceuticals, generic pharmaceuticals, and OTC products internationally. The Solta Medical segment engages in the sale of aesthetic medical devices. The Diversified segment offers pharmaceutical products in the areas of neurology and certain other therapeutic classes; generic products; ortho dermatologic; and dentistry products in the United States. The Bausch + Lomb segment offers products in the areas of vision care, surgical, and ophthalmic pharmaceuticals products. The company was formerly known as Valeant Pharmaceuticals International, Inc. and changed its name to Bausch Health Companies Inc. in July 2018. Bausch Health Companies Inc. is headquartered in Laval, Canada.
Grifols logo

Grifols

NASDAQ:GRFS
Grifols, S.A. operates as a plasma therapeutic company in Spain, the United States, Canada, and internationally. The company provides immunoglobulin to treat immunodeficiencies; albumin used to restore circulatory volume and protein loss in pathophysiological conditions, such as liver cirrhosis, cardiocirculatory failure, trauma and severe burns; alpha-1 proteinase inhibitor, a plasma protein, used to treat a genetic disease known as alpha-1; factorVIII/von Willerbrand factor and factor IX, clotting factors for the treatment of hemophilia A and von Willebrand's disease, as well as hemophilia B; antithrombin III to treat hereditary antithrombin deficiency; Fostamatinib, a spleen tyrosine kinase inhibitor; combination of fibrinogen and enzyme thrombin that acts as a biological sealant to control surgical bleeding; and plasma exchange with albumin used to treat Alzheimer's disease. It markets diagnostic testing equipment, reagents, and other equipment; biological products; manufactures and sells plasma to third parties; and involves in research activities, as well as markets pharmaceutical products for hospital pharmacies. In addition, the company offers Yimmugo PID, an immunology drug; and Yimmugo ITP, a hematology drug. Further, it develops Xembify Pre-filled syringes, FlexBag, and Prolastin vials; Xembify Biweekly dosing, Prolastin-C, Fostamatinib2, and VISTASEAL which are in Phase IV development stage; Xembify, Albumin 20% and 5%, Fibrinogen, Trimodulin, Cytotec pregnancy, and AMBAR-Next in Phase III development stage; and AKST4290 that is in Phase II clinical development. Additionally, it offers recIG, Alpha-1 AT in non-cystic fibrosis bronchiectasis, ATIII, GIGA 2339, GIGA564, and OSIG. It has collaboration agreements with Canadian Blood Services for the processing of other plasma-derived products and with GIANT; and GigaGen to develop recombinant polyclonal immunoglobulin therapies. The company was founded in 1909 and is headquartered in Barcelona, Spain.
Jazz Pharmaceuticals logo

Jazz Pharmaceuticals

NASDAQ:JAZZ
Jazz Pharmaceuticals plc identifies, develops, and commercializes pharmaceutical products for unmet medical needs in the United States, Europe, and internationally. The company offers Xywav for cataplexy or excessive daytime sleepiness (EDS) with narcolepsy and idiopathic hypersomnia; Xyrem to treat cataplexy or EDS with narcolepsy; Epidiolex for seizures associated with Lennox-Gastaut and Dravet syndromes, or tuberous sclerosis complex; Zepzelca to treat metastatic small cell lung cancer, or with disease progression on or after platinum-based chemotherapy; Rylaze for acute lymphoblastic leukemia or lymphoblastic lymphoma; Enrylaze to treat acute lymphoblastic leukemia and lymphoblastic lymphoma; Defitelio to treat severe hepatic veno-occlusive disease; and Vyxeos for newly-diagnosed therapy-related acute myeloid leukemia. It also develops Zanidatamab to treat HER2-expressing gastroesophageal adenocarcinoma (GEA), and patients with HER2-expressing metastatic GEA; Zepzelca for the treatment of patients with select relapsed/refractory solid tumors based on limited response in three solid tumor cohorts; JZP815, a pan-RAF kinase inhibitor that targets components of the mitogen-activated protein kinase; JZP898, a conditionally-activated interferon alpha molecule; Epidiolex to treat LGS, DS, and TSC; Suvecaltamide to treat parkinson's disease tremor; JZP150, a fatty acid amide hydrolase inhibitor program to treat post-traumatic stress disorder; and JZP441 to treat narcolepsy, IH, and other sleep disorders. The company has licensing and collaboration agreements with XL-protein GmbH to extend the plasma half-life of selected asparaginase product candidates; Redx Pharma plc for preclinical activities Ras/Raf/MAP kinase pathway program; and Autifony Therapeutics Limited on discovering and developing drug candidates targeting two different ion channel targets associated with neurological disorders. The company was incorporated in 2003 and is headquartered in Dublin, Ireland.
Mirati Therapeutics logo

Mirati Therapeutics

NASDAQ:MRTX
Mirati Therapeutics, Inc., a commercial-stage oncology company, develops novel therapeutics to address the genetic and immunological promoters of cancer in the United States. The company provides KRAZATI, an oral targeted treatment option for adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung (NSCLC), as well as in clinical development as a monotherapy and in combination with other agents. It also develops Sitravatinib, an investigational spectrum-selective kinase inhibitor in Phase 3 clinical development that inhibits receptor tyrosine kinases (RTKs), including TAM family receptors, split family receptors, and RET, which overcomes resistance to checkpoint inhibitor therapy through targeted reversal of an immunosuppressive tumor microenvironment that enhances antigen-specific T cell response and expanding dendritic cell-dependent antigen presentation. In addition, the company pipeline comprises the MRTX1719, an investigational synthetic lethal PRMT5 inhibitor designed to target the PRMT5/methylthioadensoine (MTA) complex and is in clinical development; MRTX0902, a selective SOS1 inhibitor that improves anti-tumor efficacy in combination with targeted mitogen-activated protein kinase (MAPK)-pathway inhibitors, and is in clinical development; and MRTX1133, an investigational lead KRAS G12D compound. It has a collaboration and license agreement with BeiGene, Ltd. to develop, manufacture, and commercialize sitravatinib; and Zai Lab Ltd. to research, develop, manufacture, and commercialize adagrasib in various indications. Mirati Therapeutics, Inc. was founded in 1995 and is headquartered in San Diego, California.
United Therapeutics logo

United Therapeutics

NASDAQ:UTHR
United Therapeutics Corporation, a biotechnology company, engages in the development and commercialization of products to address the unmet medical needs of patients with chronic and life-threatening diseases in the United States and internationally. The company offers Tyvaso DPI, an inhaled dry powder via pre-filled and single-use cartridges; Tyvaso, an inhaled solution via ultrasonic nebulizer; Remodulin (treprostinil) injection to treat patients with pulmonary arterial hypertension (PAH) to diminish symptoms associated with exercise; Orenitram, a tablet dosage form of treprostinil, to delay disease progression and improve exercise capacity in PAH patients; and Adcirca, an oral PDE-5 inhibitor to enhance the exercise ability in PAH patients. It also markets and sells Unituxin (dinutuximab) injection, a monoclonal antibody for treating high-risk neuroblastoma; and Remunity Pump, which contains a pump and separate controller for Remodulin. In addition, the company engages in developing RemoPro and Ralinepag for the treatment of PAH; Aurora-GT, a gene therapy product to rebuild the blood vessels in the lungs; and Nebulized Tyvaso, for the treatment of idiopathic pulmonary fibrosis, as well as xenografts, which are development-stage organ products. It has licensing and collaboration agreements with DEKA Research & Development Corp. to develop a semi-disposable system for the subcutaneous delivery of treprostinil; MannKind Corporation to develop and license treprostinil inhalation powder and the Dreamboat device; and Arena Pharmaceuticals, Inc. to develop Ralinepag. The company was incorporated in 1996 and is headquartered in Silver Spring, Maryland.