Opaleye Management Inc. Top Holdings and 13F Report (2024) → SHOCKING Crypto Leak… (From Crypto 101 Media) (Ad) About Opaleye Management Inc.Investment ActivityOpaleye Management Inc. has $458.86 million in total holdings as of March 31, 2024.Opaleye Management Inc. owns shares of 52 different stocks, but just 22 companies or ETFs make up 80% of its holdings.Approximately 16.80% of the portfolio was purchased this quarter.About 17.06% of the portfolio was sold this quarter.This quarter, Opaleye Management Inc. has purchased 46 new stocks and bought additional shares in 16 stocks.Opaleye Management Inc. sold shares of 15 stocks and completely divested from 8 stocks this quarter.Largest Holdings Ocular Therapeutix $60,543,556Harrow $51,869,538TG Therapeutics $34,678,800Keros Therapeutics $24,328,500Rhythm Pharmaceuticals $22,314,950 Largest New Holdings this Quarter JASPER THERAPEUTICS INC $12,788,423 HoldingLyell Immunopharma $7,481,650 HoldingCompass Therapeutics $6,276,600 HoldingSavara $4,257,900 HoldingNurix Therapeutics $3,927,987 Holding Largest Purchases this Quarter JASPER THERAPEUTICS INC 435,573 shares (about $12.79M)Lyell Immunopharma 3,355,000 shares (about $7.48M)Compass Therapeutics 3,170,000 shares (about $6.28M)Ocular Therapeutix 583,138 shares (about $5.31M)Applied Therapeutics 677,500 shares (about $4.61M) Largest Sales this Quarter Acelyrin 2,566,138 shares (about $17.32M)Crinetics Pharmaceuticals 97,500 shares (about $4.56M)Rhythm Pharmaceuticals 95,000 shares (about $4.12M)Catalyst Pharmaceuticals 252,845 shares (about $4.03M)Larimar Therapeutics 449,087 shares (about $3.41M) Sector Allocation Over TimeMap of 500 Largest Holdings ofOpaleye Management Inc. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorOCULOcular Therapeutix$60,543,556$5,306,556 ▲9.6%6,653,13813.2%MedicalHROWHarrow$51,869,538$1,330,938 ▲2.6%3,920,60011.3%MedicalTGTXTG Therapeutics$34,678,800$988,650 ▲2.9%2,280,0007.6%MedicalKROSKeros Therapeutics$24,328,500$662,000 ▲2.8%367,5005.3%MedicalRYTMRhythm Pharmaceuticals$22,314,950$4,116,350 ▼-15.6%515,0004.9%MedicalCPRXCatalyst Pharmaceuticals$16,009,419$4,030,349 ▼-20.1%1,004,3553.5%MedicalARVNArvinas$13,622,400$2,736,864 ▲25.1%330,0003.0%MedicalIOVAIovance Biotherapeutics$13,293,5400.0%897,0002.9%MedicalJASPER THERAPEUTICS INC$12,788,423$12,788,423 ▲New Holding435,5732.8%COM NEWEWTXEdgewise Therapeutics$12,129,600$620,160 ▼-4.9%665,0002.6%MedicalAPLTApplied Therapeutics$12,036,000$4,607,000 ▲62.0%1,770,0002.6%MedicalFDMT4D Molecular Therapeutics$10,963,759$1,134,949 ▲11.5%344,1232.4%MedicalCDXSCodexis$10,888,800$259,918 ▲2.4%3,120,0002.4%MedicalTARAProtara Therapeutics$10,797,3020.0%2,692,5942.4%MedicalSLRNAcelyrin$10,665,000$17,321,432 ▼-61.9%1,580,0002.3%MedicalCRNXCrinetics Pharmaceuticals$9,830,100$4,563,975 ▼-31.7%210,0002.1%MedicalETONEton Pharmaceuticals$9,171,679$315,398 ▼-3.3%2,445,7812.0%MedicalTRVITrevi Therapeutics$9,125,250$379,500 ▲4.3%2,645,0002.0%MedicalLYELLyell Immunopharma$7,481,650$7,481,650 ▲New Holding3,355,0001.6%MedicalNAMSNewAmsterdam Pharma$7,458,926$1,182,500 ▲18.8%315,3881.6%MedicalVTYXVentyx Biosciences$7,067,500$797,500 ▲12.7%1,285,0001.5%MedicalNTLAIntellia Therapeutics$7,015,050$4,291,560 ▲157.6%255,0001.5%MedicalCMPXCompass Therapeutics$6,276,600$6,276,600 ▲New Holding3,170,0001.4%MedicalXOMAXOMA$6,012,5000.0%250,0001.3%MedicalLQDALiquidia$5,826,250$737,500 ▼-11.2%395,0001.3%MedicalPCVXVaxcyte$5,806,350$341,550 ▼-5.6%85,0001.3%MedicalNYXHNyxoah$4,316,800$334,552 ▼-7.2%320,0000.9%MedicalSVRASavara$4,257,900$4,257,900 ▲New Holding855,0000.9%MedicalSYRSSyros Pharmaceuticals$4,212,831$2,290,446 ▲119.1%787,5450.9%MedicalURGNUroGen Pharma$4,050,000$750,000 ▼-15.6%270,0000.9%MedicalNRIXNurix Therapeutics$3,927,987$3,927,987 ▲New Holding267,2100.9%MedicalRVNCRevance Therapeutics$3,862,200$3,862,200 ▲New Holding785,0000.8%MedicalRLMDRelmada Therapeutics$3,529,350$548,700 ▼-13.5%759,0000.8%MedicalPTGXProtagonist Therapeutics$3,260,4110.0%112,7000.7%MedicalGOSSAMER BIO INC$3,212,9280.0%8,000,0000.7%NOTE 5.000% 6/0ZNTLZentalis Pharmaceuticals$3,152,000$3,152,000 ▲New Holding200,0000.7%MedicalALLKAllakos$3,068,100$3,068,100 ▲New Holding2,435,0000.7%MedicalGOSSGossamer Bio$2,879,329$639,667 ▼-18.2%2,440,1090.6%MedicalIBIO INC$2,760,800$2,760,800 ▲New Holding680,0000.6%COM NEWVSTMVerastem$2,494,5200.0%211,4000.5%MedicalALGSAligos Therapeutics$1,597,400$326,340 ▲25.7%1,630,0000.3%MedicalCNTXContext Therapeutics$1,529,533$184,033 ▲13.7%1,108,3570.3%MedicalPGENPrecigen$1,373,875$94,250 ▼-6.4%947,5000.3%MedicalLRMRLarimar Therapeutics$1,323,795$3,408,571 ▼-72.0%174,4130.3%MedicalFULCFulcrum Therapeutics$1,227,2000.0%130,0000.3%MedicalMORMorphoSys$1,179,100$1,451,200 ▼-55.2%65,0000.3%MedicalGKOSGlaukos$808,631$808,631 ▲New Holding8,5760.2%MedicalPMVPPMV Pharmaceuticals$802,130$802,130 ▲New Holding471,4810.2%MedicalBDSXBiodesix$764,560$154,665 ▲25.4%534,6570.2%MedicalRGLSRegulus Therapeutics$490,487$490,487 ▲New Holding170,3080.1%MedicalDSGNDesign Therapeutics$455,543$455,543 ▲New Holding113,0380.1%MedicalRPTXRepare Therapeutics$318,212$318,212 ▲New Holding67,5610.1%MedicalIDYAIDEAYA Biosciences$0$11,083,170 ▼-100.0%00.0%MedicalBHVNBiohaven$0$8,560,000 ▼-100.0%00.0%MedicalARQTArcutis Biotherapeutics$0$6,330,800 ▼-100.0%00.0%MedicalMRNSMarinus Pharmaceuticals$0$6,125,245 ▼-100.0%00.0%MedicalJSPRJasper Therapeutics$0$3,144,433 ▼-100.0%00.0%MedicalKALVKalVista Pharmaceuticals$0$1,837,500 ▼-100.0%00.0%MedicalSTROSutro Biopharma$0$1,293,396 ▼-100.0%00.0%MedicalKNSAKiniksa Pharmaceuticals$0$640,210 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data: SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools: Best-in-Class Portfolio Monitoring View the latest news, buy/sell ratings, SEC filings and insider transactions for your stocks. Compare your portfolio performance to leading indices and get personalized stock ideas based on your portfolio. Stock Ideas and Recommendations Get daily stock ideas from top-performing Wall Street analysts. Get short term trading ideas from the MarketBeat Idea Engine. View which stocks are hot on social media with MarketBeat's trending stocks report. Advanced Stock Screeners and Research Tools Identify stocks that meet your criteria using seven unique stock screeners. See what's happening in the market right now with MarketBeat's real-time news feed. 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