Vr Adviser, LLC Top Holdings and 13F Report (2025) About Vr Adviser, LLCInvestment ActivityVr Adviser, LLC has $1.18 billion in total holdings as of March 31, 2025.Vr Adviser, LLC owns shares of 37 different stocks, but just 12 companies or ETFs make up 80% of its holdings.Approximately 12.92% of the portfolio was purchased this quarter.About 6.03% of the portfolio was sold this quarter.This quarter, Vr Adviser, LLC has purchased 37 new stocks and bought additional shares in 4 stocks.Vr Adviser, LLC sold shares of 7 stocks and completely divested from 4 stocks this quarter.Largest Holdings APOGEE THERAPEUTICS INC $317,310,473METSERA INC $102,093,020Ocular Therapeutix $93,548,846Enliven Therapeutics $79,238,194KalVista Pharmaceuticals $77,363,987 Largest New Holdings this Quarter 59267L107 - METSERA INC $102,093,020 Holding83422E204 - Solid Biosciences $9,181,180 Holding805111101 - Savara $9,023,660 Holding86889P208 - SURROZEN INC $7,379,975 Holding Largest Purchases this Quarter METSERA INC 3,750,662 shares (about $102.09M)Solid Biosciences 2,481,400 shares (about $9.18M)Savara 3,257,639 shares (about $9.02M)ORUKA THERAPEUTICS INC 862,808 shares (about $8.85M)SURROZEN INC 632,931 shares (about $7.38M) Largest Sales this Quarter 4D Molecular Therapeutics 2,274,771 shares (about $7.35M)ORIC Pharmaceuticals 1,212,000 shares (about $6.76M)Trevi Therapeutics 650,951 shares (about $4.09M)Mersana Therapeutics 6,683,465 shares (about $2.30M)Applied Therapeutics 4,422,882 shares (about $2.16M) Sector Allocation Over TimeMap of 500 Largest Holdings ofVr Adviser, LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorAPOGEE THERAPEUTICS INC$317,310,4730.0%8,493,32127.0%COMMETSERA INC$102,093,020$102,093,020 ▲New Holding3,750,6628.7%COMOCULOcular Therapeutix$93,548,8460.0%12,762,4628.0%MedicalELVNEnliven Therapeutics$79,238,1940.0%4,026,3316.7%MedicalKALVKalVista Pharmaceuticals$77,363,987$5,242,091 ▲7.3%6,703,9856.6%MedicalVRDNViridian Therapeutics$52,338,9170.0%3,882,7094.5%MedicalPHVSPharvaris$48,869,704$1,686,337 ▼-3.3%3,112,7204.2%MedicalSPYRE THERAPEUTICS INC$43,329,7030.0%2,685,4483.7%COM NEWORUKA THERAPEUTICS INC$42,562,871$8,852,410 ▲26.3%4,148,4283.6%COMPRAXIS PRECISION MEDICINES I$37,490,7320.0%989,9853.2%COM NEWCOGTCogent Biosciences$34,049,6220.0%5,684,4112.9%MedicalDIANTHUS THERAPEUTICS INC$31,642,9260.0%1,744,3732.7%COMDYNE THERAPEUTICS INC$22,739,1300.0%2,173,9131.9%COMCIDARA THERAPEUTICS INC$22,649,698$6,156,024 ▲37.3%1,051,5181.9%COM NEWENGENE HOLDINGS INC$22,607,9350.0%5,046,4141.9%COMERASErasca$22,216,2160.0%16,216,2161.9%MedicalORICORIC Pharmaceuticals$17,758,501$6,762,960 ▼-27.6%3,182,5271.5%MedicalUPSTREAM BIO INC$14,047,3520.0%2,295,3191.2%COMATXSAstria Therapeutics$13,122,2380.0%2,457,3481.1%MedicalCGEMCullinan Therapeutics$10,446,3350.0%1,379,9650.9%MedicalSLDBSolid Biosciences$9,181,180$9,181,180 ▲New Holding2,481,4000.8%MedicalSVRASavara$9,023,660$9,023,660 ▲New Holding3,257,6390.8%MedicalABIVAX SA$8,411,1250.0%1,345,7800.7%SPONSORED ADSPERCEPTIVE CAP SOLUTIONS COR$7,725,0000.0%750,0000.7%CL A ORD SHSSURROZEN INC$7,379,975$7,379,975 ▲New Holding632,9310.6%COM NEWZURAZura Bio$6,479,884$3,870,000 ▲148.3%5,023,1660.6%MedicalARTIVA BIOTHERAPEUTICS INC$4,828,7070.0%1,609,5690.4%COMTRVITrevi Therapeutics$3,871,533$4,094,482 ▼-51.4%615,5060.3%MedicalAPLTApplied Therapeutics$2,722,053$2,162,347 ▼-44.3%5,567,7090.2%MedicalFDMT4D Molecular Therapeutics$2,188,648$7,347,510 ▼-77.0%677,6000.2%MedicalCASICASI Pharmaceuticals$2,132,4790.0%987,2590.2%MedicalTENAX THERAPEUTICS INC$1,364,5810.0%208,3330.1%COM NEWMRSNMersana Therapeutics$1,230,283$2,300,449 ▼-65.2%3,574,3250.1%MedicalIPSCCentury Therapeutics$1,189,081$694,540 ▼-36.9%2,498,0690.1%MedicalTNYATenaya Therapeutics$886,8220.0%1,555,5560.1%MedicalGLYCGlycoMimetics$630,0000.0%3,000,0000.1%MedicalINSTIL BIO INC$575,9530.0%33,1770.0%COM NEWMRUSMerus$0$24,910,883 ▼-100.0%00.0%MedicalAQSTAquestive Therapeutics$0$9,362,038 ▼-100.0%00.0%MedicalTERNTerns Pharmaceuticals$0$5,967,079 ▼-100.0%00.0%MedicalTSHATaysha Gene Therapies$0$5,579,561 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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