Aptose Biosciences Q3 2023 Earnings Call Transcript

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Provided by Quartr
November 9, 2023

There are 6 speakers on the call.

Operator

Good afternoon. My name is Hope, and I will be your conference operator today. I would like to welcome everyone to the Aptose Biosciences Conference Call for the Q3 Ended September 30, 2023. At this time, all participants are in a listen only mode. After the speakers' remarks, there will be a question and answer session.

Operator

11 on your telephone. You will then hear an automated message advising that your hand is raised. If you would like to withdraw your question, Thank you. As a reminder, this conference call may be recorded. I would now like to introduce Ms.

Operator

Susan Pietropaolo. Please go ahead.

Speaker 1

Thank you, Hope. Good afternoon, and welcome to the Aptose Biosciences conference call to discuss financial and operational results for the Q3 ended September 30, 2023. Earlier today, Aptose issued a press release relating to these financial results. The news release as well as related SEC filings are accessible on Aptose's website. Joining me on today's call are Doctor.

Speaker 1

William Rice, Chairman, President and CEO Doctor. Rafael Behar, Senior Vice President and Chief Medical Officer and Mr. Fletcher Payne, Senior Vice President and Chief Financial Officer. Before we proceed, I would like to remind everyone that certain statements made during this call will include forward looking statements within the meaning of U. S.

Speaker 1

And Canadian Securities Laws. Forward looking statements reflect Aptose's current expectations regarding future events. They are not guarantees of performance, and it is possible that actual results and performance could differ materially from these stated expectations. Call. They involve known and unknown risks, uncertainties and assumptions that may cause actual results, performance and achievement to differ materially from those expressed.

Speaker 1

To learn more about these risks and uncertainties, please read the risk factors set forth in Aptose's most recent annual report on Form 10 ks and SEC and SEDAR filings. Call. All forward looking statements made during this call speak only as of the date they are made. Aptose undertakes no obligation to revise or update the statements to reflect events or circumstances after the date of this call, except as required by law. We encourage you to refer to today's press release and the 10 Q for additional information and disclosures regarding today's announcements.

Speaker 1

I will now turn the call over to Doctor. Wright.

Speaker 2

Thank you, Susan. I want to welcome everyone to our call for the Q3 ended September 30, 2023. Today, I first want to remind everyone that earlier this year, We knew we had an impressive lead agent in tusvetinib for the treatment of patients with AML, but we also had a limited cash runway to develop it. Strategically, we avoided any punitive financings and any potential warrant overhang. Rather, we extended the cash runway with an at the market or ATM facility with a committed equity facility and through an investment by our partner, Omni Pharmaceutical.

Speaker 2

This was designed to give us breathing room and time to collect critical data with tuspetinib that may drive improved financing terms and potential collaborations. We then undertook the ACTIVATE expansion trial to understand tasplatinib single agent activity and to identify relapsed or refractory AML populations with unmet needs and who are particularly sensitive to our tusbetinib plus venetoclax or tusdin doublet therapy. We learned that tuspatinib as a single agent at our 80 milligram recommended Phase 2 dose is highly active in patients naive to venetoclax. With CR CRH rates of 42% across all evaluable patients, 60% in FLT3 mutated patients and nearly 30% in FLT3 wild type patients, demonstrating potent single agent activity across a breadth of patients. But we also observed that as we dose escalated above 80 milligrams to higher dose levels of tespatinib as a single agent, The response rates unexpectedly dropped.

Speaker 2

Initially, we were unsure what was driving this difference, but after careful analysis, we learned that patients entering the higher dose levels of 120 milligrams and above represented entirely different patient population. At the point in time when we transitioned above the 80 milligram dose, suddenly more than 80% of the patients coming on to our trial had failed prior therapy with venetoclax and these VIN failure AML patients are known to be far less responsive to salvage therapy. The VIN failure patients continue to respond to tusvetinib as a single agent, but at a lower response rate. So that mystery was solved. But more importantly, this rapidly emerging bend failure population revealed a unique opportunity for tasbetinib.

Speaker 2

That's because tasplatinib targets the resistance mechanisms employed by AML to become resistance to venetoclax, which includes mutations in FLT3, KIT, JAK and RAS pathways and increases in Mcl-one expression. These bend resistance mechanisms play directly into the targeting capabilities of tuspetinib and suggested tuspetinib may resensitize bend failure patients to venetoclax and that the tuspatinib venetoclax or tuspin doublet may effectively treat this patient population in critical need of new therapies. And indeed, now we have learned that the TUS Bend doublet is clearly active in the relapsed or refractory, VIN failure AML patients. In August of this year, we released our first data from 10 evaluable patients that have received a TUS VIN doubling, 9 of whom were VIN failures. The composite complete remission or CR rate was 44% among the VIN failure patients, whether they were FLT3 mutated or FLT3 wall type.

Speaker 2

That was impressive and we continue to enroll these VIN failure patients onto the TUS VIN doublet. We then released a second data cut in September, showing roughly the same composite CR rates among 15 evaluable patients. These data then generated tremendous investigator enthusiasm to place additional patients on the TUSP and doublet. By the time we reached our planned presentation at the European School of Hematology Conference last week, we had expected a total of up to 30 patients to have been dosed with the Tustin doublet. But we actually had dosed 49 patients with the doublet as of our data cut on October 23.

Speaker 2

To be clear, many of these patients were very early in their course of treatment, just 2 to 6 weeks into the treatment in many cases. The composite CR rate at this point in time with these early patients was about 29%, plus additional partial responses or PRs that emerged early for an overall response rate of 48%. While those early PRs are not yet CRs and are not counted in the composite CR rate. They are noteworthy. For example, one patient entered the trial with a bone marrow blast count of 82% and dropped quickly to 7% after receiving the TUS Bend Doublet.

Speaker 2

That's a dramatic reduction in disease burden, but not quite below 5% in the bone marrow blast, so it scored as a PR. We'll continue to treat and watch such patients with the hope that many of these responses will mature to CRs over time. In fact, For all ongoing patients on the trial, we will continue to collect response maturation data and duration of response data. And to highlight our ability to execute this trial, we're approximately 2 quarters ahead of our expected enrollment rate in the Aptivate trial and that will allow us to watch for maturation of responses and extended duration of response data earlier than we had expected and to wrap up this trial up to 2 quarters earlier than we had expected. So what will we do with our findings?

Speaker 2

First, this sets us on the registrational path with the TUS bend doublet in relapsed or refractory then failure AML patients, inclusive of both FLT3 mutated and FLT3 wild type patients. And that registrational study could begin in the second half of twenty twenty four and potentially provide an accelerated approval pathway. 2nd, data with the tusbend doublet are segueing us into the tusbetinib, venetoclax azacitidine triplet pilot study in frontline newly diagnosed AML patients. That study is planned to begin the first half of twenty twenty four and the findings could then support a tus ben hypomethylating agent registrational trial in frontline AML. Tasfentanil has demonstrated potent activity across diverse AML groups with adverse mutations, has a favorable safety and tolerability profile, is convenient as a once daily oral tablet and mechanistically targets the venetoclax resistance mechanism.

Speaker 2

This makes tasplatinib an ideal drug for frontline combination therapy and for combination therapy in the relapsed or refractory AML populations, particularly for the emerging wave of patients who fell venetoclax. In addition, these same properties of tusbetinib and its action on AML patients are leading us to include the treatment of patients with higher risk MDS and CMML in our trials going forward. We now are leveraging our clinical findings and plans to support financing and collaboration discussions. While we have no announcements to make and can make no commitments in these regards. We clearly are pursuing these paths.

Speaker 2

I now want to turn the call over to Doctor. Behar, our Chief Medical Officer and resident KOL for his insights and comments on our latest data. Raf?

Speaker 3

Thank you, Bill. I first want to highlight our latest news. We announced last week that clinical data for tasplatinib or TESST has been selected for an oral presentation at the ASH meeting in December, which will be given by our lead investigator, Doctor. Naval Daver of the MD Anderson Cancer Center. Doctor.

Speaker 3

Daver will present data from Aptose's ongoing Phase III Aptose trial tasvetinib and relapsed refractory patients with acute myeloid leukemia. We're really pleased by this recognition from our esteemed colleagues and look forward to sharing the ACTIVATE data in this forum. As Bill mentioned, just over a week ago during the European School of Hematology Meeting on AML or ESH, we reviewed all the data to date from an October 23 data from the TUS Aptivate trial. We're not going to go through a full data rehash here. We'll make this call efficient.

Speaker 3

But I just want to clarify some key points, address some misperceptions and answer some of the questions that we've been getting over the last week or so. If you did not listen to our ESH call, I encourage you to do so and you can access it on our website under the Events tab. Doctor. Diver joined us on the ESH call last week as an internationally recognized expert in the development of clinical therapeutics for AML, including combination therapies. It was extremely helpful to get his impressions of the ongoing needs in AML and how tasvetinib could help address them.

Speaker 3

One of the things we discussed is the changing AML patient population and emerging needs in the AML treatment landscape. The vast majority of U. S. Based AML patients entering clinical trials now have tried and were failed by venetoclax at some point in the course of their disease. In our ACTIVATE trial, the percentage of U.

Speaker 3

S.-based patients who have failed venetoclax has grown to about 90%. This leaves a patient population with highly resistant mutation patterns and dismal response rates to salvage therapy with CR rates often in the single digits, whether treated with monotherapies or drug combinations. This extremely challenging patient population with a rapidly emerging medical need is what all of us who are trying to develop AML treatments in relapsed refractory populations are up against. We're seeing an entirely different group of patients than drugs that were developed just a few years ago. Indeed.

Speaker 3

What we're seeing in the Aptose Biosciences trial, the majority of patients have failed prior therapies with venetoclax and have unmutated SLIT3 AML, patient population that accounts for an estimated 70% of AML cases. With few or no effective treatment options, being able to potentially target the larger FLT3 unmutated patient population and to do so safely is a key differentiator for tastatinib. Now for people who shake their heads because there's so much going on in AML and it's to determine potential winners in this space, it's important to note that dispetinib is differentiated by its clinical activity in the SLIT3 unmutated population. So the positive data we've generated thus far asplatinib, which includes responses in that FLT3 unmutated or wild type AML makes it that much more exciting. And there is room for many other AML drugs in development too.

Speaker 3

AML is an extremely heterogeneous disease with broadly resistant mutation patterns. It will take combination therapies of drugs targeting different kinases of other pathways to manage the disease across different populations. As we get into review of our data highlights, I want to give a quick explanation of what we mean by evaluable patients as it's defined in our protocol. Briefly. We consider evaluable any patient that has reached their 2nd response assessment at the end of cycle 1 or has had an objective response at their 1st response assessment.

Speaker 3

Participants that discontinue treatment for disease progression after that first assessment are in fact considered evaluable. Only patients who don't undergo a response assessment or have stable disease with less than one cycle of treatment are considered not evaluable or technically in evaluable. Currently, about 85% of our study participants are considered evaluable by the end of cycle 1, but we also have several ongoing patients that have not yet reached this milestone and will do so in the coming weeks. For example, in our latest data cut with 31 evaluable patients out of the 49 patients dosed with the Tuxpin doublet, Many have very recently entered the trial and have only just finished one cycle of treatment with duspetinib, having been dosed in September October, with many patients pending a value ability assessment in the next 2 to 3 weeks. Data reported in ESH are therefore early and we expect more of the responses noted to continue to mature.

Speaker 3

We We'll have more valuable patients over time, including next month at ASH when we'll provide another update. A quick note on patient enrollment. As of today, more than 150 patients have been treated with tasetinib. 91 patients have received tasetinib as a single agent. And as Bill said, we have anticipated dosing up to 30 patients with test spend by the ESH 2023 conference.

Speaker 3

However, due to investigator enthusiasm, We ended up with more than 49 patients as of October 23 and patients continue being enrolled. Now let's talk about the safety profile. In the most recent data cut from October 23, the favorable safety profile remained consistent for TUS and TUS then treated relapsedrefractory AML patients with no new or unexpected safety signals noted. We've reviewed the safety profile of tislemed often, so I'll keep it brief here. In short, Tispedim continues to avoid many of the typical toxicities observed with other agents, including FLT3, IDH1 and 2 and menin inhibitors, such as QTC prolongation, differentiation syndrome and elevations of muscle enzymes like CPK that are related to treatment.

Speaker 3

We have not observed these as a clinical concern in our treatment. Some quick highlights of the day we presented at the ESH AML meeting regarding taspedinib as a single agent. Taspedinib as a single agent was well tolerated and highly active among relapsed or refractory AML patients with a diversity of genotypes. Tufts single agent delivered a 42% and 60% CRC response ER interest rates across all patients and across split 3 mutated patients respectively. And among in the evaluable then naive patient population treated at 80 milligrams, the recommended Phase 2 dose for tasplatinib.

Speaker 3

Tasplatinib demonstrated 29% CRCRTRH rate in MENAuf FLT3 unmutated or wild type patients at this 80 milligram RP2D dose. This unlocks the potential for tislelatinib to treat an additional 70% to 75% of the AML population without the FLT3 mutation that is not currently addressed by any approved tyrosine kinase inhibitor. Tuspendib single agent response rates compare favorably to gilterritin matched patient populations. Details on this interesting comparison are presented in our slide deck from the meeting, which available on our website. Let's turn to the Dublin data.

Speaker 3

In addition to the safety and efficacy of cystatinib we reported at ESH, We also presented a poster that warrants mentioned here. Suspendiv directly targets pathways involved in bend resistance. By shutting down these pathways to spend it appears to clinically resensitize prior ven failure patients to venetoclax. Our overall response rates for the test ven doublet includes several recent preliminary responses. And as of last week, we had dosed 49 patients, 31 of whom were evaluable to date.

Speaker 3

Keen investigator interest has led to this increased rate of enrollment, and we expect to report on additional patients at ASH in December. Our evaluable patients showed an overall response rate of 48%, that's 15 out of the 31 evaluable patients. 81% or 25 out of the 31 evaluable patients were prior VIN failures. 44% overall response rate was observed in this VEN failure population. There was a 60% overall response rate in the FLT3 mutant population and a 43 overall response rate in the FLT3 unmutated population.

Speaker 3

As I mentioned, most patients are early in the course of treatment, having initiated dosing in the past 2 to 6 weeks, We do expect these responses to mature over time. Our experience with the TUS Bendelbitt will inform how best to carry out the triplet combination with the TUS HMA venetoclax in the frontline setting. In the near term, we continue to collect data to demonstrate that the doublet is active in patients with prior venetoclax exposure, both with and without the FLT3 mutation and to meet and share with potential partners how we might be able to position tasatinib for frontline triplet therapy and maintenance therapy and move tasplenib and Aptose onto a clear path for success. Indeed, tasplenib with its proven breadth of activity and safety profile may address the most sizable markets in AML, and we are developing it as such. The interest in taspenib from potential partners continues to grow and we are engaged in multiple productive discussions because taspenib looks like large biotech or big pharma drug.

Speaker 3

Therefore, we endeavor to design our patient accruals to meet the needs of Aptose, meet the needs of regulatory agencies and to meet the desires of potential partners. We look forward to sharing more at the upcoming ASH conference and we are very pleased that test clinical data was recognized and selected for oral presentation by Doctor. Dawber. We will also plan on releasing our next set of updated data at around time. As Doctor.

Speaker 3

Dauber described in the question and answer session, after our clinical update call at ESH, the safety and efficacy data that we're seeing with the tisbet and venetoclax combination is very encouraging and suggest that TUS may effectively treat the growing number of end failures that we're seeing in relapsedrefractory AML. We're now looking forward to moving TUS forward into a tasbatinib, venetoclax, azacitidine triplet for the treatment of frontline newly diagnosed AML patients. The spin up safety profile is key here and we believe that it has the potential to be the ideal drug for combination therapy in AML, both in the frontline and in the relapsed refractory settings. So to sum up our timelines and milestones, and is more mature clinical data set, particularly for the test side of the double arm at ASH in December. Also during the Q4 of this year,

Speaker 2

Hello, everyone. For some reason, we're unable to hear Fletcher, so I'm going to I'd like to start by noting that in addition to our comments on this call, additional information may be found in today's press release and the 10 Q followed by the As discussed in our financial statements, the company plans to raise additional funds coupon business operations. During the 2023, we used the 2022 ATM facility, the 2023 committed equity facility and the Hanmi subscription agreement to raise capital. We continue to use these methods to raise capital and we are also actively evaluating other options to raise capital, including debt, equity issuance and corporate collaborations. Lastly, we continue to evaluate ways to reduce operational expenses.

Speaker 2

Based on current operations, the company expects that cash on hand plus available capital from Hanmi's subscription agreement, Committed Equity Facility and the ATM facility to provide the company with sufficient resources to fund planned company operations, including research and development through March of 2024. I would direct you to also review the company's risk factors and the discussion in the going concern footnote in our 10 Q. Now let's review the Q3 of 2023 financials. We continue our disciplined financial management of our operations and prioritization of our investments in the tesuspatinib Clinical Program. We ended the Q3 of 2023 with approximately $17,700,000 in cash, cash equivalents and investments, decrease of approximately $5,600,000 as compared to June 30, 2020.

Speaker 2

The $5,600,000 decrease in cash and investments as a result of the use of funds for the Aptivate study and operating expenses, which was offset by an increase in cash from financing activities. On a cumulative basis through September 30, 2023, the company has raised a total of $6,100,000 $3,000,000 from the Hanmi subscription agreement, $1,900,000 gross proceeds from the 2022 ATM facility and $1,200,000 gross proceeds from the 2023 Committed Equity Utility. During the quarter, the net loss was approximately $11,400,000 translating into approximately $1.76 per share loss 1st loss per share compared to $9,800,000 loss or $0.0159 loss per share from the same period in 2022. As of November 9, 2023, Aptose has 7,806,923 common shares outstanding. All references to loss per share and shares outstanding have been presented to reflect the 1 for 15 reverse stock split completed on June 6, 2023.

Speaker 2

As seen in the income statement, we had no revenues during the 1st 9 months of 2023. Research and development expenses were approximately $8,300,000 for the quarter compared to $6,600,000 during the same quarter of 2022. Program costs for tuspedanum were $5,800,000 for the 3 months ended September 30, 2023, compared to $3,000,000 for the 3 months ended September 30, 2022. The higher program costs for tasapatinib and the current period represents the enrollment of patients in our Aptivate clinical trial, clinical materials, the healthy volunteer trial that we've completed and other expenses. Program costs for luxepinib were $648,000 for the 3 months ended September 30, 2023 and decreased by approximately $742,000 compared to $1,400,000 for the 3 months ended September 30, 2022, primarily due to lower clinical trial costs and lower manufacturing costs as a result of the current G3 formulation, which required less API or active pharmaceutical ingredient than the prior formulation.

Speaker 2

G and A expenses were $3,400,000 for the quarter compared to $3,500,000 from the same quarter of 2022. The decrease is primarily due to lower stock based compensation, We now would like to open the call for questions. And please feel free to pose questions to any of us. So operator, if you could, please introduce the questions.

Operator

Need to press star 11 on your telephone. You will then hear an automated message advising that your hand is raised. Our first question comes from John Newman with Canaccord Genuity.

Speaker 4

Just curious here, I know that earlier in the study, there were a lot of patients that were doing very well And those patients were able to go to transplant. And I'm curious if the mechanism by which that can occur is the same. So are physicians still able to sort of make whatever call that they Believe is in the patient's best interest and say this patient should go to transplant or is there anything different about the study at this point in time, especially for the doublet? Thanks.

Speaker 2

Okay. So John, the earlier patients you were talking about were on the single agent tusfetinib and now we're primarily talking about the tusbandoublet. I'm going to ask Doctor. Behar to address Epson's.

Speaker 3

Sure. Yes. So I think I understand the question. So you're correct that we had several patients go to transplant in the single agent portion of the study. And the rules haven't changed.

Speaker 3

The physicians can continue to do whatever is in the best interest of the patient. We would encourage them to take the patients to transplant if that is an option. We're hoping that The ability to reduce their blast count and reduce their disease burden might allow more patients to go to transplant than would otherwise. But as we said in the call, it is still early. So decisions about transplant are likely not made yet in many of these patients that have just started the study in the last weeks, couple to months.

Speaker 2

John, did that answer your question? Is there anything else?

Speaker 4

It does. That does answer my question. Thank you.

Speaker 2

All right. Thank you, John.

Operator

Our next question comes from Gregory Renza with RBC Capital Markets. Your line is now open.

Speaker 5

Hi, Bill and team. It's Anish on for Greg. Congrats on the quarter and thanks for taking my questions. Just firstly on the expansion into high risk MDS and CMML for tasvetinib. What aspects of the data to date give confidence on this sort of this expansion opportunity?

Speaker 5

How should we be thinking about mechanistic overlap? And then just when thinking about this sort of progression and development for tasplatinib, how should we be thinking about resource allocation and any

Speaker 2

So I'm going to ask Doctor. Behar to address the first part of that that fits right into his expertise in the high risk MDS in human milk. Pat?

Speaker 3

Yes. Thanks for that question. So the higher risk MDS patients, particularly those patients that have increased blast in the bone marrow that are just shy of that AML threshold, a very similar pathophysiology and unfortunately very similar outcomes to patients with frank AML. In fact, the ICC, the International Classification Consortium Committee recently redesignated these patients with more than 10% blasts as being MDSAML because of the shared physiology and outcome. What we observed in our study is that we have several FLT3 unmutated patients that have very MDS like mutation patterns, mutations and things like splicing factors, genes like ASX-one types of mutations that we associate with AML with myelodysplasia related changes.

Speaker 3

So this is the clinical rationale for extending treatment of suspended into this very AML like MDS population. CMML also shares some of these pathophysiologic features, Also has a very proliferative phenotype with regard to the monocytes that give the disease its name. And we think that the particular access of activity for tispebib might be particularly favorable in that patient population. We don't want to exclude them from this potential benefit. We know that there aren't that many of them out there and we hope that we get a few in our trials so we can at least explore the activity in this really underserved patient population.

Speaker 2

Okay. I'll take on the next part. So regarding the MDS patients, as Doctor. Bayard said, there is a need. There's also a great deal of larger pharmas, larger biotech companies who are interested in seeing data in those patients because it can represent a large commercial opportunity.

Speaker 2

Regarding the resource allocation, currently we're forming the tusbandoublet study with patients. As I said, those patients Been accruing very rapidly. We expect to be able to tidy up that trial probably 1.5 to 2 quarters earlier than expected. So in terms of our next top priorities for how we're going to allocate the resources, the next one is the next top priority is that triplet, the VIN, The TUS BIN HMA triplet, it's the pilot study in say 20 to 40 patients. There's tremendous interest in driving this drug to frontline newly diagnosed patients and we'd like to get data there as quickly as possible.

Speaker 2

The next priority then would be the MDS MML patients. Again, tremendous interest from a variety of additional resources outside of our company that are interested in that patient population. Beyond that, then we would look to the registration trials that could then start. The first would be in the doublet patients, so that would be tusked in and the relapsed refractory patients who have failed venetoclax previously. And then after that would be the triplet, the registration trial for the triplet and frontline newly diagnosed patients.

Speaker 2

So did that Anish, thanks for the question. Did that answer it?

Speaker 5

Yes, great. Thanks so much for the color.

Speaker 2

Okay. Thanks for being here today.

Operator

I'm currently showing no further questions. I will now turn the call back to Doctor. Rice for closing remarks.

Speaker 2

Okay. Thank you so much, Hope. I also want to thank everyone for joining us this afternoon. As you can tell, we're really excited about the growing body of safety and efficacy data on tuspatinib and the tespatinib venetoclax combination in these very difficult to treat patient populations of AML. And we believe As always, we thank our patients, investigators and employees for their important role in this effort.

Speaker 2

Our clinical team has been key in ramping up enrollment in the AptiBay trial collecting data for our latest data cut and I continue to recognize them for their execution. We appreciate our shareholders and analysts who continue to Fortis and we look forward to keeping you updated on our progress. I want to thank all of you and have a wonderful evening. Take care. Bye bye.

Operator

Thank you, ladies and gentlemen. That concludes today's conference. You may all disconnect and have a wonderful day.

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Key Takeaways

  • Aptose extended its cash runway through a non‐punitive ATM facility, committed equity agreements and a Hanmi Pharmaceutical investment, avoiding warrant overhang while gathering critical tuspetinib data.
  • At the 80 mg Phase 2 dose, tuspetinib single – agent achieved a 42% CR/CRh rate in relapsed/refractory AML, including 60% in FLT3-mutated and 29% in FLT3 wild-type patients.
  • The tuspetinib + venetoclax doublet has enrolled 49 patients (31 evaluable) with a 29% composite CR rate and 48% overall response rate in venetoclax-failure AML, driving enrollment two quarters ahead of plan.
  • A registrational study for the doublet in relapsed/refractory venetoclax-failure AML is targeted for H2 2024, alongside a H1 2024 pilot of a tuspetinib + venetoclax + azacitidine triplet in frontline AML.
  • As of September 30, 2023, Aptose held $17.7 million in cash, reported a Q3 net loss of $11.4 million, and expects funding into March 2024 while pursuing additional financing and cost‐reduction measures.
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Earnings Conference Call
Aptose Biosciences Q3 2023
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