Quantum-Si Q4 2024 Earnings Report

Quantum-Si EPS Results

• Actual EPS: N/A
• Consensus EPS: -$0.18
• Beat/Miss: N/A
• One Year Ago EPS: N/A

Quantum-Si Revenue Results

• Actual Revenue: N/A
• Expected Revenue: $1.23 million
• Beat/Miss: N/A
• YoY Revenue Growth: N/A

Quantum-Si Announcement Details

• Quarter: Q4 2024
• Date: 3/6/2025
• Time: After Market Closes
• Conference Call Date: Monday, March 3, 2025
• Conference Call Time: 4:30PM ET

Quantum-Si (NASDAQ:QSI), a life sciences company, engages in the development of single-molecule detection platform to enable Next Generation Protein Sequencing (NGPS). The company's platform is comprised of the Platinum NGPS instrument; the Platinum Analysis Software service; and reagent kits and semiconductor chips for use with its instruments. It is used in protein identification, protein variants, antibody characterization, biomarker identification, and post translational modification analysis applications. The company was founded in 2013 is headquartered in Branford, Connecticut.

Quantum-Si Q4 2024 Earnings Call Transcript

Key Takeaways

• Record revenue growth: Q4 2024 revenue reached $1.2 M (up 52% QoQ) and full-year revenue was $3.1 M (up 183% YoY), reflecting strong commercial adoption of the Platinum platform.
• Expanded customer and distribution network: Sold the 50th Platinum instrument in Q4 and diversified end users across academia, biotech, pharma, government, and CROs, while adding 18 international distribution partners.
• Strengthened cash position: Raised $36.2 M via ATM in Q4 and $50 M in January 2025, providing cash runway into the second half of 2027.
• 2025 financial guidance: Anticipate at least $900 K in Q1 revenue (100% YoY growth), with adjusted operating expenses ≤ $103 M and cash usage ≤ $95 M for the full year.
• Funding risk: Ongoing uncertainty around NIH budget for 2025 may delay capital spending by U.S. academic researchers, although pharma, biotech, and international markets are expected to be unaffected.

Presentation

[Operator]

Thank you for standing by, and welcome to Quantum SI's Fourth Quarter twenty twenty four Earnings Conference Call. At this time, all participants are in listen only mode. After the speakers' presentation, there will be a question and answer As a reminder, today's program is being recorded. And now I'd like to introduce your host of today's program, Catherine Atkins, Senior Vice President of Commercial Markets. Please go ahead.

[Katherine Atkinson, SVP - Commercial Markets at Quantum-Si]

Good afternoon, everyone, and thank you for joining us. Earlier today, Quantum SI released financial results for the fourth quarter and full year ended 12/31/2024. A copy of the press release is available on the company's website. Joining me today are Jeff Hawkins, our President and Chief Executive Officer as well as Jeff Keis, our Chief Financial Officer. Before we begin, I would like to remind you that management will be making certain forward looking statements within the meaning of the federal securities laws.

[Katherine Atkinson, SVP - Commercial Markets at Quantum-Si]

These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated. Additional information regarding these risks and uncertainties appears in the section entitled Forward Looking Statements of our press release. For a more complete list and description of risk factors, please see the company's filings made with the Securities and Exchange Commission. This conference call contains time sensitive information that is accurate only as of the live broadcast date today, 03/03/2025. Except as required by law, the company disclaims any intention or obligation to update or revise any forward looking statements.

[Katherine Atkinson, SVP - Commercial Markets at Quantum-Si]

During this call, we will also be referring to certain financial measures that are not prepared in accordance with U. S. Generally Accepted Accounting Principles or GAAP. A reconciliation of these non GAAP financial measures to the most directly comparable GAAP financial measures is included in the press release filed earlier today. With that, let me turn the call over to Jeff Hawkins.

[Jeff Hawkins, President & CEO at Quantum-Si]

Good afternoon, and thank you for joining us. On today's call, we will provide a business update, review our operating results for the fourth quarter and full year of 2024 and provide our initial thoughts on 2025. After that, we will open the call for questions. I will begin with a reminder of our three corporate priorities to accelerate commercial adoption, to deliver on our innovation roadmap and to preserve our financial strength. Our first corporate priority is to accelerate commercial adoption.

[Jeff Hawkins, President & CEO at Quantum-Si]

2024 was an important year in the commercialization of our next generation protein sequencing technology and platinum instrument. The year began with our transition into full commercial launch at the end of the first quarter, followed by consistent quarter over quarter revenue growth throughout the year and concluded with our first quarter in excess of $1,000,000 in revenue. Along the way, we significantly diversified our customer base from one that entered the year made up of largely academic researchers in The United States to a customer base spanning multiple market segments and geographies. Today, our customer base has a healthy mix of academic, biotech, pharma, government and contract research organizations. In addition, we built an international distribution channel that currently has 18 partners, giving us access to an attractive growing global market opportunity for our products.

[Jeff Hawkins, President & CEO at Quantum-Si]

I am pleased with how we closed out 2024 with total revenues of $1,200,000 in the fourth quarter and $3,100,000 for the full year 2024. These results represent a 52% increase in revenue over the third quarter of twenty twenty four and a 183% increase in annual revenue on a year over year basis. The changes we made to our commercial strategy throughout 2024 paid dividends in the fourth quarter as we observe greatly improved commercial execution across all aspects of our strategy from lead generation to sales execution, delivering our strongest quarter ever in terms of both revenue and new instrument sales. We are also pleased to report that during the fourth quarter of twenty twenty four, we achieved a significant milestone having sold our fiftieth platinum instrument. In addition to nearly tripling revenue in 2024 as compared to 2023, we also executed on key distribution agreements for our products globally.

[Jeff Hawkins, President & CEO at Quantum-Si]

As announced in November of twenty twenty four, we entered into a distribution agreement with Avantor for the North American market. This agreement augments our current direct sales efforts and once fully implemented, significantly increases the number of sales professionals actively engaged in selling our products across all end user markets in North America. We are currently in the sales training and implementation phase of this relationship and expect to complete this process during the first quarter of twenty twenty five. Turning now to our global channel, we exited 2024 with 18 international distribution partners. The international expansion we executed on during 2024 added coverage to our existing direct and distribution footprint in Western Europe, Eastern Europe and Asia and expanded our presence into new countries within The Middle East, Africa, South America and the South Pacific regions.

[Jeff Hawkins, President & CEO at Quantum-Si]

While we are still in the early stages of our international commercialization efforts, we are very pleased with the initial end user traction we are seeing as well as the interest in our platform in general. One key learning from the early commercialization effort is that despite a rapidly growing interest in proteomics research in these regions, the cost of many of the legacy proteomics instruments as well as the infrastructure and specialized staff required to run these systems makes them inaccessible to many researchers. Platinum's low capital cost, simplified workflow and automated data analysis provides a realistic option for researchers in these regions looking to integrate an advanced proteomics platform into their research. We are optimistic that this is an early indication of the potentially compelling international opportunity for our technology and we plan to continue to build out our international channel network to fully capture this emerging opportunity in 2025 and beyond. In addition to our focus on commercial execution during 2024, we established a dedicated scientific affairs team to work directly with customers and key opinion leaders to publish and present data demonstrating the value of next generation protein sequencing.

[Jeff Hawkins, President & CEO at Quantum-Si]

In addition to the focus on external data generation, our Scientific Affairs team works closely with our commercial and R and D teams to publish data about specific aspects of our technology, like data analysis or specific applications of our technology, like protein barcoding. Over the course of December of twenty twenty four and January of twenty twenty five, '4 manuscripts were submitted for peer review and in parallel published as preprints on BioRxiv. The first paper was from our R and D team and covered our new protein barcoding kit, including the workflow and analytical performance validation results. Importantly, the validation data determined a lower limit of detection as low as 50 femtomole and a tenfold dynamic range demonstrating the method's sensitivity in detecting low abundance variance. The second paper was also from our R and D team and was focused on ProteoView, our comprehensive bioinformatics pipeline for single amino acid variants.

[Jeff Hawkins, President & CEO at Quantum-Si]

The study described in this paper demonstrates the ability of ProteoView to perform robust single amino acid variant detection and quantification with applications ranging from proteoform characterization to protein mixtures and quality control assays. The third paper was from researchers at the University of Virginia. This foundational study illustrates the capacity of next generation protein sequencing to detect proteoform variation at the single amino acid level, including variants associated with disease phenotypes that are not detectable with existing technologies like mass spectrometry. And finally, the fourth paper was from researchers at Northwestern University. This study highlights the synergy of complementary protein detection methods, in this case, mass spectrometry and next generation protein sequencing, to more comprehensively characterize proteoforms relevant to biological interactions.

[Jeff Hawkins, President & CEO at Quantum-Si]

We are excited to see these first four manuscripts being submitted for peer review publication and expect that trend to continue throughout 2025 as our scientific affairs team is actively engaged with researchers across the broad range of applications and market segments to publish the results of their ongoing research. Finally, I am pleased to announce that we have formed a world class Scientific Advisory Board led by Doctor. Gloria Schenkman from the University of Virginia. Our Scientific Advisory Board is made up of an outstanding group of scientists from academic research and industry that bring deep experience with protein and DNA sequencing, protein modifications in relation to disease, bioengineering and molecular delivery systems, as well as consumable development and product development. I would encourage you to visit our website to learn more about our Scientific Advisory Board members.

[Jeff Hawkins, President & CEO at Quantum-Si]

We look forward to collaborating with this distinguished group of scientists as we continue to expand the utility and utilization of next generation protein sequencing in the global proteomics market. Our second priority is to deliver on our innovation roadmap. Over the course of 2024, our R and D team delivered two new sequencing kits, a new library prep kit, a barcoding kit and two new software workflows, specifically protein inference and a single amino acid variant detection and quantification tool called ProteoView. At a high level, the kit launches expanded our proteome coverage, significantly reduced the sample input amount required and improved the overall sample success rates across the broad range of proteins and applications. When combined with the software workflows, customers experienced a consistent flow of new capabilities that allowed them to pursue an ever increasing range of protein analysis applications, sample types and proteins of interest.

[Jeff Hawkins, President & CEO at Quantum-Si]

In addition, in January, we announced the launch of PlatinumPro with shipping expected to begin during the first quarter of twenty twenty five. Platinum Pro is an evolution of Platinum that offers a streamlined and more efficient processing experience for the user, the ability to process data onboard or in the cloud and includes Pro Mode, which enables customers to develop custom applications using the power of our single molecule kinetic detection technology. Next, I would like to provide a recap of the innovation roadmap we laid out at our Investor Day on 11/20/2024. First, we reviewed the proteomics market and the long term growth drivers. The proteomics market is a large, important and growing market, which is still in its relative infancy.

[Jeff Hawkins, President & CEO at Quantum-Si]

Some examples of the long term growth drivers we shared include large scale screening studies that once completed will drive the need for follow on studies to more deeply characterize the most clinically and therapeutically actual proteins identified. Additionally, the move to greater use of artificial intelligence tools whether in drug development, protein engineering or multiomics analysis will require vast amounts of data to be generated to train the models. In both cases, we believe that tools like next generation protein sequencing will be a key tool to drive these research initiatives forward. Second, we laid out a new instrument and consumable architecture that can scale to billions of reads and when combined with other technology development initiatives creates a clear path to de novo sequencing. The Proteus platform will be the first platform to incorporate this new architecture, and we expect Proteus to launch in the second half of twenty twenty six.

[Jeff Hawkins, President & CEO at Quantum-Si]

At a high level, Proteus will offer significantly more reads per sample, more samples per run and greater workflow automation than our current platform. As an example, our current platform, Platinum, processes a single consumable per run and that consumable contains 2,000,000 wells. Proteus is being designed to process two consumables at a time and each consumable is expected to contain up to 80,000,000 wells for a total of 160,000,000 wells per run. This expanded number of wells can be used to process more samples per run or can be used for extremely deep analysis of a single or small number of samples. From a development perspective, the Proteus program is derisked compared to a typical new platform development project in two ways.

[Jeff Hawkins, President & CEO at Quantum-Si]

First, we can utilize many aspects of our current commercially available technology, such as surface chemistry, consumable fabrication methods, library prep and sequencing chemistry. And second, we can take advantage of the advancements in the field of optics that have been developed over the past decade to meet the needs of next generation DNA sequencing platforms. Finally, we share data from our research initiatives that show the vast capability of our core technology to be extended into other areas of proteomics beyond protein sequencing. Based on the data presented, we believe our core technology is the only commercially available technology that can enable single molecule, top down and bottoms up proteomics methods. In summary, we believe that our Proteus platform and core technology are capable of addressing the broadest range of proteomics analysis methods of any technology in the market today.

[Jeff Hawkins, President & CEO at Quantum-Si]

We expect to unlock that potential through a combination of both internal R and D initiatives as well as strategic partnerships to ensure that Proteus will enable every lab to be a core lab without the need to own multiple instruments or have specialized facilities and staff to perform proteomics research. If you'd like to learn more about any of these topics, I would encourage you to visit the Investor Relations section of our website, where we have a comprehensive slide deck and audio recording of the full event. In the coming months, we will certainly provide you with updates on the Proteus development process to allow you to understand our progress relative to our anticipated launch date in the second half of twenty twenty six. The key milestone this year is successful protein sequencing on a prototype Proteus system by the end of twenty twenty five. We certainly have numerous other incremental milestones that we will achieve throughout the development process.

[Jeff Hawkins, President & CEO at Quantum-Si]

And as those items come up, we will provide you updates as appropriate. Additionally, for 2025, we announced today that we expect to launch a version four sequencing kit in the third quarter of the year. We expect that this new sequencing kit will further increase proteome coverage and protein accessibility via new recognizers and cutters. We are also continuing to advance other product development initiatives across library prep, application development and software, and we expect to provide updates to you in the coming months on these programs. Our third priority is to preserve our financial strength.

[Jeff Hawkins, President & CEO at Quantum-Si]

We remain committed to utilizing our capital in the most efficient manner that maximizes shareholder value. We will continue to be nimble and adjust our capital deployment strategy as the business or market may require. To that end, post our Investor Day presentations and partnership announcements in November of twenty twenty four, we observed a significant increase in interest from investors as the long term strategy was now clear and the market was able to better understand the full potential of our uniquely differentiated technology. Based on this market interest, we raised capital through our at the market facility in December as well as raising additional capital at the January. Jeff will go into more details, but the combination of these capital raises effectively provides us another year of cash runway as we work to execute on our commercial strategy and innovation roadmap.

[Jeff Hawkins, President & CEO at Quantum-Si]

I will now turn the call over to Jeff to review our financial results.

[Jeff Keyes, CFO at Quantum-Si]

Thanks, Jeff. Now I'll review the details of our operating results for the fourth quarter and full year 2024. Revenue in Q4 twenty twenty four was approximately $1,200,000 which consisted of revenue from our platinum instrument, consumable kits and related services. Gross profit was $610,000 and gross margin was 51. As I have been saying throughout 2024, our gross margin percentage will be somewhat variable for the foreseeable future as we work through our continued commercialization efforts and may be impacted by the timing and mix of instruments versus consumable sales.

[Jeff Keyes, CFO at Quantum-Si]

Our margin has also been impacted and may continue to be impacted by the acquisition costs and any accounting adjustments to underlying inventory that predates the commercial launch of the Platinum line of instruments. Our gross margin for Q4 twenty twenty four includes approximately a 2% benefit for inventory utilized during the quarter that was carried at low or no value and dates back to prior to the initial commercialization. We do expect to see more variances that will flow through our gross margin as we move forward, and I will highlight them if they are material. Revenue for the full year 2024 was $3,100,000 and gross profit was $1,600,000 and gross margin was 52%. Similar to the comment I just made about Q4, our gross margin for the full year 2024 includes approximately a 3% benefit for inventory utilized during the quarter that was carried at low or no value.

[Jeff Keyes, CFO at Quantum-Si]

Turning to operating expenses. GAAP total operating expenses for the fourth quarter of twenty twenty four were $31,300,000 compared to $28,100,000 in the fourth quarter of twenty twenty three, while adjusted operating expenses were $26,700,000 for the fourth quarter of twenty twenty four compared to $26,300,000 for the fourth quarter of twenty twenty three. Overall, we have essentially kept our adjusted operating expenses flat while funding the ramp up of our commercial operations. For the full year 2024, our GAAP total operating expenses were $110,200,000 compared to $111,700,000 in the prior year, a decrease of about 1%. Included in total operating expenses are R and D and SG and A expenses.

[Jeff Keyes, CFO at Quantum-Si]

R and D expenses were $59,600,000 in 2024 compared to $67,000,000 in 2023, a 11% decrease year over year. SG and A expenses were $50,500,000 in 2024 compared to $44,600,000 in 2023, an increase of 13%. As a reminder, we executed an R and D realignment in August of twenty twenty three that streamlined our R and D efforts on focused product delivery to the market and a portion of the year over year decrease is the impact of the 2023 restructuring program. In addition, in November 2024, we initiated a corporate wide restructuring program to streamline and focus corporate resources as well as align required resources to focus on our recently announced Proteus platform development. All in all, the year over year change in R and D expenditures reflects the impact of the aforementioned restructuring programs, while the optimization activities in November 2024 are expected to align and optimize spend on our core R and D programs, including Proteus development, while keeping forward total R and D spend roughly equivalent to 2024.

[Jeff Keyes, CFO at Quantum-Si]

Overall, SG and A expenses increased year over year as planned with the majority of the year over year increase in Q4 twenty twenty four as we ramped up our commercialization efforts. Stepping back, it is important to note that we have kept overall operating expenses and adjusted operating expenses flat year over year, while at the same time delivering multiple products to the market, initiating and funding a game changing development program with Proteus and funding our commercial operations ramp. Our dividend and interest income in the fourth quarter of twenty twenty four was $2,200,000 compared to $2,300,000 in the fourth quarter of twenty twenty three. For the full year 2024, dividend and interest income was $11,400,000 compared to $9,500,000 for the full year of 2023. Overall, we benefited year over year from higher interest rates relative to our overall cash, cash equivalents and marketable securities position.

[Jeff Keyes, CFO at Quantum-Si]

As of 12/31/2024, we had $209,600,000 in cash and cash equivalents and investments in marketable securities. Included within the $209,600,000 are the gross proceeds from our ATM facility raised in the fourth quarter of $36,200,000 Not included in the 209,600,000 is the gross proceeds from our capital raise that closed on 01/06/2025, of $50,000,000 Taking into consideration the $209,600,000 of cash, cash equivalents and marketable securities at 12/31/2024, and the gross proceeds of $50,000,000 from our capital raise on 01/06/2025, as well as our continued financial discipline and focused efforts on capital allocation, we expect to have cash runway into the second half of twenty twenty seven. For 2025, there are two key activities that are evolving that currently limit our full view into 2025 revenue that we are tracking against. These two items are our Aventor distribution relationship in North America and the current uncertainty surrounding the NIH funding environment for 2025. As Jeff mentioned earlier, we are working through the process of training and onboarding the Aventor organization, which we expect to be complete by the end of the first quarter.

[Jeff Keyes, CFO at Quantum-Si]

Once these onboarding activities are completed and initial traction on sales are observed, we will have more clarity on the full impact of Aventor's contribution to our 2025 revenue. Now turning to the NIH funding environment, as many of you have already heard from other companies in the life science tools space, there is uncertainty regarding NIH funding that has the potential to impact the academic research market in The United States. The degree of this impact is hard to predict until the NIH budget and spending priorities are finalized by the new administration. On a positive note, our international opportunity and our U. S.

[Jeff Keyes, CFO at Quantum-Si]

Opportunity in other market segments such as pharma and biotech are all not expected to be impacted by the NIH funding uncertainty. Having said that, for the first quarter of twenty twenty five, we anticipate revenue to be at least $900,000 This level of revenue represents approximately 100% growth year over year in the first quarter and takes into account the typical drop off in life science tool companies seen in terms of quarter over quarter revenue when moving from Q4 into Q1, minimal contribution from Avantor and the uncertainty around and the potential to delay some academic customers in The U. S. Market from finalizing their capital spending plans for 2025. Turning to adjusted operating expenses and anticipated cash usage for 2025.

[Jeff Keyes, CFO at Quantum-Si]

We're able to provide more clarity based on our past run rates, continued corporate efficiency initiatives and our development roadmap. Our preliminary guidance for adjusted operating expenses for 2025 is $103,000,000 or less and total estimated cash used for 2025 will be $95,000,000 or less. Now I'll turn the call over to the operator to open the line for questions.

[Operator]

Our first question comes from the line of Kyle Mixon from Canaccord Genuity. Your question please? Kyle Mixon, your line is open.

[Kyle Mikson, Managing Director & Senior Research Analyst at Canaccord Genuity - Global Capital Markets]

Hey guys, thanks for the questions. So you launched the Pro system in January. Did you sell any since the announcement? And how has that impacted sales of the legacy platinum boxes and consumables since?

[Jeff Hawkins, President & CEO at Quantum-Si]

Yes, Kyle. So we as you said, we announced the launch of Platinum Pro in earlier this quarter. We expect to start shipping the machine before the end of the quarter. We're not sort of giving out a specific number of machines at this point. We haven't seen any impact right now on the platinum sales.

[Jeff Hawkins, President & CEO at Quantum-Si]

There's obviously two different price points of those devices. So some people may still acquire the platinum while it's available and others may move directly to pro. And given the consumables are the same across the machines, we also haven't seen any impact on consumable ordering patterns of platinum users, even those who may be considering sort of an upgrade in the future to a platinum pro.

[Kyle Mikson, Managing Director & Senior Research Analyst at Canaccord Genuity - Global Capital Markets]

Got it. Thanks, Jeff. And I just want to confirm, actually I guess taking a step back, I know that you guys kind of provided expectations for essentially quarterly revenue going forward, but was any of this $1,200,000 in the fourth quarter, was that pushed from 3Q or maybe pulled forward from the first quarter of twenty twenty five?

[Jeff Hawkins, President & CEO at Quantum-Si]

Yes, nothing was pushed from Q3. I think we certainly saw some end of year buying decisions occur in the fourth quarter. I wouldn't say it was sort of a significant level of those. I wouldn't go as far as calling it a budget flush, but there were certainly some folks who knowing that platinum would likely see a price increase and that we had announced that Platinum Pro was coming in the first half of the year back at our Investor Day in November of twenty twenty four. We did see a few areas where we believe customers may have pulled those purchase positions forward, but again not a significant trend in either direction.

[Kyle Mikson, Managing Director & Senior Research Analyst at Canaccord Genuity - Global Capital Markets]

All right. That makes sense. And again, I think this was sort of talked a little bit in the guidance expectations, but would you mind kind of clarifying the expectations for the Aventor partnership this year, because that pivotal for some of the potential targets that you have?

[Jeff Hawkins, President & CEO at Quantum-Si]

Yes. So on Aventor, again, we signed the distribution agreement in November of twenty twenty four as a standard in these types of distribution agreements. We have a phase where we're implementing our products into their operating system so that they can be ordered and fulfilled through the system. And then we have the training of the actual sales professionals. So they have sort of meetings that were set up throughout the first quarter of the year as is typical with commercial organizations.

[Jeff Hawkins, President & CEO at Quantum-Si]

So we've been slotting into those meetings and providing training for the teams and now the teams as they get trained are out beginning to interface with our direct reps and really strategize and coordinate at a territory level. So as we said when we announced the distribution agreement, we expected Q1 to really be that training and implementation phase. We expect to see some contribution from the relationship in the second quarter of the year and really see more of the acceleration from that relationship in the back half of the year after their reps have been trained and been out in the territories for a period of time to build their funnels and ultimately be able to deliver more of a ramp in the second half of the year.

[Kyle Mikson, Managing Director & Senior Research Analyst at Canaccord Genuity - Global Capital Markets]

Got it. Okay. And then in light of the recent the U. S. Hoopla and the ADBT conferences, can you just talk about the recent feedback from the both the Proteomics and the Genomics communities and how they're sort of interacting so far with the technology and that kind of value proposition?

[Jeff Hawkins, President & CEO at Quantum-Si]

Sure. I think at AGBT, which is obviously a more focused show in genomics, next generation DNA sequencing, some of the spatial technologies. There were obviously a lot of new product announcements or new entrants into the space. So lots of competitive noise in the space, certainly within the genomics field. NIH funding was certainly a hot topic amongst the academic researchers.

[Jeff Hawkins, President & CEO at Quantum-Si]

So not normally a core event for us. So we never expected to be a huge source of sort of what we would call more lead generation or marketing activities, but we did have people there in attendance presenting scientific data and posters on the technology and we had very good traffic at those poster sessions, lots of great questions from people really in that community thinking about that multi omic workflow. How do they go from RNA sequencing and incorporate proteomics technologies to sort of close that loop. Very similar to what University of Virginia talked about in their paper that was preprint on bio archive. So that's maybe a good analog of sort of how the genomics community at that meeting was interfacing with us with a protein sequencing technology.

[Jeff Hawkins, President & CEO at Quantum-Si]

Hupo, obviously a very targeted event, nowhere near the size of AGBT, but very focused on the proteomics market, the proteomics customers. We had tremendous booth traffic there. We had interest at posters that were a mix of some data we presented, also data that customers presented, other workshops and activities. So very positive feedback we're getting each time we bring out new capabilities that gets people talking about new applications. And ultimately in these events as we've talked about on these calls before, a mix of customers presenting data and some of that peer to peer exchange of information is a very valuable sort of tool in driving the awareness and ultimately the adoption.

[Kyle Mikson, Managing Director & Senior Research Analyst at Canaccord Genuity - Global Capital Markets]

All right. Maybe on that note, would you mind like maybe at relatively high level, could you talk about why the amino acid binder like well based approach, why you're confident that's going to be successful here relative to like a NanoPore based approach that we've seen? Just coming off the Roche kind of comments, I guess, always move to ADVT things like that. Just why is like your approach better positioned, but potentially versus something that we've kind of seen in like more of like R and D kind of like phase?

[Jeff Hawkins, President & CEO at Quantum-Si]

Yes. Well, I think Kyle, it's a little hard to know exactly how to compare to Nanopore based approaches for protein sequencing given there aren't any commercially available products that utilize that technology. And there are certainly some very early stage research papers that have been published on trying to apply NanoCore technologies. But most of those papers, as is often the case with early technology development, are focused on very simple samples, perhaps amino acids with spacers in them to improve the reading accuracy or the ability to detect the changes in amino acids. So a common technology feasibility approach, but not necessarily something that we know that what the specs would look like in a commercial environment and how to think about positioning our technology against that.

[Jeff Hawkins, President & CEO at Quantum-Si]

I think what we're focused on with our approach is unlike DNA, where NanoFours have been applied, you have four DNA bases to deal with, everything is negatively charged. In amino acids, we're talking 20, we're talking about a wide range of properties of those amino acids and the sequence context of those amino acids is a very challenging endeavor. So we while perhaps nanophores will get there, we think it's a significantly harder challenge than perhaps DNA in nanophores. In terms of how we focus on our approach, what we like about our approach is a couple of things. One is, our amino acid recognizers are capable, they typically detect two or three amino acids and the relevant sort of post translational modifications or changes.

[Jeff Hawkins, President & CEO at Quantum-Si]

That approach will prevent us from needing to have 20 different recognizers, which we think trying to scale up to these really large numbers of potential recognizers would be a very difficult biochemistry problem. So sort of our kinetic detection and that ability to have these multi affinity sort of recognizes for different amino acids, we think is definitely an advantage from a development perspective. And when we talk about sort of the engineering architecture, what we like about the direction we're going with Proteus is we really put ourselves on a consumable architecture that can be scaled to billions of reads sort of the type of capacity you're bound to need to get the de novo sequencing. And then you're really leveraging a lot of the optical detection technology capability that's been evolved over the last decade or so. So we really like that sort of trying to leverage a lot of that capability that's out there getting on to that architecture that will scale and underpinned by sort of our unique kinetic detection with those amino acid recognizers.

[Kyle Mikson, Managing Director & Senior Research Analyst at Canaccord Genuity - Global Capital Markets]

Perfect. And then maybe just on that last note and this will be a final question for me. Could you maybe confirm if the Proteus architecture and the initial assay is locked down? Like how is that progressing? I know you have the I guess second half of next year launch, but in terms of like some of the technical milestones, how are those going?

[Jeff Hawkins, President & CEO at Quantum-Si]

Yes. So good question, Kyle. So maybe I'll start with what we said in the call, which is our key milestone we want to achieve this year is that we demonstrate our next generation protein sequencing chemistry on that Proteus platform and the consumable on sort of a prototype of that platform and consumable. So that we expect to do by the end of the year. I'd say a couple of things about sort of how we're progressing, right.

[Jeff Hawkins, President & CEO at Quantum-Si]

So at our Investor Day, we showed some of the early technology feasibility data around the consumable fabrication method, the change from lifetime detection to color ratio. So that was some of that early data. We talked about the partnerships we did to help de risk and accelerate. So SkyWater around the consumable, Planet Innovation around the instrument, NVIDIA around AI and compute. And then more recently, you probably saw that we partnered with IDEXX Health and Sciences, really the leader in high performing optical systems in the life science space.

[Jeff Hawkins, President & CEO at Quantum-Si]

So we feel really good about the partners we have around us, sort of how the technology has progressed from what we showed in November and are very confident we can get to that goal of having sequencing on a prototype platform by the end of the year. If we achieve that goal, Kyle, then we're right where we'd want to be in terms of getting to that second half of twenty twenty six launch. So as we go this year, we'll certainly provide other updates, but really right now progressing the way we like, set up well for that end of year milestone and assuming we hit that, really gets us then to that second half twenty twenty six launch.

[Kyle Mikson, Managing Director & Senior Research Analyst at Canaccord Genuity - Global Capital Markets]

Got it. Okay. Thanks for the help, Jeff.

[Jeff Hawkins, President & CEO at Quantum-Si]

Thank you.

[Operator]

Thank you. And our next question comes from the line of Douglas MacPherson from H. C. Wainwright. Your question please.

[Douglas Macpherson, Equity Research Associate at H.C. Wainwright & Co., LLC]

Hi there. Nice to speak with you and congrats on a good quarter.

[Jeff Hawkins, President & CEO at Quantum-Si]

Thanks, Doug.

[Douglas Macpherson, Equity Research Associate at H.C. Wainwright & Co., LLC]

So similar to what was touched on by the last caller, I recall last quarter there was some variability in the sales cycle, sometimes taking a little bit longer than expected. As you're gaining more experience with more customers, are you starting to see an experience sort of a more predictable cadence to those sales cycles?

[Jeff Hawkins, President & CEO at Quantum-Si]

Yes, good question, Doug. So I think the sales cycle we're seeing is certainly longer than it has been historically in our market for an instrument of a similar price. I think we're comfortable with now what that sales cycle looks like and that we're seeing it consistently, but it is still elongated from what it's historically been in our space for a device of this sort of price point.

[Douglas Macpherson, Equity Research Associate at H.C. Wainwright & Co., LLC]

Sure. Thank you for that. And then as far as target markets, you said mostly it's been academic researchers, but you're branching out and getting some traction with CMOs, biotechs, large pharma, government. What do you see as the largest market? And are there any markets that you find it a little difficult to crack?

[Douglas Macpherson, Equity Research Associate at H.C. Wainwright & Co., LLC]

And you feel like it's an untapped market and maybe would like to undertake some initiatives in order to penetrate into that those markets?

[Jeff Hawkins, President & CEO at Quantum-Si]

Yes. So two questions there, Doug. Let me take the first one. So as we exited 2023, our customer base, as I said on the prepared remarks, was largely academic. As we exited 2024, it's about a fiftyfifty split now between academic customers and those academics are both in The U.

[Jeff Hawkins, President & CEO at Quantum-Si]

S. And in Western Europe and then those other segments, pharma, biotech, government. So really good diversification of that base of customers. We'd expect that diversification to continue as we go forward in terms of more and more of those biotech pharma etcetera sort of coming online. The second part of your question, Doug, was more about the untapped opportunities.

[Jeff Hawkins, President & CEO at Quantum-Si]

So I think the key one right now that we see line of sight to given the diversification we're already seeing with our tech in terms of end users really is that international opportunity. We had a couple of partners earlier in the year and then added to that international distribution channel over the course of 2024. And I think as I said in the prepared remarks, really seeing an interesting opportunity in these other regions of the world where perhaps they don't have the capital to buy a $500,000 or $1,000,000 piece of equipment. They don't have the infrastructure scientifically or bioinformatically to analyze the data and do the laboratory workflow. So really feel like there could be a nice opportunity across multiple end segments within that X sort of OUS or outside The United States sort of opportunity through those channel partners.

[Jeff Hawkins, President & CEO at Quantum-Si]

That's why we built into that network over the course of 2024 and we'll continue to do that in 2025. Really feel like that's more of the untapped opportunity right now, because I think the diversification of the base in general is going well in all regions and we will continue to sort of push on that and invest in that sort of that distribution or decentralization of the customer base.

[Douglas Macpherson, Equity Research Associate at H.C. Wainwright & Co., LLC]

Cool. All right. Thanks for the color on that. And then last one for me. Beyond the Avantor agreement, I recall you had intended to do some internal expansion of your own commercial team.

[Douglas Macpherson, Equity Research Associate at H.C. Wainwright & Co., LLC]

Have you brought on a lot of new people? And then sort of what phase are they in? Are they still under that whatever it was three to six months of training or are you starting to see them out in the field and even sort of delivering a return on that investment from your internal commercial teams?

[Jeff Hawkins, President & CEO at Quantum-Si]

Sure. Yes. Good question. So, we did do some additions to close out the year and right into the start of this year. As we sit here right now on this call, we have our sort of our commercial team, our direct team sort of staffed the way we expected it to be staffed for this point in 2025.

[Jeff Hawkins, President & CEO at Quantum-Si]

Now obviously, we expect there to be some modest hiring throughout the year, as we continue to scale up. Some of that could be in the sales type of goals, but also in the application support and sort of that more scientific based support and service as that installed base keeps growing. In terms of where are they at in the process, the majority of those sales professionals are in territory and have been out there now for at least that three month period, but there are some that came on later in the year or came on first thing this year that are still in that training and ramp up phase. So over the course of the next quarter or so, all those folks will sort of be at an operating scale. And then anybody who would come on new obviously would go through the same type of training and funnel build and progression.

[Douglas Macpherson, Equity Research Associate at H.C. Wainwright & Co., LLC]

Okay. So we might sort of see that impact in the back half of twenty twenty five similar to the Avantra agreement?

[Jeff Hawkins, President & CEO at Quantum-Si]

Yes, I agree with that. I think that I would say two things about it. One is our reps are getting are in that phase of being in the territory working their funnels and working their space. They're now interfacing with those Avantor reps who just got trained. So we should start to see some of the synergies of those groups working together to sort of share leads and build the pipelines as we get into the back half of the year.

[Jeff Hawkins, President & CEO at Quantum-Si]

Similar with our international channel partners, many of those came on in the second half of the year. We just held a big channel partner training meeting last week. So those folks now are getting more and more engaged with the tech, getting trained, getting their application support people up to speed. And we should see those folks out now able to start to build their funnels and then execute on winning new customers as we move into the second quarter and second half of the year.

[Operator]

Thank you, ladies and gentlemen. This does conclude the question and answer session of today's program. I'd like to hand the program back to Jeff Hawkins for any further remarks.

[Jeff Hawkins, President & CEO at Quantum-Si]

All right. Thank you. We are excited about the progress during 2024 and are looking forward to delivering on our commercial scale up and technology roadmaps during 2025. We look forward to providing you more updates on our next call. Thank you for attending.

[Operator]

Thank you, ladies and gentlemen, for your participation in today's conference. This does conclude the program. You may now disconnect. Good day.

Participants

Executives

• Katherine Atkinson, SVP - Commercial Markets
• Jeff Hawkins, President & CEO
• Jeff Keyes, CFO

Analysts

• Kyle Mikson, Managing Director & Senior Research Analyst at Canaccord Genuity - Global Capital Markets
• Douglas Macpherson, Equity Research Associate at H.C. Wainwright & Co., LLC