| 2/14/2020 | Casdin Capital LLC | 3,098,121 | $46.97M | 4.3% | +1.6% | 7.946% | |
| 2/14/2020 | Bank of America Corp DE | 13,808 | $0.21M | 0.0% | -13.5% | 0.035% | |
| 2/14/2020 | Bank of New York Mellon Corp | 62,868 | $0.95M | 0.0% | +5.0% | 0.161% | |
| 2/14/2020 | Marshall Wace North America L.P. | 128,098 | $1.94M | 0.0% | N/A | 0.329% | |
| 2/13/2020 | Platinum Investment Management Ltd. | 208,038 | $3.15M | 0.1% | -20.7% | 0.534% | |
| 2/12/2020 | ProShare Advisors LLC | 11,036 | $0.17M | 0.0% | -13.0% | 0.028% | |
| 2/12/2020 | Citigroup Inc. | 6,876 | $0.10M | 0.0% | +248.7% | 0.018% | |
| 2/11/2020 | Atria Investments LLC | 12,356 | $0.19M | 0.0% | N/A | 0.032% | |
| 2/11/2020 | OneAscent Financial Services LLC | 12,557 | $0.19M | 0.1% | N/A | 0.032% | |
| 2/10/2020 | Barclays PLC | 19,272 | $0.29M | 0.0% | +90.2% | 0.049% | |
| 2/10/2020 | Bank of Montreal Can | 2,652 | $40K | 0.0% | +57.3% | 0.007% | |
| 2/6/2020 | State Street Corp | 363,517 | $5.51M | 0.0% | +9.4% | 0.932% | |
| 2/5/2020 | New York State Common Retirement Fund | 17,170 | $0.26M | 0.0% | -19.4% | 0.044% | |
| 1/31/2020 | Bailard Inc. | 14,000 | $0.21M | 0.0% | N/A | 0.036% | |
| 1/31/2020 | Ikarian Capital LLC | 8,674 | $0.13M | 0.0% | N/A | 0.022% | |
| 1/29/2020 | Eventide Asset Management LLC | 3,393,894 | $51.45M | 1.4% | +14.8% | 8.705% | |
| 1/29/2020 | Russell Investments Group Ltd. | 18,668 | $0.28M | 0.0% | -69.7% | 0.048% | |
| 1/27/2020 | California Public Employees Retirement System | 34,299 | $0.52M | 0.0% | N/A | 0.088% | |
| 12/17/2019 | Evoke Wealth LLC | 18,100 | $0.19M | 0.0% | N/A | 0.046% | |
| 12/10/2019 | Gilder Gagnon Howe & Co. LLC | 4,146,675 | $42.55M | 0.5% | -0.6% | 10.635% | |
| 11/27/2019 | Metropolitan Life Insurance Co NY | 7,418 | $76K | 0.0% | N/A | 0.019% | |
| 11/27/2019 | Barclays PLC | 10,133 | $0.10M | 0.0% | -38.2% | 0.026% | |
| 11/27/2019 | Eventide Asset Management LLC | 2,955,432 | $30.32M | 1.0% | -15.4% | 7.580% | |
| 11/27/2019 | State Street Corp | 332,151 | $3.41M | 0.0% | +20.0% | 0.852% | |
| 11/4/2019 | Alps Advisors Inc. | 77,331 | $0.79M | 0.0% | -4.1% | 0.197% | |
| 11/1/2019 | Russell Investments Group Ltd. | 61,641 | $0.63M | 0.0% | N/A | 0.157% | |
| 8/17/2019 | Platinum Investment Management Ltd. | 226,558 | $3.34M | 0.1% | +7.7% | 0.576% | |
| 8/15/2019 | OneAscent Financial Services LLC | 11,227 | $0.17M | 0.1% | N/A | 0.029% | |
| 8/14/2019 | Citadel Advisors LLC | 229,066 | $3.38M | 0.0% | +31.5% | 0.582% | |
| 8/14/2019 | Vanguard Group Inc. | 884,348 | $13.05M | 0.0% | +75.4% | 2.248% | |
| 8/13/2019 | Laurion Capital Management LP | 143,544 | $2.12M | 0.0% | +1,199.4% | 0.365% | |
| 8/13/2019 | BlackRock Inc. | 1,623,423 | $23.94M | 0.0% | +43.0% | 4.127% | |
| 8/13/2019 | Virtus ETF Advisers LLC | 18,579 | $0.27M | 0.1% | N/A | 0.047% | |
| 8/13/2019 | Northern Trust Corp | 182,801 | $2.70M | 0.0% | +17.0% | 0.465% | |
| 8/12/2019 | Bank of New York Mellon Corp | 52,912 | $0.78M | 0.0% | +23.2% | 0.157% | |
| 8/10/2019 | Charles Schwab Investment Management Inc. | 43,202 | $0.64M | 0.0% | +35.0% | 0.128% | |
| 8/10/2019 | Artal Group S.A. | 23,524 | $0.35M | 0.0% | -88.2% | 0.070% | |
| 8/7/2019 | Alps Advisors Inc. | 80,675 | $1.19M | 0.0% | N/A | 0.240% | |
| 8/7/2019 | JPMorgan Chase & Co. | 5,349 | $79K | 0.0% | +52.8% | 0.016% | |
| 8/6/2019 | Wells Fargo & Company MN | 30,021 | $0.44M | 0.0% | +253.1% | 0.089% | |
| 6/16/2019 | Gilder Gagnon Howe & Co. LLC | 1,829,228 | $30.13M | 0.3% | N/A | 5.436% | |
| 5/10/2019 | Harvard Management Co. Inc. | 332,610 | $5.48M | 1.4% | -19.1% | 0.967% | |
| 5/8/2019 | Laurion Capital Management LP | 11,047 | $0.18M | 0.0% | -94.0% | 0.032% | |
| 5/7/2019 | Spark Investment Management LLC | 24,800 | $0.41M | 0.0% | -5.7% | 0.072% | |
| 5/1/2019 | Rhumbline Advisers | 15,342 | $0.25M | 0.0% | N/A | 0.045% | |
| 4/25/2019 | BNP Paribas Arbitrage SA | 3,014 | $50K | 0.0% | N/A | 0.009% | |
| 4/24/2019 | Oppenheimer & Co. Inc. | 20,000 | $0.33M | 0.0% | N/A | 0.060% | |
| 4/9/2019 | Aries Wealth Management | 12,000 | $0.20M | 0.1% | N/A | 0.036% | |
| 2/14/2019 | Opaleye Management Inc. | 505,000 | $2.88M | 1.1% | -30.3% | 1.523% | |
| 2/14/2019 | Two Sigma Investments LP | 18,324 | $0.10M | 0.0% | N/A | 0.055% | |
| 2/14/2019 | Principal Financial Group Inc. | 270,000 | $1.54M | 0.0% | -34.3% | 0.814% | |
| 2/13/2019 | Casdin Capital LLC | 2,643,317 | $15.07M | 2.6% | +17.4% | 7.973% | |
| 2/13/2019 | Geode Capital Management LLC | 21,739 | $0.12M | 0.0% | +42.9% | 0.066% | |
| 2/12/2019 | Bessemer Group Inc. | 237,277 | $1.35M | 0.0% | N/A | 0.716% | |
| 2/12/2019 | Northern Trust Corp | 66,414 | $0.38M | 0.0% | +21.8% | 0.200% | |
| 2/11/2019 | Bank of New York Mellon Corp | 15,754 | $90K | 0.0% | N/A | 0.048% | |
| 2/8/2019 | BlackRock Inc. | 556,381 | $3.17M | 0.0% | +224.2% | 1.678% | |
| 2/8/2019 | Harvard Management Co. Inc. | 411,379 | $2.35M | 0.5% | +23.7% | 1.241% | |
| 2/8/2019 | New York State Common Retirement Fund | 4,700 | $27K | 0.0% | N/A | 0.014% | |
| 2/4/2019 | Anchor Capital Advisors LLC | 181,505 | $1.04M | 0.0% | N/A | 0.548% | |
| 1/28/2019 | TRV GP IV LLC | 8,008,204 | $45.65M | 100.0% | N/A | 24.156% | |
| 12/13/2018 | Vanguard Group Inc | 144,456 | $1.74M | 0.0% | +92.6% | 0.436% | |
| 11/23/2018 | Vanguard Group Inc. | 144,456 | $1.74M | 0.0% | +92.6% | 0.436% | |
| 11/15/2018 | Platinum Investment Management Ltd. | 73,700 | $0.89M | 0.0% | +47.4% | 0.222% | |
| 11/15/2018 | Opaleye Management Inc. | 725,000 | $8.71M | 2.2% | +31.8% | 2.187% | |
| 11/13/2018 | Laurion Capital Management LP | 284,124 | $3.41M | 0.0% | -18.8% | 0.857% | |
| 11/9/2018 | FIL Ltd | 956,784 | $11.49M | 0.0% | +15.8% | 2.905% | |
| 11/9/2018 | BlackRock Inc. | 171,629 | $2.06M | 0.0% | +71.6% | 0.521% | |
| 11/8/2018 | Bollard Group LLC | 30,000 | $0.36M | 0.0% | N/A | 0.091% | |
| 9/18/2018 | Northern Trust Corp | 13,267 | $0.18M | 0.0% | N/A | 0.040% | |
| 8/20/2018 | Casdin Capital LLC | 2,035,818 | $27.48M | 3.8% | N/A | 6.180% | |
| 8/15/2018 | Millennium Management LLC | 111,736 | $1.51M | 0.0% | N/A | 0.339% | |
| 8/15/2018 | Nexthera Capital LP | 150,000 | $2.03M | 0.3% | N/A | 0.455% | |
| 8/15/2018 | Platinum Investment Management Ltd. | 50,000 | $0.68M | 0.0% | N/A | 0.152% | |
| 8/15/2018 | Acuta Capital Partners LLC | 170,000 | $2.30M | 0.4% | N/A | 0.516% | |
| 8/14/2018 | Opaleye Management Inc. | 550,000 | $7.43M | 1.9% | N/A | 1.670% | |
| 8/14/2018 | Point72 Hong Kong Ltd | 8,098 | $0.11M | 0.0% | N/A | 0.025% | |
| 8/14/2018 | Point72 Asset Management L.P. | 8,100 | $0.11M | 0.0% | N/A | 0.025% | |
| 8/14/2018 | Voya Investment Management LLC | 250,937 | $3.39M | 0.0% | N/A | 0.762% | |
| 8/13/2018 | Laurion Capital Management LP | 350,000 | $4.73M | 0.0% | N/A | 1.018% | |
| 8/11/2018 | Harvard Management Co. Inc. | 332,610 | $4.49M | 1.1% | N/A | 0.968% | |
| 8/11/2018 | Citadel Advisors LLC | 86,805 | $1.17M | 0.0% | N/A | 0.253% | |
| 8/10/2018 | Tiverton Asset Management LLC | 9,267 | $0.13M | 0.0% | N/A | 0.027% | |
| 8/9/2018 | BlackRock Inc. | 100,000 | $1.35M | 0.0% | N/A | 0.291% | |
| 8/3/2018 | Dean Capital Investments Management LLC | 41,322 | $0.56M | 0.4% | N/A | 0.120% | |
