Osiris Therapeutics, Inc. is a biotechnology company specializing in regenerative medicine and cellular therapies. Headquartered in Columbia, Maryland, the company focuses on developing and commercializing treatments that harness the healing potential of human cells and tissues. Osiris’s research and development efforts have centered on mesenchymal stem cell (MSC) technology, aimed at addressing a range of orthopedic, inflammatory and graft-versus-host disease (GvHD) indications.
The company’s most widely recognized products include Prochymal®, one of the first allogeneic stem cell therapies to receive regulatory approval for the treatment of acute GvHD in pediatric patients, and Grafix®, a cryopreserved placental membrane used in advanced wound care. Beyond these flagship products, Osiris has explored additional cell-based and tissue-based offerings targeting osteoarthritis, cartilage repair and gastrointestinal conditions. The company’s pipeline has featured both proprietary and partnered programs leveraging its MSC platform.
Founded in 1992, Osiris has been a pioneer in translating cell biology research into clinical applications. Over the years, the company has built a robust intellectual property portfolio covering methods of isolating and expanding MSCs, as well as formulations for specific therapeutic uses. Osiris has conducted clinical trials across North America, Europe and Asia-Pacific, collaborating with academic medical centers and biopharmaceutical partners to advance its technologies through late-stage development.
In 2019, Osiris Therapeutics was acquired by Smith & Nephew plc, a global medical technology firm, in order to integrate its regenerative medicine capabilities into a broader orthopedics and wound care product offering. Today, the former Osiris assets continue to serve healthcare providers worldwide, supporting treatment of chronic wounds, orthopedic injuries and immune-mediated disorders through innovative cellular and tissue-based solutions.
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