Otsuka Holdings Co., Ltd. (OTCMKTS: OTSKY) is a global healthcare company headquartered in Tokyo, Japan, with operations spanning pharmaceuticals, nutraceuticals and consumer products. Founded in 1921, Otsuka has grown from a domestic manufacturer of tonics and over-the-counter remedies into a diversified enterprise focused on innovative therapies and wellness solutions. The company employs a network of research facilities, production sites and sales offices across Asia, North America, Europe and other regions, supporting a broad portfolio of products and services.
In the pharmaceutical sector, Otsuka is best known for developing and marketing treatments for central nervous system disorders, nephrology and oncology. Flagship products include Abilify (aripiprazole), one of the world’s leading antipsychotic medications, and Samsca (tolvaptan), used to manage hyponatremia and autosomal dominant polycystic kidney disease. In addition to small-molecule drugs, the company is advancing biologics, digital therapeutics and targeted cancer therapies through collaborations with academic institutions and biotech partners.
Otsuka’s nutraceutical division offers a range of specialty nutritional products designed to support health and well-being. Key offerings include the Pocari Sweat electrolyte drink, Calorie Mate balanced nutrition bars and SoyJoy snack bars, which are marketed in over 20 countries. The company also operates Otsuka Pharmaceutical Factory, which focuses on contract manufacturing and packaging services, and Otsuka America Pharmaceutical, which handles US-based research, regulatory affairs and commercialization efforts.
Under the leadership of President and CEO Yoshihito Ishizuka, Otsuka has emphasized innovation, sustainability and patient-centric care. The company continues to invest heavily in research and development, seeking breakthroughs in neurology, nephrology and oncology while exploring new modalities such as digital health platforms. With a commitment to corporate social responsibility, Otsuka endeavors to address unmet medical needs and contribute to global health through both established products and emerging therapies.
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