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5Am Venture Management, LLC Top Holdings and 13F Report (2026)

About 5Am Venture Management, LLC

Investment Activity

  • 5Am Venture Management, LLC has $360.21 million in total holdings as of March 31, 2026.
  • 5Am Venture Management, LLC owns shares of 20 different stocks, but just 11 companies or ETFs make up 80% of its holdings.
  • Approximately 2.43% of the portfolio was purchased this quarter.
  • About 18.98% of the portfolio was sold this quarter.
  • This quarter, 5Am Venture Management, LLC has purchased 21 new stocks and bought additional shares in 0 stocks.
  • 5Am Venture Management, LLC sold shares of 1 stock and completely divested from 3 stocks this quarter.

Largest Holdings

Erasca
$56,403,011
Tyra Biosciences
$39,422,113
CAMP4 THERAPEUTICS CORP
$25,882,691

Largest New Holdings this Quarter

00166B105 - ALX Oncology
$6,129,937 Holding
75120L209 - RALLYBIO CORP
$2,617,338 Holding

Largest Purchases this Quarter

ALX Oncology
3,057,325 shares (about $6.13M)
RALLYBIO CORP
291,788 shares (about $2.62M)

Largest Sales this Quarter

Erasca
1,919,433 shares (about $31.06M)

Sector Allocation Over Time

Map of 500 Largest Holdings of5Am Venture Management, LLC

 
 
Selling
 
 
Neutral
 
 
Buying
Issuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSector
Erasca, Inc. stock logo
ERAS
Erasca
$56,403,011$31,056,426 â–¼-35.5%3,485,97115.7%Medical
Entrada Therapeutics, Inc. stock logo
TRDA
Entrada Therapeutics
$51,191,5030.0%4,056,37914.2%Medical
Tyra Biosciences, Inc. stock logo
TYRA
Tyra Biosciences
$39,422,1130.0%1,029,29810.9%Medical
CAMP4 THERAPEUTICS CORP
$25,882,6910.0%5,869,0917.2%COM
Centessa Pharmaceuticals PLC Sponsored ADR stock logo
CNTA
Centessa Pharmaceuticals
$23,075,1350.0%580,9456.4%Medical
Pharvaris N.V. stock logo
PHVS
Pharvaris
$22,532,2000.0%797,6006.3%Medical
MAPLIGHT THERAPEUTICS INC
$19,313,7240.0%950,0115.4%COM
TECTONIC THERAPEUTIC INC
$18,751,8610.0%606,6605.2%COM
Celldex Therapeutics, Inc. stock logo
CLDX
Celldex Therapeutics
$15,773,4040.0%497,2704.4%Medical
ARTIVA BIOTHERAPEUTICS INC
$15,155,2780.0%2,353,3044.2%COM
Eyepoint Pharmaceuticals, Inc. stock logo
EYPT
Eyepoint Pharmaceuticals
$13,534,5000.0%1,050,0003.8%Medical
SURROZEN INC
$11,287,8750.0%387,5003.1%COM NEW
Zentalis Pharmaceuticals, Inc. stock logo
ZNTL
Zentalis Pharmaceuticals
$9,238,1160.0%3,947,9132.6%Medical
GH Research PLC stock logo
GHRS
GH Research
$8,051,6700.0%572,6652.2%Medical
Protara Therapeutics, Inc. stock logo
TARA
Protara Therapeutics
$7,136,5640.0%1,369,7822.0%Medical
Biohaven Ltd. stock logo
BHVN
Biohaven
$6,251,7030.0%738,9721.7%Medical
ALX Oncology Holdings Inc. stock logo
ALXO
ALX Oncology
$6,129,937$6,129,937 â–²New Holding3,057,3251.7%Medical
SKYE BIOSCIENCE INC
$5,950,4120.0%9,681,7631.7%COM NEW
RALLYBIO CORP
$2,617,338$2,617,338 â–²New Holding291,7880.7%COM
Silence Therapeutics PLC Sponsored ADR stock logo
SLN
Silence Therapeutics
$2,509,5740.0%476,2000.7%Medical
Viridian Therapeutics, Inc. stock logo
VRDN
Viridian Therapeutics
$0$22,922,836 â–¼-100.0%00.0%Medical
Enliven Therapeutics, Inc. stock logo
ELVN
Enliven Therapeutics
$0$11,896,146 â–¼-100.0%00.0%Medical
Rallybio Corporation stock logo
RLYB
Rallybio
$0$2,491,040 â–¼-100.0%00.0%Medical

Showing largest 100 holdings. View all holdings.
SEC Filings and Trading Data