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Samsara Biocapital, LLC Top Holdings and 13F Report (2026)

About Samsara Biocapital, LLC

Investment Activity

  • Samsara Biocapital, LLC has $1.03 billion in total holdings as of March 31, 2026.
  • Samsara Biocapital, LLC owns shares of 22 different stocks, but just 6 companies or ETFs make up 80% of its holdings.
  • Approximately 9.82% of the portfolio was purchased this quarter.
  • About 1.14% of the portfolio was sold this quarter.
  • This quarter, Samsara Biocapital, LLC has purchased 21 new stocks and bought additional shares in 2 stocks.
  • Samsara Biocapital, LLC sold shares of 3 stocks and completely divested from 2 stocks this quarter.

Largest Holdings

Scholar Rock
$339,088,572
ALUMIS INC
$139,785,175
SEPTERNA INC
$75,673,546
KALARIS THERAPEUTICS INC
$74,710,427

Largest New Holdings this Quarter

85220G109 - SPYGLASS PHARMA INC
$54,668,882 Holding
00860C102 - AGOMAB THERAPEUTICS NV
$6,294,000 Holding
19249H103 - Coherus Oncology
$5,794,285 Holding

Largest Purchases this Quarter

SPYGLASS PHARMA INC
2,109,953 shares (about $54.67M)
SUTRO BIOPHARMA INC
858,369 shares (about $21.38M)
ALUMIS INC
588,235 shares (about $12.96M)
AGOMAB THERAPEUTICS NV
600,000 shares (about $6.29M)
Coherus Oncology
3,428,571 shares (about $5.79M)

Largest Sales this Quarter

PALVELLA THERAPEUTICS INC NE
66,385 shares (about $8.27M)
ABIVAX SA
18,861 shares (about $2.10M)
X4 PHARMACEUTICALS INC
127,434 shares (about $526.30K)

Sector Allocation Over Time

Map of 500 Largest Holdings ofSamsara Biocapital, LLC

 
 
Selling
 
 
Neutral
 
 
Buying
Issuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSector
Scholar Rock Holding Corporation stock logo
SRRK
Scholar Rock
$339,088,5720.0%6,897,65232.9%Medical
Mineralys Therapeutics, Inc. stock logo
MLYS
Mineralys Therapeutics
$159,045,8780.0%5,871,01815.5%Medical
ALUMIS INC
$139,785,175$12,958,817 â–²10.2%6,345,21913.6%COM
SEPTERNA INC
$75,673,5460.0%3,149,1287.4%COM
KALARIS THERAPEUTICS INC
$74,710,4270.0%12,948,0817.3%COM
SPYGLASS PHARMA INC
$54,668,882$54,668,882 â–²New Holding2,109,9535.3%COM SHS
NEUROGENE INC
$34,617,2800.0%1,717,1273.4%COM
Inventiva S.A. Sponsored ADR stock logo
IVA
Inventiva
$28,831,1680.0%5,194,8052.8%Medical
SUTRO BIOPHARMA INC
$26,476,142$21,381,972 â–²419.7%1,062,8722.6%COM SHS
JADE BIOSCIENCES INC
$13,611,6120.0%968,7981.3%COM NEW
VTV THERAPEUTICS INC
$11,838,3510.0%298,4961.2%CL A NEW
Aquestive Therapeutics, Inc. stock logo
AQST
Aquestive Therapeutics
$10,375,0000.0%2,500,0001.0%Medical
X4 PHARMACEUTICALS INC
$7,568,498$526,302 â–¼-6.5%1,832,5660.7%COM NEW
Nkarta, Inc. stock logo
NKTX
Nkarta
$7,401,1750.0%3,507,6660.7%Medical
Arcellx, Inc. stock logo
ACLX
Arcellx
$6,989,4380.0%60,8730.7%Medical
UPSTREAM BIO INC
$6,624,4230.0%736,0470.6%COM
ABIVAX SA
$6,300,294$2,100,172 â–¼-25.0%56,5810.6%SPONSORED ADS
AGOMAB THERAPEUTICS NV
$6,294,000$6,294,000 â–²New Holding600,0000.6%SPONSORED ADS
Rani Therapeutics Holdings, Inc. stock logo
RANI
Rani Therapeutics
$6,245,8000.0%8,500,0000.6%Medical
Coherus Oncology, Inc. stock logo
CHRS
Coherus Oncology
$5,794,285$5,794,285 â–²New Holding3,428,5710.6%Medical
PALVELLA THERAPEUTICS INC NE
$4,790,549$8,274,891 â–¼-63.3%38,4320.5%COM
Gossamer Bio, Inc. stock logo
GOSS
Gossamer Bio
$2,372,6110.0%7,222,5590.2%Medical
CONTINEUM THERAPEUTICS INC
$0$825,760 â–¼-100.0%00.0%CL A
NUVATION BIO INC
$0$40,959 â–¼-100.0%00.0%*W EXP 02/10/202

Showing largest 100 holdings. View all holdings.
SEC Filings and Trading Data