Vr Adviser, LLC Top Holdings and 13F Report (2024)

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About Vr Adviser, LLC

Investment Activity

Vr Adviser, LLC has $2.10 billion in total holdings as of March 31, 2024.
Vr Adviser, LLC owns shares of 38 different stocks, but just 17 companies or ETFs make up 80% of its holdings.
Approximately 20.10% of the portfolio was purchased this quarter.
About 19.22% of the portfolio was sold this quarter.
This quarter, Vr Adviser, LLC has purchased 36 new stocks and bought additional shares in 14 stocks.
Vr Adviser, LLC sold shares of 6 stocks and completely divested from 7 stocks this quarter.

Largest Holdings

APOGEE THERAPEUTICS INC: $564,381,180
4D Molecular Therapeutics: $140,184,000
Ocular Therapeutix: $116,138,404
SPYRE THERAPEUTICS INC: $82,375,691
Merus: $80,613,336

Largest New Holdings this Quarter

ENGENE HOLDINGS INC: $43,491,005 Holding
Edgewise Therapeutics: $33,163,640 Holding
Aquestive Therapeutics: $23,666,664 Holding
ADVERUM BIOTECHNOLOGIES INC: $22,007,765 Holding
Immatics: $18,392,500 Holding

Largest Purchases this Quarter

Ocular Therapeutix: 4,986,702 shares (about $45.38M)
ENGENE HOLDINGS INC: 2,565,841 shares (about $43.49M)
DIANTHUS THERAPEUTICS INC: 1,166,667 shares (about $35.00M)
Edgewise Therapeutics: 1,818,182 shares (about $33.16M)
4D Molecular Therapeutics: 975,969 shares (about $31.09M)

Largest Sales this Quarter

Celcuity: 915,538 shares (about $19.78M)
Cabaletta Bio: 1,000,000 shares (about $17.06M)
Merus: 358,000 shares (about $16.12M)
SPYRE THERAPEUTICS INC: 200,932 shares (about $7.62M)
Terns Pharmaceuticals: 1,087,059 shares (about $7.13M)

Sector Allocation Over Time

Selling

Neutral

Buying

Latest 13F Holdings and Changes Since Previous Quarterly Filing

Issuer Name	Holdings Value	Approximate Purchase/Sale	Change in Shares	Shares Held	% of Portfolio	Sector
APOGEE THERAPEUTICS INC	$564,381,180		0.0%	8,493,321	26.8%	COM
FDMT 4D Molecular Therapeutics	$140,184,000	$31,094,372 ▲	28.5%	4,400,000	6.7%	Medical
OCUL Ocular Therapeutix	$116,138,404	$45,378,988 ▲	64.1%	12,762,462	5.5%	Medical
SPYRE THERAPEUTICS INC	$82,375,691	$7,621,351 ▼	-8.5%	2,171,782	3.9%	COM NEW
MRUS Merus	$80,613,336	$16,120,740 ▼	-16.7%	1,790,214	3.8%	Medical
PHVS Pharvaris	$78,472,455		0.0%	3,395,606	3.7%	Medical
KALV KalVista Pharmaceuticals	$74,121,810	$25,582,020 ▲	52.7%	6,249,731	3.5%	Medical
ELVN Enliven Therapeutics	$70,823,162	$18,846,436 ▲	36.3%	4,026,331	3.4%	Medical
VRDN Viridian Therapeutics	$67,985,569	$840 ▲	0.0%	3,882,671	3.2%	Medical
DIANTHUS THERAPEUTICS INC	$62,831,190	$35,000,010 ▲	125.8%	2,094,373	3.0%	COM
DYNE THERAPEUTICS INC	$61,717,390		0.0%	2,173,913	2.9%	COM
APLT Applied Therapeutics	$61,710,000	$19,210,000 ▲	45.2%	9,075,000	2.9%	Medical
ORIC ORIC Pharmaceuticals	$60,424,746	$27,034,452 ▲	81.0%	4,394,527	2.9%	Medical
ATXS Astria Therapeutics	$50,791,678	$5,388,459 ▲	11.9%	3,608,645	2.4%	Medical
MRSN Mersana Therapeutics	$50,749,440		0.0%	11,328,000	2.4%	Medical
ENGENE HOLDINGS INC	$43,491,005	$43,491,005 ▲	New Holding	2,565,841	2.1%	COM
PRAXIS PRECISION MEDICINES I	$43,087,809	$21,509,550 ▲	99.7%	706,126	2.0%	COM NEW
HLVX HilleVax	$34,507,250		0.0%	2,075,000	1.6%	Medical
COGT Cogent Biosciences	$34,468,002	$2,990,400 ▲	9.5%	5,129,167	1.6%	Medical
EWTX Edgewise Therapeutics	$33,163,640	$33,163,640 ▲	New Holding	1,818,182	1.6%	Medical
CABA Cabaletta Bio	$26,681,021	$17,060,000 ▼	-39.0%	1,563,952	1.3%	Medical
ARVN Arvinas	$25,915,089		0.0%	627,788	1.2%	Medical
TSHA Taysha Gene Therapies	$25,830,000	$4,054,943 ▼	-13.6%	9,000,000	1.2%	Medical
AQST Aquestive Therapeutics	$23,666,664	$23,666,664 ▲	New Holding	5,555,555	1.1%	Medical
TERN Terns Pharmaceuticals	$22,369,980	$7,131,107 ▼	-24.2%	3,410,058	1.1%	Medical
ADVERUM BIOTECHNOLOGIES INC	$22,007,765	$22,007,765 ▲	New Holding	1,556,419	1.0%	COM NEW
CELC Celcuity	$20,952,000	$19,775,621 ▼	-48.6%	970,000	1.0%	Medical
ABIVAX SA	$19,244,654	$4,965,103 ▲	34.8%	1,345,780	0.9%	SPONSORED ADS
IMTX Immatics	$18,392,500	$18,392,500 ▲	New Holding	1,750,000	0.9%	Medical
LYRA Lyra Therapeutics	$16,023,298	$3,110 ▲	0.0%	2,576,093	0.8%	Medical
CG ONCOLOGY INC	$15,365,000	$15,365,000 ▲	New Holding	350,000	0.7%	COM
IPSC Century Therapeutics	$14,233,456	$14,233,456 ▲	New Holding	3,405,133	0.7%	Medical
TRVI Trevi Therapeutics	$11,808,229	$959 ▲	0.0%	3,422,675	0.6%	Medical
TNYA Tenaya Therapeutics	$8,135,558	$8,135,558 ▲	New Holding	1,555,556	0.4%	Medical
MLYS Mineralys Therapeutics	$7,172,202	$7,172,202 ▲	New Holding	555,554	0.3%	Medical
SLRN Acelyrin	$6,325,513		0.0%	937,113	0.3%	Medical
EYPT EyePoint Pharmaceuticals	$5,167,500		0.0%	250,000	0.2%	Medical
OLMA Olema Pharmaceuticals	$872,115		0.0%	77,042	0.0%	Medical
RAYZEBIO INC	$0	$250,574,382 ▼	-100.0%	0	0.0%	COM
AMBRX BIOPHARMA INC	$0	$29,476,800 ▼	-100.0%	0	0.0%	COM
RYTM Rhythm Pharmaceuticals	$0	$22,800,339 ▼	-100.0%	0	0.0%	Medical
SVRA Savara	$0	$16,450,000 ▼	-100.0%	0	0.0%	Medical
GHRS GH Research	$0	$7,646,297 ▼	-100.0%	0	0.0%	Medical
ADVM Adverum Biotechnologies	$0	$3,875,073 ▼	-100.0%	0	0.0%	Medical
MIST Milestone Pharmaceuticals	$0	$1,544,830 ▼	-100.0%	0	0.0%	Medical