Dyadic International Q3 2023 Earnings Call Transcript

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Provided by Quartr
November 8, 2023

There are 7 speakers on the call.

Operator

Good evening, and welcome to the Dyadic International's Third Quarter 2023 Financial Results Conference Call. Currently, all participants are in a listen only mode. Following management's prepared remarks, there will be a brief question and answer session. As a reminder, this conference call is being recorded today, November 8, 2023. I would now like to turn the call over to Ms.

Operator

Ping Rawson, Dyadic's Chief Financial Officer, please go ahead.

Speaker 1

Thank you. Good evening, and welcome, everyone, to I hope you have had the opportunity to review Dyadic's press release Announcing financial results for the quarter ended September 30, 2023, and the recent company highlights. You may access our release and Form 10 Q under the Investors section of the company's website atydix.com. On today's call, our President and CEO, Mark Emalfarb, will give a review of our Q3 business and corporate highlights, including a summary of our recent research and development efforts. Our Chief Business Officer, Joe Hazleton, will join Mark for the business updates.

Speaker 1

I will follow with a review of our financial results in more detail. We'll then hold a brief question and answer session. At this time, I would like to inform you that certain commentary made on this conference call may be considered forward looking statements, which involves risks and uncertainties and other factors that could cause Dyadic's actual results, performance, scientific or otherwise, All achievements to be materially different from those expressed or implied by these forward looking statements. Dyadic expressly disclaims any duty to provide updates to its forward looking statements, whether because of new information, future events or otherwise. Participants are directed to the risk factors set forth in Dyadic's risk report filed with the SEC.

Speaker 1

It is now my pleasure to pass the call to our CEO, Mark Emalfourg. Mark?

Speaker 2

Thank you, Ping. Hello, everyone, and thank you for joining Dyadic's Q3 2023 conference call. We have accelerated the momentum seen in the first half of twenty twenty three as our C1 technology continues to garner praise and recognition for its speed and efficiency in the U. S. And internationally from academia, industry and government agencies.

Speaker 2

We have also gained significant traction with our Dappicus platform, focused launch less than 12 months ago in both the alternative protein and bio industrial markets. On today's call, Joe and I will discuss our strategic plan for revenue growth, notable technological advances And recent business development successes we continue to achieve across each of our core markets. We will focus the discussion I'm not just providing an update on our Q3 scientific and business results, but also expand on our strategy to improve our revenue outlook in the short term and beyond. We are not just excited about our current and future prospects. We believe the success of our corporate strategy is beginning to be realized As evidenced by our September announcement of an agreement inclusive of upfront fees, the positive data from our first in human Phase 1 study I recently announced advancements in our own internal recombinant serum albumin projects, which have accelerated opportunities to enter into additional collaborations And partnerships such as the memorandum of understanding with the Italian government's foundation, Biotechna Polo di Siena, It performs the functions of an anti pandemic hub with a particular focus on the development and production of vaccines and monoclonal antibodies for the treatment of emerging epidemic and pandemic pathologies and the recently announced research collaboration with Vaccine And now immunotherapy center in Massachusetts General Hospital.

Speaker 2

We believe that We are at or near the precipice of applying our microbial protein production platforms, C1 and DAPA plus to develop antigens, Antibodies, enzymes and other proteins across each of our core verticals that we believe will lead to monetization It can significantly increase shareholder value for Dyadic and our collaborators. What makes Dyadic unique from other providers of expression platforms It is our industrial heritage. The majority of cell lines used for manufacture of biologic vaccines and therapeutics It started at research scales and tried to improve scale and yield at pharmaceutical price points. Dyadic Microbial platforms Have a long history of economically producing large scale bio industrial proteins and enzymes, which we are leveraging to manufacture Biopharmaceutical proteins with upstream costs and quantities that are closer to industrial margins providing our collaborators improved Pricing Flexibility. All platforms used in biomanufacturing must meet certain requirements in order to be commercialized.

Speaker 2

All platforms must be able to be properly cloned and expressed, correctly modified and folded functional proteins. What makes a particular platform an ideal choice for commercialization is one that is also rapid, highly productive and cost effective. This is why the C1 protein production platform is uniquely suited to meet the rising demand for vaccines, monoclonal antibodies, therapeutics and other proteins. C1 can produce standard or complex Proteins have been demonstrated to be comparable in function and quality to those produced in other cell lines like Chinese hamster ovary or CHO cells And baculovirus, which are inject cells. C1 has now completed a Phase 1 human trial with favorable preliminary safety data and has the capability to produce larger quantities of proteins at lower cost and in less time than the traditional eukaryotic We have shown that the C1 platform is up to 300 times more productive And baculovirus insect cells, which are being used in both human and animal health to produce certain vaccines and C1 also has significantly Short of fermentation time and no viruses that need to be removed in downstream processing, such as either bacovirus Our Chinese Hemp Sorobary chose cells, enabling the production and release of recombinant vaccines more rapidly in greater quantities And lower cost and traditional cell lines currently being used today.

Speaker 2

This is why we believe our C1 filamentous fungal protein production platform A distinct advantage is versus traditional eukaryotic cell lines currently used to manufacture vaccines and biologic drugs. In our human and animal core verticals, we are excited to have entered into a research and development project with another top 5 pharmaceutical company, Our new vaccine project in a large infectious disease market worth over $4,000,000,000 As previously mentioned, We have signed a memorandum of understanding with the Foundation Biotechnicalo De Ciena or FBS, which functions to perform As an anti pandemic hub with a particular focus on the development and production of vaccines and monoclonal antibodies for the treatment of emerging epidemic, pandemic pathologies. Scientific development at FVS is led by one of the world's foremost leading experts In vaccine development, Doctor. Rino Rapioli. Prior to his role at FBS, Doctor.

Speaker 2

Rapioli was the Global Head of Vaccines Research Novartis vaccine and diagnostics and most recently served as the Chief Scientific and Head of External R and D at the Vaccines Division of GlaxoSmithKline. FBS is prepared and equipped To conduct research, clinical study, regulatory approval, development, manufacture and commercialization of vaccines and therapeutic proteins using the company's C1 protein production platform. We're also continuing to expand the adoption of our C1 protein production platform, Such as the recently announced research collaboration with the Vaccine Immunotherapy Center at Massachusetts General Hospital To express vaccines for influenza A and other infectious diseases is part of a U. S. 5.8 $1,000,000 awards from the Department of Defense.

Speaker 2

Dyadic continues to strive to stay at the forefront of scientific advancement And we've been focusing on designing better performing biomolecules. In addition to the advancing C1 technology We've now developed C1 cell lines to express complex proteins such as conjugating antigens and ferritin nanoparticles. The interest in ferritin based nanoparticle production Has been increasing due to our ability to enhance rigidity and C1 to produce ferritin nanoparticles in a 1 step manufacturing process as opposed to the current 2 step method used by other technologies, potentially improving the speed and cost Effectiveness of the production process. We currently have ongoing animal studies with C1 expressed adjuvanted ferritin nanoparticle H5N1 And hemagglutinin inhibition HI levels. In other animal studies, T1 expressed the adjuvant A MHC II H1N1 antigen targeting seasonal influenza showed high neutralizing antibody levels.

Speaker 2

Additionally, the C1Xpress adjuvanted, full spike SARS CoV-two antigen has shown high neutralizing Antibail levels after single dose in ongoing animal trial. In the area of therapeutic proteins, We have signed additional fully funded research projects for the development and commercialization of therapeutic antibodies in the 3rd quarter. One such agreement is with a multinational pharmaceutical company to develop multiple C1 cell lines and produce monoclonal antibodies targeting infectious diseases, as well as another fully funded project to develop a C1 cell line for monoclonal antibody against We have also endeavored to expand our portfolio with potential new commercial products. This quarter, Dyadic entered into development commercialization agreement with European company Bjornay to develop messenger RNAs using our C1 technology. Messenger RNAs help to quickly develop Active COVID-nineteen vaccine critical for pandemic response.

Speaker 2

But the therapeutic applications extend beyond infectious disease in areas Such as cancer, where mRNAs encoding cancer antigens may help immune cells destroy tumors and substantially extend survival In rare diseases, where RNA based gene therapy is potentially capable of delivering a healthy copy of the phorbe gene to the cell. In this project, we are combining Bjorna's novel eukaryotic bioRNA platform with Dyadic's industrially proven C1 protein production platform To provide the pharmaceutical industry with a potentially more cost efficient platform for manufacturing large quantities of lower cost messenger RNAs, enabling access to mRNA vaccines and drugs for a broader global population. We've continued our focus on building and sustaining longer term strategic partnerships with our pharmaceutical partners, Such as advancing commercial products and clinical development of human and animal health vaccines with Rubik One Health for the African continent and the recent production of C1 expressed human infectious disease vaccine antigens under cGMP guidelines as well as other non GMP products with Epigen in India. We believe the C1 production platform can be a global solution to emerging infectious disease threats and pandemic response And not just humans, but also in Animal Health. In addition to the production of large quantities of antigens, antibodies and complex biomolecules, These products can also be made rapidly and cost effectively for developed and emerging countries, making C1a Potential pandemic preparedness platform for response or stockpiling.

Speaker 2

In addition to what we shared today, discussions are ongoing with several parties Interested in the potential adoption of the C1 platform across countries of all income levels. In addition to Rubik, we are increasing our penetration of the Animal Health markets for vaccines and therapeutic proteins. Animal Health continues to be an active, attractive segment For Dyadic, due to the higher margin sensitivity of Pharmaceutical Biologics and the significant impact that an outbreak can have on the global supply chain and potentially human health. The recognition, data and scientific advancements we are generating have accelerated our efforts in animal health As well as we have expanded our collaboration with Fibro, AbbViec and have initiated the fully funded research and development project with a new animal health company for development of a C1 expressed livestock vaccine antigen. Our 3rd vertical of alternative proteins continues to be an area of great excitement for Dyadic and one which we believe also holds their term potential promise in terms of opportunity and revenue.

Speaker 2

Dyadic is continuing to dedicate resources and support for the existing and future projects within this rapidly growing segment. Roughly 1 year ago, Dyadic launched the DABELIS platform, a filamentous thrombo based microbial gene expression And protein production platform, which is further designed and customized to enable the rapid development and large scale manufacturing of low cost enzymes, Proteins, metabolites and other biologic products for use in non pharmaceutical applications such as food, nutrition, Health and wellness. The agreement we signed in September to utilize our DAPAVIS platform to develop and commercialize certain non Animal dairy enzymes used in production of food products demonstrates the potential for our Daphylus platform to deliver results as well as the increased interest in this segment. In this agreement, we received an upfront payment of $600,000 in October for product development and are eligible to receive certain potential success fees as early as the first half of twenty twenty four In addition to future milestones and royalties, also in the Q3, Dyadic signed a fully funded research collaboration for the development of an enzyme for dispersion and absorption of injected drugs to reduce tissue damage. This means on the loan accounts for a $900,000,000 market across multiple applications.

Speaker 2

These are just a few of the examples of how our focus on shorter term product commercialization opportunities that have less time, cost and risk Associated with development is beginning to show results. This focus has accelerated our capability to develop Internal pipeline of proteins and enzymes with commercial potential across our core verticals, whose utilization is not dependent on lengthy and extensive clinical development programs. We have made further progress in developing animal free, recombinant serum albumin products It has demonstrated the analytical comparability to commercially available reference samples, bringing us another step closer to commercialization and monetization. We are currently providing samples of recombinant serum albumin and enzyme catalysts in order to accelerate commercialization with potential collaborators, We complete additional functional testing for different grades of products that can be offered. To further support revenue growth, we've initiated development Additional pipeline projects such as cell culture media and other proteins and enzymes across our core verticals at different grades and price points from multiple applications in pharmaceutical and non pharmaceutical markets, which we believe will improve our capability to drive near term revenues.

Speaker 2

I will now turn the call over to our Chief Business Officer, Joe Hackelton to provide an update on our Phase 1 trial progress and discuss Dyadic's strategy plan for revenue and growth and potential. Carol?

Speaker 3

Thank you, Mark. I'm happy to report that the Phase I trial for DYAI-one hundred has completed and the process for building the final study report has begun. For background, to establish a track record of safety in humans for antigens produced From our C1 protein production platform, the ongoing Phase 1 trial is a randomized double blind placebo controlled trial to evaluate the safety of the DYAI-one hundred COVID-nineteen recombinant protein or RBD booster vaccine in 30 healthy adults in South Africa at Two different dose levels. Dosing of all patients was completed in late February and the last patient last visit took place in September. The database lock occurred last week and we anticipate providing top line results in the coming weeks with the final full clinical study report to follow.

Speaker 3

Day 9 safety data for all patients was presented at the Data Safety Monitoring Board meeting in the 2nd quarter, which found no major vaccine related safety events at either dose level. And to date, there have been no serious adverse events reported. Given the evolving regulatory and market outlook for COVID, we're in discussions with Rubik One Health, our South African partner to evaluate the next development phase of the COVID-nineteen booster Pending the market conditions. We're continuing to validate the C1 platform to reduce clinical development risk for our partners and adding to our strong repository of safety, efficacy and productivity data regarding the C1 platform across a wide range of vaccines and antibodies. As we enter the Q4, we also want to provide greater insight into our strategic planning and execution to improve near term revenue potential.

Speaker 3

As Mark discussed earlier, we've made progress advancing our pharmaceutical and non pharmaceutical microbial platforms across our core verticals in 2023. Like our partners, we are not immune to the current economic climate. In pharmaceutical development, whether human or animal, in tough economic markets, Funding for research and development is scaled back to focus on shorter term revenue generating potentials. The same holds true for other markets such as Despite the current economic situation, we've been able to sign agreements with equity commercialization options or upfront freeze across our core verticals in 2023, In addition to adding fully funded research and development projects with key human and animal health pharmaceutical companies and non pharmaceutical partners. While this is encouraging, it is also why we have our foundation of micro to platforms is not just important, but also valuable.

Speaker 3

Through our protein expression systems, we not only enable our partners to develop targets, but we also have the capability to develop product opportunities of our own such as the recombinant human albumin and recombinant bovine albumin as Mark had mentioned earlier. In challenging economic Our strategy and that of our partners aligns on these types of product opportunities that do not require lengthy clinical trials, Significant development costs or additional regulatory reviews. By focusing on high value product opportunities, we are still advancing our microbial protein production platforms by demonstrating that our pipeline products such as enzyme catalysts for animal free proteins that have analytical and functional properties equal to or better than currently commercialized products. At the same time, we're expanding the adoption of our technology with existing and new partners to increase the number of to express influenza vaccine antigens. By increasing the volume of internal pipeline products and external partnerships across our We believe we can accelerate more consistent revenue generation in the coming year that is not strictly reliant on platform licensing and inclusive of potential product licensing for targets such as recombinant albumin, enzyme catalysts or cell culture media components.

Speaker 3

As we are commercializing our current product opportunities and broadening our internal pipeline, we also must continue to invest in our infrastructure and capability to efficiently exploit the increase in potential opportunities and broaden our targeted outreach across our core verticals. To accelerate our capability, we've expanded our leadership team with the addition of a seasoned pharmaceutical business development and marketing executive, Doug Pace. Mr. Pace started his career with large pharmaceutical companies such as Novartis and Pfizer working on both small and large molecule products in the oncology and biosimilar markets. He was most recently engaged in licensing of HealthTech platform technologies to large pharmaceutical companies that improved patient engagement.

Speaker 3

These had an immediate impact illustrated by a significant increase in unique client engagements And a 300% increase in new followers in the last 45 days versus the 45 days preceding his hire on a leading social networking app. While I can't predict the future or provide a definitive timeline for increased revenues, what I can say is that we are wholly focused on executing our strategic plan of driving internal product opportunities and capitalizing on our external collaborations and partnerships to increase revenue in the coming year. The most salient example continues to be our recombinant serum albumin products. As the global serum albumin market is Approximately $5,700,000,000 market growing at over 6% a year due to the increased use across a multitude of markets in human and animal health. In the Pharmaceutical segment, cirinabulin is not only being developed as a potential treatment for disease, but it is currently being used in the product development of vaccines As a carrier protein for therapeutics and as a common reagent in R and D.

Speaker 3

There are many different grades and price points for serum albumin across these and other markets Endatic has the potential to produce animal free recombinant cerinabulin at competitive pricing due to our highly productive C1 and DAPAVIS Microbial platforms using low cost media. We now have the initial analytics demonstrating our recombinant albumin is comparable to commercialized record samples on the market today, which improves our ability to commercialize a research grade product in the coming year. It also provides potential opportunities for larger sub exit options such as joint ventures or spin offs as products like recombinant albumin have been the foundation for companies such as Albiomedics, which was purchased in 2022 for over CHF 400,000,000 British pounds. Another example of near term opportunity has been borne out of our fully funded co development and co marketing agreement signed early this year with Farmbox. This has utilized our DAPTIS platform for the development of a cellulosic enzyme for use in biofuels and other segments.

Speaker 3

Dyadic will have the potential to license this enzyme as part of our portfolio of offerings to potential clients in the bio industrial market in the coming year. Hopefully, what we shared today instills the same enthusiasm and confidence that the Dyadic leadership team has in the company's future growth potential. Advancements to both our C1 Adaptive's platforms further enhance the speed, quality and productivity of these cell lines for targeted product opportunities Such as increasing our infectious disease antigen library to include seasonal and pandemic influenza, new COVID variants, rabies as well as other antigens and antibodies as potential product opportunities for the C1 platform. For the depth This platform will continue to evaluate new technologies to increase stability and productivity to further reduce the cost of manufacturing the common enzymes and proteins for margin sensitive markets. While the future is bright, we still have work ahead to maximize and monetize the various opportunities that lay before us.

Speaker 3

And Mark and I have revised and begun execution of our strategic plan to ensure we have the right infrastructure and resources to adequately address key business opportunities and accelerate near term revenue across our core verticals. I'll now turn the call back to Mark for some final comments on the Q3. Mark?

Speaker 2

Thank you, Joe. We will continue to leverage our decades of commercial scale industrial manufacturing knowledge and experience to accelerate near term product development opportunities across our core verticals. In parallel, we remain fiscally to help fund advancements of our science in critical areas. We continue to believe that our C1 platform is well positioned to be an alternative platform In developing and manufacturing next generation vaccines, antibodies and other therapeutic proteins for public health In future pandemics, we're happy to see C1 is gaining more recognition globally within academia, government and industry. We've refined our strategic plan and begun execution in core areas where our technologies such as our Dappervis platform can have the greatest impact And we're evaluating new opportunities aligned with our verticals in targeted markets of high potential return that are in need of cost effective solutions such as alternative proteins.

Speaker 2

With that, I'd like to turn the call over to our CFO, Kim Rawson, to run through our financials.

Speaker 1

Thank you, Mark. Thank you, everyone, for joining our call today. I will now go over our key financial results for the quarter ended September 30, 2023. You can find additional information in our earnings press release and Form 10 Q, which we filed earlier today. Research and development revenue and the license revenue for the Q3 of 2023 decreased to approximately $397,000 compared to $880,000 for the same period a year ago.

Speaker 1

Cost of research and development revenue for the quarter decreased to approximately $106,000 compared to $603,000 for the same period a year ago. The decrease in revenue and cost of revenue for the quarter was due to several research projects Winding down or on hold as a result of a lab relocation at one of our major contract research organizations. Research and development revenue and the license revenue for the 9 months ended September 30, 2023 slightly increased to approximately $2,212,000 compared to $2,187,000 for the same period a year ago. Cost of research and development revenue for the 9 months ended September 30, 2023 increased to approximately $1,626,000 compared to $1,419,000 for the same period a year ago. In the Q3 of 2023, we have signed several new research collaborations as we announced.

Speaker 1

We expect our research revenue will kick up in the 4th quarter and our total revenue for 2023 will be in line with 2022. Research and development expenses for the quarter decreased to approximately $716,000 compared to $744,000 for the same period a year ago. Research and development expenses for the 9 months Year to date decreased to approximately $2,444,000 compared to $3,917,000 for the same period a year ago. The decrease primarily reflected the winding down activity related to Company's Phase 1 clinical trial of BYA-one hundred COVID-nineteen vaccine candidate as patient dosing was completed in February 2023. G and A expenses for the quarter decreased by 7.3% to approximately $1,282,000 compared to $1,383,000 for the same period a year ago.

Speaker 1

G and A expenses for the 9 months decreased by 12.4 percent to approximately $4,165,000 compared to $4,753,000 for the same period a year ago. The decrease principally reflected Decreases in business development and Investor Relations expenses, accrued expenses related to management incentives and insurance expenses as well as legal expenses. Net loss for the Quarter was approximately $1,614,000 or 0 point 0 $6 per share compared to $1,809,000 or 6 Net loss for the 9 months was approximately $4,724,000 or $0.16 per share compared to $7,589,000 or $0.27 per share for the same period a year ago. As of September 30, 2023, cash, cash equivalents and the carrying value of investment grade securities, including accrued interest, were approximately $8,200,000 compared to $12,700,000 as of December 31, In October, we received an upfront payment of $600,000 For product development and the licensing of our Adaptabas platform for animal free dairy enzyme products, Our projections for our annual cash burn of 2023 will be less than $6,000,000 We expect that our existing cash balance will be sufficient to fund our operations into late 2024. With that, I will now ask the operator to begin our Q and A session.

Speaker 1

Joe will John Mark and I to answer your questions. If time permits, the operator will allow additional questions from those who have already spoken. Operator?

Operator

Thank you. And today's first question comes from John Van with Zacks. Please go ahead.

Speaker 4

Thank you and good afternoon everyone. I was reading through the firm box Details and wanted to see

Speaker 5

if you could give me a

Speaker 4

better understanding of what the cellulosic enzymes Renewable Biofuels is that something like auto fuel or something like that? I just wanted to get a sense of that opportunity and what it might represent.

Speaker 2

Yes. So I'll let Joe speak to some of that, but it's basically similar to what we did before with Abengoa and DuPont And with Codexis and Chao, our non compete ended a couple of years ago with DuPont and the market for cellulosic sugars Seems to be coming back as the cost of oil is going higher and there's a growing demand for enzymes to reduce The cost of digesting the biomass to make fermentable sugars to make renewable fuel. So that's one of the opportunities. One of the other things that we're working on It's an enzyme for pulp and paper with a customer that has a market for that that's looking for a new supplier.

Speaker 4

Okay. And is it auto related that fuel or is it for some other type of

Speaker 2

Yes. Well, of course, it's partly auto related, of course, renewable fuel for cars, Like ethanol example, but cellulosic ethanol, not for corn, but it's also just cellulosic sugars, which we use for fuels and chemicals And for other obviously fuels as well.

Speaker 4

Okay. Very good. And then as you look at those the latest three programs that you added The bioRNA enzymes and the DoD program, how would you rank those in terms of contribution To your efforts.

Speaker 2

Well, again, I think I just want to remind people, We get gene sequences from customers, put them in the cells, make proteins, give them back to samples and the customers move those forward. Of course, then some of these new products we're working on, on our own as well. But basically, I would say that, for common and healing albumin is one of our major focuses. We picked up new programs in the last quarter for an enzyme for use for biosimilars, which we talked about Earlier in the conference call, we picked up 3 antibodies to be going potentially into the clinic. So we're just During the preliminary work of taking their genes, creating cell lines, producing proteins and providing them back, providing the likes of quality, the yields, We potentially can go into a preclinical and then clinical trials.

Speaker 2

And the beautiful thing, to be honest, all those sweet proteins are very targeted proteins And Bart is Hitler. And so if we go into clinical trials, not only would our customers benefit, We'll benefit through the exposure that they get from the U. S. Government to BARDA and also all over the world. There's some really Horrible infectious disease that they're looking for new products for.

Speaker 2

I don't know if I've answered all your questions, but I didn't, John. Maybe you can ask me which one I missed.

Speaker 4

No, I mean, I just was trying to get a sense, so I think you did, Mark. Thank you.

Operator

Thank you. And ladies and gentlemen, our next question today comes from Paul Rosenbaum with SWR. Please go ahead.

Speaker 6

Thanks, Mark and the whole team. You've done a wonderful job. I'm very excited about the potential. But as a major shareholder, what I'm concerned about, and I'm sure a lot of other people are, is You've got existing cash that lasted till late 2024, that's technically less than a year. And do you have any capital plan that you can share with the shareholders?

Speaker 6

Or are you saying to us that You really don't need to raise any more cash over the next year.

Speaker 2

I think what we're saying is, Ping stated earlier, we expect that our existing cash balance will be sufficient to fund operation into late 2024. And that's without getting any other cash in, Whether it be highlighted in our activity pursuant near term product and license opportunities to generate some of that cash, We also believe we will generate revenue in the coming year through not only product and license opportunities, but potential Spin offs of some of the technology as we advance these products further down the line towards commercialization. And this is in Business partners. And as a management team, we're focused on execution of our strategic plan to ensure we have the right infrastructure and resources

Speaker 6

So just so I understand this, between your existing cash flow And what you expect to bring in revenue next year that you feel that you can go on without any raising any additional

Speaker 2

Well, what we said is we have $8,200,000 in September 30, we've got another $600,000 that came in. We're bringing estimated this year $606,000,000 So that would have from our ninethirty forward Put us in the $8,800,000 of cash and we're looking at all alternatives as to how to Bring in cash from either products, licensing and or other methods, which potentially could even be somewhere down the road of financing.

Operator

Thank you. And our next question today comes from Skip Gazzo with Conning Road Rental. Please go ahead.

Speaker 5

Hey, Mark. Hi, team. I think my question just got answered because I see that you're burning about $500,000 a month negative cash flow. And that was my exact Jen, you got 16 months and you're out of money if you didn't bring in any revenue. So but I think you just answered that unless you want to go into it a little bit more.

Speaker 2

No, I think that we just answered it. Thanks for your question and your support.

Operator

Thank you. And ladies and gentlemen, that concludes our question and session, I'd like to turn the conference back over to Dyadic's CEO, Mr. Emilfarb for closing comments.

Speaker 2

In 2023, We are seeing the impact of our Phase 1 human safety trial further validate the C1 platform for pharmaceutical use in human and animal health. We're also beginning to realize the investment in Adaptabas platform in alternative proteins has already led to a revenue event. We remain focused on improving the value of Dyadic for the life science industry, which will in turn improve value for shareholders and improve access to affordable vaccines and therapeutics globally. We have refined our focus and revised our business strategies to exploit existing and new commercialization opportunities in the near term while enabling us to fulfill our mission as a global biotechnology company to improve the way we feed, I want to thank you for joining us in today's 3Q 2023 conference call, And we look forward to keeping you updated as we advance our commercial and scientific initiatives on the next call. Please keep an eye out for our other periodic updates.

Operator

Thank you. The conference has now concluded.

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Dyadic International Q3 2023
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