NASDAQ:AKYA Akoya Biosciences Q4 2023 Earnings Report $1.12 -0.01 (-0.88%) Closing price 05/7/2025 03:59 PM EasternExtended Trading$1.07 -0.05 (-4.20%) As of 05/7/2025 06:40 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Earnings HistoryForecast Akoya Biosciences EPS ResultsActual EPS-$0.22Consensus EPS -$0.27Beat/MissBeat by +$0.05One Year Ago EPS-$0.50Akoya Biosciences Revenue ResultsActual Revenue$26.49 millionExpected Revenue$26.12 millionBeat/MissBeat by +$370.00 thousandYoY Revenue GrowthN/AAkoya Biosciences Announcement DetailsQuarterQ4 2023Date3/4/2024TimeAfter Market ClosesConference Call DateMonday, March 4, 2024Conference Call Time5:00PM ETUpcoming EarningsAkoya Biosciences' Q1 2025 earnings is scheduled for Monday, May 12, 2025, with a conference call scheduled at 5:00 PM ET. Check back for transcripts, audio, and key financial metrics as they become available.Q1 2025 Earnings ReportConference Call ResourcesConference Call AudioConference Call TranscriptPress Release (8-K)Annual Report (10-K)Earnings HistoryCompany ProfilePowered by Akoya Biosciences Q4 2023 Earnings Call TranscriptProvided by QuartrMarch 4, 2024 ShareLink copied to clipboard.There are 10 speakers on the call. Operator00:00:00Good day, and thank you for standing by. Welcome to the Koya Biosciences 4th Quarter 2023 Earnings Conference Call. At this time, all participants are in a listen only mode. After the speakers' presentation, there will be a question and answer session. Please be advised that today's conference is being recorded. Operator00:00:25I would now like to hand the conference over to your first speaker today, Priyam Shah, Head of Investor Relations. Please go ahead. Speaker 100:00:36Thank you, operator, and thank you to everyone who's joining us today on this call. I'm Priyam Shah, Head of Investor Relations at Aquoia Biosciences. On the call today, we have Brian McElgin, Chief Executive Officer and Johnny Eck, Chief Financial Officer. Earlier today, Aequa released financial results for the Q4 ended December 31, 2023. A copy of the press release is available on the company's website. Speaker 100:01:00Before we begin, I'd like to remind you that management will make statements during this call that include forward looking statements within the meaning of federal securities laws, which are made pursuant to the Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995. Any statements contained in this call that relate to expectations or predictions of future events, results or performance are forward looking statements. Actual results may differ materially from those expressed or implied in the forward looking statements due to a variety of factors. For a list and description of the risks and uncertainties associated with Ocoya's business, please refer to the risks identified in our filings with the U. S. Speaker 100:01:40Securities and Exchange Commission, including in the Risk Factors section of our annual report on Form 10 ks for the year ended December 31, 2023 to be filed today March 4, 2024. We urge you to consider these factors, and you should be aware that these statements are considered estimates only and are not a guarantee of future performance. This conference call contains time sensitive information and is accurate only as of the live broadcast today, March 4, 2024. Aquia disclaims any intention or obligation, except as required by law, to update or revise any financial projections or forward looking statements, whether because of new information, future events or otherwise. The audio portion of this call will be archived on the Investors section of our website later today under the heading Events. Speaker 100:02:29With that, I will now turn the call over to Brian. Speaker 200:02:32Thank you, Priyam, and good afternoon or evening to everyone. We appreciate you joining us today. During today's conference call, I will begin by giving a broad overview of our performance in the Q4 and full year 2023. I will review our business advancements and provide insights into the latest developments in our product offerings. Following that, Johnny will go deeper into our financials, key trends and provide an outlook for the future of the business. Speaker 200:03:03As pre announced at the JPMorgan Healthcare Conference in January, Aquia had a strong Q4 in 2023 with record breaking revenue of $26,500,000 and full year 2023 revenue of $96,600,000 representing a 29% annual growth from prior year. We exited the year with gross margin of 62.7% in the 4th quarter. In parallel to a strong top line growth and margin expansion throughout the year, We made efforts to leverage our cost structure limiting our 2023 operating expenses to only a 4% growth from prior year, enabling a more substantial portion of revenue growth to fall to our bottom line. Within our 2024 forecast, we expect both strong top line growth and margin expansion while we continue to manage our costs. And we are projecting operating cash flow breakeven by the end of this year. Speaker 200:04:09Johnny will touch upon this in greater detail later in the call. Our cumulative installed base now stands at nearly 1200 instruments, the largest in the field and covers the entire spectrum of spatial biology markets from discovery to translational and ultimately to clinical. Throughout 2023, we invested in key strategic areas including reagent menu expansion, throughput and workflow simplification and improved software capabilities, collectively contributing to meaningful reagent revenue expansion and increases in the pull through across our platforms. In the Q4, we saw continued signs of the return on these investments as reagent revenue grew 52% from the prior year period. We are pleased to report that we now have over 11 60 peer reviewed publications citing Akoyos Technologies as of year end 2023, a 50% growth from the prior year period, demonstrating the widening adoption and utility of Aquia solutions by our customers. Speaker 200:05:21Aquia has achieved important milestones in a short period of time that has solidified our market leadership position and will continue to pay dividends. As noted, OCOI has the largest and an actively publishing customer base that will continue to highlight and scientifically promote the current and future capabilities of our offerings. Next, we provide complete end to end solutions with high throughput workflows that deliver high quality spatial phenotyping at any level of multiplexing. And finally, our solutions span the entire continuum from discovery to clinical applications. The result as noted is a clear path to operating cash flow breakeven by year's end. Speaker 200:06:08Our R and D and operational efforts have been optimized to deliver enhancements and workflow efficiencies and drive an expanding menu of high value applications. Let me briefly review our key recent product line of improvements and 2 additional high value partnerships. First, the recent rollout of the PhenoCycleFusion 2.0 represents a noteworthy milestone, setting a new industry standard in capacity, multiplexing and data quality. Customers can now process twice as many samples per week compared to previous capabilities, establishing the PhenoCycla Fusion 2.0 as the highest throughput spatial discovery platform available in the market, providing multiplexing across a broad range from just a few proteins to up to 100. In parallel, we released our Pheno Imager HT 2.0 upgrade for our translational and clinical research customers. Speaker 200:07:09Like the Fusion 2.0, this upgrade similarly represents a transformative enhancement, resulting in a 5 fold increase in workflow speed. More than half of our customers have received a 2.0 fuel upgrade across both platforms as of year end 2023. These upgrades and the ongoing expansion of Coya's PinaCode content menu were the main drivers of the increases in consumable revenue in the Q4. We also recently announced 2 groundbreaking partnerships. First, we announced our partnership with Thermo Fisher to deliver advanced spatial multi omic workflows by combining the Thermo Fisher View RNA technology with Acoia's spatial biology solutions. Speaker 200:07:582nd, along with our partners at Enable Medicine, we announced the release of MaxFuse, an AI and reinforced learning driven multimodal data integration algorithm on the Enable Medicine cloud platform. This next generation analytical methodology allows our customers to directly integrate into one analysis Aquoia's spatial proteomic data with single cell RNA data. As a result, our customers' single cell RNA Seq data, which is not spatial, is mapped to Aquoia's spatial proteomic data, creating an informatically derived spatial multiomic dataset. This transformative solution allows customers using Aquoia's platforms and single cell RNAseq platforms to leverage and integrate these independent datasets from different platforms to drive profound new multi omic discoveries. This is likely the first of many such AI based analytical approaches to come. Speaker 200:09:08Our platform improvements and partnerships further strengthen our position to lead the market in offering powerful new spatial phenotyping solutions and we remain committed to continuing to lead the market providing the industry's best end to end solutions across multiple market segments. While these new solutions certainly expand our discovery horizons, downstream, we are also witnessing a continued expansion and acceleration of the clinical utility of spatial technologies. Spatial phenotyping is becoming central to emerging clinical biomarker efforts in immuno oncology and the rapidly growing antibody drug conjugate market. Our 78% growth in our services revenue compared to the prior year is a clear indication of this as we secure additional late stage clinical trial partnerships. Our demonstrated organizational clinical expertise, the capabilities of the Pheno Imager HD platform, our co marketing partnership with Agilent and our companion diagnostic partnership with Acrovant are all key drivers of the expansion of this part of our business. Speaker 200:10:23Now importantly, Acrovant also received breakthrough device designation on the ACR-three sixty eight Onco Signature assay run on our HD platform through our CLIA lab and fast track designation for their therapeutic ACR-three sixty eight and we look forward to their Phase 2 clinical trial interim results in the near future. We continue to expand our qualified service provider network that includes the industry's top contract research organizations. Aquia qualifies these partners and provides ongoing white glove to support to help ensure their success in offering lab services on Aquia's platforms. The network serves as a valuable commercial amplifier and helps advance the adoption of our platforms in translational studies and clinical trials. We are humble and appreciative that these successes and ongoing efforts have attracted preeminent global thought leaders in immunobiology to join our newly established Scientific Advisory Board. Speaker 200:11:35Doctor. Gary Nolan, Aquoia's founder and the inventor of the penicylar and co inventor of Maxius has transitioned from his role on the Board of Directors to serve as the new Chair of the Scientific Advisory Board. Accompanying him will be Doctor. James Allison, 2018 Nobel Laureate and the father of the immuno oncology revolution as well as Doctor. Padmeesh Sharma, a visionary physician scientist in the field of immuno oncology and immunotherapy, both currently at MD Anderson. Speaker 200:12:11These three initial members of Aquia's Scientific Advisory Board will inform Aquia's strategic direction and provide expertise in translational, clinical and diagnostic applications of Aquia's spatial biology solutions. Lastly, like others in the industry, we observed some ongoing macro pressures impacting capital equipment purchases, prolonged instrument sales cycles and continued underperformance in our business in China. We anticipate these challenges to persist at least through the Q1 of 2024. In summary, our focus for 2024 revolves around 3 key initiatives. 1st, expand applications and implement continued workflow efficiency improvements on the Pheno Select Lithusion and the Pheno Imager HD to drive the continued high growth of our reagent revenue resulting in increases in system pull through. Speaker 200:13:122nd, achieve operating cash flow breakeven by year end 2024 by focusing on improving efficiencies, cost effectiveness and gross margin expansion. And 3rd, continue to drive our clinical partnerships to achieve our goal of delivering a menu of high value companion diagnostics to advance patient care. With that, I will now turn the call over to Johnny to discuss our financial results. Johnny? Speaker 300:13:41Thanks, Brian. As Brian highlighted, total revenue for the Q4 of 2023 was $26,500,000 a 25% growth compared to the same period in 2022. Full year 2023 revenue was $96,600,000 representing a 29% growth from the prior year. Our robust year over year growth was seen globally across our diversified revenue channel and strong portfolio of products and services. Product revenue including instruments, reagents and software totaled $16,700,000 for the 4th quarter. Speaker 300:14:24We sold 51 instruments, of which 15 were PhenoCyclers and 36 were from the Pheno Imager portfolio, generating total instrument revenue of $9,200,000 for the quarter. As Brian noted earlier, continued macro pressures and underperformance in China impacted our results and we expect this trend to continue in the near term. Our global installed base now comprises 11 83 instruments, including 342 phenocyclers and 841 phenol imagers. A total of 230 Fusion instruments have shipped since the full commercial launch at the start of 2022 and we now have a total installed base of 205 for the combined Phenocycler fusion system. The majority of Phenocyclers are being sold in combination with the fusion and we expect this combination to drive increased reagent pull through with an expanding menu of panels and faster workflows from the ongoing 2.0 field upgrades. Speaker 300:15:33Approximately half of the installed base of PhenoCycler fusions and HTs in the field have been upgraded to 2.0 models as of year end 2023 and we expect the majority of the remaining instruments in the field to upgrade throughout the remainder of 2024. All new PhenoCycler Fusion and HT systems are being sold directly as a 2.0 model as of the start of 2024. We delivered $6,900,000 in reagent revenue in the Q4, reflecting a 52% increase from the prior year period. The annualized 4th quarter reagent pull through applicable to both PhenoCycler and HT is now in the high $30,000 range. This is a notable improvement compared to the annualized pull through per instrument 2022, which was in the high $20,000 range to the low $30,000 range for both the PhenoCycler and the HT. Speaker 300:16:35This growth can be attributed to the increased utilization of PhenoCyclers paired with a Fusion, faster workflows and a growing utility of PhenoCODE panels across the instrument portfolio. We are strategically positioning reagents to play a more significant role in our revenue mix with customers increasing their utility and pull through across our platforms as we pair more phenocyclers with fusions in the field, enhance instrument portfolio through the 2.0 upgrades and refine our reagent manufacturing, operations planning and supply chain efforts. Services and other revenue totaled $9,800,000 for the 4th quarter, an increase of 78% over the prior year period. Services have been a substantial growth segment for us as our instrument warranty and field service revenue have rapidly expanded, in addition to our lab services business continuing to drive higher value studies through new and existing biopharma partnerships. Gross profit was $16,600,000 in the 4th quarter, representing a 38% growth over the prior year period and gross margin was 62.7% for the 4th quarter versus 56.8% in the prior year period. Speaker 300:18:00The timing and contribution of revenue from our lab services business contributed approximately 250 basis points of margin to the strong 4th quarter gross margin results. As we drive increases in our reagent revenue mix, execute on our identified operation optimization efforts for reagents and leverage recent manufacturing investments, we expect to further drive the expansion of our gross margin in 2024 and beyond in the range of a couple of 100 basis points annually. Operating expense for the quarter totaled $26,100,000 as compared to $29,600,000 in the prior year period, indicative of a reduced spend pattern throughout 2023 while we continued our meaningful top line growth. Total OpEx for 2023 grew only 4%, while top line revenue grew 29% from the prior year and gross margin expanded further indicating that our efforts to leverage our cost structure have been very impactful throughout 2023. Through ongoing strategic efforts, we expect to further lower our operating costs this year, helping us achieve projected operating cash flow break even as we exit 2024. Speaker 300:19:24We ended the quarter with approximately $83,100,000 of cash and cash equivalents. Common shares outstanding and fully diluted shares, including the impact of outstanding options and unvested restricted stock awards are $49,100,000 as of December 31, 2023. In summary, we are pleased to report another exceptional quarter with record breaking revenue of $26,500,000 and full year 2023 revenue of $96,600,000 a 29% growth over the prior year. Aquia's installed base has now reached nearly 1200 instruments, solidifying our position as an industry leader in spatial biology. Our strategic focus for 2024 remains on driving reagent revenue growth and increasing pull through across our growing installed base to realize the scalability of spatial biology. Speaker 300:20:23We've also implemented important operational changes to enhance efficiency, drive gross margin improvement and achieve cost advantages, all while maintaining strong top line growth. As such, we are confident in our ability to sustain strong growth throughout 2024 and beyond and we project reaching our very important goal of operating cash flow breakeven as we exit 2024. At this time, we are providing a revenue guidance range of $114,000,000 to $118,000,000 for 2024. And back to you, Brian. Speaker 200:21:01Thank you, Johnny. We're pleased to report a strong quarter and announced multiple exciting new developments across our product portfolio. We look forward to executing on our strategic objectives throughout the remainder of the year as we drive the business towards positive cash flow. We're thankful for the hard work of our fellow dedicated Aquoyans as well as for the support of our customers and shareholders. Ocoya remains very well positioned for growth and we're excited about the opportunities that lie ahead as we deliver new space of solutions from the discovery to the clinical markets. Speaker 200:21:39At this point, we will open the call for questions. Operator? Operator00:21:44Thank you. Our first question comes from the line of Subbu Nambi from Guggenheim. Your line is open. Speaker 400:22:14Hey guys, thank you for taking my question. The first topic I want to cover is gross margins. How should we think about quarterly pacing for gross margin throughout the year? And as you think about puts and takes, a big one is your progress towards bringing a lot of these reagents manufacturing in house. In the long term, how will this benefit gross margins? Speaker 400:22:34And in the near term, does this bring transitory pressure? And then I have one follow-up. Speaker 200:22:39Yes. This is Brian. I'll let thank you, Subbu, for your question. I'll let Johnny maybe dig into some of the details. Largely speaking, the positive gross margins for the quarter were really a function of two things. Speaker 200:22:54Number 1 is the mix. We saw the reagent revenue number was we had a significant expansion of our reagent revenue in the 4th quarter as a result of a lot of the efforts that we've been putting in over the last year or so. That was one large contributor and obviously those reagents are much higher in their margins. And the second one is our service revenue, with the advancements of a lot of our clinical programs also took a significant step up. And now we're really at a place where we're able to leverage that infrastructure and that cost basis. Speaker 200:23:28So as that revenue grows, it does start to contribute to the bottom line. In terms of bringing the manufacturing in house, the facilities all built out, personnel are there, and we really are just now beginning to put on the shelf reagents that were manufactured internally. And that is really the other driver for longer term gross margin contribution. And then I'll let Johnny maybe give some color on the specifics of the gross margin throughout the year. Speaker 300:24:00Yes. Thanks, Subbu and thanks, Brian. As Brian mentioned, we had a couple of 100 basis point contribution in Q4 from some milestones achieved in the ABS business, which as you can see in Q4 lifted that margin to a healthy 63%. Our sort of operating, if you exclude that ABS and the operating gross margin, really the exit was sort of in the 60%, 61%. And so we expect that sort of move ratably through the year. Speaker 300:24:31It'll be a bit lumpy as events happen, certainly from any of the ABS revenue may move that. But from an operating gross margin, as Brian highlighted, we have begun the operation, some of the manufacturing in house and it's really a factor of how much of that transitions in house over time as we also scale and start to achieve more and more efficiencies through the year, which is so I would look at it as a pretty linear pacing. It will be impacted by mix, of course, as mix happens through the year. If we happen to have a quarter where reagents are stronger than the instruments, etcetera, maybe it'll move. But generally, it's a relatively linear pacing to kind of get to our exit, which allows for movement of a couple of 100 basis points from our baseline that we've established exiting 2023. Speaker 400:25:23Super helpful. Thank you both. And regarding again the reagents, which is largely PhenoQuote Signature and Discovery panels, I'm guessing. First, what is the expected contribution you embedded in the full year guidance? And then second, at what point in the year would you expect contributions to become more material? Speaker 400:25:42And lastly, do you expect an increase in penetration of these reagents in your CRO and large pharma accounts this year? Speaker 200:25:49Yes, it's a good question. I think we're beginning to realize some of the benefits of our content strategy. So I think it's going to be it's going to continue to be an accelerant for us throughout the year. I don't we're now at a point where we're beginning to realize some of those benefits. With respect to your question on our content expansion efforts, your question on CROs and biopharma, yes, I do think our specifically our targeted signature panels that are really on to be run on the HT or within the field of immuno oncology. Speaker 200:26:27Those ready made panels, I think we really start to get to scale studies, Subbu and around the second half, we're going to be doing some very large scale studies. And I think that is one of the contributors why we expect to see continued reagent expansion throughout the year. One clarification when at least it may get lost. When we say ABS, we're referring there to our CLIA lab services or advanced biopharma solutions group. So ABS really is lab services, they're synonymous. Speaker 200:26:56So thank you, Subbu. Speaker 400:26:58Thank you so much guys. Operator00:27:01Thank you. One moment for our next question. Our next question comes from the line of Kyle Mixon from Canaccord. Your line is open. Speaker 500:27:14Hey, thanks guys. Congrats on the year and the quarter. I want to kind of break down the guidance a little more, Brian and Johnny. So some of these assumptions here, could placement slow down this year given the recent launches and the upgrades? And then on pull through, could that increase by another like $10,000 by the end of this year, even though most of the tailwinds seem to be in 2023 or at least the inflection point seem to be that year, at least that's what the communication seem to be. Speaker 500:27:39And then on services, like, sounds like a great backlog there. Just talk about visibility that you have at this point. And then of course like China, obviously, it's going to be an issue until 1Q, but maybe how are you thinking about that in the second half of the year? Thanks. Speaker 200:27:54So I think I got all those and if I don't Kyle let me know. So the 2.0 isn't going to slow down placements. Those are field upgrades. I think they're just going to make those installs even more powerful in terms of their pull through. It is those upgrades that was a contributor to the reagent acceleration that we saw in the second half. Speaker 200:28:19And we do think as we course the year, we do think quarter over quarter we'll see that reagent number continue to climb. The services business is growing per your question solely because of the nature of the partnerships that we're securing. They're much later stage, they're of much higher value and the 70 plus percent bump you saw in that portion of our business is probably the strongest indicator that one can see it externally of the type of projects that we're taking on are being later stage higher value projects that really give us a lot of confidence that we will realize our clinical strategy of securing additional clinical trial assays and companion diagnostic deals. And we will achieve our goal of having CDX products in the queue contributing a significant portion of our revenue in the near future. So that's sort of the commentary I think on everything. Speaker 200:29:25I think I got everything you asked about Kyle. Speaker 500:29:28Yes. Just on China also, if you have any sense on the back half of the year. Thanks. Speaker 200:29:33Yes. Look, I think consistent with many of our peers, we're going to assume that the first half is still pretty challenging. And if there is recovery, it's going to be incremental in second half. It's just not something you count on. And as we look at our game of achieving operating cash flow breakeven, we've got to do that within the context of a revenue goal that takes advantage of our diversified portfolio from CERT lab services to reagents and instruments, but it's not so aspirational that we put that profitability goal at risk. Speaker 200:30:04So we're trying to be very balanced in having a top line goal and a margin goal that doesn't require significant changes in the current business environment. Speaker 500:30:15Okay. That was great, Brian. Thanks so much. Just a quick one on MaxView algorithm with Enable. Speaker 100:30:19Yes. Speaker 500:30:20Definitely differentiated from a clinical perspective. I heard Nolan talking about that. Could you just maybe walk through that a bit more, just double click on the clinical side Speaker 600:30:28of that? Speaker 500:30:28And then Well, I'm sorry, Guy. Speaker 200:30:31Go ahead. Go ahead. Sorry. Speaker 500:30:33Just wondering if that's like the first of many kind of like unique one off software solutions for the ecosystem that you kind of roll out with your other partners too, like just in addition to enable you by their partners, right? So just curious about that. Speaker 200:30:44We do. Look, the way I look at that with Mike's sort of simple brand, if you play chat GPT or some of those image creators, I think you have at least a qualitative sense of the kind of power that these sorts of approaches can bring. I would largely say, Kyle, in the near term, this is really a tool for your discovery researchers. And effectively, as I noted on the call, what it allows you to do, it allows you to take single cell RNA seek data and leveraging the MaxView algorithm the phenoCyclar fusion high plex protein data, you informatically make that non spatial data spatial by using the MaxFUSE algorithm. So this allows our customers not to do a multi omic study 1 at a time, but rather leveraging the large, large datasets that exist for single cell, whether it's an internally or with third parties to leverage that dataset and your Acoides fetal cycle infusion data to make it spatial. Speaker 200:31:41I would encourage everybody to go read the 2 Nature papers that Doctor. Nolan has done on this. It really is quite astounding and they validated it to a pretty deep extent. So I do think this is many of additional approaches to common and we'll continue to look at partners like Enable or others as vehicles to implement these in a user friendly manner knowing that a skilled informatician can do GitHub type approaches regardless. Speaker 500:32:10Okay. That was helpful. Thanks guys. Appreciate it. Speaker 200:32:12Thanks, Kyle. Operator00:32:14Thank you. One moment for our next question. Our next question comes from the line of Tejal Sawant from Morgan Stanley. Your line is open. Speaker 700:32:25Hey guys. Hey, good evening. How are you? Brian, just to kick things off over here, placements came in a little bit light in the 4th quarter, even on a sequential basis. I think in the Q3, you've done almost, I think it was in the high 60s, if I remember right. Speaker 700:32:44Can you just walk us through sort of that dynamic? Was it entirely driven by macro and some of those elongated purchase decision cycles that you called out in China as well? Or was there any shift in the competitive landscape here? Specifically, I mean, the one that we've been getting questions on is Lunafor. So just curious as to any if you could parse out that dynamic and the sequential step down in placements? Speaker 200:33:09Yes. It's Tejas, thank you for the question. It's certainly the former that's driving it. I mean, what we saw Tejas in Q3 and Q4 was quarters were becoming increasingly backloaded in month 3. So that's largely that is the largest dynamic, the largest driver there. Speaker 200:33:29I think the visibility of Lunafor and the question is I think is largely a result of them sort of being integrated with Bio Techne and having a lot more visibility and marketing power. And we'll see how that competitive dynamic shakes out over the coming quarters because I think they're really just getting going. Speaker 700:33:50Got it. Fair enough. And then in terms of just the academic budget environment, last couple of weeks, you've had a few inbounds and just cracks over in Europe and Horizon and some questions around the continuing resolution here in the U. S. As well. Speaker 700:34:07You guys are obviously over index there like a lot of your spatial peers. So just curious as to what you're baking into the guide and what you're hearing from your academic customers at the moment? Speaker 200:34:17Yes. I would say, Tejas, I think similar to my prior commentary to Kyle, what we've tried to bake into our guide is really a continuation of the existing market pressures that we were all feeling in Q3 and certainly Q4 on the capital side. So I think that's going to be our approach. We feels like we've been living in continuing resolutions and questions on the NIH budget for over a decade. It's just perhaps a little bit more acute now. Speaker 200:34:44So that's kind of how we're looking at it. What is, Tejas, in our control and I think where we're realizing some successes is in areas that are less prone to being impacted by macros, which is the reagent utilization on our platform and the advancing of our clinical opportunities, which are in the well funded arenas of immuno oncology, as I noted on the call. So we're going to continue to focus on those areas. They are again less prone to some of these macro dynamics and the ROIs are significant for us. So that will be our area a key areas of focus to mitigate any instrument pressures. Speaker 700:35:22Got it. And then one final one, one for you, Brian, and one for Johnny. Brian, I know you've sort of like shifted the focus a little bit in 2023, to optimizing existing solutions, driving consumables growth, etcetera. But how should we think about the product development roadmap, perhaps not in 2024, but over the next couple of years here? And Johnny, I Speaker 100:35:49think, Speaker 700:35:54full year of cash flow breakeven for you guys? Speaker 200:35:58So I'll take the first part first and then Johnny the second. So you can think of our product development priorities focused on workflow simplifications throughout this year and getting over the clinical finish line and getting additional partnerships, whether or not we speak to those publicly is to be determined. So that is the priority now, but you're correct longer term in terms of platforms, there are really two areas that I think are opportunities for the company. Number 1 is ensuring that we have an IVD grade system because we will have a menu of products. So it's ensuring that that roadmap is solidified. Speaker 200:36:36On the other extreme, in the upstream discovery market, we are going to we are already at a place where spatial biology is going to be done at scale. Large scale studies, large scale database studies. So getting the instruments to a place where they can do that, having the reagents at a place where they can support that and algorithms like MaxFuse to be able to leverage these large datasets. Spatial is going to go the direction that we've seen all other powerful life sciences tools go, which is studies are getting larger and larger at scale. And there is true sample elasticity in this market. Speaker 200:37:12You make the systems faster, easier and more affordable to use and there will be more samples. So longer term, Tayejop, those are the 2 avenues of full additional platform development opportunities for us. Speaker 300:37:25And Tay, just to your question on 2025, certainly we haven't guided obviously to 2025, but we don't expect to move top line or margin. We expect those to continue to be strong, continue to grow. And really it's about maintaining a reasonable OpEx, which we absolutely expect to be able to do, which drives a full year sort of a cash flow from ops, a good full year cash flow from ops in 2025 that's positive. So, and the building blocks sort of build themselves, if we continue to execute and maintain that OpEx where we expect it to, that's our target absolutely. Speaker 700:37:59Got it. Thanks guys. Appreciate the time. Speaker 200:38:01Thanks, Sanjay. Operator00:38:03Thank you. One moment for our next question. Our next question comes from the line of Jon Sauerbier from UBS. Your line is open. Speaker 300:38:17Good evening and thanks for taking Speaker 800:38:18my question. I was wondering if you could just talk a little bit more on the announcement with Thermo and the vRNA assays. I guess any initial feedback from customers there and what is the demand you're seeing on most YOMIQ capabilities? Speaker 200:38:30Yes. I think for us in kind of reverse order, John, thank you for the question and for your time. We look at RNA as something that's complementary to our HiPlex protein technology platform on the phenocyclic fusion. So we really are focused on integrating an RNA solution that is at a plex level that's consistent with that beam. And the vuRNA technology is perfectly suited to do that. Speaker 200:38:58It's a really a high resolution amplified single cell resolution platform. And so we're just beginning to integrate and roll that stuff out. We just announced it. So a lot of the hard work is happening right now. I think we'll probably be talking more about some of those details at AACR. Speaker 200:39:19And the demand from our customers to have a complementary RNA technology is strong. And I think both the vuRNA implementation, but equally important perhaps John and we'll see how it plays out. I think algorithmic approaches like MaxPeats do represent a transformative addition on how people leverage not just their own data, but publicly available data to get informatically derived multiomics solution. So I think both are important. Speaker 800:39:52Thanks. And as a follow-up, you have customers who started to adopt in Fusion 22 and now I guess you have 50% at the 2.0 upgrade. What is the runway you think here that you have for some of these users to hit full utilization and just talk about longer term where you think the pull through could go? Speaker 200:40:09I realize now Kyle asked a little bit about specifics on pull through. So we have right now, John, about 2 thirds of all the Athena cyclers are sitting with the Fusion. And we'll probably get through most of those upgrades kind of throughout this year. And as we look at pull through on that system, like as Johnny noted, kind of in the high 30s as we exited the year. We exited last year somewhere around the high 20s or so. Speaker 200:40:36So I think that trend line continues throughout 2024 and into 2025, doing 40, 50, 60s. I think we can easily get to that realm. Many of our high end users are operating at 5x plus that average pull through number. So I think there's an opportunity for us to really raise the curve on all of them. What we're seeing, particularly with the 2.0, John, is a real pressing need amongst our phenocycler fusion users to really start to press the plex level even more. Speaker 200:41:11So you're at 50, 60, 70 plex and they're doing that with more samples. And that's why the PhenoCycler Fusion 2.0 users are the highest pull through users. So it's about moving all of those customers up to that 2.0. Speaker 300:41:27Thanks for taking Speaker 200:41:27the questions. Thanks, John. Operator00:41:30Thank you. One moment for our next question. Our next question comes from the line of Mark Massaro from BTIG. Your line is open. Speaker 600:41:48Hey guys. Thanks for taking the questions and congratulations on a strong 2023. I guess my first one is on the guidance, 114% to 118%, I think it calls for 18% to 22%. In your pre announced in January, you talked about 20% plus. So obviously, you're in line with that. Speaker 600:42:08I'm just curious if the 18% somehow might be factoring in pressures related to macro or China or elongated sales cycles? And then maybe can you just give us a sense for the demand environment in the U. S? Obviously, that's been a stronger territory for you with respect to other geographic regions. So just give us a sense for perhaps anything you have on geographic growth and how we should think about that this year? Speaker 200:42:41Yes, I'll do those. Thanks, Mark. I appreciate your question and your time. So if you go through and look at our growth across the regions, North America, as you noted, was the strongest and we think it will continue to be the strongest. It was in the sort of high 30% realm. Speaker 200:43:00And I think it will probably stay there. And I don't think these geographic trends change meaningfully in 2024. EMEA was kind of in the low 20s mark in terms of its year over year growth in 2023. And then APAC was like high single digits and most of that was because the team was able to pivot to other regions, Japan, Australia, etcetera, Korea, South Korea to get to compensate for the contraction in APAC. I think those trends continue into 2024. Speaker 200:43:36I think you're right in terms of the low end of the range is really intended to account for those pressures being even more pronounced. One thing though, if and when we do, Mark, secure more partnerships like Acrovant, those are largely additive to our guide. There may be a portion of those that's embedded within our expectations for continued growth of our services business. But additional large scale CDX deals, like another Acrobon with a large biopharma that would be additive to that range. And certainly if and when those do occur, we'll clarify that. Speaker 200:44:20So hopefully that answers your questions. Speaker 600:44:23Yes, that's helpful. And then my last question, could you maybe zero in a little bit about what you're seeing in terms of customer demand for PhenoCo discovery and signature panels? And then any way to as we're tuning up our models, how should we think about reagent growth? Obviously, this is a year where you're coming into the year with about 1200 systems. Just give us a sense for how you think reagent growth might track relative to prior years? Speaker 200:44:55Yes. I'll let Johnny speak to how much detail we want to give because we don't guide on a product basis. But I would say, Mark, that reagents is going to be in terms of dollars are probably our largest growth driver because it's moving so quickly as you saw from I think it was a 5.7% in Q3 and a 6.9% in Q4. So you can see we're beginning to realize the benefits of many of the workflow solutions that we put on the market. And then we think those trends maybe not linearly continue throughout the year. Speaker 200:45:31So that's how I would look at that. And John, I don't know if you want to add any more color in terms of the specifics on reagents. Speaker 300:45:38No. Only to say to highlight sort of what you said, which if you think look back to 2022, obviously, it was sort of in that 4,000,000 dollars range, moved into the $5,000,000 plus range in 'twenty three and really exited 'twenty three and that's called $7,000,000 per quarter. And we expect that to continue. It's sort of natural taking these steps and certainly will be an important focus that will help to drive the margin goals that we have as well in 2024. Speaker 600:46:07Okay. Actually, if I can sneak one more in, great progress on getting to that operating cash flow breakeven by year end 2024, certainly a year ahead of expectations from recent comments. Speaker 100:46:24There's been Speaker 600:46:24a decent amount of M and A. Some of it's been larger, some of it's been smaller. But as you're about to turn the corner to cash flow breakeven, are there certain assets out there, even if they are of the tuck in variety that might be enticing to you? And maybe just speak, if you will, about the M and A environment broadly? Speaker 200:46:47Yes. I think you've got a couple of buckets of M and A, Mark. I think you've got some activity that's really driven around companies trying to find synergies as a way to continue to capitalize their business. And then you've got these larger deals like the OLink deal. I think they're kind of falling into those 2 buckets. Speaker 200:47:09I think for us, Mark, our number one priority for 2024, we have everything that we need in our technology stack. It's really just delivering on what we need to in terms of growth with reagents at the center of that. And then securing additional and then continue to expand our biopharma business. So there's nothing that is of immediate need that would be better done with an M and A. That said, we are always keeping our head on a swivel and looking at opportunities and trying to do that in a kind of in a reasonable resource method. Speaker 200:47:48Okay. Speaker 600:47:48Thanks for the time. Speaker 200:47:49Thanks, Mark. Operator00:47:51Thank you. One moment for our next question. And our next question comes from the line of Rachel Van Stol from JPMorgan. Your line is open. Speaker 900:48:07Perfect. Good afternoon. Thanks for taking the questions. Speaker 400:48:10So I want to follow-up on some Speaker 900:48:11of the earlier questions around placements. Can you just kind of walk us through what are your base case assumptions for placements this year in 2024? In the past, you talked about a run rate of a few 100 instruments per year. Should we model that for this year as well? And then what are the potential sources of upside and downside on that this year? Speaker 900:48:29Thanks. Speaker 200:48:30Yes. Thank you, Rachel. Your numbers are right. I think a couple of 100 is fair. We probably wouldn't get more specific in that. Speaker 200:48:36And then I think the upside, I think we still have upsides certainly on the reagents as we expand our content, as we get the 2 O's fully utilized in the field with their increased capacity, as software solutions like MaxFuse become more prominent and our panels continue to roll out. So I think there's certainly upside there. I also feel like, we have opportunities to continue to advance our clinical partnership portfolio, to hopefully to secure additional significant partnerships in that realm and much of that would be additive to our top line whether it's this year or next year. We try not to we have not baked into our base financial fundamentals an assumption around additional significant CDX deals. But when they do come, as I noted earlier, that would be a source of upside. Speaker 900:49:34Great. And then I just wanted to push on the macro backdrop a little bit more. You talked about how 4Q continued to have some of those macro pressures impacting capital equipment purchases. So can you talk about how that trend has continued into January February, as customers have kind of had some of these budgets reset on Jan 1? And then you highlighted that China was an area of weakness, from some of this capital purchase spending, but were there any other geographies that were notably impacted by the macro backdrop as well? Speaker 900:50:01Thanks. Speaker 200:50:03Obviously, you can have exchange rate issues that effectively drives up your ASP. But that's not to the point I think where beyond the macros, it's really impacting our top line. And I think as I noted earlier, it's really Rachel just about some budget tightening, but also an increased in diligence and approval circles around many capital purchases just like we do internally with our own capital purchases. So those are the large scale dynamics in play. Speaker 900:50:41Great. And then just on January, February trends, could you walk us through how some of those conversations trended in January, February so Speaker 200:50:48far? Yes. I mean, I'm hesitant to give any specific guidance on Q1 other than to say we have as an expectation in our full year guide that the market trends that we saw in second half and in Q4 will continue into Q1 and the rest of the year. Speaker 900:51:08Sounds good. Thank you. Speaker 200:51:09Thanks, Rachel. Operator00:51:11Thank you. I'm not showing any further questions in the queue. I'd like to turn the call back over to Brian McKelligan for any closing remarks. Speaker 200:51:18Yes. Well, thank you, Victor, for hosting us. Thank you to everybody for your time. I think for Acoya, we have and will continue to demonstrate and realize the benefits of our strategy, with ultimately that being, as we noted, hitting operating cash flow breakeven by the end of the year with our reagent growth and the margin expansion along with that being core contributors. But again, as I noted, we're also seeing real significant movement and opportunities for us to take that next leap as a company and continue to advance our portfolio from a research based product to additionally a clinical based product. Speaker 200:51:54And we'll continue to share those successes with all of you as part of future calls. So I thank you for your time and I look forward to following up with each of you soon. Operator00:52:07Thank you for your participation in today's conference. This does concludeRead morePowered by Conference Call Audio Live Call not available Earnings Conference CallAkoya Biosciences Q4 202300:00 / 00:00Speed:1x1.25x1.5x2x Earnings DocumentsPress Release(8-K)Annual report(10-K) Akoya Biosciences Earnings HeadlinesAKOYA BIOSCIENCES INVESTOR ALERT by the Former Attorney General of Louisiana: Kahn Swick & Foti, LLC Investigates Adequacy of Price and Process in Proposed Sale of Akoya Biosciences, Inc. - AKYAMay 7 at 3:46 PM | businesswire.comAkoya Biosciences, Inc. (NASDAQ:AKYA) Receives $3.21 Average Target Price from AnalystsMay 7 at 2:39 AM | americanbankingnews.comWatch This Robotics Demo Before July 23rdJeff Brown, the tech legend who picked shares of Nvidia in 2016 before they jumped by more than 22,000%... Just did a demo of what Nvidia’s CEO said will be "the first multitrillion-dollar robotics industry."May 8, 2025 | Brownstone Research (Ad)Canaccord Genuity Group Lowers Akoya Biosciences (NASDAQ:AKYA) Price Target to $1.80May 2, 2025 | americanbankingnews.comAkoya Unveils ADC Breast Cancer Assay, Validates IO60 Spatial Panel At AACR 2025April 26, 2025 | nasdaq.comAkoya expands portfolio with new ADC breast cancer assay at AACR 2025April 25, 2025 | markets.businessinsider.comSee More Akoya Biosciences Headlines Get Earnings Announcements in your inboxWant to stay updated on the latest earnings announcements and upcoming reports for companies like Akoya Biosciences? Sign up for Earnings360's daily newsletter to receive timely earnings updates on Akoya Biosciences and other key companies, straight to your email. Email Address About Akoya BiosciencesAkoya Biosciences (NASDAQ:AKYA), a life sciences technology company, provides spatial biology solutions focused on transforming discovery and clinical research in North America, the Asia Pacific, Europe, the Middle East, and Africa. The company offers PhenoCycler instrument, a compact bench-top fluidics system that integrates with a companion microscope to automate image acquisition; and PhenoImager platform that enables researchers to visualize, analyze, quantify, and phenotype cells in situ, in fresh frozen or FFPE tissue sections, and tissue microarrays utilizing an automated and high-throughput workflow. It also provides PhenoCycler and PhenoImager reagents; and biopharma services. In addition, the company offers analysis software partnerships ecosystem; inForm Tissue, an automated image analysis software package for accurately visualizing and quantifying biomarkers in tissue sections; Phenoptr, which provides functions that consolidate and analyze output tables created by inForm software; and phenoptrReports, a software that generates shareable reports and visualizations based on the phenoptr output in an intuitive front-end GUI. It has a collaboration agreement with NeraCare that enables personalized therapy selection for early-stage melanoma patients. The company was incorporated in 2015 and is headquartered in Marlborough, Massachusetts.View Akoya Biosciences ProfileRead more More Earnings Resources from MarketBeat Earnings Tools Today's Earnings Tomorrow's Earnings Next Week's Earnings Upcoming Earnings Calls Earnings Newsletter Earnings Call Transcripts Earnings Beats & Misses Corporate Guidance Earnings Screener Earnings By Country U.S. Earnings Reports Canadian Earnings Reports U.K. Earnings Reports Latest Articles Disney Stock Jumps on Earnings—Is the Magic Sustainable?Archer Stock Eyes Q1 Earnings After UAE UpdatesFord Motor Stock Rises After Earnings, But Momentum May Not Last Broadcom Stock Gets a Lift on Hyperscaler Earnings & CapEx BoostPalantir Stock Drops Despite Stellar Earnings: What's Next?Is Eli Lilly a Buy After Weak Earnings and CVS-Novo Partnership?Is Reddit Stock a Buy, Sell, or Hold After Earnings Release? 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There are 10 speakers on the call. Operator00:00:00Good day, and thank you for standing by. Welcome to the Koya Biosciences 4th Quarter 2023 Earnings Conference Call. At this time, all participants are in a listen only mode. After the speakers' presentation, there will be a question and answer session. Please be advised that today's conference is being recorded. Operator00:00:25I would now like to hand the conference over to your first speaker today, Priyam Shah, Head of Investor Relations. Please go ahead. Speaker 100:00:36Thank you, operator, and thank you to everyone who's joining us today on this call. I'm Priyam Shah, Head of Investor Relations at Aquoia Biosciences. On the call today, we have Brian McElgin, Chief Executive Officer and Johnny Eck, Chief Financial Officer. Earlier today, Aequa released financial results for the Q4 ended December 31, 2023. A copy of the press release is available on the company's website. Speaker 100:01:00Before we begin, I'd like to remind you that management will make statements during this call that include forward looking statements within the meaning of federal securities laws, which are made pursuant to the Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995. Any statements contained in this call that relate to expectations or predictions of future events, results or performance are forward looking statements. Actual results may differ materially from those expressed or implied in the forward looking statements due to a variety of factors. For a list and description of the risks and uncertainties associated with Ocoya's business, please refer to the risks identified in our filings with the U. S. Speaker 100:01:40Securities and Exchange Commission, including in the Risk Factors section of our annual report on Form 10 ks for the year ended December 31, 2023 to be filed today March 4, 2024. We urge you to consider these factors, and you should be aware that these statements are considered estimates only and are not a guarantee of future performance. This conference call contains time sensitive information and is accurate only as of the live broadcast today, March 4, 2024. Aquia disclaims any intention or obligation, except as required by law, to update or revise any financial projections or forward looking statements, whether because of new information, future events or otherwise. The audio portion of this call will be archived on the Investors section of our website later today under the heading Events. Speaker 100:02:29With that, I will now turn the call over to Brian. Speaker 200:02:32Thank you, Priyam, and good afternoon or evening to everyone. We appreciate you joining us today. During today's conference call, I will begin by giving a broad overview of our performance in the Q4 and full year 2023. I will review our business advancements and provide insights into the latest developments in our product offerings. Following that, Johnny will go deeper into our financials, key trends and provide an outlook for the future of the business. Speaker 200:03:03As pre announced at the JPMorgan Healthcare Conference in January, Aquia had a strong Q4 in 2023 with record breaking revenue of $26,500,000 and full year 2023 revenue of $96,600,000 representing a 29% annual growth from prior year. We exited the year with gross margin of 62.7% in the 4th quarter. In parallel to a strong top line growth and margin expansion throughout the year, We made efforts to leverage our cost structure limiting our 2023 operating expenses to only a 4% growth from prior year, enabling a more substantial portion of revenue growth to fall to our bottom line. Within our 2024 forecast, we expect both strong top line growth and margin expansion while we continue to manage our costs. And we are projecting operating cash flow breakeven by the end of this year. Speaker 200:04:09Johnny will touch upon this in greater detail later in the call. Our cumulative installed base now stands at nearly 1200 instruments, the largest in the field and covers the entire spectrum of spatial biology markets from discovery to translational and ultimately to clinical. Throughout 2023, we invested in key strategic areas including reagent menu expansion, throughput and workflow simplification and improved software capabilities, collectively contributing to meaningful reagent revenue expansion and increases in the pull through across our platforms. In the Q4, we saw continued signs of the return on these investments as reagent revenue grew 52% from the prior year period. We are pleased to report that we now have over 11 60 peer reviewed publications citing Akoyos Technologies as of year end 2023, a 50% growth from the prior year period, demonstrating the widening adoption and utility of Aquia solutions by our customers. Speaker 200:05:21Aquia has achieved important milestones in a short period of time that has solidified our market leadership position and will continue to pay dividends. As noted, OCOI has the largest and an actively publishing customer base that will continue to highlight and scientifically promote the current and future capabilities of our offerings. Next, we provide complete end to end solutions with high throughput workflows that deliver high quality spatial phenotyping at any level of multiplexing. And finally, our solutions span the entire continuum from discovery to clinical applications. The result as noted is a clear path to operating cash flow breakeven by year's end. Speaker 200:06:08Our R and D and operational efforts have been optimized to deliver enhancements and workflow efficiencies and drive an expanding menu of high value applications. Let me briefly review our key recent product line of improvements and 2 additional high value partnerships. First, the recent rollout of the PhenoCycleFusion 2.0 represents a noteworthy milestone, setting a new industry standard in capacity, multiplexing and data quality. Customers can now process twice as many samples per week compared to previous capabilities, establishing the PhenoCycla Fusion 2.0 as the highest throughput spatial discovery platform available in the market, providing multiplexing across a broad range from just a few proteins to up to 100. In parallel, we released our Pheno Imager HT 2.0 upgrade for our translational and clinical research customers. Speaker 200:07:09Like the Fusion 2.0, this upgrade similarly represents a transformative enhancement, resulting in a 5 fold increase in workflow speed. More than half of our customers have received a 2.0 fuel upgrade across both platforms as of year end 2023. These upgrades and the ongoing expansion of Coya's PinaCode content menu were the main drivers of the increases in consumable revenue in the Q4. We also recently announced 2 groundbreaking partnerships. First, we announced our partnership with Thermo Fisher to deliver advanced spatial multi omic workflows by combining the Thermo Fisher View RNA technology with Acoia's spatial biology solutions. Speaker 200:07:582nd, along with our partners at Enable Medicine, we announced the release of MaxFuse, an AI and reinforced learning driven multimodal data integration algorithm on the Enable Medicine cloud platform. This next generation analytical methodology allows our customers to directly integrate into one analysis Aquoia's spatial proteomic data with single cell RNA data. As a result, our customers' single cell RNA Seq data, which is not spatial, is mapped to Aquoia's spatial proteomic data, creating an informatically derived spatial multiomic dataset. This transformative solution allows customers using Aquoia's platforms and single cell RNAseq platforms to leverage and integrate these independent datasets from different platforms to drive profound new multi omic discoveries. This is likely the first of many such AI based analytical approaches to come. Speaker 200:09:08Our platform improvements and partnerships further strengthen our position to lead the market in offering powerful new spatial phenotyping solutions and we remain committed to continuing to lead the market providing the industry's best end to end solutions across multiple market segments. While these new solutions certainly expand our discovery horizons, downstream, we are also witnessing a continued expansion and acceleration of the clinical utility of spatial technologies. Spatial phenotyping is becoming central to emerging clinical biomarker efforts in immuno oncology and the rapidly growing antibody drug conjugate market. Our 78% growth in our services revenue compared to the prior year is a clear indication of this as we secure additional late stage clinical trial partnerships. Our demonstrated organizational clinical expertise, the capabilities of the Pheno Imager HD platform, our co marketing partnership with Agilent and our companion diagnostic partnership with Acrovant are all key drivers of the expansion of this part of our business. Speaker 200:10:23Now importantly, Acrovant also received breakthrough device designation on the ACR-three sixty eight Onco Signature assay run on our HD platform through our CLIA lab and fast track designation for their therapeutic ACR-three sixty eight and we look forward to their Phase 2 clinical trial interim results in the near future. We continue to expand our qualified service provider network that includes the industry's top contract research organizations. Aquia qualifies these partners and provides ongoing white glove to support to help ensure their success in offering lab services on Aquia's platforms. The network serves as a valuable commercial amplifier and helps advance the adoption of our platforms in translational studies and clinical trials. We are humble and appreciative that these successes and ongoing efforts have attracted preeminent global thought leaders in immunobiology to join our newly established Scientific Advisory Board. Speaker 200:11:35Doctor. Gary Nolan, Aquoia's founder and the inventor of the penicylar and co inventor of Maxius has transitioned from his role on the Board of Directors to serve as the new Chair of the Scientific Advisory Board. Accompanying him will be Doctor. James Allison, 2018 Nobel Laureate and the father of the immuno oncology revolution as well as Doctor. Padmeesh Sharma, a visionary physician scientist in the field of immuno oncology and immunotherapy, both currently at MD Anderson. Speaker 200:12:11These three initial members of Aquia's Scientific Advisory Board will inform Aquia's strategic direction and provide expertise in translational, clinical and diagnostic applications of Aquia's spatial biology solutions. Lastly, like others in the industry, we observed some ongoing macro pressures impacting capital equipment purchases, prolonged instrument sales cycles and continued underperformance in our business in China. We anticipate these challenges to persist at least through the Q1 of 2024. In summary, our focus for 2024 revolves around 3 key initiatives. 1st, expand applications and implement continued workflow efficiency improvements on the Pheno Select Lithusion and the Pheno Imager HD to drive the continued high growth of our reagent revenue resulting in increases in system pull through. Speaker 200:13:122nd, achieve operating cash flow breakeven by year end 2024 by focusing on improving efficiencies, cost effectiveness and gross margin expansion. And 3rd, continue to drive our clinical partnerships to achieve our goal of delivering a menu of high value companion diagnostics to advance patient care. With that, I will now turn the call over to Johnny to discuss our financial results. Johnny? Speaker 300:13:41Thanks, Brian. As Brian highlighted, total revenue for the Q4 of 2023 was $26,500,000 a 25% growth compared to the same period in 2022. Full year 2023 revenue was $96,600,000 representing a 29% growth from the prior year. Our robust year over year growth was seen globally across our diversified revenue channel and strong portfolio of products and services. Product revenue including instruments, reagents and software totaled $16,700,000 for the 4th quarter. Speaker 300:14:24We sold 51 instruments, of which 15 were PhenoCyclers and 36 were from the Pheno Imager portfolio, generating total instrument revenue of $9,200,000 for the quarter. As Brian noted earlier, continued macro pressures and underperformance in China impacted our results and we expect this trend to continue in the near term. Our global installed base now comprises 11 83 instruments, including 342 phenocyclers and 841 phenol imagers. A total of 230 Fusion instruments have shipped since the full commercial launch at the start of 2022 and we now have a total installed base of 205 for the combined Phenocycler fusion system. The majority of Phenocyclers are being sold in combination with the fusion and we expect this combination to drive increased reagent pull through with an expanding menu of panels and faster workflows from the ongoing 2.0 field upgrades. Speaker 300:15:33Approximately half of the installed base of PhenoCycler fusions and HTs in the field have been upgraded to 2.0 models as of year end 2023 and we expect the majority of the remaining instruments in the field to upgrade throughout the remainder of 2024. All new PhenoCycler Fusion and HT systems are being sold directly as a 2.0 model as of the start of 2024. We delivered $6,900,000 in reagent revenue in the Q4, reflecting a 52% increase from the prior year period. The annualized 4th quarter reagent pull through applicable to both PhenoCycler and HT is now in the high $30,000 range. This is a notable improvement compared to the annualized pull through per instrument 2022, which was in the high $20,000 range to the low $30,000 range for both the PhenoCycler and the HT. Speaker 300:16:35This growth can be attributed to the increased utilization of PhenoCyclers paired with a Fusion, faster workflows and a growing utility of PhenoCODE panels across the instrument portfolio. We are strategically positioning reagents to play a more significant role in our revenue mix with customers increasing their utility and pull through across our platforms as we pair more phenocyclers with fusions in the field, enhance instrument portfolio through the 2.0 upgrades and refine our reagent manufacturing, operations planning and supply chain efforts. Services and other revenue totaled $9,800,000 for the 4th quarter, an increase of 78% over the prior year period. Services have been a substantial growth segment for us as our instrument warranty and field service revenue have rapidly expanded, in addition to our lab services business continuing to drive higher value studies through new and existing biopharma partnerships. Gross profit was $16,600,000 in the 4th quarter, representing a 38% growth over the prior year period and gross margin was 62.7% for the 4th quarter versus 56.8% in the prior year period. Speaker 300:18:00The timing and contribution of revenue from our lab services business contributed approximately 250 basis points of margin to the strong 4th quarter gross margin results. As we drive increases in our reagent revenue mix, execute on our identified operation optimization efforts for reagents and leverage recent manufacturing investments, we expect to further drive the expansion of our gross margin in 2024 and beyond in the range of a couple of 100 basis points annually. Operating expense for the quarter totaled $26,100,000 as compared to $29,600,000 in the prior year period, indicative of a reduced spend pattern throughout 2023 while we continued our meaningful top line growth. Total OpEx for 2023 grew only 4%, while top line revenue grew 29% from the prior year and gross margin expanded further indicating that our efforts to leverage our cost structure have been very impactful throughout 2023. Through ongoing strategic efforts, we expect to further lower our operating costs this year, helping us achieve projected operating cash flow break even as we exit 2024. Speaker 300:19:24We ended the quarter with approximately $83,100,000 of cash and cash equivalents. Common shares outstanding and fully diluted shares, including the impact of outstanding options and unvested restricted stock awards are $49,100,000 as of December 31, 2023. In summary, we are pleased to report another exceptional quarter with record breaking revenue of $26,500,000 and full year 2023 revenue of $96,600,000 a 29% growth over the prior year. Aquia's installed base has now reached nearly 1200 instruments, solidifying our position as an industry leader in spatial biology. Our strategic focus for 2024 remains on driving reagent revenue growth and increasing pull through across our growing installed base to realize the scalability of spatial biology. Speaker 300:20:23We've also implemented important operational changes to enhance efficiency, drive gross margin improvement and achieve cost advantages, all while maintaining strong top line growth. As such, we are confident in our ability to sustain strong growth throughout 2024 and beyond and we project reaching our very important goal of operating cash flow breakeven as we exit 2024. At this time, we are providing a revenue guidance range of $114,000,000 to $118,000,000 for 2024. And back to you, Brian. Speaker 200:21:01Thank you, Johnny. We're pleased to report a strong quarter and announced multiple exciting new developments across our product portfolio. We look forward to executing on our strategic objectives throughout the remainder of the year as we drive the business towards positive cash flow. We're thankful for the hard work of our fellow dedicated Aquoyans as well as for the support of our customers and shareholders. Ocoya remains very well positioned for growth and we're excited about the opportunities that lie ahead as we deliver new space of solutions from the discovery to the clinical markets. Speaker 200:21:39At this point, we will open the call for questions. Operator? Operator00:21:44Thank you. Our first question comes from the line of Subbu Nambi from Guggenheim. Your line is open. Speaker 400:22:14Hey guys, thank you for taking my question. The first topic I want to cover is gross margins. How should we think about quarterly pacing for gross margin throughout the year? And as you think about puts and takes, a big one is your progress towards bringing a lot of these reagents manufacturing in house. In the long term, how will this benefit gross margins? Speaker 400:22:34And in the near term, does this bring transitory pressure? And then I have one follow-up. Speaker 200:22:39Yes. This is Brian. I'll let thank you, Subbu, for your question. I'll let Johnny maybe dig into some of the details. Largely speaking, the positive gross margins for the quarter were really a function of two things. Speaker 200:22:54Number 1 is the mix. We saw the reagent revenue number was we had a significant expansion of our reagent revenue in the 4th quarter as a result of a lot of the efforts that we've been putting in over the last year or so. That was one large contributor and obviously those reagents are much higher in their margins. And the second one is our service revenue, with the advancements of a lot of our clinical programs also took a significant step up. And now we're really at a place where we're able to leverage that infrastructure and that cost basis. Speaker 200:23:28So as that revenue grows, it does start to contribute to the bottom line. In terms of bringing the manufacturing in house, the facilities all built out, personnel are there, and we really are just now beginning to put on the shelf reagents that were manufactured internally. And that is really the other driver for longer term gross margin contribution. And then I'll let Johnny maybe give some color on the specifics of the gross margin throughout the year. Speaker 300:24:00Yes. Thanks, Subbu and thanks, Brian. As Brian mentioned, we had a couple of 100 basis point contribution in Q4 from some milestones achieved in the ABS business, which as you can see in Q4 lifted that margin to a healthy 63%. Our sort of operating, if you exclude that ABS and the operating gross margin, really the exit was sort of in the 60%, 61%. And so we expect that sort of move ratably through the year. Speaker 300:24:31It'll be a bit lumpy as events happen, certainly from any of the ABS revenue may move that. But from an operating gross margin, as Brian highlighted, we have begun the operation, some of the manufacturing in house and it's really a factor of how much of that transitions in house over time as we also scale and start to achieve more and more efficiencies through the year, which is so I would look at it as a pretty linear pacing. It will be impacted by mix, of course, as mix happens through the year. If we happen to have a quarter where reagents are stronger than the instruments, etcetera, maybe it'll move. But generally, it's a relatively linear pacing to kind of get to our exit, which allows for movement of a couple of 100 basis points from our baseline that we've established exiting 2023. Speaker 400:25:23Super helpful. Thank you both. And regarding again the reagents, which is largely PhenoQuote Signature and Discovery panels, I'm guessing. First, what is the expected contribution you embedded in the full year guidance? And then second, at what point in the year would you expect contributions to become more material? Speaker 400:25:42And lastly, do you expect an increase in penetration of these reagents in your CRO and large pharma accounts this year? Speaker 200:25:49Yes, it's a good question. I think we're beginning to realize some of the benefits of our content strategy. So I think it's going to be it's going to continue to be an accelerant for us throughout the year. I don't we're now at a point where we're beginning to realize some of those benefits. With respect to your question on our content expansion efforts, your question on CROs and biopharma, yes, I do think our specifically our targeted signature panels that are really on to be run on the HT or within the field of immuno oncology. Speaker 200:26:27Those ready made panels, I think we really start to get to scale studies, Subbu and around the second half, we're going to be doing some very large scale studies. And I think that is one of the contributors why we expect to see continued reagent expansion throughout the year. One clarification when at least it may get lost. When we say ABS, we're referring there to our CLIA lab services or advanced biopharma solutions group. So ABS really is lab services, they're synonymous. Speaker 200:26:56So thank you, Subbu. Speaker 400:26:58Thank you so much guys. Operator00:27:01Thank you. One moment for our next question. Our next question comes from the line of Kyle Mixon from Canaccord. Your line is open. Speaker 500:27:14Hey, thanks guys. Congrats on the year and the quarter. I want to kind of break down the guidance a little more, Brian and Johnny. So some of these assumptions here, could placement slow down this year given the recent launches and the upgrades? And then on pull through, could that increase by another like $10,000 by the end of this year, even though most of the tailwinds seem to be in 2023 or at least the inflection point seem to be that year, at least that's what the communication seem to be. Speaker 500:27:39And then on services, like, sounds like a great backlog there. Just talk about visibility that you have at this point. And then of course like China, obviously, it's going to be an issue until 1Q, but maybe how are you thinking about that in the second half of the year? Thanks. Speaker 200:27:54So I think I got all those and if I don't Kyle let me know. So the 2.0 isn't going to slow down placements. Those are field upgrades. I think they're just going to make those installs even more powerful in terms of their pull through. It is those upgrades that was a contributor to the reagent acceleration that we saw in the second half. Speaker 200:28:19And we do think as we course the year, we do think quarter over quarter we'll see that reagent number continue to climb. The services business is growing per your question solely because of the nature of the partnerships that we're securing. They're much later stage, they're of much higher value and the 70 plus percent bump you saw in that portion of our business is probably the strongest indicator that one can see it externally of the type of projects that we're taking on are being later stage higher value projects that really give us a lot of confidence that we will realize our clinical strategy of securing additional clinical trial assays and companion diagnostic deals. And we will achieve our goal of having CDX products in the queue contributing a significant portion of our revenue in the near future. So that's sort of the commentary I think on everything. Speaker 200:29:25I think I got everything you asked about Kyle. Speaker 500:29:28Yes. Just on China also, if you have any sense on the back half of the year. Thanks. Speaker 200:29:33Yes. Look, I think consistent with many of our peers, we're going to assume that the first half is still pretty challenging. And if there is recovery, it's going to be incremental in second half. It's just not something you count on. And as we look at our game of achieving operating cash flow breakeven, we've got to do that within the context of a revenue goal that takes advantage of our diversified portfolio from CERT lab services to reagents and instruments, but it's not so aspirational that we put that profitability goal at risk. Speaker 200:30:04So we're trying to be very balanced in having a top line goal and a margin goal that doesn't require significant changes in the current business environment. Speaker 500:30:15Okay. That was great, Brian. Thanks so much. Just a quick one on MaxView algorithm with Enable. Speaker 100:30:19Yes. Speaker 500:30:20Definitely differentiated from a clinical perspective. I heard Nolan talking about that. Could you just maybe walk through that a bit more, just double click on the clinical side Speaker 600:30:28of that? Speaker 500:30:28And then Well, I'm sorry, Guy. Speaker 200:30:31Go ahead. Go ahead. Sorry. Speaker 500:30:33Just wondering if that's like the first of many kind of like unique one off software solutions for the ecosystem that you kind of roll out with your other partners too, like just in addition to enable you by their partners, right? So just curious about that. Speaker 200:30:44We do. Look, the way I look at that with Mike's sort of simple brand, if you play chat GPT or some of those image creators, I think you have at least a qualitative sense of the kind of power that these sorts of approaches can bring. I would largely say, Kyle, in the near term, this is really a tool for your discovery researchers. And effectively, as I noted on the call, what it allows you to do, it allows you to take single cell RNA seek data and leveraging the MaxView algorithm the phenoCyclar fusion high plex protein data, you informatically make that non spatial data spatial by using the MaxFUSE algorithm. So this allows our customers not to do a multi omic study 1 at a time, but rather leveraging the large, large datasets that exist for single cell, whether it's an internally or with third parties to leverage that dataset and your Acoides fetal cycle infusion data to make it spatial. Speaker 200:31:41I would encourage everybody to go read the 2 Nature papers that Doctor. Nolan has done on this. It really is quite astounding and they validated it to a pretty deep extent. So I do think this is many of additional approaches to common and we'll continue to look at partners like Enable or others as vehicles to implement these in a user friendly manner knowing that a skilled informatician can do GitHub type approaches regardless. Speaker 500:32:10Okay. That was helpful. Thanks guys. Appreciate it. Speaker 200:32:12Thanks, Kyle. Operator00:32:14Thank you. One moment for our next question. Our next question comes from the line of Tejal Sawant from Morgan Stanley. Your line is open. Speaker 700:32:25Hey guys. Hey, good evening. How are you? Brian, just to kick things off over here, placements came in a little bit light in the 4th quarter, even on a sequential basis. I think in the Q3, you've done almost, I think it was in the high 60s, if I remember right. Speaker 700:32:44Can you just walk us through sort of that dynamic? Was it entirely driven by macro and some of those elongated purchase decision cycles that you called out in China as well? Or was there any shift in the competitive landscape here? Specifically, I mean, the one that we've been getting questions on is Lunafor. So just curious as to any if you could parse out that dynamic and the sequential step down in placements? Speaker 200:33:09Yes. It's Tejas, thank you for the question. It's certainly the former that's driving it. I mean, what we saw Tejas in Q3 and Q4 was quarters were becoming increasingly backloaded in month 3. So that's largely that is the largest dynamic, the largest driver there. Speaker 200:33:29I think the visibility of Lunafor and the question is I think is largely a result of them sort of being integrated with Bio Techne and having a lot more visibility and marketing power. And we'll see how that competitive dynamic shakes out over the coming quarters because I think they're really just getting going. Speaker 700:33:50Got it. Fair enough. And then in terms of just the academic budget environment, last couple of weeks, you've had a few inbounds and just cracks over in Europe and Horizon and some questions around the continuing resolution here in the U. S. As well. Speaker 700:34:07You guys are obviously over index there like a lot of your spatial peers. So just curious as to what you're baking into the guide and what you're hearing from your academic customers at the moment? Speaker 200:34:17Yes. I would say, Tejas, I think similar to my prior commentary to Kyle, what we've tried to bake into our guide is really a continuation of the existing market pressures that we were all feeling in Q3 and certainly Q4 on the capital side. So I think that's going to be our approach. We feels like we've been living in continuing resolutions and questions on the NIH budget for over a decade. It's just perhaps a little bit more acute now. Speaker 200:34:44So that's kind of how we're looking at it. What is, Tejas, in our control and I think where we're realizing some successes is in areas that are less prone to being impacted by macros, which is the reagent utilization on our platform and the advancing of our clinical opportunities, which are in the well funded arenas of immuno oncology, as I noted on the call. So we're going to continue to focus on those areas. They are again less prone to some of these macro dynamics and the ROIs are significant for us. So that will be our area a key areas of focus to mitigate any instrument pressures. Speaker 700:35:22Got it. And then one final one, one for you, Brian, and one for Johnny. Brian, I know you've sort of like shifted the focus a little bit in 2023, to optimizing existing solutions, driving consumables growth, etcetera. But how should we think about the product development roadmap, perhaps not in 2024, but over the next couple of years here? And Johnny, I Speaker 100:35:49think, Speaker 700:35:54full year of cash flow breakeven for you guys? Speaker 200:35:58So I'll take the first part first and then Johnny the second. So you can think of our product development priorities focused on workflow simplifications throughout this year and getting over the clinical finish line and getting additional partnerships, whether or not we speak to those publicly is to be determined. So that is the priority now, but you're correct longer term in terms of platforms, there are really two areas that I think are opportunities for the company. Number 1 is ensuring that we have an IVD grade system because we will have a menu of products. So it's ensuring that that roadmap is solidified. Speaker 200:36:36On the other extreme, in the upstream discovery market, we are going to we are already at a place where spatial biology is going to be done at scale. Large scale studies, large scale database studies. So getting the instruments to a place where they can do that, having the reagents at a place where they can support that and algorithms like MaxFuse to be able to leverage these large datasets. Spatial is going to go the direction that we've seen all other powerful life sciences tools go, which is studies are getting larger and larger at scale. And there is true sample elasticity in this market. Speaker 200:37:12You make the systems faster, easier and more affordable to use and there will be more samples. So longer term, Tayejop, those are the 2 avenues of full additional platform development opportunities for us. Speaker 300:37:25And Tay, just to your question on 2025, certainly we haven't guided obviously to 2025, but we don't expect to move top line or margin. We expect those to continue to be strong, continue to grow. And really it's about maintaining a reasonable OpEx, which we absolutely expect to be able to do, which drives a full year sort of a cash flow from ops, a good full year cash flow from ops in 2025 that's positive. So, and the building blocks sort of build themselves, if we continue to execute and maintain that OpEx where we expect it to, that's our target absolutely. Speaker 700:37:59Got it. Thanks guys. Appreciate the time. Speaker 200:38:01Thanks, Sanjay. Operator00:38:03Thank you. One moment for our next question. Our next question comes from the line of Jon Sauerbier from UBS. Your line is open. Speaker 300:38:17Good evening and thanks for taking Speaker 800:38:18my question. I was wondering if you could just talk a little bit more on the announcement with Thermo and the vRNA assays. I guess any initial feedback from customers there and what is the demand you're seeing on most YOMIQ capabilities? Speaker 200:38:30Yes. I think for us in kind of reverse order, John, thank you for the question and for your time. We look at RNA as something that's complementary to our HiPlex protein technology platform on the phenocyclic fusion. So we really are focused on integrating an RNA solution that is at a plex level that's consistent with that beam. And the vuRNA technology is perfectly suited to do that. Speaker 200:38:58It's a really a high resolution amplified single cell resolution platform. And so we're just beginning to integrate and roll that stuff out. We just announced it. So a lot of the hard work is happening right now. I think we'll probably be talking more about some of those details at AACR. Speaker 200:39:19And the demand from our customers to have a complementary RNA technology is strong. And I think both the vuRNA implementation, but equally important perhaps John and we'll see how it plays out. I think algorithmic approaches like MaxPeats do represent a transformative addition on how people leverage not just their own data, but publicly available data to get informatically derived multiomics solution. So I think both are important. Speaker 800:39:52Thanks. And as a follow-up, you have customers who started to adopt in Fusion 22 and now I guess you have 50% at the 2.0 upgrade. What is the runway you think here that you have for some of these users to hit full utilization and just talk about longer term where you think the pull through could go? Speaker 200:40:09I realize now Kyle asked a little bit about specifics on pull through. So we have right now, John, about 2 thirds of all the Athena cyclers are sitting with the Fusion. And we'll probably get through most of those upgrades kind of throughout this year. And as we look at pull through on that system, like as Johnny noted, kind of in the high 30s as we exited the year. We exited last year somewhere around the high 20s or so. Speaker 200:40:36So I think that trend line continues throughout 2024 and into 2025, doing 40, 50, 60s. I think we can easily get to that realm. Many of our high end users are operating at 5x plus that average pull through number. So I think there's an opportunity for us to really raise the curve on all of them. What we're seeing, particularly with the 2.0, John, is a real pressing need amongst our phenocycler fusion users to really start to press the plex level even more. Speaker 200:41:11So you're at 50, 60, 70 plex and they're doing that with more samples. And that's why the PhenoCycler Fusion 2.0 users are the highest pull through users. So it's about moving all of those customers up to that 2.0. Speaker 300:41:27Thanks for taking Speaker 200:41:27the questions. Thanks, John. Operator00:41:30Thank you. One moment for our next question. Our next question comes from the line of Mark Massaro from BTIG. Your line is open. Speaker 600:41:48Hey guys. Thanks for taking the questions and congratulations on a strong 2023. I guess my first one is on the guidance, 114% to 118%, I think it calls for 18% to 22%. In your pre announced in January, you talked about 20% plus. So obviously, you're in line with that. Speaker 600:42:08I'm just curious if the 18% somehow might be factoring in pressures related to macro or China or elongated sales cycles? And then maybe can you just give us a sense for the demand environment in the U. S? Obviously, that's been a stronger territory for you with respect to other geographic regions. So just give us a sense for perhaps anything you have on geographic growth and how we should think about that this year? Speaker 200:42:41Yes, I'll do those. Thanks, Mark. I appreciate your question and your time. So if you go through and look at our growth across the regions, North America, as you noted, was the strongest and we think it will continue to be the strongest. It was in the sort of high 30% realm. Speaker 200:43:00And I think it will probably stay there. And I don't think these geographic trends change meaningfully in 2024. EMEA was kind of in the low 20s mark in terms of its year over year growth in 2023. And then APAC was like high single digits and most of that was because the team was able to pivot to other regions, Japan, Australia, etcetera, Korea, South Korea to get to compensate for the contraction in APAC. I think those trends continue into 2024. Speaker 200:43:36I think you're right in terms of the low end of the range is really intended to account for those pressures being even more pronounced. One thing though, if and when we do, Mark, secure more partnerships like Acrovant, those are largely additive to our guide. There may be a portion of those that's embedded within our expectations for continued growth of our services business. But additional large scale CDX deals, like another Acrobon with a large biopharma that would be additive to that range. And certainly if and when those do occur, we'll clarify that. Speaker 200:44:20So hopefully that answers your questions. Speaker 600:44:23Yes, that's helpful. And then my last question, could you maybe zero in a little bit about what you're seeing in terms of customer demand for PhenoCo discovery and signature panels? And then any way to as we're tuning up our models, how should we think about reagent growth? Obviously, this is a year where you're coming into the year with about 1200 systems. Just give us a sense for how you think reagent growth might track relative to prior years? Speaker 200:44:55Yes. I'll let Johnny speak to how much detail we want to give because we don't guide on a product basis. But I would say, Mark, that reagents is going to be in terms of dollars are probably our largest growth driver because it's moving so quickly as you saw from I think it was a 5.7% in Q3 and a 6.9% in Q4. So you can see we're beginning to realize the benefits of many of the workflow solutions that we put on the market. And then we think those trends maybe not linearly continue throughout the year. Speaker 200:45:31So that's how I would look at that. And John, I don't know if you want to add any more color in terms of the specifics on reagents. Speaker 300:45:38No. Only to say to highlight sort of what you said, which if you think look back to 2022, obviously, it was sort of in that 4,000,000 dollars range, moved into the $5,000,000 plus range in 'twenty three and really exited 'twenty three and that's called $7,000,000 per quarter. And we expect that to continue. It's sort of natural taking these steps and certainly will be an important focus that will help to drive the margin goals that we have as well in 2024. Speaker 600:46:07Okay. Actually, if I can sneak one more in, great progress on getting to that operating cash flow breakeven by year end 2024, certainly a year ahead of expectations from recent comments. Speaker 100:46:24There's been Speaker 600:46:24a decent amount of M and A. Some of it's been larger, some of it's been smaller. But as you're about to turn the corner to cash flow breakeven, are there certain assets out there, even if they are of the tuck in variety that might be enticing to you? And maybe just speak, if you will, about the M and A environment broadly? Speaker 200:46:47Yes. I think you've got a couple of buckets of M and A, Mark. I think you've got some activity that's really driven around companies trying to find synergies as a way to continue to capitalize their business. And then you've got these larger deals like the OLink deal. I think they're kind of falling into those 2 buckets. Speaker 200:47:09I think for us, Mark, our number one priority for 2024, we have everything that we need in our technology stack. It's really just delivering on what we need to in terms of growth with reagents at the center of that. And then securing additional and then continue to expand our biopharma business. So there's nothing that is of immediate need that would be better done with an M and A. That said, we are always keeping our head on a swivel and looking at opportunities and trying to do that in a kind of in a reasonable resource method. Speaker 200:47:48Okay. Speaker 600:47:48Thanks for the time. Speaker 200:47:49Thanks, Mark. Operator00:47:51Thank you. One moment for our next question. And our next question comes from the line of Rachel Van Stol from JPMorgan. Your line is open. Speaker 900:48:07Perfect. Good afternoon. Thanks for taking the questions. Speaker 400:48:10So I want to follow-up on some Speaker 900:48:11of the earlier questions around placements. Can you just kind of walk us through what are your base case assumptions for placements this year in 2024? In the past, you talked about a run rate of a few 100 instruments per year. Should we model that for this year as well? And then what are the potential sources of upside and downside on that this year? Speaker 900:48:29Thanks. Speaker 200:48:30Yes. Thank you, Rachel. Your numbers are right. I think a couple of 100 is fair. We probably wouldn't get more specific in that. Speaker 200:48:36And then I think the upside, I think we still have upsides certainly on the reagents as we expand our content, as we get the 2 O's fully utilized in the field with their increased capacity, as software solutions like MaxFuse become more prominent and our panels continue to roll out. So I think there's certainly upside there. I also feel like, we have opportunities to continue to advance our clinical partnership portfolio, to hopefully to secure additional significant partnerships in that realm and much of that would be additive to our top line whether it's this year or next year. We try not to we have not baked into our base financial fundamentals an assumption around additional significant CDX deals. But when they do come, as I noted earlier, that would be a source of upside. Speaker 900:49:34Great. And then I just wanted to push on the macro backdrop a little bit more. You talked about how 4Q continued to have some of those macro pressures impacting capital equipment purchases. So can you talk about how that trend has continued into January February, as customers have kind of had some of these budgets reset on Jan 1? And then you highlighted that China was an area of weakness, from some of this capital purchase spending, but were there any other geographies that were notably impacted by the macro backdrop as well? Speaker 900:50:01Thanks. Speaker 200:50:03Obviously, you can have exchange rate issues that effectively drives up your ASP. But that's not to the point I think where beyond the macros, it's really impacting our top line. And I think as I noted earlier, it's really Rachel just about some budget tightening, but also an increased in diligence and approval circles around many capital purchases just like we do internally with our own capital purchases. So those are the large scale dynamics in play. Speaker 900:50:41Great. And then just on January, February trends, could you walk us through how some of those conversations trended in January, February so Speaker 200:50:48far? Yes. I mean, I'm hesitant to give any specific guidance on Q1 other than to say we have as an expectation in our full year guide that the market trends that we saw in second half and in Q4 will continue into Q1 and the rest of the year. Speaker 900:51:08Sounds good. Thank you. Speaker 200:51:09Thanks, Rachel. Operator00:51:11Thank you. I'm not showing any further questions in the queue. I'd like to turn the call back over to Brian McKelligan for any closing remarks. Speaker 200:51:18Yes. Well, thank you, Victor, for hosting us. Thank you to everybody for your time. I think for Acoya, we have and will continue to demonstrate and realize the benefits of our strategy, with ultimately that being, as we noted, hitting operating cash flow breakeven by the end of the year with our reagent growth and the margin expansion along with that being core contributors. But again, as I noted, we're also seeing real significant movement and opportunities for us to take that next leap as a company and continue to advance our portfolio from a research based product to additionally a clinical based product. Speaker 200:51:54And we'll continue to share those successes with all of you as part of future calls. So I thank you for your time and I look forward to following up with each of you soon. Operator00:52:07Thank you for your participation in today's conference. This does concludeRead morePowered by