Avantor Q1 2025 Earnings Report

Avantor EPS Results

• Actual EPS: $0.23
• Consensus EPS: $0.23
• Beat/Miss: Met Expectations
• One Year Ago EPS: $0.22

Avantor Revenue Results

• Actual Revenue: $1.58 billion
• Expected Revenue: $1.61 billion
• Beat/Miss: Missed by -$25.75 million
• YoY Revenue Growth: -5.90%

Avantor Announcement Details

• Quarter: Q1 2025
• Date: 4/25/2025
• Time: Before Market Opens
• Conference Call Date: Friday, April 25, 2025
• Conference Call Time: 8:00AM ET

Avantor (NYSE:AVTR) engages in the provision of mission-critical products and services to customers in the biopharma, healthcare, education and government, advanced technologies, and applied materials industries in the Americas, Europe, Asia, the Middle East, and Africa. The company offers materials and consumables, such as purity chemicals and reagents, lab products and supplies, formulated silicone materials, customized excipients, customized single-use assemblies, process chromatography resins and columns, analytical sample prep kits, education and microbiology products, clinical trial kits, peristaltic pumps, and fluid handling tips. It also provides equipment and instrumentation products, including filtration systems, virus inactivation systems, incubators, analytical instruments, evaporators, ultra-low-temperature freezers, biological safety cabinets, and critical environment supplies. In addition, the company offers services and specialty procurements comprising onsite lab and production, clinical, equipment, procurement and sourcing, and biopharmaceutical material scale-up and development services. Further, it provides scientific research support services, such as DNA extraction, bioreactor servicing, clinical and biorepository, and compound management services. The company was founded in 1904 and is headquartered in Radnor, Pennsylvania.

Avantor Q1 2025 Earnings Call Transcript

Key Takeaways

• Avantor announced a CEO transition, with Michael Stubblefield to step down once his successor is in place as the Board searches for a leader with a proven growth and value creation track record.
• In Q1, organic revenue declined 2% year-over-year, driven by lab solutions underperformance from academic/government funding caution and a 40% drop in bench-stage biotech funding, while bioscience production was modestly below plan due to weaker controlled environment consumables.
• Despite top-line pressures, adjusted EBITDA margin rose 20 basis points to 17% and adjusted EPS of $0.23 met plan, supported by a multi-year cost transformation that is on track to deliver $300 million in run-rate savings by end-2026 and has been expanded to $400 million by end-2027.
• The company revised its 2025 guidance to organic revenue growth of –1% to +1% (reported –2% to flat), adjusted EBITDA margin of 17.5%–18.5%, adjusted EPS of $1.02–$1.10, and free cash flow of $650 million–$700 million, with Q2 organic revenue expected to be flat to modestly up.
• To accelerate growth, Avantor is transforming its Lab Solutions business under new President Cory Walker by enhancing supply-chain efficiency, rolling out an AI-enabled e-commerce platform, optimizing pricing, and expanding its portfolio via distribution agreements with Abcam, Fujifilm Irvine Scientific, and Merck KGaA.

Presentation

[Operator]

Good morning. My name is Emily, and I will be your conference operator today. At this time, I would like to welcome everyone to Avantor's First Quarter twenty twenty five Earnings Results Conference Call. After the presentation, you will have the opportunity to ask any questions. I will now turn the call over to Alison Hosack, Senior Vice President of Global Communications.

[Operator]

Ms. Hosack, you may begin the conference.

[Allison Hosak, Senior VP - Global Communications at Avantor]

Good morning, and thank you for joining us. Our speakers today are Michael Stubblefield, President and Chief Executive Officer and Brent Jones, Executive Vice President and Chief Financial Officer. The press release and a presentation accompanying this call are available on our Investor Relations website at ir.avantoursciences.com. A replay of this webcast will also be made available on our website after the call. Following our prepared remarks, we will open the line for questions.

[Allison Hosak, Senior VP - Global Communications at Avantor]

During this call, we will be making forward looking statements within the meaning of The U. S. Federal securities laws, including statements regarding events or developments that we believe or anticipate may occur in the future. These forward looking statements are subject to a number of risks and uncertainties, including those set forth in our SEC filings. Actual results might differ materially from any forward looking statements that we make today.

[Allison Hosak, Senior VP - Global Communications at Avantor]

These forward looking statements speak only as of the date that they are made. We do not assume any obligation to update these forward looking statements as a result of new information, future events or other developments. This call will include a discussion of non GAAP measures. A reconciliation of these non GAAP measures can be found in the press release and in the supplemental disclosure package on our Investor Relations website. With that, I will now turn the call over to Michael.

[Michael Stubblefield, President and CEO at Avantor]

Thank you, Ali, and good morning, everyone. I appreciate you joining us today. Before we get into our first quarter results, I want to address the CEO transition announcement we made this morning. After careful consideration, our Board of Directors and I agreed that now is the right time to initiate a transition in Avantor's leadership. The Board has initiated a search process to identify the company's next CEO and we'll look for someone who has a strong track record of delivering growth and value creation.

[Michael Stubblefield, President and CEO at Avantor]

I plan to step down once a successor is in place and I'm committed to a smooth transition. In the meantime, as I will discuss in detail shortly, our entire leadership team is focused on taking steps to accelerate growth and strengthen the business. With that, let's turn to Slide three. I want to acknowledge that we are not satisfied with our first quarter performance. While we delivered earnings and margin in line with our plan, revenue in both segments fell short of our expectations.

[Michael Stubblefield, President and CEO at Avantor]

We entered 2025 with a clear focus on innovation driven growth, margin expansion and deleveraging. However, sentiment in some of our end markets, education and government turned cautionary as customers reacted to policy changes announced by the new administration. Also funding fell approximately 40% in the quarter for bench stage biotech companies leading to additional demand weakness for this important customer segment in our biopharma end market. We expect this market backdrop to continue pressuring demand for the foreseeable future which is reflected in RESET guidance. While we cannot change the market environment, we intend to take every action within our control to enhance growth in both lab solutions and bioscience production, while continuing to expand margins and reduce leverage.

[Michael Stubblefield, President and CEO at Avantor]

Specific to our lab business, we are making immediate and significant changes to drive growth. We are excited to have Cory Walker, President of Lab Solutions fully onboarded. Given his prior experience with our business, he has ramped quickly and is conducting a deep dive into the business evaluating every aspect of our strategy and execution. In the near term, he is working closely with the commercial team to grow and retain key accounts and aggressively pursue new accounts. In addition to the work that Corey has initiated, we have recently implemented a range of actions that will strengthen our business.

[Michael Stubblefield, President and CEO at Avantor]

First, our delivery excellence initiative is focused on ensuring greater supply chain efficiency and resilience. By improving data accuracy, accelerating fulfillment speeds and optimizing inventory, we are enabling differentiated service levels to our customers that will drive growth across all channels. Second, we are accelerating digital enhancements to our platform including the rollout of our new AI enabled e commerce platform to further streamline the customer experience. Another important step is strategically optimizing our approach to pricing by leveraging the integration of digital technologies. This transformation is expected to unlock new opportunities, maximize value and improve profitability and growth.

[Michael Stubblefield, President and CEO at Avantor]

The program will be implemented in a phased approach with the first go live scheduled for later this quarter. We also continue to focus on expanding our portfolio with highly attractive new products. In the first quarter, we made meaningful progress with the addition and advancement of several high impact platforms including signing a new distribution agreement with Abcam, a market leader in the antibody space with over 100,000 SKUs that will make their high quality antibodies and reagents available to Avantor's customers across the globe, broadening our collaboration agreement with Fujifilm Irvine Scientific, a trusted provider of cell culture media and bioproduction reagents. The agreement includes enhanced distribution rights across The United States, Canada, Puerto Rico, Latin America and Mexico and makes an additional 1,500 SKUs fully accessible through Avantor's distribution networks expanding our collaborative distribution agreement with the life science business of Merck KGaA Darmstadt Germany for Western Europe, further leveraging their market leading lab filtration products in our portfolio. This agreement includes over 1,900 SKUs encompassing well known brands and accelerating commercialization and adoption of recently launched JT Baker viral inactivation solution which plays a critical role in downstream viral clearance within the monoclonal antibody production workflow.

[Michael Stubblefield, President and CEO at Avantor]

This solution is now specified into a significant number of platforms with many more currently in late stage evaluation. While we take steps to accelerate growth, we're also maintaining our relentless focus on efficiency and cost discipline across the company. We drove another quarter of outperformance in our multi year cost transformation initiative and remain on track to deliver on our $300,000,000 run rate target exiting 2026. I'm pleased to announce that we have expanded the initiative and now expect to generate approximately $400,000,000 in run rate gross savings by the end of twenty twenty seven. Brent will share more details on this shortly.

[Michael Stubblefield, President and CEO at Avantor]

Turning to Slide four, let's take a closer look at our performance. In the first quarter, our organic revenue declined 2% year over year driven primarily by underperformance in our lab business. While we were awarded several new contracts and secured extensions of a number of existing contracts in the quarter, including a renewal of our supply agreement with Regeneron, the work Cory and his team are doing to accelerate the pace of new account acquisition will be critical to returning this platform to growth. Organic revenue within our Biosciences production segment also came in modestly below plan as growth in process ingredients and excipients as well as double digit growth in our single use offering was offset by weaker demand for our controlled environment consumables that are used to maintain the integrity of our customers clean rooms. While this revenue is sticky and highly recurring in nature, this lower demand is mostly attributable to customers placing tighter controls on usage in response to the current macro environment while still maintaining throughput.

[Michael Stubblefield, President and CEO at Avantor]

Although we are encouraged by end market fundamentals and continued momentum in our bioprocessing order book, we are not satisfied with overall growth and are taking action to improve performance across our organization. Despite the top line pressure, adjusted EBITDA margin increased 20 basis points year over year to reach 17%. This reflects the continued benefits of our multi year cost transformation initiatives. Adjusted EPS came in at $0.23 consistent with our plan. Given continued macro and policy related headwinds, we are revising our full year revenue guidance.

[Michael Stubblefield, President and CEO at Avantor]

We expect continued spending caution from education and government customers especially in The U. S. Due to concerns about funding. Additionally, the entire market continues to digest potential impact of tariffs and we have been working diligently to mitigate the impact of current tariffs on our results. Based on the tariffs in place today, we have approximately 2% COGS exposure with China, which is our most significant tariff risk.

[Michael Stubblefield, President and CEO at Avantor]

Our tariff exposure to the rest of the world is modest by comparison. Brett will walk you through the details of our updated guidance at the end of the presentation. As I reflect on the quarter and look ahead, I'm encouraged that we delivered earnings in line with our plan despite a challenging external environment. That speaks to the strength of our execution and the benefits of our structural cost actions. Nevertheless, we are not satisfied with our growth and we are taking aggressive actions to reignite the top line regardless of the macro backdrop.

[Michael Stubblefield, President and CEO at Avantor]

With that, I'll now turn it over

[Michael Stubblefield, President and CEO at Avantor]

to Brent.

[R. Brent Jones, EVP & CFO at Avantor]

Thank you, Michael, and good morning, everyone. I'm starting with the numbers on Slide five. First quarter reported revenue was $1,580,000,000 Taking into account the divestiture of our Clinical Services business, together with the impact of FX, organic revenue declined 2%. Proprietary content outperformed third party for the second consecutive quarter.

[R. Brent Jones, EVP & CFO at Avantor]

Our sales performance was primarily impacted by the headwinds affecting lab solutions that Michael just discussed. While bioscience production overall was modestly below expectations, we saw continued growth with our process ingredients, excipients and double digit growth in single use offerings. We also had another strong quarter of order intake reflecting continued improvement in the bioprocessing end market. Adjusted gross profit for the quarter was $535,000,000 representing a 33.8% adjusted gross margin. This is a decline of 20 basis points year over year impacted by the clinical services divestiture, but a 40 basis points improvement sequentially.

[R. Brent Jones, EVP & CFO at Avantor]

Adjusted EBITDA was $270,000,000 in the quarter, representing a 17% margin and consistent with our expectations. This represents a 20 basis points improvement year over year and 60 basis points excluding the impact of clinical services. Our cost transformation initiative was an important contributor to our margin performance. Notably, adjusted SG and A expense was down $21,000,000 or 7%. Adjusted operating income was $243,000,000 at a 15.4% margin.

[R. Brent Jones, EVP & CFO at Avantor]

Interest and tax expenses were in line with our expectations. As a result, adjusted earnings per share were $0.23 for the quarter, a $01 year over year improvement. Our adjusted EPS performance in the quarter reflects the flow through of our adjusted EBITDA results as well as continued reductions in net interest expense. Moving to cash flow, we generated $82,000,000 in free cash flow in the quarter. Our free cash flow includes approximately $19,000,000 of one time costs related to the execution of our cost transformation initiative.

[R. Brent Jones, EVP & CFO at Avantor]

Q1's free cash flow was also negatively impacted by working capital timing and annual incentive compensation payments. Our adjusted net leverage ended the quarter at 3.2 times adjusted EBITDA. Deleveraging remains our top capital allocation priority and we continue to target adjusted net leverage sustainably below three times. Let's now take a closer look at each of our segments. Lab Solutions revenue was $1,070,000,000 for the quarter, a decline of 3% versus prior year on an organic basis.

[R. Brent Jones, EVP & CFO at Avantor]

As Michael noted, this decline was due in part to the impact of funding uncertainty within The U. S. Higher education system, which comprises approximately 5% of our total enterprise revenue. These impacts largely manifested in reduced levels of capital spend along with the general slowdown in lab activity affecting consumables demand as well. As Michael noted, funding for bench stage biotech companies continues to be soft leading to additional demand weakness for this important customer segment in our biopharma end market.

[R. Brent Jones, EVP & CFO at Avantor]

Finally, we also felt the impact of increased competitive intensity that reduced volumes at a handful of customers. Turning to profitability, adjusted operating income for Lab Solutions was $139,000,000 for the quarter with a 13.1 margin. Adjusted operating income margin was flat sequentially from Q4 and up 30 basis points year over year despite the headwinds to the top line. The margin performance was driven by strong operational cost management and continued savings from our cost transformation initiative. Bioscience production revenue was $516,000,000 in Q1, essentially flat year over year on an organic basis.

[R. Brent Jones, EVP & CFO at Avantor]

Bioprocessing, which represents about two thirds of the segment delivered low single digit growth. While this is below expectations, the underlying business fundamentals are very encouraging. As Michael mentioned, we had solid growth in sales of our process ingredients and excipients and double digit growth in our single use offerings including MasterFLEX. However, these were offset by lower demand for controlled environment consumables. We had yet another quarter of strong order intake within bioprocessing, reflecting ongoing momentum and recovery of this end market.

[R. Brent Jones, EVP & CFO at Avantor]

Our NuSil branded silicones platform grew mid single digits, while electronic materials was stable sequentially with an expected year over year decline. Adjusted operating income for bioscience production was $123,000,000 for the quarter representing a 23.9% margin. Adjusted operating income margin was down year over year due to modest freight and absorption headwinds. As Michael noted in his opening remarks, we are revising our 2025 guidance to reflect the current uncertainties related to funding and policy related headwinds and competitive intensity. For the full year, we now expect organic revenue growth of negative 1% to positive 1%.

[R. Brent Jones, EVP & CFO at Avantor]

Our clinical services divestiture represents a 2% headwind and based on current spot rates, we now expect a 1% tailwind from FX versus the FX headwind in our prior assumptions. This leads to a reported revenue decline of negative 2% to flat. Our key FX assumption is continuation of the dollar euro exchange rate of approximately 1.12. We also assumed a modest headwind in China related to tariff impacts on demand. On a segment basis, we now expect lab solutions growth to be minus low single digits to flat.

[R. Brent Jones, EVP & CFO at Avantor]

We continue to expect bioscience production to be up mid single digits. However, to the headwinds in controlled environment consumables, we now expect bioprocessing growth to be mid single digits. We expect adjusted EBITDA margin to be 50 basis points lower, 17.5% to 18.5%, while adjusted EPS and free cash flow remain unchanged at $1.02 to $1.1 and $650,000,000 to $700,000,000 respectively. In terms of Q2, we expect organic revenue growth to be flat to modestly up. Our clinical services divestiture represents a 3% headwind and based on current spot rates, we expect a 1.5% tailwind from FX.

[R. Brent Jones, EVP & CFO at Avantor]

This leads to reported revenue growth of flat to modestly down year over year. On a segment basis, we expect Lab Solutions to be flat to modestly down and Bioscience production to be up mid single digits. We expect modest sequential improvement in EBITDA margin to the mid-17s. We expect that the external environment will continue to be dynamic, particularly with respect to the potential impacts of a global restructuring of international trade agreements and related taxation. While our manufacturing footprint and supply chain are significantly in region for region, we do have a meaningful amount of cross border trade, particularly in our lab solutions business.

[R. Brent Jones, EVP & CFO at Avantor]

The updated guidance does not assume any material impact to demand or earnings from the potential tariffs. In the event renegotiated trade agreements do not adequately prevent tariff related headwinds, we are prepared to mitigate by leveraging our global supply chain. We have a broad product offering that gives our customers optionality and we will work closely with our customers to ensure that we are able to offset tariff surcharges to the extent possible. Finally, an update on our cost transformation. This initiative has not only made a material impact on our financial results, but it has also sharpened our focus on conversion to the bottom line and to cash.

[R. Brent Jones, EVP & CFO at Avantor]

Our actions have been carefully designed and executed to ensure that our critical capabilities remain intact. As a reminder, we exited 2024 with over $130,000,000 of in year savings and an exit run rate of approximately $165,000,000 well ahead of plan. In 2025, we expect to generate an incremental $75,000,000 of in year gross savings and exit 2025 with run rate savings in excess of $250,000,000 We have clear line of sight to exiting 2026 with the promised $300,000,000 of run rate cost savings. As we more deeply live into our new segments and operating model, we continue to identify further opportunities for productivity. As a result, we are expanding the initiative and now expect to exit 2027 with at least $400,000,000 of run rate cost savings.

[R. Brent Jones, EVP & CFO at Avantor]

While we aren't currently forecasting material impact to fiscal twenty twenty five, we are committed to frontloading the incremental savings as much as possible. In the current environment, we believe it is critical to control our controllables as much as possible and these incremental cost actions are an important example of this. With that, I will turn the call back to Michael.

[Michael Stubblefield, President and CEO at Avantor]

Thank you, Brent. Before we move into Q and A, I would like to briefly recap today's key takeaways and reiterate our priorities moving forward. First, we remain confident in the strength and resilience of the Avantor platform. Our Lab Solutions segment is built on differentiated capabilities, a broad and expanding portfolio and global supply chain that enables us to reliably serve our customers around the world. Our bioscience production platform has a leading bioprocessing franchise and we are the leading supplier of medical grade silicone formulations.

[Michael Stubblefield, President and CEO at Avantor]

Second, our multi year cost transformation initiative continues to be a powerful driver of margin expansion and strong free cash flow even as we navigate near term top line headwinds. We are expanding this initiative and remain committed to best in class operational discipline and execution. Finally, while growth particularly in Lab Solutions is not where we want it to be, we are taking decisive action. Under Cory Walker's leadership, we are strengthening the foundation of the business and enhancing the commercial strategy to position Lab Solutions for long term success. We look forward to updating you on our progress in the quarters ahead.

[Michael Stubblefield, President and CEO at Avantor]

With that, I'll now turn the call over to the operator to begin the Q and A session.

[Operator]

Thank We have a question from Michael Ryskin with Bank of America. Please go ahead.

[Michael Ryskin, Managing Director at Bank of America Merrill Lynch]

Great. Thanks for taking the question. I guess my first one, Brent, I'll just ask on the guidance because that's kind of where you left off. The 2Q guide, think you said mid single digits BPS, flat to modestly up for the whole company. That seems like a pretty aggressive step up from 1Q, both in terms of percentage growth and just in dollar amount.

[Michael Ryskin, Managing Director at Bank of America Merrill Lynch]

Are you was there anything timing related in any of that clean room controlled environment? Was there anything timing related with some of those customer agreements? Are you expecting any change in the underlying market? Just sort of what's driving that improvement both 1Q to 2Q and for the rest of the year to hit your revised guide?

[R. Brent Jones, EVP & CFO at Avantor]

Yes, Michael. Thanks for the question there. We're it's really a continuation of the current environment there. I mean, when you're talking about growth rates, they're always the year over year. So what's going on with the comparable?

[R. Brent Jones, EVP & CFO at Avantor]

Q2 is always a very strong quarter for us. And obviously, it's informed by all the momentum we're seeing in the quarter so far here. So I think the other piece I'd add is we thought very carefully about the re guide for the year as well as Q2. And to use the line I use all the time, we think we have a balance of we think it's importantly prudent there. So we really view the BPS Q1 as an anomaly there and in terms of timing of things.

[R. Brent Jones, EVP & CFO at Avantor]

So we think that's a very sensible guide for the full year. So I'm we're comfortable with what we put out there.

[Michael Ryskin, Managing Director at Bank of America Merrill Lynch]

Okay. And then for the follow-up, I think you called out 2% COGS exposure to China as your more significant one. Just to be more specific on tariffs, can you say like what are you factoring into the new fiscal year guide? I saw that you didn't change your EPS numbers. So are you offsetting some of that exposure with price or with other mitigation techniques?

[Michael Ryskin, Managing Director at Bank of America Merrill Lynch]

Just sort of like what's built in into your guide from a tariff set now?

[R. Brent Jones, EVP & CFO at Avantor]

Yes. So what we said specifically there is for the full year guide, we have some modest demand reduction in China. As you'll recall, we don't have significant revenue in China there. So that's a very modest piece and that's due to the bilateral tariffs. Other than that, we don't have any significant tariff assumptions built into the guide here.

[R. Brent Jones, EVP & CFO at Avantor]

That's where we walk through the specifics. The primary exposure there is the 2% of COGS related to China, which we're as we noted in the remarks, we have a number of levers in region, for region, alternate suppliers. We have a wide array of materials. Again, this is primarily a Lab Solutions dynamic And obviously, to offset with price, and if these things became very material, that could adjust things. But we're taking a no impact to the guide from tariffs.

[Michael Ryskin, Managing Director at Bank of America Merrill Lynch]

Okay. Thank you.

[R. Brent Jones, EVP & CFO at Avantor]

Thank you.

[Operator]

Thank you. Our next question comes from the line of Vijay Kumar with Evercore. Please go ahead, Vijay.

[Vijay Kumar, Senior Managing Director at Evercore ISI]

Hi, guys. Good morning and thank you for taking my question. Michael, maybe my first one for you. I just look at the BPP segment. It looks like the advanced tech and health care were more or less in line with expectations and most of the changes came from control environment substance.

[Vijay Kumar, Senior Managing Director at Evercore ISI]

But my understanding is these are products which should be tied with the production volumes. So what is that true? And if so, then why were customers cautious in Q1? Was this just a timing of order, timing element and that's what gives you the confidence here why BPP should go be up mid singles in 2Q?

[Michael Stubblefield, President and CEO at Avantor]

Good morning, Vijay, and thanks for the questions. I think that is a really great place to start. When we unpack the performance in BPS segment, consistent with what we said generally across the enterprise, we're not entirely satisfied with where the quarter played out. And I've taken a number of actions to address the pockets of weakness that we saw in the quarter, and we're certainly starting to see even over the last several weeks some impacts of some of those actions. Now on a little bit more granular level, when we look at bioprocessing, which is about two thirds of the revenue on that platform, we remain incredibly optimistic about the end market fundamentals there.

[Michael Stubblefield, President and CEO at Avantor]

We had a great quarter on processed ingredients excipients. We highlighted double digit growth on single use, including MasterFLEX. That was offset in the quarter by headwinds in the controlled environment consumables category that you mentioned, Vijay. That's an important part of the platform in that it helps maintain the integrity of these clean rooms. It's specified into the these clean rooms and it's quite sticky in revenue.

[Michael Stubblefield, President and CEO at Avantor]

What we were seeing in the quarter was customers looking for various levers to address the macro headwinds, including inflation and observing opportunities that they had in the quarter optimize usage. We're leaning in there and we're optimistic about or encouraged by some of the actions that we've taken there. And just given the strength of the order book across the bioprocessing platform, we continue to be encouraged by the trending that we're seeing there and feel really confident about the outlook that we've given here today.

[Vijay Kumar, Senior Managing Director at Evercore ISI]

Understood. And maybe my follow-up is on the lab side. I think you mentioned higher comparative intensity. Maybe if you could just elaborate on the comparative dynamics within the channels part of the business.

[Michael Stubblefield, President and CEO at Avantor]

That's a great question, Vijay. We've talked a lot in our remarks today about the macro environment and the demand headwinds that we're seeing across the market, given a lot of the funding and policy related headwinds that we're all of us in this space are experiencing. And it's against that macro backdrop that we do see a heightened level of competition. And at an account level, that heightened competition does manifest itself in different ways. We highlighted quite a number of new account wins and extensions, including a really important extension with Regeneron.

[Michael Stubblefield, President and CEO at Avantor]

But as Brent noted in his remarks, we also did see some shifting within a few of our accounts that did lead to lower volumes. Now against that macro and competitive backdrop, I think it highlights the importance of the decisive actions that we are taking today to strengthen the business. We're certainly focused under Cory's leadership here of driving aggressively to retain and grow our key accounts. And the overall action plan that we put in place here is really meant to strengthen the business regardless of the macro backdrop that we're in.

[Operator]

Thank you. The next question comes from Rachel Van Hinstahl with JPMorgan. Please go ahead, Rachel.

[Rachel Vatnsdal, Analyst at JPMorgan Chase]

Great. Good morning and thanks so much for taking the questions today.

[Rachel Vatnsdal, Analyst at JPMorgan Chase]

So I wanted to

[Rachel Vatnsdal, Analyst at JPMorgan Chase]

dig into the performance within Lab Solutions. You highlighted some of the weakness within academic and government given that's 5% of your total co revenues. You also noted that there's not only weakness on the capital equipment side, but also on the lab activity side. So can you break down for us what did you see for equipment declines within your academic and government customers? And then also, what did you see for consumable declines?

[Rachel Vatnsdal, Analyst at JPMorgan Chase]

And then within that segment overall, for academic and government, what are you assuming for declines this year in the updated guide? Thanks.

[Michael Stubblefield, President and CEO at Avantor]

Yes. Thanks for the question, Rachel. Obviously, very relevant for the environment that we're in. So just to recap a couple of the key points here around the performance in the quarter. Lab platform for us fell roughly 3% in the quarter.

[Michael Stubblefield, President and CEO at Avantor]

And as we think about how we're reflecting the current macro environment in the updated guidance that we've provided, really using a lot of the same approach that we had last year where we're projecting current trends to persist through the balance of the year. We have baked in the headwinds that we're seeing here, particularly in the academic and government environment as you suggest. The U. S. Higher education market, the sentiment did turn decisively more cautious following the announcement of the NIH funding actions.

[Michael Stubblefield, President and CEO at Avantor]

And we saw that manifest itself with customers in a number of ways. Firstly, looking to optimize existing cash and funding. And so you do definitely see a pullback in equipment and instruments. Also, just some caution on hiring of new scientists initiating of new programs, which is a part of how we grow that business. And that's where the consumables piece of this comes in is just a muted level of activity.

[Michael Stubblefield, President and CEO at Avantor]

Generally speaking, given the uncertainty these universities have around funding on a full year basis. But when we look ahead here, together with the actions that we're taking to strengthen the business, we think the current environment is well covered in our updated outlook for the year.

[Rachel Vatnsdal, Analyst at JPMorgan Chase]

Great. And then just for my follow-up here, I just wanted to dig into some of the pricing dynamics. So you've highlighted some of the weakened funding on not only the biotech side, but also with your academic and government customers, also just the broader environment with tariffs as well. So there's a few moving pieces on the pricing front. I believe your prior assumption within guidance was 1% to 2% pricing contribution for the year.

[Rachel Vatnsdal, Analyst at JPMorgan Chase]

So what is your ability to take price in this new regime that we're seeing relative to a few months ago? And what are you assuming for pricing contribution in the guide? And then if I could sneak in a follow-up, I'm getting a bunch of questions on the tariff answer earlier in the discussion. Can you just clarify for us, is that 2% China cost, is that going to be fully absorbed in the guidance? Or is that not baked in at this point?

[Michael Stubblefield, President and CEO at Avantor]

Happy to address both of those. I'll cover the pricing questions, Rachel, and we'll have Brent give you some additional detail on the tariffs there. So as you know, pricing is an important part of our algorithm here. And the level of impact, I think you highlighted, I think, appropriate way to model this. And as we got into the year and got through contracting season administration, I think it's played out largely as we had expected and in line with the guidance that we had given there.

[Michael Stubblefield, President and CEO at Avantor]

Probably the one dynamic to consider, which is reflected in Q1 as well as through the rest of the year is just the increased competition for new accounts, new business that is printing at modestly lower margins than what we would typically see just given the competitive intensity there. But for the business that we have today and for the contracted customers, pricing has played out. The other thing I would point out or highlight or take you back to is the actions that we outlined that we're taking to strengthen the business. One of those is in the pricing area. And while we think we're pretty good at this and it is a complex platform that we run to administer pricing across 6,000,000 SKUs, we are taking some additional steps and then making some additional investments to strengthen our pricing capabilities, really looking to leverage the integration of a number of digital technologies that will significantly advance our capabilities in this area, making us more agile, able to do more tailoring.

[Michael Stubblefield, President and CEO at Avantor]

And in this dynamic environment, the capabilities that we're adding here will enhance profitability and growth, and that will roll out on a phased approach starting here this quarter. Brent, do you want to answer the tariff question?

[R. Brent Jones, EVP & CFO at Avantor]

Sure, Rachel. So the 2% of COGS was dimensionalizing the total exposure. We did have the other comment on we have taken a little demand out in China there on the revenue side.

[R. Brent Jones, EVP & CFO at Avantor]

But on the cost side, the 2% of COGS is the exposure. We have not explicitly included that in the guide. Per all the commentary we made, we will do everything to offset that. But one day the tariff rates are X, the other they're Y. Our view is don't overly speculate.

[R. Brent Jones, EVP & CFO at Avantor]

We just indicate there's risk around that and we're doing everything we can to execute around it.

[Operator]

Thank you. Our next question comes from the line of Tycho Peterson with Jefferies. Please go ahead, Tycho.

[Tycho Peterson, Managing Director at Jefferies Financial Group]

Thanks. Michael, I'll take the beta on the bioprocess order book. You characterized it as strong. Just maybe a little more color on demand trends. I assume book to bill above one.

[Tycho Peterson, Managing Director at Jefferies Financial Group]

Can you maybe just give us some flavor of what that looks like? And is this mostly emerging biotech? Is it CDMOs? A little bit of end market mix color too.

[Michael Stubblefield, President and CEO at Avantor]

Heiko, that's a really important point to articulate here today is we are optimistic about the end market fundamentals, and that's really informed by now well more than a year of momentum that we see, not only on the top line, but also in the building of the order book, which gives us confidence in the outlook. And we see that strength in the order book, which you can assume is as strong as some of the other numbers that you've seen printed, if not stronger, pretty broad based. It's across the portfolio, ingredients, excipients. We were really encouraged by strong double digit growth of our single use offering, including MaskReflex in the quarter. And just given how pervasive our platform is, we're agnostic around modality, around indication type.

[Michael Stubblefield, President and CEO at Avantor]

And so it's pretty safe to assume with the broad exposure that we have and the momentum that we see that we don't really see a lot of differences between large pharma, biotechs, CDMOs. We see the strength pretty uniform across the space.

[Tycho Peterson, Managing Director at Jefferies Financial Group]

Okay. And then back to this issue on the controlled environmental consumables. Can you just break out the percentage of revenues or mix? I mean we've never really heard you talk about this business before. So how large is it?

[Tycho Peterson, Managing Director at Jefferies Financial Group]

And what do you think it takes to turn it around? I mean, we're still in a tough budget environment. So is there anything you can do proactively?

[Michael Stubblefield, President and CEO at Avantor]

Great questions, Tycho. So we actually incorporate that into our bioprocessing categorization. That's what's included in the two thirds of our revenue. Classically, that application would reliably grow mid to high single digits. And even as recently as fourth quarter, it was growing high single digits.

[Michael Stubblefield, President and CEO at Avantor]

So the pullback that we saw in Q1 was certainly unexpected. But as we started to spot some of the optimization and usage, the team has kicked into action, and we have really ramped up commercial intensity and account level activities to drive improved performance there. And when we look at order trends, daily rate of sales over in those categories over the last month or so, I think we're encouraged by the actions that we're taking are certainly having the intended effect in moving things in the right direction here.

[Operator]

Our next question comes from Dan Brennan with TD Cowen.

[Daniel Brennan, Managing Director at TD Cowen]

Great. Thank you. Maybe just one back to the tariff situation. Sorry, to kind of revisit this. I just want to kind of make sure I understand it.

[Daniel Brennan, Managing Director at TD Cowen]

So for the 145% tariff that The U. S. Is placing on China, so the 2% of COGS, right, it sounds like you guys are not including any impact from that. I know you're talking about you'll offset it. I'm just trying to figure that out.

[Daniel Brennan, Managing Director at TD Cowen]

And could you speak a little bit to more broadly what percent of your U. S. Sales are sourced OUS? So if you even outside of China and Europe, because they're still expected to be right now a 10% minimum tariff on those. I'm just trying to figure out like have you assumed those impacts and you're just

[Daniel Brennan, Managing Director at TD Cowen]

trying to offset them or you're not assuming those impacts

[Daniel Brennan, Managing Director at TD Cowen]

at all would be my first question.

[R. Brent Jones, EVP & CFO at Avantor]

Yes, Dan. So we're not assuming those impacts. It is so dynamic right now. As we noted, the China exposure is the lion's share of the exposure.

[R. Brent Jones, EVP & CFO at Avantor]

We do have some of the other jurisdictions. It's obviously a significant difference, 135%, one hundred and forty five % versus 10% tariffs there. But the exposure to China and dwarfs the other ones, we will do our best to offset. But again, it's the environment is so dynamic. Sort of knew any estimation we'd have there would be wrong.

[R. Brent Jones, EVP & CFO at Avantor]

So that's the approach we've taken.

[Michael Stubblefield, President and CEO at Avantor]

And Dan, maybe just to follow on and add a little bit more color to the topic and put that 2% of COGS in context. Our cost basis that we have, that would in the current what we know currently about the tariffs on imports from China into The U. S, that's less than $100,000,000 of exposure for us. And I think it's important to highlight the number of levers that we have to offset that, whether it be alternate sourcing optionality for our customers.

[Michael Stubblefield, President and CEO at Avantor]

We have a significant number of the SKUs that we have purchased out of China that can be sourced from other suppliers that are specified into our customers' workflows here and it would be appropriate for them to use. We have inventory hedges against some of these things. And ultimately, we have the flexibility to incorporate tariff surcharges as necessary. But the situation is extremely fluid. There's been talk this week that perhaps the rates could cut in half.

[Michael Stubblefield, President and CEO at Avantor]

So we're continuing to follow it closely. We're working closely with our customers on how best to mitigate this. And I think we're in a good position to offset this as it plays out.

[Daniel Brennan, Managing Director at TD Cowen]

Got it. And then maybe just a follow-up on the lab side. I know there's been a few questions asked, but would love to unpack that a little bit more. So could you just speak to what happened to your higher ed business in the quarter and kind of what you're assuming? And then I don't know if you sized it, the bench stage biotech business, which you talked about being weak.

[Daniel Brennan, Managing Director at TD Cowen]

How big is that? And kind of how have you thought about that outlook? And then I apologize, you talked about the competitive intensity. Michael, you and I have spoken that there's a lot of mom and pops distributors still out there, so it's not just you and Thermo. So I'm just wondering if you could speak a little bit also just unpack that a little bit.

[Daniel Brennan, Managing Director at TD Cowen]

Like it sounds like you lost some share in the quarter. Just wanted to understand like if you think about the overall market for lab distribution, are you growing well below that now? Or are

[Daniel Brennan, Managing Director at TD Cowen]

you still growing roughly in line? Thank you.

[Michael Stubblefield, President and CEO at Avantor]

Yes. Let me do my best to unpack the questions there. I think the heart of it obviously rests on our shared disappointment with the performance of the platform in the quarter, and it underscores the importance of having Corie on board here and the aggressive actions that we're taking.

[Michael Stubblefield, President and CEO at Avantor]

We acknowledge the macro backdrop is challenging. It's challenging for everyone right now. And we're not just trying to hide behind that and certainly doing everything within our control to maximize the growth of the platform and certainly strengthen it over the long term. The headwinds in funding or associated with funding uncertainty in academia and government, I think, are well documented. As a category, at an enterprise level, I think you'll see in some of our disclosures today, we're off mid single digits for the portion of that that's in The U.

[Michael Stubblefield, President and CEO at Avantor]

S. You're off well into the double digits. And we have assumed that those trends continued. Biotech funding has been weak. It now rests at levels that were probably lower than where they were at even three years ago.

[Michael Stubblefield, President and CEO at Avantor]

And that has been said, I think, number of occasions at an enterprise level, that's low single digit exposure for us, but it's all in the lab. And when you flip it into the lab segment, that's probably around 10% of our overall exposure. And similar to the assumptions we've made on academia and government, reflected in the current guidance is that those headwinds persist through the balance of the year. We're not incorporating any recovery for that. And of course, we are taking actions as those actions take hold and are successful, that could provide us some upside to where we rest.

[Michael Stubblefield, President and CEO at Avantor]

The market isn't a duopoly. It's highly fragmented. There are a number of players here. We're all facing the same challenges. And I think we're navigating the headwinds and the competitive intensity as well as anyone.

[Michael Stubblefield, President and CEO at Avantor]

In the quarter, certainly, we did see some movement at some of the accounts. We also had a number of wins. And so it's hard to say how our numbers compared to others other than to acknowledge we're not satisfied with it. We're well positioned to serve this space. And as the actions take hold that we've initiated and the market recovers, we're well positioned for long term growth here.

[Operator]

Our next question comes from Doug Schenkel with Wolfe Research. Doug, please go ahead.

[Doug Schenkel, Managing Director at Wolfe Research LLC]

Good morning and thank you for taking my questions. And before asking my two, I just want to thank you, Michael, for all your help over the years. So I know today is not the end, but I know you're moving out. So congrats on that. And again, thank you for all your help.

[Doug Schenkel, Managing Director at Wolfe Research LLC]

So on just a couple of things. First, on bioprocessing. Obviously, this has come up a little bit. But on one hand, you sound good on the order book and trends. On the other hand, you lowered expectations for bioprocessing.

[Doug Schenkel, Managing Director at Wolfe Research LLC]

Is that largely just a function of the environment and wanting to be a little bit more conservative given everything that's going on outside your control in spite of the fact that, that business actually looks okay? And then the second topic is really a longer term question. I think a lot of us appreciate the efforts you're making to aggressively control what you can control in terms of cost. In a scenario where the company returns to more normal ish mid single digit level growth in 2026 with higher growth from higher margin businesses, it seems like mathematically you could drive 100 to 150 basis points of margin expansion in that scenario? Again, not asking you to guide, but I just want you to tell me if I'm doing my math right.

[Doug Schenkel, Managing Director at Wolfe Research LLC]

Thank you.

[Michael Stubblefield, President and CEO at Avantor]

Both very good questions, Doug. Let me take the first one on bioprocessing. We'll have Brent give you some color on incremental margins as growth returns to the platform. So starting with BPP, bioprocessing platform, there is a lot of momentum. I'd just reiterate what I've already said.

[Michael Stubblefield, President and CEO at Avantor]

We're encouraged by the end market fundamentals, and our order book has been strong. And that's across that platform, whether it be processed ingredients or single use or even these controlled environment consumables. The guide at mid single digits that Brent outlined does reflect the low single digit growth for the platform in Q1 and kind of rolls that into the full guide here. But when we look at the order book and the trending that we're seeing, we do see the incremental improvement in the business, particularly here in the second quarter, and think that the guide is, to use Brent's word, is prudent. We thought about it quite carefully.

[Michael Stubblefield, President and CEO at Avantor]

And looking at the positioning and the data, we are taking actions similar to what we're doing on lab to drive the business. And I think there's a lot working here within our bioprocessing platform to be excited about.

[R. Brent Jones, EVP & CFO at Avantor]

Doug, talking about the margin point and again, absolutely not making future guidance there. But just with particularly what we can do on the BPF side of the business, incremental margins you can print there are fantastic, once you get to the right levels of growth. Obviously, the lab lack of growth, degrowth, we do have meaningful fixed cost against that, and that impacts margins for sure.

[R. Brent Jones, EVP & CFO at Avantor]

We've talked about the 20% EBITDA margin 19.6% accounting for the Clinical Services divestiture. This platform absolutely wants to be above 20% margin there. We just need the right growth entitlement against it. And I think your comment is absolutely correct there, but let's get further in the year, let us get back to the right kind of demand environment, and that will absolutely be a topic when we get into guidance for 2026.

[Operator]

Thank you. The next question comes from Luke Sergott with Barclays. Luke, please go ahead.

[Luke Sergott, Analyst at Barclays Capital]

Great. Thanks guys. I just want to talk about the business transformation and especially on the lab sciences side that you guys talking about doing the improvements there. How much of the change that you're taking a look at is due to substandard or suboptimal portfolio? I'm

[Luke Sergott, Analyst at Barclays Capital]

just trying

[Luke Sergott, Analyst at Barclays Capital]

to get a sense of what you guys need to do from an investment standpoint to kind of fend off the competitive dynamics there.

[R. Brent Jones, EVP & CFO at Avantor]

Good questions, Luke. Where I'd start with that is just highlighting our focus on enhancing and positioning the growth of that business to weather the current macro environment. And there's going to be lot of the prospects to it. Corey has now been on the ground here for a month. Fortunately, he knows the business well from his time here before and has ramped quickly.

[R. Brent Jones, EVP & CFO at Avantor]

And he's moving aggressively to interrogate the business strategy execution, maybe no stone unturned and working very, very closely with the commercial team in the near term to drive new account acquisition and retention of existing accounts. But there are a number of other things that we are doing to strengthen the business, investing to deliver differentiated service levels that are important to our customers in these sensitive end markets, enhancing the customer experience and streamlining that experience through an AI enabled e commerce platform that's now been live here in The U. S. For a bit, and we're in the midst of rolling it out in Europe, investing in enhanced pricing capabilities. And as always continuing to drive innovation into our portfolio.

[R. Brent Jones, EVP & CFO at Avantor]

And we're really excited by the content that we were able to add to the portfolio in the first quarter. And I wouldn't say any of these actions are specific one single data point we're getting out of the market. It really just is a reflection of we understand the environment that we're in and we understand the expectations that we have for this business, and we are doing everything we can to control the business in this environment and strengthen it. And I think we're confident in the actions that we're taking will give us the best chance to grow this platform long term.

[Luke Sergott, Analyst at Barclays Capital]

All right. Great. And then just a follow-up here, talk about the incremental $100,000,000 on the cost out. Brent, you talked about trying to do what you can and front load that in the earlier years. Like what can you do just digging a little bit more there on specifics that you run the risk there or have to strike a balance without disrupting your overall sales force or the momentum you're trying to build within the two segments?

[R. Brent Jones, EVP & CFO at Avantor]

Yes, Luke, that's absolutely very well taken, and we tried to address a little bit of that directly in the prepared remarks. I mean, I think the first thing I'd start with there is the program to date, we think, has been done really clean, hasn't led any disruption. I mean, look, at the end of the day, even though we want to rationalize the cost base, job one is growth, absolutely focused on growth across both sides of the business. And I think another reason we've executed so rapidly or a consequence of that is you want to minimize the disruption to the org. So moving to the left, so to speak, is really valuable there.

[R. Brent Jones, EVP & CFO at Avantor]

Some of these things I mean these really are the insights. Core's leadership is going to be really helpful for it as well. But just as you understand the segment structure is better here, that unlocks sort of more of what we have existing. But some of these things will take some time, but they're really important like we're going to have an initiative on digitization in connection with manufacturing. That's going to both make go long ways towards delighting our customers as well as really enhancing our cost.

[R. Brent Jones, EVP & CFO at Avantor]

Michael made a number of the comments on tech enablement on pricing. You're going to see that for many other commercial pieces. So we're going to balance that where do we move faster, where do we move left on it versus some of these things that take time, but we think we'll have very decisive impacts on the business. So that's how we're thinking about it.

[Operator]

Thank you. Our next question comes from Tegha Savant with Morgan Stanley. Please go ahead.

[Tejas Savant, Analyst at Morgan Stanley]

Hey guys, good morning and thanks for the time. Brent, maybe starting with you at a relatively high level, that 200 bps reduction in organic growth, can you just bridge us to that between education and government, the controlled environment, consumables, the competitive intensity you guys cited and then a little bit of a haircut on China? Like if you were to parse it out, that 200 bps, how would you do it?

[R. Brent Jones, EVP & CFO at Avantor]

Yes. What I do bridging that to us is it's almost it's largely driven by the policy environment and then the biotech funding piece. So it's largely lab solutions. When you look at the underlying segment piece of it, very modest piece on the critical environment and our China sales are so small there that that wouldn't be a significant portion of the bridge. So it's all in many respects when you think about it, it's taking the Q1 rates on growth and really extending them to the year.

[R. Brent Jones, EVP & CFO at Avantor]

And you can see sort of the Q1 decrement really is what we're turning into the full year guide update.

[Tejas Savant, Analyst at Morgan Stanley]

Got it. That's helpful. And then Michael, one for you again at a high level. Last quarter, we spoke a little bit offline about your ability to help customers navigate the shifting tariff environment and some of the supply chain derisking that they're looking to do. Why isn't this an opportunity for you to perhaps even gain some share from customers who are currently sourcing direct or sourcing from smaller distributors in the months ahead of vendor consolidation as a theme we hear about from some of these customers?

[Tejas Savant, Analyst at Morgan Stanley]

Conversely, are any of your customers choosing to go direct and just sort of disintermediate the middleman? Or in combination with this increased competitive intensity you called out, does that just nullify any benefit from potential share gains at the moment?

[Michael Stubblefield, President and CEO at Avantor]

Great questions, Tejas. When we look at the environment that we're in and particularly the global nature of our supply chain, the broad product assortment and optionality that it gives our customers, we think we are uniquely positioned to support our customers through this challenging environment. And in times of dislocation like this or where there's friction in the system, it certainly gives you an opportunity to get close to your customers and be a solution provider to them. And given all the flexibility that we've talked about and optionality that we offer, we are working very closely with our customers, both existing as well as potential that are looking to find ways to address the current macro headwinds that we're all facing. And so yes, certainly, we'd never want to imply for our remarks today that we're not looking at it that way.

[Michael Stubblefield, President and CEO at Avantor]

And with the work that Cory is certainly leading together with our commercial associates who are deeply engaged with our customers. We are moving as aggressively as we can, not only to support the customers but to strengthen and grow the business. And with all that we have here, our value proposition is certainly enhanced in an environment like this. And your point there about our folks cutting out the middleman, that's not a trend that we've experienced in this environment. And I think that's largely just due the value proposition and strength of the supply chain that looks like ours, the unparalleled customer access that we provide, the agility, the choice and the ability to serve these customers the way we do really is an important part of our differentiated platform here.

[Tejas Savant, Analyst at Morgan Stanley]

Got it. Appreciate the color, Michael. Thank you, and thanks for the help over the years.

[Michael Stubblefield, President and CEO at Avantor]

Thank you.

[Operator]

Thank you. Those are all the questions we have time for today. And so I will hand back to Michael Stubblefield for closing remarks.

[Michael Stubblefield, President and CEO at Avantor]

Yes. Thank you all for joining us today. As you've heard through our prepared remarks and through our Q and session here, we are not satisfied with our overall results. And hopefully, you sense the urgency that we're moving to enhance performance and maximize value in this environment, including through the upsizing of our cost reduction initiatives. The Board and our entire leadership team are committed to achieving this objective, and we look forward to discussing our progress as we move forward.

[Michael Stubblefield, President and CEO at Avantor]

Until then, be well, everyone. Thank you.

[Operator]

Thank you, everyone, for joining us today. This concludes our call, and you may now disconnect your line.

Participants

Executives

• Allison Hosak, Senior VP - Global Communications
• Michael Stubblefield, President and CEO
• R. Brent Jones, EVP & CFO

Analysts

• Michael Ryskin, Managing Director at Bank of America Merrill Lynch
• Vijay Kumar, Senior Managing Director at Evercore ISI
• Rachel Vatnsdal, Analyst at JPMorgan Chase
• Tycho Peterson, Managing Director at Jefferies Financial Group
• Daniel Brennan, Managing Director at TD Cowen
• Doug Schenkel, Managing Director at Wolfe Research LLC
• Luke Sergott, Analyst at Barclays Capital
• Tejas Savant, Analyst at Morgan Stanley