NASDAQ:AMRN Amarin Q1 2025 Earnings Report $10.99 +0.01 (+0.09%) Closing price 04:00 PM EasternExtended Trading$10.92 -0.07 (-0.64%) As of 07:53 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. ProfileEarnings HistoryForecast Amarin EPS ResultsActual EPS-$0.04Consensus EPS -$0.06Beat/MissBeat by +$0.02One Year Ago EPSN/AAmarin Revenue ResultsActual RevenueN/AExpected Revenue$50.75 millionBeat/MissN/AYoY Revenue GrowthN/AAmarin Announcement DetailsQuarterQ1 2025Date5/7/2025TimeBefore Market OpensConference Call DateWednesday, May 7, 2025Conference Call Time8:00AM ETUpcoming EarningsAmarin's Q2 2025 earnings is scheduled for Wednesday, July 30, 2025, with a conference call scheduled on Tuesday, August 5, 2025 at 12:00 AM ET. Check back for transcripts, audio, and key financial metrics as they become available.Conference Call ResourcesConference Call AudioConference Call TranscriptSlide DeckPress Release (8-K)Quarterly Report (10-Q)Earnings HistoryCompany ProfileSlide DeckFull Screen Slide DeckPowered by Amarin Q1 2025 Earnings Call TranscriptProvided by QuartrMay 7, 2025 ShareLink copied to clipboard.There are 6 speakers on the call. Operator00:00:00Welcome to Amarin Corporation's conference call to discuss its first quarter twenty twenty five business update and financial results. I would like to turn the conference call over to Mark Marmer, Vice President, Corporate Communications and Investor Relations at Amarin. Speaker 100:00:19Good morning, everyone, and thank you for joining us. Turning to slide two and our forward looking statements. Please be aware that this conference call will contain forward looking statements that are intended to be covered under the Safe Harbor provided under federal securities law. We may not achieve our goals, carry out our plans or intentions, or meet the expectations disclosed in our forward looking statements. Actual results or events could differ materially, so you should not place undue reliance on these statements. Speaker 100:00:50We assume no obligation to update these statements as circumstances change. Our forward looking statements do not reflect the potential impact of significant transactions we may enter into such as mergers, acquisitions, dispositions, joint ventures, or any material agreements that we may enter into, amend, or terminate. For additional information concerning the risk factors that could cause actual results to differ materially, please see the Risk Factors section of our annual report on Form 10 ks for the year ended 12/31/2024, and the quarterly report on Form 10 Q for the quarter ended 03/31/2025, which have been filed with the SEC and are available through the Investor Relations section of our website at www.amarincorp.com. We encourage everyone to read these documents. An archive of this call will be posted on Ameren's website in the Investor Relations section. Speaker 100:01:53Turning to slide three and today's agenda. Aaron Berg, Ameren's President and Chief Executive Officer, will provide an update on the state of our business. Pete Fishman, Ameren's Chief Financial Officer, will review our first quarter twenty twenty five financial results. And at the end of the presentation, Aaron will provide closing remarks followed by a question and answer session. I will now turn the call over to Aaron Berg, President and Chief Executive Officer of Ameren. Speaker 100:02:20Aaron? Speaker 200:02:22Thank you, Mark. Good morning, everyone, and thanks for joining us today. I want to start by sharing some of the key accomplishments that point to the foundational work that's been done over the last two years, setting the stage for meaningful future growth for the company. In The US, we continued our strategy of focusing on managed care access to maximize branded revenue in an increasingly genericized market. In Europe, our revamped leadership team implemented a new targeted strategy focused on a very high risk patient group, those with established cardiovascular disease, or ECVD. Speaker 200:02:58This population eligible for Viseka is estimated to be more than six million patients in secondary prevention in Western Europe alone. This strategy has been pulled through in both pricing and reimbursement efforts, as well as the overall brand strategy. We also extended our European IP out to 2,039, providing a much longer runway to maximize the value of Biskeppa. We expanded our rest of the world presence by entering into additional regional partnerships, including in Southeast Asia, MENA, and Australia. Our R and D and medical affairs teams continued their efforts on advancing medical community understanding around the science and potential of Vascepa to impact CV risk globally. Speaker 200:03:44And we also took aggressive, meaningful steps to reduce operating costs, manage our cash, and improve our supply position. With these strategic and operational actions, we strengthened the foundation of the company, improving the potential for future growth. And while still early on, we are seeing tangible results. Since the first quarter of twenty twenty three, we've significantly increased the number of countries globally where Vascepa is reimbursed and launched, from seven in 2023 to 20 one today. While many of these countries remain in the early stages of commercialization, the steps we've taken widen and deepen the footprint for broader patient impact and further diversify sources of revenue generation. Speaker 200:04:30We've stabilized Vascepa as a profitable enterprise in The US and have maintained a leading market share. Vascepa is accelerating revenue growth, albeit off a small base, across European markets with patent protection through 02/1939. While encouraging, we know there's tremendous untapped opportunity in Europe and room for significant growth. We've achieved regulatory and early commercial success through our rest of the world partnerships. Is now commercialized in nine rest of the world markets to date through these partnerships. Speaker 200:05:05Our R and D and medical affairs teams have continued to advance the science behind Vascepa, with nearly 100 abstracts and publications, more than 150 educational initiatives since 2023 across Europe, and a strong presence at major global medical congresses. And we've efficiently managed our cash over 10 consecutive quarters while maintaining a debt free balance sheet. While we're proud of this progress, we know we're just scratching the surface of the full potential in many markets globally, and we have much more work to do in pursuit of opportunities to unlock the value of the product and the company as a whole. We're moving with purpose, determined to advance patient treatment and reduce cardiovascular risk globally, while delivering value to shareholders. And we will continue to take any steps to assure we're on the right path to realizing the full potential in the near term. Speaker 200:06:02This is very much top of mind for our Board and management team and has been the guiding force behind the transformational strategic, operational and financial improvements we made over the last several years. Now let's turn to our first quarter performance. Turning to slide five. In the first quarter of twenty twenty five, we made meaningful progress across every facet of the business, strategically, operationally and financially, progress that continues to position us well to realize the full potential of the Vascepa franchise and maximize value for patients and shareholders. Overall, we've made progress in our three key segments. Speaker 200:06:44First in Europe, on the commercialization front, Veskepa revenues continued the gradual growth we saw in 2024, with $5,400,000 in revenues in the quarter, representing 16% sequential quarterly growth. This early yet meaningful growth was driven by continued success in Spain, The UK and Central Eastern Europe markets. Building on the success, we continue to find ways to accelerate growth where Veskepa has been launched. In Italy, the team has been focused on pricing and reimbursement to expand regional access. We've secured access in 14 of 21 local regions to date, which represent more than 85% of the total eligible market in Italy, reflecting positive interest in high density areas. Speaker 200:07:34This initial market access work sets the stage for a more efficient and effective broad commercial launch to drive anticipated growth later in 2025. Elsewhere in Europe, our team has made meaningful progress on market access and advancing pricing and reimbursement efforts. Specifically, we secured reimbursement in Austria and launched commercially in April. We also continue active engagement with authorities in Norway and Ireland, with decisions in those markets expected later this year. Second, in The U. Speaker 200:08:10S, we are continuing to efficiently generate cash with VASCEPA more than four years after the introduction of the first generic products. We began 2025 by retaining all of our major exclusive accounts from Q4 twenty twenty four, and that continued through the first quarter. This is a positive sign as we continue focusing on generating revenue and maximizing the profitability of The US branded business. Similar to the seasonality impact we experienced in 2023 and 2024, we expect to see prescription volume pick up in the second quarter, with possible declines in the third and fourth quarter. Moving forward, given market dynamics, while we anticipate year over year declines consistent with prior years, we continue to extract strong value from The U. Speaker 200:08:59S. Through efficient, focused commercial execution and remain prepared to launch our authorized generic, when deemed necessary and advantageous to the company to fully maximize the contribution from the product through its life cycle. And third, across various regions in the rest of the world, 2024 was a year where, together with our partners, we drove regulatory progress in many markets and in 2025 have shifted to focusing on early commercialization. We began 2025 by working with our partners to drive early demand for Vascepa across many markets. BeningPharm in China continued advancing promotional efforts in cardiovascular risk reduction for at risk patients with access to private hospitals and high risk patients in public hospitals, with inpatient ACS patients as the priority in this initial stage of the commercial CVRR launch. Speaker 200:09:57Their efforts are currently focused on the self pay market in China as they continue working towards inclusion on the National Retail Drug Listing, or NRDL, for 2026. As a reminder, China is a very large market opportunity for Vascepa, with an estimated three thirty million CBD patients and one of the highest CBD death rates in the world. According to a recent report on cardiovascular health and disease in China, CBD accounted for forty four to forty seven percent of all deaths in urban and rural areas, meaning two out of every five deaths were due to CBD. We're confident Edding can make a difference in this critical market with Vascepa. In Australia, through the efforts with our partner CSL Securis, Vascepa was included in a new clinical guideline for diagnosing and managing acute coronary syndromes issued by the National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand. Speaker 200:10:59And most recently, the 2024 edition of Management of Type two Diabetes, a handbook for general practice by the Royal Australian College of General Practitioners, now includes Veskepa in the lipid lowering medication overview section under complications, type two diabetes, and cardiovascular risk. This means we now have two strong local clinical recommendations supporting Veskepa use. These are important milestones that reinforce the value of Veskepta in helping reduce cardiovascular risk in high risk patients, from those patients with recent ACS to those living with diabetes. While still very early in the launch, CSL Securis is continuing to see strong in market demand for Veskepta. The opportunity to make an impact on cardiovascular disease risk in this market is notable, and we've seen a steady end market demand increase since launch in January. Speaker 200:11:59According to the Australian Institute of Health and Welfare, approximately one point three million patients in Australia have established cardiovascular disease, which represents a significant opportunity for Veskepa. Biologics continue to advance market access efforts in the MENA region, including important progress with the Ministry of Health in Saudi Arabia to further expand access for patients with public reimbursement there. This progress is important because with over thirty percent of adults 18 at risk of CBD in The Kingdom Of Saudi Arabia, there is an urgent need to address CBD there. Across Southeast Asia, regulatory efforts advanced in seven additional markets led by our partner Lotus, currently keeping us on track for first approval in the region in 2026. These markets provide additional opportunities to drive future growth. Speaker 200:12:56In addition, we continue to advance the science supporting Vascepa globally by leveraging our medical affairs team to attendance and international KOL involvement in education at multiple major global and regional medical conferences complemented by local educational efforts to strengthen scientific advocacy and launch activities. We also continue to pursue securing additional scientific publications in numerous regions locally, primarily focused on commercialized markets. Together, these efforts reinforce the growing global demand and potential for VASCEPA, backed by a solid foundation of science, regulatory approvals, and partnerships with strong commercial presence. From a financial perspective, we took decisive action to address a key overhang for the company and continued to make smart decisions to balance spending with cash preservation, always with a focus on driving shareholder value. Specifically, we took proactive action to address our listing status on NASDAQ by completing a one for 20 ADS ratio change to preserve our NASDAQ listing. Speaker 200:14:07With this complete, we have regained full compliance with NASDAQ. And we continue to keep our operating expenses in line and importantly retained a solid cash position with no debt. In summary, the first quarter provided continued foundational progress for our path ahead. We have a global product with a broad label in many markets, demonstrating proven therapeutic impact and value in the fight against CBD, the number one killer worldwide, and in changing the lives of at risk patients wherever it's available. We have a global network supporting Amarin has a solid financial base with no debt that can support our operations and growth into the future. Speaker 200:14:52And we have a dedicated team committed to seeing through the realization of the true potential of VASCEPA and further cementing our role in impacting the lives of patients worldwide. While we focus on the opportunity for this product around the world, we will do so prudently and with a significant focus on the bottom line. As we've always done, we will continue to look for opportunities to reduce operating expenses while investing wisely to maximize the value of the product globally. And with that, let me turn the call over to Pete Fishman, who will take us through the financial results. Pete? Speaker 300:15:27Thank you, Aaron. Good morning, everyone. Turning to slide seven. In the first quarter of twenty twenty five, we reported total net revenue of $42,000,000 including net product revenue of $41,000,000 and $1,000,000 of licensing and royalty revenue compared to total net revenue of $56,500,000 in the first quarter of twenty twenty four. U. Speaker 300:15:49S. Product revenue was 35,700,000.0 compared to $48,100,000 in the first quarter of twenty twenty four. This decline was driven by lower net selling price due to generic competition and a decrease in volume. As a reminder, we typically see the bulk of the full year U. S. Speaker 300:16:07Declines in volume and price in the first quarter of the year. Despite the revenue decline, The U. S. Business continues to deliver significant cash with a remarkable track record for a branded product this far out from the introduction of generics. European product revenue was $5,400,000 a $3,500,000 increase over the prior year period, driven primarily by continued in market demand growth in Spain, The UK, and Central Eastern European markets. Speaker 300:16:37Product revenue also reflects revenue from our partnerships throughout the rest of the world, where we are in the early stages of commercialization in numerous regions. While in the first quarter of twenty twenty five, we recorded minimal net product revenue from our partners compared to $5,200,000 during the first quarter of twenty twenty four, there continues to be in market demand growth sequentially quarter over quarter in all geographies where our partners have launched. It is important to note that product revenues in the current year period were impacted by launch supply order timing from our partners in the fourth quarter of twenty twenty four to meet initial and anticipated 2025 in market demand based on the growth trends seen in 2024. As Aaron mentioned earlier, many of our partners are now shifting focus toward early commercialization, and therefore, our partnership revenue will be variable quarter to quarter and year to year based on restocking timing relative to in market demand. Cost of goods sold was $16,900,000 in the first quarter compared to $24,600,000 in the prior year period. Speaker 300:17:46Gross margin on product revenue was 59% compared to 55% in the prior year period, driven primarily by changes to the customer mix. Total operating expenses were $41,900,000 including $36,600,000 in SG and A and $5,300,000 in R and D, which is a reduction of approximately 8% compared to the prior year period and reflects our efficient management of expenses and cash usage. We will continue to focus on deploying our capital prudently on value driven efforts to maximize impact of Vascepa for patients around the world. Turning to the bottom line, first quarter twenty twenty five net loss was $15,700,000 compared to a net loss of $10,000,000 in the prior year period, primarily reflecting the impact of The U. S. Speaker 300:18:37Generic market. Turning to Slide eight and our balance sheet. We have continued to focus on controlling costs and effectively managing our cash. As of 03/31/2025, Amarin has aggregate cash and investments of $282,000,000 with no debt. We have continued to make significant progress rightsizing our operations while improving our strategic focus and navigating the ongoing challenges to our U. Speaker 300:19:04S. Product revenue. While doing this, we have also made investments to further expand the reach of VASCEPA globally. As a result of these efforts, we have kept our cash burn below 10% over the last ten quarters. We will continue to remain focused on operational expenditures to ensure prudent cash management. Speaker 300:19:24In addition, we continue to make progress renegotiating supply purchase agreements, which have helped draw down our overall supply significantly over the last two years and rightsize our supply commitments for current and future demand. Importantly, given our current supply position and the setup of our overall supply chain, we have not seen any impact nor do we expect to see any material impact in future quarters from U. S. Or ex U. S. Speaker 300:19:50Tariffs. In summary, Amarin continues to have a solid financial base and strong structure to support our path ahead. Let me now turn the call back over to Aaron for closing remarks before we begin the Q and A. Aaron? Speaker 200:20:05Thanks, Pete. Turning to slide 10, as you've heard today, the company is in a very solid position as we begin 2025. We've made progress across all of our priorities by proactively modifying our strategy to drive the future opportunity for growth. We know there's more work to do to fully capitalize on the untapped global potential for Vascepa, and we'll continue to consider all opportunities available to us to ensure we unlock this value. This is what continues to drive our priorities and guide the actions we continue to take to maximize shareholder value. Speaker 200:20:42I want to reiterate a key point that continues to bring us back to the global value potential for Vascepa. Simply stated, we have in our hands a product that can significantly help address the scourge that is cardiovascular disease today, still the number one killer globally. Today Vascepa is available to clinicians and has been proven to be a valuable tool in the global fight against cardiovascular disease. We remain committed to accelerating the pace and expanding the scope of access to this tremendous drug. And in conjunction with widely used lipid lowering agents focused on LDL lowering, there continues to be growing evidence that Vascepa can directly address cardiovascular risk and potentially reduce the incidence of cardiovascular events worldwide. Speaker 200:21:31That's the opportunity and clear mandate for us. Finally, I'd like to take a moment to thank the entire Amarin team and our partners around the world for their continued commitment and dedication. Your efforts are deeply appreciated and know that you're impacting the lives of at risk patients around the world every day. Thank you. With that, operator, let's begin the Q and A portion of the call. Operator00:21:57Certainly. At this time, we will be conducting a question and answer session. If you would like to ask a question, please press star one on your telephone keypad. A confirmation tone will indicate your line is in the question queue. You may press star 2 if you would like to remove your question from the queue. Operator00:22:16For participants using speaker equipment, it may be necessary to pick up your handset before pressing the star keys. One moment please while we poll for questions. Your first question for today is from Jessica Fye with JPMorgan. Speaker 300:22:37Hello. This is Adam on for Jess. Thank you for taking our question. I just wanted to ask, rest of world revenues of less than 100,000 fell significantly year over year and sequentially. I just wanted to ask what drove this decline and should we expect it to bounce back up going forward? Speaker 300:22:56Thank you. Speaker 200:22:59Thanks for the question. So rest of the world, first of all, we're very encouraged by the position we're in, in spite of the fact that there was, the revenues for Q1 were limited. As we said in the past, the way that these individual countries report will make the quarterly revenue variable. And it will be choppy as we get started. They're just launching. Speaker 200:23:27We're very early. They're operating off a small base and the way shipments go in some quarters they'll be there and in some quarters they won't. But overall we expect growth. We're encouraged by the end market demand we're seeing in the countries where we've launched. And it's very recent, right? Speaker 200:23:46If you've heard in the script how early we are in so many of these countries in the last twelve months just launching, getting off the ground. We learned from the experience in The US that it's a brand that takes some time to build a foundation and it starts to ramp up. But we have good partners. We know that there's an unmet need. The product's being received well. Speaker 200:24:10Scientific foundation's being built. Pricing reimbursements being accessed. And we're very encouraged and optimistic about where we'll go going forward. But it still may be choppy quarter to quarter. Thank you. Operator00:24:37Your next question for today is from Roana Ruiz with Leerink. Speaker 400:24:44Hi. This is Maisie on for Roana. Just one from us, but, really just more of a science question. But given the established data now on REDUCE IT and cardiovascular outcomes, what additional real world evidence or clinical development plans do you have to potentially expand labeling or strengthen differentiation against generics, particularly as we continue to see the evolution in the lipid management landscape with all the newer emerging therapies? Speaker 200:25:16Thanks, Maisie. Appreciate the question. So I'll start off, and then we have Doctor. Steve Ketchum here with us, and Steve can add on. So I'll try and dissect the question a little bit. Speaker 200:25:30We were always looking and have been very active in generating new data to differentiate the product. Now I'll separate generics for a minute because that's a little bit of a different animal. But certainly to show the value of IPE and the uniqueness of IPE and given the number of publications that I cited in the script and didn't even talk about what we've generated over the last decade really, which is hundreds and hundreds of publications to show the uniqueness. That's one thing that we've done exceptionally well and certainly since REDUCE IT, the team has done a remarkable job mining that data to show the differentiation. Some of the new therapies, it's exciting to hear talk of LP or possible rebirth of CTEP inhibition and those products and look forward to where those products take us. Speaker 200:26:29I think what's encouraging for us is one, it shows there's still residual risk after LDL lowering alone, even though they're focused on LDL lowering with CTEP inhibitors. And even when LDL is treated, there's still significant cardiovascular events. And that's even when patients have LDLs that are low. And that's where Vascepa comes in. And we generate a lot of data to show, certainly REDUCE IT showed that because it was on top of standard of care. Speaker 200:26:59Vascepa is available today with significant cardiovascular risk reduction. So maybe those other products come out and maybe they're good for a sub segment of patients individually. But this is a product that could certainly make a difference today. And we certainly hope that the scientific community focuses on that. And even though in The US we're challenged because of the generic market and our investment in medical education has been limited, the rest of the world and Europe, especially Europe with protection to 02/1939, we've got a long runway and we intend to be very, continue to be very aggressive generating new data to show that this product is available today and is unique and can make a difference in residual risk beyond standard of care. Speaker 200:27:48And that will be whether these new products come out or not. And those products could be years away. But today, the scientific community and practitioners and patients, everybody can benefit from Vascepa Today. And that's one thing that we're certainly optimistic about. Steve, don't know if you want to talk about some of the work that you've done in generating new data, maybe some of the things coming up, Speaker 500:28:13some of the data we presented at ACC that shows the uniqueness as well. Yeah, absolutely. So of course, know, REDUCE IT is the focal point of our development program. And we continue to, continues to be a rich data source. And as Aaron mentioned, we've focused over the past period of time on highlighting the strength of the data irrespective of baseline LDL C, irrespective of baseline LP. Speaker 500:28:44As Aaron mentioned, we do see that we have a complimentary therapy that's got very robust data. We also continue to have a strong presence at all of the major international medical congresses. Recently at ACC, as Aaron mentioned, we continue to support data from external collaborators looking into mechanisms of action of EPA. And this includes anti inflammatory effects on various pathways, effects on protein expression, and we look forward to continuing to have a strong presence at future congresses this year. Thanks to you. Speaker 500:29:27Thanks Aaron. Speaker 200:29:28And Maji that's, just to build on it. The data that's been generated has led to over 50 guideline recommendations globally, and that's because of the scientific foundation and the uniqueness of the product. So today there can be a difference made in cardiovascular risk reduction. And that can be done with Vascepa and Veskepa and other countries and hopefully that's recognized increasingly. Given that we're so early in so many countries launching, we think we're poised for growth. Speaker 200:30:02We're confident that we've made the right changes, have the right strategy, seen the effects of that, have good partners. We're looking forward to, we're very bullish on where we'll go going forward. Thank you. Speaker 400:30:15Thank you for the thoughtful response. Operator00:30:24We have reached the end of the question and answer session, and I will now turn the call back to Aaron for closing remarks. Speaker 200:30:32Thank you, operator. Thank you. Thanks everyone for taking the time to join us this morning. We appreciate the interest and continued interest in the company. Again, as we said, we're looking forward to where we go moving ahead. Speaker 200:30:49We've made the right changes and look forward to growth as we go forward and look forward to giving you further updates. But thanks again for your time. Appreciate it. Operator00:31:00This concludes today's conference, and you may disconnect your lines at this time. Thank you for your participation.Read morePowered by Key Takeaways Global Commercial Expansion: Vascepa is launched in 20 countries with Q1 European revenues of $5.4 M (+16% quarter-over-quarter) and early commercialization in nine rest-of-world markets, with ongoing access efforts in Italy, Austria, Norway, and Ireland. US Business Stability: Despite generic competition, Amarin retained all major exclusive accounts, stabilized Vascepa as a profitable branded franchise, anticipates seasonal Q2 volume growth, and remains prepared to launch an authorized generic to maximize lifecycle value. Strategic and Operational Improvements: The company extended European patent protection to 2039, refined US managed-care and European ECVD strategies, secured partnerships in Southeast Asia, MENA, and Australia, and implemented cost and supply chain optimizations while maintaining a debt-free balance sheet. Strong Financial Position: Q1 net revenue was $42 M (US $35.7 M; Europe $5.4 M) with a net loss of $15.7 M versus $10 M a year ago, alongside $282 M in cash and investments, no debt, and a cash burn under 10% for ten consecutive quarters. Scientific Leadership and Future Growth: Amarin’s R&D and medical affairs teams have produced nearly 100 abstracts, over 150 educational initiatives, and more than 50 global guideline recommendations, reinforcing Vascepa’s differentiated role in residual cardiovascular risk reduction and the company’s commitment to unlocking its full potential. AI Generated. May Contain Errors.Conference Call Audio Live Call not available Earnings Conference CallAmarin Q1 202500:00 / 00:00Speed:1x1.25x1.5x2x Earnings DocumentsSlide DeckPress Release(8-K)Quarterly report(10-Q) Amarin Earnings HeadlinesEarnings Update: Amarin Corporation plc (NASDAQ:AMRN) Just Reported And Analysts Are Boosting Their EstimatesMay 10, 2025 | finance.yahoo.comAmarin Corp PLC (AMRN) Q1 2025 Earnings Call Highlights: Strategic Global Expansion Amidst ...May 8, 2025 | finance.yahoo.comTrump Predicts Dollar DownfallREAD THIS VERY CAREFULLY: If you have $100,000 or more saved for retirement, this may make you VERY angry... This is what President Trump said: "Our currency is crashing and will soon no longer be the world standard, which will be our greatest defeat, frankly, in 200 years." Why Would He Say This?May 22, 2025 | Augusta Precious Metals (Ad)Amarin Reports First Quarter 2025 Financial ResultsMay 7, 2025 | finance.yahoo.comAmarin Q1 2025 Earnings PreviewMay 6, 2025 | msn.com7AMRN : Exploring Amarin Corp's Earnings ExpectationsMay 6, 2025 | benzinga.comSee More Amarin Headlines Get Earnings Announcements in your inboxWant to stay updated on the latest earnings announcements and upcoming reports for companies like Amarin? Sign up for Earnings360's daily newsletter to receive timely earnings updates on Amarin and other key companies, straight to your email. Email Address About AmarinAmarin (NASDAQ:AMRN), a pharmaceutical company, engages in the development and commercialization of therapeutics for the treatment of cardiovascular diseases in the United States, European countries, Canada, Lebanon, and the United Arab Emirates. The company offers VASCEPA, a prescription-only omega-3 fatty acid product, used as an adjunct to diet for reducing triglyceride levels in adult patients with severe hypertriglyceridemia. It sells its products principally to wholesalers and specialty pharmacy providers. The company has a collaboration with Mochida Pharmaceutical Co., Ltd. to develop and commercialize drug products and indications based on the active pharmaceutical ingredient in Vascepa. The company was formerly known as Ethical Holdings plc and changed its name to Amarin Corporation plc in 1999. Amarin Corporation plc was incorporated in 1989 and is headquartered in Dublin, Ireland.View Amarin ProfileRead more More Earnings Resources from MarketBeat Earnings Tools Today's Earnings Tomorrow's Earnings Next Week's Earnings Upcoming Earnings Calls Earnings Newsletter Earnings Call Transcripts Earnings Beats & Misses Corporate Guidance Earnings Screener Earnings By Country U.S. Earnings Reports Canadian Earnings Reports U.K. Earnings Reports Latest Articles Alibaba's Earnings Just Changed Everything for the StockCisco Stock Eyes New Highs in 2025 on AI, Earnings, UpgradesSymbotic Gets Big Earnings Lift: Is the Stock Investable Again?D-Wave Pushes Back on Short Seller Case With Strong EarningsAppLovin Surges on Earnings: What's Next for This Tech Standout?Can Shopify Stock Make a Comeback After an Earnings Sell-Off?Rocket Lab: Earnings Miss But Neutron Momentum Holds Upcoming Earnings PDD (5/27/2025)AutoZone (5/27/2025)Bank of Nova Scotia (5/27/2025)NVIDIA (5/28/2025)Synopsys (5/28/2025)Bank of Montreal (5/28/2025)Salesforce (5/28/2025)Costco Wholesale (5/29/2025)Marvell Technology (5/29/2025)Canadian Imperial Bank of Commerce (5/29/2025) Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. 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There are 6 speakers on the call. Operator00:00:00Welcome to Amarin Corporation's conference call to discuss its first quarter twenty twenty five business update and financial results. I would like to turn the conference call over to Mark Marmer, Vice President, Corporate Communications and Investor Relations at Amarin. Speaker 100:00:19Good morning, everyone, and thank you for joining us. Turning to slide two and our forward looking statements. Please be aware that this conference call will contain forward looking statements that are intended to be covered under the Safe Harbor provided under federal securities law. We may not achieve our goals, carry out our plans or intentions, or meet the expectations disclosed in our forward looking statements. Actual results or events could differ materially, so you should not place undue reliance on these statements. Speaker 100:00:50We assume no obligation to update these statements as circumstances change. Our forward looking statements do not reflect the potential impact of significant transactions we may enter into such as mergers, acquisitions, dispositions, joint ventures, or any material agreements that we may enter into, amend, or terminate. For additional information concerning the risk factors that could cause actual results to differ materially, please see the Risk Factors section of our annual report on Form 10 ks for the year ended 12/31/2024, and the quarterly report on Form 10 Q for the quarter ended 03/31/2025, which have been filed with the SEC and are available through the Investor Relations section of our website at www.amarincorp.com. We encourage everyone to read these documents. An archive of this call will be posted on Ameren's website in the Investor Relations section. Speaker 100:01:53Turning to slide three and today's agenda. Aaron Berg, Ameren's President and Chief Executive Officer, will provide an update on the state of our business. Pete Fishman, Ameren's Chief Financial Officer, will review our first quarter twenty twenty five financial results. And at the end of the presentation, Aaron will provide closing remarks followed by a question and answer session. I will now turn the call over to Aaron Berg, President and Chief Executive Officer of Ameren. Speaker 100:02:20Aaron? Speaker 200:02:22Thank you, Mark. Good morning, everyone, and thanks for joining us today. I want to start by sharing some of the key accomplishments that point to the foundational work that's been done over the last two years, setting the stage for meaningful future growth for the company. In The US, we continued our strategy of focusing on managed care access to maximize branded revenue in an increasingly genericized market. In Europe, our revamped leadership team implemented a new targeted strategy focused on a very high risk patient group, those with established cardiovascular disease, or ECVD. Speaker 200:02:58This population eligible for Viseka is estimated to be more than six million patients in secondary prevention in Western Europe alone. This strategy has been pulled through in both pricing and reimbursement efforts, as well as the overall brand strategy. We also extended our European IP out to 2,039, providing a much longer runway to maximize the value of Biskeppa. We expanded our rest of the world presence by entering into additional regional partnerships, including in Southeast Asia, MENA, and Australia. Our R and D and medical affairs teams continued their efforts on advancing medical community understanding around the science and potential of Vascepa to impact CV risk globally. Speaker 200:03:44And we also took aggressive, meaningful steps to reduce operating costs, manage our cash, and improve our supply position. With these strategic and operational actions, we strengthened the foundation of the company, improving the potential for future growth. And while still early on, we are seeing tangible results. Since the first quarter of twenty twenty three, we've significantly increased the number of countries globally where Vascepa is reimbursed and launched, from seven in 2023 to 20 one today. While many of these countries remain in the early stages of commercialization, the steps we've taken widen and deepen the footprint for broader patient impact and further diversify sources of revenue generation. Speaker 200:04:30We've stabilized Vascepa as a profitable enterprise in The US and have maintained a leading market share. Vascepa is accelerating revenue growth, albeit off a small base, across European markets with patent protection through 02/1939. While encouraging, we know there's tremendous untapped opportunity in Europe and room for significant growth. We've achieved regulatory and early commercial success through our rest of the world partnerships. Is now commercialized in nine rest of the world markets to date through these partnerships. Speaker 200:05:05Our R and D and medical affairs teams have continued to advance the science behind Vascepa, with nearly 100 abstracts and publications, more than 150 educational initiatives since 2023 across Europe, and a strong presence at major global medical congresses. And we've efficiently managed our cash over 10 consecutive quarters while maintaining a debt free balance sheet. While we're proud of this progress, we know we're just scratching the surface of the full potential in many markets globally, and we have much more work to do in pursuit of opportunities to unlock the value of the product and the company as a whole. We're moving with purpose, determined to advance patient treatment and reduce cardiovascular risk globally, while delivering value to shareholders. And we will continue to take any steps to assure we're on the right path to realizing the full potential in the near term. Speaker 200:06:02This is very much top of mind for our Board and management team and has been the guiding force behind the transformational strategic, operational and financial improvements we made over the last several years. Now let's turn to our first quarter performance. Turning to slide five. In the first quarter of twenty twenty five, we made meaningful progress across every facet of the business, strategically, operationally and financially, progress that continues to position us well to realize the full potential of the Vascepa franchise and maximize value for patients and shareholders. Overall, we've made progress in our three key segments. Speaker 200:06:44First in Europe, on the commercialization front, Veskepa revenues continued the gradual growth we saw in 2024, with $5,400,000 in revenues in the quarter, representing 16% sequential quarterly growth. This early yet meaningful growth was driven by continued success in Spain, The UK and Central Eastern Europe markets. Building on the success, we continue to find ways to accelerate growth where Veskepa has been launched. In Italy, the team has been focused on pricing and reimbursement to expand regional access. We've secured access in 14 of 21 local regions to date, which represent more than 85% of the total eligible market in Italy, reflecting positive interest in high density areas. Speaker 200:07:34This initial market access work sets the stage for a more efficient and effective broad commercial launch to drive anticipated growth later in 2025. Elsewhere in Europe, our team has made meaningful progress on market access and advancing pricing and reimbursement efforts. Specifically, we secured reimbursement in Austria and launched commercially in April. We also continue active engagement with authorities in Norway and Ireland, with decisions in those markets expected later this year. Second, in The U. Speaker 200:08:10S, we are continuing to efficiently generate cash with VASCEPA more than four years after the introduction of the first generic products. We began 2025 by retaining all of our major exclusive accounts from Q4 twenty twenty four, and that continued through the first quarter. This is a positive sign as we continue focusing on generating revenue and maximizing the profitability of The US branded business. Similar to the seasonality impact we experienced in 2023 and 2024, we expect to see prescription volume pick up in the second quarter, with possible declines in the third and fourth quarter. Moving forward, given market dynamics, while we anticipate year over year declines consistent with prior years, we continue to extract strong value from The U. Speaker 200:08:59S. Through efficient, focused commercial execution and remain prepared to launch our authorized generic, when deemed necessary and advantageous to the company to fully maximize the contribution from the product through its life cycle. And third, across various regions in the rest of the world, 2024 was a year where, together with our partners, we drove regulatory progress in many markets and in 2025 have shifted to focusing on early commercialization. We began 2025 by working with our partners to drive early demand for Vascepa across many markets. BeningPharm in China continued advancing promotional efforts in cardiovascular risk reduction for at risk patients with access to private hospitals and high risk patients in public hospitals, with inpatient ACS patients as the priority in this initial stage of the commercial CVRR launch. Speaker 200:09:57Their efforts are currently focused on the self pay market in China as they continue working towards inclusion on the National Retail Drug Listing, or NRDL, for 2026. As a reminder, China is a very large market opportunity for Vascepa, with an estimated three thirty million CBD patients and one of the highest CBD death rates in the world. According to a recent report on cardiovascular health and disease in China, CBD accounted for forty four to forty seven percent of all deaths in urban and rural areas, meaning two out of every five deaths were due to CBD. We're confident Edding can make a difference in this critical market with Vascepa. In Australia, through the efforts with our partner CSL Securis, Vascepa was included in a new clinical guideline for diagnosing and managing acute coronary syndromes issued by the National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand. Speaker 200:10:59And most recently, the 2024 edition of Management of Type two Diabetes, a handbook for general practice by the Royal Australian College of General Practitioners, now includes Veskepa in the lipid lowering medication overview section under complications, type two diabetes, and cardiovascular risk. This means we now have two strong local clinical recommendations supporting Veskepa use. These are important milestones that reinforce the value of Veskepta in helping reduce cardiovascular risk in high risk patients, from those patients with recent ACS to those living with diabetes. While still very early in the launch, CSL Securis is continuing to see strong in market demand for Veskepta. The opportunity to make an impact on cardiovascular disease risk in this market is notable, and we've seen a steady end market demand increase since launch in January. Speaker 200:11:59According to the Australian Institute of Health and Welfare, approximately one point three million patients in Australia have established cardiovascular disease, which represents a significant opportunity for Veskepa. Biologics continue to advance market access efforts in the MENA region, including important progress with the Ministry of Health in Saudi Arabia to further expand access for patients with public reimbursement there. This progress is important because with over thirty percent of adults 18 at risk of CBD in The Kingdom Of Saudi Arabia, there is an urgent need to address CBD there. Across Southeast Asia, regulatory efforts advanced in seven additional markets led by our partner Lotus, currently keeping us on track for first approval in the region in 2026. These markets provide additional opportunities to drive future growth. Speaker 200:12:56In addition, we continue to advance the science supporting Vascepa globally by leveraging our medical affairs team to attendance and international KOL involvement in education at multiple major global and regional medical conferences complemented by local educational efforts to strengthen scientific advocacy and launch activities. We also continue to pursue securing additional scientific publications in numerous regions locally, primarily focused on commercialized markets. Together, these efforts reinforce the growing global demand and potential for VASCEPA, backed by a solid foundation of science, regulatory approvals, and partnerships with strong commercial presence. From a financial perspective, we took decisive action to address a key overhang for the company and continued to make smart decisions to balance spending with cash preservation, always with a focus on driving shareholder value. Specifically, we took proactive action to address our listing status on NASDAQ by completing a one for 20 ADS ratio change to preserve our NASDAQ listing. Speaker 200:14:07With this complete, we have regained full compliance with NASDAQ. And we continue to keep our operating expenses in line and importantly retained a solid cash position with no debt. In summary, the first quarter provided continued foundational progress for our path ahead. We have a global product with a broad label in many markets, demonstrating proven therapeutic impact and value in the fight against CBD, the number one killer worldwide, and in changing the lives of at risk patients wherever it's available. We have a global network supporting Amarin has a solid financial base with no debt that can support our operations and growth into the future. Speaker 200:14:52And we have a dedicated team committed to seeing through the realization of the true potential of VASCEPA and further cementing our role in impacting the lives of patients worldwide. While we focus on the opportunity for this product around the world, we will do so prudently and with a significant focus on the bottom line. As we've always done, we will continue to look for opportunities to reduce operating expenses while investing wisely to maximize the value of the product globally. And with that, let me turn the call over to Pete Fishman, who will take us through the financial results. Pete? Speaker 300:15:27Thank you, Aaron. Good morning, everyone. Turning to slide seven. In the first quarter of twenty twenty five, we reported total net revenue of $42,000,000 including net product revenue of $41,000,000 and $1,000,000 of licensing and royalty revenue compared to total net revenue of $56,500,000 in the first quarter of twenty twenty four. U. Speaker 300:15:49S. Product revenue was 35,700,000.0 compared to $48,100,000 in the first quarter of twenty twenty four. This decline was driven by lower net selling price due to generic competition and a decrease in volume. As a reminder, we typically see the bulk of the full year U. S. Speaker 300:16:07Declines in volume and price in the first quarter of the year. Despite the revenue decline, The U. S. Business continues to deliver significant cash with a remarkable track record for a branded product this far out from the introduction of generics. European product revenue was $5,400,000 a $3,500,000 increase over the prior year period, driven primarily by continued in market demand growth in Spain, The UK, and Central Eastern European markets. Speaker 300:16:37Product revenue also reflects revenue from our partnerships throughout the rest of the world, where we are in the early stages of commercialization in numerous regions. While in the first quarter of twenty twenty five, we recorded minimal net product revenue from our partners compared to $5,200,000 during the first quarter of twenty twenty four, there continues to be in market demand growth sequentially quarter over quarter in all geographies where our partners have launched. It is important to note that product revenues in the current year period were impacted by launch supply order timing from our partners in the fourth quarter of twenty twenty four to meet initial and anticipated 2025 in market demand based on the growth trends seen in 2024. As Aaron mentioned earlier, many of our partners are now shifting focus toward early commercialization, and therefore, our partnership revenue will be variable quarter to quarter and year to year based on restocking timing relative to in market demand. Cost of goods sold was $16,900,000 in the first quarter compared to $24,600,000 in the prior year period. Speaker 300:17:46Gross margin on product revenue was 59% compared to 55% in the prior year period, driven primarily by changes to the customer mix. Total operating expenses were $41,900,000 including $36,600,000 in SG and A and $5,300,000 in R and D, which is a reduction of approximately 8% compared to the prior year period and reflects our efficient management of expenses and cash usage. We will continue to focus on deploying our capital prudently on value driven efforts to maximize impact of Vascepa for patients around the world. Turning to the bottom line, first quarter twenty twenty five net loss was $15,700,000 compared to a net loss of $10,000,000 in the prior year period, primarily reflecting the impact of The U. S. Speaker 300:18:37Generic market. Turning to Slide eight and our balance sheet. We have continued to focus on controlling costs and effectively managing our cash. As of 03/31/2025, Amarin has aggregate cash and investments of $282,000,000 with no debt. We have continued to make significant progress rightsizing our operations while improving our strategic focus and navigating the ongoing challenges to our U. Speaker 300:19:04S. Product revenue. While doing this, we have also made investments to further expand the reach of VASCEPA globally. As a result of these efforts, we have kept our cash burn below 10% over the last ten quarters. We will continue to remain focused on operational expenditures to ensure prudent cash management. Speaker 300:19:24In addition, we continue to make progress renegotiating supply purchase agreements, which have helped draw down our overall supply significantly over the last two years and rightsize our supply commitments for current and future demand. Importantly, given our current supply position and the setup of our overall supply chain, we have not seen any impact nor do we expect to see any material impact in future quarters from U. S. Or ex U. S. Speaker 300:19:50Tariffs. In summary, Amarin continues to have a solid financial base and strong structure to support our path ahead. Let me now turn the call back over to Aaron for closing remarks before we begin the Q and A. Aaron? Speaker 200:20:05Thanks, Pete. Turning to slide 10, as you've heard today, the company is in a very solid position as we begin 2025. We've made progress across all of our priorities by proactively modifying our strategy to drive the future opportunity for growth. We know there's more work to do to fully capitalize on the untapped global potential for Vascepa, and we'll continue to consider all opportunities available to us to ensure we unlock this value. This is what continues to drive our priorities and guide the actions we continue to take to maximize shareholder value. Speaker 200:20:42I want to reiterate a key point that continues to bring us back to the global value potential for Vascepa. Simply stated, we have in our hands a product that can significantly help address the scourge that is cardiovascular disease today, still the number one killer globally. Today Vascepa is available to clinicians and has been proven to be a valuable tool in the global fight against cardiovascular disease. We remain committed to accelerating the pace and expanding the scope of access to this tremendous drug. And in conjunction with widely used lipid lowering agents focused on LDL lowering, there continues to be growing evidence that Vascepa can directly address cardiovascular risk and potentially reduce the incidence of cardiovascular events worldwide. Speaker 200:21:31That's the opportunity and clear mandate for us. Finally, I'd like to take a moment to thank the entire Amarin team and our partners around the world for their continued commitment and dedication. Your efforts are deeply appreciated and know that you're impacting the lives of at risk patients around the world every day. Thank you. With that, operator, let's begin the Q and A portion of the call. Operator00:21:57Certainly. At this time, we will be conducting a question and answer session. If you would like to ask a question, please press star one on your telephone keypad. A confirmation tone will indicate your line is in the question queue. You may press star 2 if you would like to remove your question from the queue. Operator00:22:16For participants using speaker equipment, it may be necessary to pick up your handset before pressing the star keys. One moment please while we poll for questions. Your first question for today is from Jessica Fye with JPMorgan. Speaker 300:22:37Hello. This is Adam on for Jess. Thank you for taking our question. I just wanted to ask, rest of world revenues of less than 100,000 fell significantly year over year and sequentially. I just wanted to ask what drove this decline and should we expect it to bounce back up going forward? Speaker 300:22:56Thank you. Speaker 200:22:59Thanks for the question. So rest of the world, first of all, we're very encouraged by the position we're in, in spite of the fact that there was, the revenues for Q1 were limited. As we said in the past, the way that these individual countries report will make the quarterly revenue variable. And it will be choppy as we get started. They're just launching. Speaker 200:23:27We're very early. They're operating off a small base and the way shipments go in some quarters they'll be there and in some quarters they won't. But overall we expect growth. We're encouraged by the end market demand we're seeing in the countries where we've launched. And it's very recent, right? Speaker 200:23:46If you've heard in the script how early we are in so many of these countries in the last twelve months just launching, getting off the ground. We learned from the experience in The US that it's a brand that takes some time to build a foundation and it starts to ramp up. But we have good partners. We know that there's an unmet need. The product's being received well. Speaker 200:24:10Scientific foundation's being built. Pricing reimbursements being accessed. And we're very encouraged and optimistic about where we'll go going forward. But it still may be choppy quarter to quarter. Thank you. Operator00:24:37Your next question for today is from Roana Ruiz with Leerink. Speaker 400:24:44Hi. This is Maisie on for Roana. Just one from us, but, really just more of a science question. But given the established data now on REDUCE IT and cardiovascular outcomes, what additional real world evidence or clinical development plans do you have to potentially expand labeling or strengthen differentiation against generics, particularly as we continue to see the evolution in the lipid management landscape with all the newer emerging therapies? Speaker 200:25:16Thanks, Maisie. Appreciate the question. So I'll start off, and then we have Doctor. Steve Ketchum here with us, and Steve can add on. So I'll try and dissect the question a little bit. Speaker 200:25:30We were always looking and have been very active in generating new data to differentiate the product. Now I'll separate generics for a minute because that's a little bit of a different animal. But certainly to show the value of IPE and the uniqueness of IPE and given the number of publications that I cited in the script and didn't even talk about what we've generated over the last decade really, which is hundreds and hundreds of publications to show the uniqueness. That's one thing that we've done exceptionally well and certainly since REDUCE IT, the team has done a remarkable job mining that data to show the differentiation. Some of the new therapies, it's exciting to hear talk of LP or possible rebirth of CTEP inhibition and those products and look forward to where those products take us. Speaker 200:26:29I think what's encouraging for us is one, it shows there's still residual risk after LDL lowering alone, even though they're focused on LDL lowering with CTEP inhibitors. And even when LDL is treated, there's still significant cardiovascular events. And that's even when patients have LDLs that are low. And that's where Vascepa comes in. And we generate a lot of data to show, certainly REDUCE IT showed that because it was on top of standard of care. Speaker 200:26:59Vascepa is available today with significant cardiovascular risk reduction. So maybe those other products come out and maybe they're good for a sub segment of patients individually. But this is a product that could certainly make a difference today. And we certainly hope that the scientific community focuses on that. And even though in The US we're challenged because of the generic market and our investment in medical education has been limited, the rest of the world and Europe, especially Europe with protection to 02/1939, we've got a long runway and we intend to be very, continue to be very aggressive generating new data to show that this product is available today and is unique and can make a difference in residual risk beyond standard of care. Speaker 200:27:48And that will be whether these new products come out or not. And those products could be years away. But today, the scientific community and practitioners and patients, everybody can benefit from Vascepa Today. And that's one thing that we're certainly optimistic about. Steve, don't know if you want to talk about some of the work that you've done in generating new data, maybe some of the things coming up, Speaker 500:28:13some of the data we presented at ACC that shows the uniqueness as well. Yeah, absolutely. So of course, know, REDUCE IT is the focal point of our development program. And we continue to, continues to be a rich data source. And as Aaron mentioned, we've focused over the past period of time on highlighting the strength of the data irrespective of baseline LDL C, irrespective of baseline LP. Speaker 500:28:44As Aaron mentioned, we do see that we have a complimentary therapy that's got very robust data. We also continue to have a strong presence at all of the major international medical congresses. Recently at ACC, as Aaron mentioned, we continue to support data from external collaborators looking into mechanisms of action of EPA. And this includes anti inflammatory effects on various pathways, effects on protein expression, and we look forward to continuing to have a strong presence at future congresses this year. Thanks to you. Speaker 500:29:27Thanks Aaron. Speaker 200:29:28And Maji that's, just to build on it. The data that's been generated has led to over 50 guideline recommendations globally, and that's because of the scientific foundation and the uniqueness of the product. So today there can be a difference made in cardiovascular risk reduction. And that can be done with Vascepa and Veskepa and other countries and hopefully that's recognized increasingly. Given that we're so early in so many countries launching, we think we're poised for growth. Speaker 200:30:02We're confident that we've made the right changes, have the right strategy, seen the effects of that, have good partners. We're looking forward to, we're very bullish on where we'll go going forward. Thank you. Speaker 400:30:15Thank you for the thoughtful response. Operator00:30:24We have reached the end of the question and answer session, and I will now turn the call back to Aaron for closing remarks. Speaker 200:30:32Thank you, operator. Thank you. Thanks everyone for taking the time to join us this morning. We appreciate the interest and continued interest in the company. Again, as we said, we're looking forward to where we go moving ahead. Speaker 200:30:49We've made the right changes and look forward to growth as we go forward and look forward to giving you further updates. But thanks again for your time. Appreciate it. Operator00:31:00This concludes today's conference, and you may disconnect your lines at this time. Thank you for your participation.Read morePowered by