MaxCyte Q2 2025 Earnings Report

MaxCyte EPS Results

• Actual EPS: -$0.12
• Consensus EPS: -$0.10
• Beat/Miss: Missed by -$0.02
• One Year Ago EPS: N/A

MaxCyte Revenue Results

• Actual Revenue: $8.51 million
• Expected Revenue: $9.57 million
• Beat/Miss: Missed by -$1.06 million
• YoY Revenue Growth: N/A

MaxCyte Announcement Details

• Quarter: Q2 2025
• Date: 8/6/2025
• Time: After Market Closes
• Conference Call Date: Wednesday, August 6, 2025
• Conference Call Time: 4:30PM ET

MaxCyte (NASDAQ:MXCT), a life sciences company, discovers, develops, and commercializes next-generation cell therapies in the United States and internationally. Its products include ExPERT ATx, a static electroporation instrument for small to medium scale transfection; ExPERT STx, a flow electroporation for protein production and drug development, as well as expression of therapeutic targets for cell-based assays; ExPERT GTx, a flow electroporation for large scale transfection in therapeutic applications; and ExPERT VLx for very large volume cell-engineering. The company also provides disposable processing assemblies (PAs) to process and electroporate cells; and accessories supporting PAs, such as electroporation buffer solution and software protocols. It licenses and sells its instruments and technology; and sells its consumables to developers of cell therapies, as well as to pharmaceutical and biotechnology companies for use in drug discovery and development, and bio-manufacturing. MaxCyte, Inc. was incorporated in 1998 and is headquartered in Rockville, Maryland.

MaxCyte Q2 2025 Earnings Call Transcript

Key Takeaways

• Positive Sentiment: The company delivered $8.5 million in Q2 total revenue with core revenue up 8% year-over-year and instrument sales up 22%, reflecting sustained growth in a difficult market.
• Negative Sentiment: MaxSight lowered its 2025 core revenue guidance to flat to down 10% ($29.5 M–$32.5 M) from prior growth expectations, citing customer inventory management, program consolidations, and capex hesitancy.
• Positive Sentiment: Integration of SecurDx is on track, with the gene-editing risk assessment pipeline more than doubling and at least $2 million in full-year revenue expected.
• Positive Sentiment: MaxSight signed two new strategic platform licenses with Adacel Bio and Anoka AB, bringing the total SPL count to 31 and demonstrating the resilience of its licensing model.
• Positive Sentiment: The company ended Q2 with $165 million in cash and investments, no debt, and asserts that existing capital suffices to reach profitability without additional financing.

Presentation

[Operator]

Good day, and thank you for standing by. Welcome to the MaxSight Second Quarter Earnings Conference Call. At this time, all participants are in a listen only mode. After speakers' presentation, there will be a question and answer session. To ask a question during the session, you will need to press 111, You will hear an automated message advising your hand is raised.

[Operator]

To withdraw your question, please press 11, again. Today's conference is being recorded. I would now like to hand the conference over to your first speaker today, Eric Abdao, Investor Relations. Please go ahead.

[Erik Abdow, Investor Relations at MaxCyte]

Good afternoon, everyone. Thank you for participating in today's conference call. Joining me on the call for MaxSight, we have Maher Masud, President and Chief Executive Officer and Doug Swierski, Chief Financial Officer. Earlier today, MaxSight released financial results for the second quarter ended 06/30/2025. A copy of the press release is available on the company's website.

[Erik Abdow, Investor Relations at MaxCyte]

Before we begin, I need to read the following statement. Statements or comments made during this call may be forward looking statements within the meaning of federal securities laws. Any statements contained in this call that relate to expectations or predictions of future events, results or performance are forward looking statements. Actual results may differ materially from those expressed or implied in any forward looking statements due to a variety of factors, which are discussed in detail in our SEC filings. Except as required by applicable law, the company has no obligation to publicly update any forward looking statements whether because of new information, future events or otherwise.

[Erik Abdow, Investor Relations at MaxCyte]

And with that, I will turn the call over to Maher.

[Maher Masoud, President, CEO & Director at MaxCyte]

Thank you, Eric. Good afternoon, everyone, and thank you for joining MaxSite's second quarter twenty twenty five earnings call. MaxSight reported financial results that were in line with our expectations in the second quarter. To cover the highlights, we sustained growth in a difficult end market. We also recently signed two new strategic platform licenses with Anoka AB and Adasib Bio, bringing the total number of new SPLs this year to three.

[Maher Masoud, President, CEO & Director at MaxCyte]

We continue to focus on investing in the business with discipline, while positioning the company to achieve profitability with our existing capital. And lastly, we progressed well into integration of SecurDx, which is a substantial long term opportunity for MaxSight. Despite what was a strong first half of the year, short term external headwinds have begun to impact our expectations for growth in the second half. First, in recent months, we faced a decrease in spending at a large SPL partner customer related to PA inventory management and reorganization of manufacturing operations impacting leases. Second, we have seen some customers rationalize programs and wind down operations entirely, which has resulted in lower expectations for PA and licenses revenue.

[Maher Masoud, President, CEO & Director at MaxCyte]

Last, we have seen continued capital equipment purchasing hesitancy from customers related to the uncertain funding and regulatory environment in cell therapy. Taking these factors into account, we are lowering our core revenue guidance range for 2025. To walk you through our updated guidance, we now expect core business revenue, which does not include SPL program related revenue to be flat to down 10% in 2025, representing approximately 29,500,000.0 to $32,500,000 in 2025 revenue compared to $32,500,000 in 2024. This compares to our previous guidance range of 8% to 15% growth or approximately $35,000,000 to $37,000,000 Both ranges include approximately $2,000,000 in revenue from SecurDx, which we continue to expect. The change of the guidance midpoint is 5,000,000 relative to our previous plan.

[Maher Masoud, President, CEO & Director at MaxCyte]

The first factor in the guidance reduction is about 1,500,000.0 in PAs relative to our prior plan. Half of this is a result of inventory management at the previously mentioned customer, and the other half is related to softness across other preclinical and clinical customers due to program consolidation. Additionally, about 2,000,000 of the guidance reduction is related to licenses relative to our power plant. About a quarter of licenses impact was from our largest customer reorganizing manufacturing operations, and about three fourths is related to other clinical customers consolidating programs or shutting down operations. The remaining one and a half million of the guidance cut is related to softness in instruments as customers remain hesitant with capital equipment purchases.

[Maher Masoud, President, CEO & Director at MaxCyte]

As we look forward, we have had detailed discussions with this customer and can confirm that this is not a movement away from our platform or changes in the outlook for their therapeutic. We are working with the customer to determine the timing of future purchases as they continue to optimize their manufacturing network. While we are disappointed in the change in expectations for this year, we remain confident in the value proposition that MaxSite offers to the cell and gene therapy industry. And based on the current opportunities in the pipeline, we expect to return back to growth in 2026. With such growth, including continued growth in Asia Pacific, an increasing number of clinical programs utilizing our platform and the launch of a new platform later this year that we believe will add to our top line growth.

[Maher Masoud, President, CEO & Director at MaxCyte]

To cover our second quarter financial results and developments in more detail, we reported $8,500,000 in total revenue, which included core revenue of $8,200,000 and SPL program related revenue of $300,000 which was in line with our expectations. Within the core business, instrument installed base grew to eight fourteen as of June 30, with instrument revenue of $2,100,000 in the second quarter, which grew 22% year over year. While the capital equipment spending environment has not fully recovered, we are optimistic about the improved growth instrument sales. License revenue was 2,600,000.0, which was flat year over year. PA or processing assembly revenue increased 5% year over year, stepping down slightly for recent quarters.

[Maher Masoud, President, CEO & Director at MaxCyte]

License and PA revenue were impacted by some customers consolidating programs. Turning to the SPL program related line, revenue was 300,000 in the quarter, representing revenue primarily from KashJebi commercial royalties, as we had not recognized any milestones during the quarter. During Vertex's second quarter earnings call, they highlighted the positive momentum they have seen with KASJEVY worldwide with an acceleration in patient initiations, cell collections, and number of patients completing their treatment journey. Vertex points to the progress they are making in 2025, as well as the growth of Kashtari positions them for in 2026. And they have met their goal of authorized treatment centers or ATCs with more than 75 ATCs activated globally.

[Maher Masoud, President, CEO & Director at MaxCyte]

We are encouraged by their continued investment in their ATC network to be able to support the launch of this critical product. There are now one hundred and fifteen patients who have completed cell collection. With twenty nine patients now having completed their patient journey, which includes 16 in the second quarter, equating to $30,000,000 in revenue for the second quarter for Vertex. Additionally, two fifty patients have now been referred by physicians to activate treatment centers to initiate treatment. As patients initiations and cell collections continues to ramp, Vertex expects commensurate increases in infusions, but noted that because of timing of infusions is predicated on patient scheduling choices, there may be revenue variability from quarter to quarter.

[Maher Masoud, President, CEO & Director at MaxCyte]

We continue to believe that cash chevy interest and demand remains very high around the globe, and we are very excited by the truly transformative nature of the treatment. Over the last week, we were excited to sign two new SPL agreements with Adacide Bio and Anoka AB, bringing our total number of SPL agreements to 31. Adacet Bio, who is working to develop allogeneic gamma delta T cell therapies for cancer and autoimmune diseases, will utilize our expert platform to expand their manufacturing capabilities to include non viral gene editing delivery. We are also excited to be supporting Anoka AB, a T cell immunotherapy company developing a deep pipeline of T cell receptor engineered therapies or TCRs. MaxSide's platform will provide both companies with technical, scientific, and regulatory support as they advance their pipelines and missions forward.

[Maher Masoud, President, CEO & Director at MaxCyte]

We view these new SPL signings and our continued ability to grow instrument placements in a difficult environment as a testament to the resilience of our platform as a critical manufacturing tool for advanced therapies. To provide a better understanding of our SPL portfolio, we've added a new deck to our investor relations website, which we hope you will look through, highlighting the SPLs in our portfolio and their current clinical programs and progress. Our business model remains strong as we're continuing to sign new SPLs that will provide value over the near, mid and long term. And our existing customer base continues to advance their respective research and clinical programs. As it stands today, 14 of our SPL clients have active programs in the clinic, while others are working on earlier programs.

[Maher Masoud, President, CEO & Director at MaxCyte]

We are supporting a total of 18 active clinical programs, which is consistent with the beginning of the year. Given the dynamic environment this year, four clinical programs shut down, but four new programs entered the clinic, which is a testament to our strong business model. We expect that at times some of our SBL customers will rationalize programs, but our highly differentiated platform and unparalleled scientific support allows us to sign new SBLs thereby continually increasing number of clinical programs we support. Some of the 18 programs of support have also progressed further along in the clinic so far this year. To highlight the progress, five of the current 18 clinical programs are set to enter pivotal studies in the next six to eighteen months.

[Maher Masoud, President, CEO & Director at MaxCyte]

As I mentioned, while programs can fail or be slowed and deprioritized, that is the nature of the industry and built into our business model. We continue to sign new SPLs and have seen recent SPL signings result in new programs moving into clinical development. Since the IPO, the number of max side has appeal agreements and active clinical programs supported has grown substantially. And we've continued to see diversification or clinical revenue compared to just a few years ago. With trials across a vast number of our SPLs, such as for blood cancer, solid tumor, genetic diseases, neurodegenerative diseases, and autoimmune diseases.

[Maher Masoud, President, CEO & Director at MaxCyte]

Our differentiated platform, leading support, engineering know how, and FDA master file have positioned MaxSight to continue to sign three to five SPLs a year for the foreseeable future. As we look beyond cash service, the second wave of potential therapies coming to market. MaxSight supports five clinical programs that are expected to enter pivotal studies in the next six to eighteen months, and could be approved and launched in 2027 and 2028. Such approvals all provide us participation in the economics in the form of royalties, annual license fees, and significant expansion of processing assembly use. Our ability to disclose and discuss these programs is limited by confidential agreements with our customers.

[Maher Masoud, President, CEO & Director at MaxCyte]

However, on slide eight of the new deck, we've detailed the five programs across five SPLs. CRISPR Therapeutics, Lujan, Immunogene, Caribou, and one undisclosed SPL that we believe could enter pivotal studies within this timeframe. We also support 13 programs currently in phase one, which we believe have potential approvals beyond 2028 and other 19 programs currently in preclinical development with launch potential in 2032 and beyond. As you know, not every program will make it to FDA approval. However, we capture value for both successful programs and programs that do not achieve their endpoints.

[Maher Masoud, President, CEO & Director at MaxCyte]

As we add SPLs and our existing SPLs bring more programs to the clinic, the opportunity set will continue to grow. Turning to our cell and gene therapy services formerly under a subsidiary SecurDx, which we have now merged into MaxSite. We are pleased with the performance of the business so far this year, remaining on track to meet our annual revenue expectation, and we are seeing good traction in booking projects. Since the acquisition earlier this year, we have been successfully integrating these services into MaxSight. The three assays available through SecureDX, screening, nomination, and confirmation are available to both ex vivo and in vivo therapy developers at different stages of development, starting in the discovery stage through preclinical development and IND enabling studies.

[Maher Masoud, President, CEO & Director at MaxCyte]

SecureDX provides a robust and efficient on and off target assessment and decreases time to clinic and improves likelihood of program success. In the evolving cell and gene therapy industry, safety has become increasingly important from a regulatory perspective and secure his gene editing risk assessment services aligned with regulatory guidance from the FDA and other agencies. We've seen positive momentum in adoption of secure technology in clinical studies. For instance, OneSeq, a technology invented by SecureDX and GuideSeq, a technology invented by Mass General Hospital and licensed exclusively to SecureDX were both used in the gene editing risk assessments performed by Children's Hospital of Philadelphia and Penn and the first of its kind personalized gene editing therapy approved by regulators and administered to the infant KJ for a rare genetic disease, which has received national coverage. We believe that the opportunity for SecureDx is very large and not just in rare disease.

[Maher Masoud, President, CEO & Director at MaxCyte]

SecureDx offers both off target and off target analysis to support gene knockouts and gene insertions in advanced therapies. The assay support early development to IND filings for both in vivo and ex vivo therapies, and we expect Secure's addressable market to be the entire field of modified cell and gene therapies. We are very optimistic about the commercial uptake for SecurDx and believe that it has significant growth potential over the coming years. The sales pipeline so far this year is more than twice as much as it was heading into 2025. Despite what remains a challenging backdrop in cell and gene therapy, we see vast potential for these therapies to provide life changing treatments to patients challenged with disease.

[Maher Masoud, President, CEO & Director at MaxCyte]

A belief that is shared across the industry landscape of regulators, academics, drug developers. We were encouraged by the cell and gene therapy roundtable hosted by the FDA in June and subsequent commentary from leaders at the Department of Health and Human Services. In our view, the message was clear. It has become apparent that cell and gene therapy is a priority at the agency. They support increasing the focus on curative therapies while moving away from managing costly chronic diseases.

[Maher Masoud, President, CEO & Director at MaxCyte]

They have committed to cell and gene therapy research and desire for payment reform and regulatory flexibility. And they have emphasized the need to accelerate cell and gene therapy development timelines. Over the long term, we share in the belief that cell and gene therapies have the potential to cure disease and reduce associated costs and patient burden. Maxar remains extremely well positioned to benefit for the growth of this industry over time. Given the long term belief we have in the industry, we continue to make disciplined investments to position the company for the future.

[Maher Masoud, President, CEO & Director at MaxCyte]

Our organic investments continue to be in new products and product enhancements, while our inorganic investment focus has been on solving critical pain points in the industry as seen with SecureDX. We are able to invest in our business given the strength of the balance sheet, as well as our focus on driving growth with efficient and lean operations. Our management team is committed to carefully managing MagSafe's financial health and continually evaluating ways to run our business more efficiently without sacrificing growth investments. With our existing balance sheet, MagSafe expects to achieve profitability without additional capital needs. To wrap up, I will highlight that we officially delisted from the AIM markets on June 26, following our annual meeting of stockholders and are now solely listed on NASDAQ.

[Maher Masoud, President, CEO & Director at MaxCyte]

We believe this was in the best interest of MaxSite and our stakeholders. We are thankful to our UK shareholders for their continued support. In summary, while I'm disappointed with the operational headwinds of our customers that have resulted in a reduced financial outlook for 2025, we are working diligently to build a growing and profitable business and position MaxSite for the future. My focus of growing MaxSite with multiple product offerings while improving operational efficiencies to reduce our annual burn to put us on track towards profitability remains solidly on track. We remain very optimistic and confident about MaxSize position in cell and gene therapy.

[Maher Masoud, President, CEO & Director at MaxCyte]

And over time, we believe MaxSize platforms and SPL business model will benefit from the growth of the industry. With that, I will now turn the call over to Doug to discuss our financial results. Doug?

[Douglas Swirsky, CFO at MaxCyte]

Thank you, Maher. Total revenue in the 2025 was $8,500,000 compared to $10,400,000 in the 2024, representing an 18% decline. Our milestone revenue remains lumpy from quarter to quarter, which can impact year over year comparisons in total reported revenue. We reported core revenue of $8,200,000 compared to $7,600,000 in the comparable prior year quarter, which represents growth of 8% year over year. Within core revenue, instrument revenue was $2,100,000 compared to $1,800,000 in the 2024, license revenue was $2,600,000 compared to $2,600,000 in the 2024, and Processing Assembly, or PA, revenue was $3,100,000 compared to $3,000,000 in the 2024.

[Douglas Swirsky, CFO at MaxCyte]

PA revenue in the second quarter benefited from ordering patterns impacted by the uncertain tariff environment. Assay service revenue, which includes SecureDX, was $100,000 in the second quarter. Other revenue was $300,000 compared to $200,000 in the 2024. Total Secured DX revenue was roughly $300,000 as a portion of the revenue was in the licenses line during the quarter. As discussed earlier, both license revenue and PA revenue were negatively impacted in the 2025 by customers consolidating programs, we were encouraged by the trend in instrument revenue, which returned to growth year over year.

[Douglas Swirsky, CFO at MaxCyte]

42% of our core revenue was derived from SPL customers in the 2025, which compares to 51% in the comparable prior year quarter. We recognized $300,000 of SPL program related revenue in the 2025 compared to $2,900,000 in the 2024. As Maher mentioned, SPL program related revenue was almost entirely from KASJEVY commercial royalties as we did not recognize any milestones during the quarter. Moving down the P and L, gross margin was 82% in the 2025 compared to 86% in the second quarter of the prior year. Excluding inventory provisions and SPL program related revenue, non GAAP adjusted gross margin was 83% in the 2025 compared to non GAAP adjusted gross margin of 82% in the 2024.

[Douglas Swirsky, CFO at MaxCyte]

Total operating expenses for the 2025 were $21,200,000 compared to $20,900,000 in the 2024. Operating efficiency continues to be a focus for us, and I want to highlight that operating expenses decreased for the 2025 compared to the first half of last year. Although this decrease was modest, we were able to achieve this despite absorbing the cost structure of SecurDx as well as expenses related to the acquisition of the business. Expenses also included investments in new product initiatives that we believe will begin paying dividends later this year and help drive revenue growth in 2026. We finished the second quarter with combined total cash, equivalents and investments of $165,200,000 and no debt.

[Douglas Swirsky, CFO at MaxCyte]

The decrease from the beginning of the year includes approximately $7,000,000 of purchase transaction and onetime costs associated with the acquisition of SecurDx. Continuing to our 2025 guidance, as Maher discussed in detail, we are updating our outlook and now expect core revenue of flat to a 10% decline compared to 2024, inclusive of revenue from SecureDX. We continue to expect at least $2,000,000 in full year revenue from SecureDX. We anticipate SecureDX revenue will be weighted towards the 2025, and we are comfortable with the revenue outlook for this business, which is supported by executed customer contracts. Additionally, we are reiterating SPL program related revenue guidance, which is expected to be approximately $5,000,000 in 2025, and which includes both expected revenue from pre commercial and commercial milestones and sales based royalties.

[Douglas Swirsky, CFO at MaxCyte]

We would like to note that our SPL program related revenue outlook is a risk adjusted forecast that is achievable under a variety of potential outcomes across our SPLs and the planned clinical progress and commercial success of our customers. Lastly, we now expect to end 2025 with approximately 155,000,000 in cash equivalents and investments on our balance sheet. This updated guidance is a result of our lower revenue expectations. MaxSite continues to be in a healthy financial position, and we remain committed to being disciplined in our spend and investments to drive long term growth for MaxSite and its shareholders. Now I'll turn the call back over to Maher.

[Maher Masoud, President, CEO & Director at MaxCyte]

Thank you, Doug. We firmly believe in MaxSight's value proposition within the cell and gene therapy industry and look forward to continuing to support our customers as their programs progress. With that, I will turn the call back over to the operator for the Q and A. Operator?

[Operator]

Thank you. At this time, we'll conduct a question and answer session. And our first question comes from the line of Matt Larue of William Blair. Your line is now open. Hi, good afternoon.

[Matt Larew, Research Analyst - Healthcare at William Blair]

Thanks for taking the question. Maybe starting with the reorg of manufacturing operations for your largest customer. It sounds like that took you a little bit off guard. I think it'd be helpful to know just exactly what your conversations with that customer have involved, how long, I guess, you expect this transition to occur and how much certainty versus opacity there is in terms of knowing what the future is there?

[Maher Masoud, President, CEO & Director at MaxCyte]

Matt, thanks for the question. Let me take that, and Doug, feel free to add on. So without giving too much details to that customer, it is our largest customer. We do have certainty as to where they are moving forward from here. This was just a short term consolidation of manufacturing.

[Maher Masoud, President, CEO & Director at MaxCyte]

It will have no impact to our future licensing revenue from that customer. This is a short term pocket that we saw with them, that we and we have visibility and we're always in constant dialogue with this customer. So we know what to expect going into the second half as well as into next year from this customer. We don't we don't see and we have no reason to believe that there will be any more major changes to the manufacturing operations at this point. In fact, let me add have that. Have

[Matt Larew, Research Analyst - Healthcare at William Blair]

Maybe oh, go ahead.

[Maher Masoud, President, CEO & Director at MaxCyte]

Me add, we feel very confident there won't be any more major changes for manufacturing from this customer.

[Matt Larew, Research Analyst - Healthcare at William Blair]

The gist of it being perhaps less instruments needed to less license revenue and less PA ordering because they're going to work through inventory?

[Maher Masoud, President, CEO & Director at MaxCyte]

Precisely, on the short term. That's exactly right, Matt.

[Matt Larew, Research Analyst - Healthcare at William Blair]

Okay.

[Matt Larew, Research Analyst - Healthcare at William Blair]

Okay, great. And then just kind of ending with Doug's comments around OpEx down modestly quarter over quarter and flattish year over year. If you just kind of think back the last several years here, core revenue is roughly flattish over the last several years, but obviously there's been a big tick up in spend. And just wondering relative to where the cash balance is today and also again thinking about investing for the future, if given the challenges you're facing, might be an opportunity to find additional efficiencies within the organization.

[Maher Masoud, President, CEO & Director at MaxCyte]

Yeah, great question, Matt. I mean, as I mentioned, obviously, within our current capital stock, we're going to be our goal is to be profitable within the foreseeable future. And I still feel confident we're on track towards that. There's always efficiencies we're going look towards across the organization and really how we how we go about with our growth projections. If you look at what Doug said, we're kind of proud of this. We actually absorbed the expenses of SecurDx and we're still slightly modestly less in terms of the OpEx than we were last year before we acquired SecurDx.

[Maher Masoud, President, CEO & Director at MaxCyte]

So you can tell that the eye of diligence that we have towards how we operate the company, we will continue to have the same eye of diligence and ensuring that we're always looking at ways to get us to that path profitability and at the same time have growth over the years. Doug, do want to add anything to that?

[Douglas Swirsky, CFO at MaxCyte]

I think that's good.

[Matt Larew, Research Analyst - Healthcare at William Blair]

You.

[Maher Masoud, President, CEO & Director at MaxCyte]

Thanks, Dan.

[Operator]

Thank you. One moment for our next question. And our next question comes from the line of Dan Arias of Stifel. Your line is now.

[Rohan Walcott, Equity Research Associate at Stifel Financial Corp]

Hey, guys. This is Rohan on for Dan. Thanks for taking my questions. Considering the updated guidance and your statements made today on the current business environment, customer sentiment, how should we contemplate quarterly cadence from 3Q to 4Q as we head into the back 2025? Anything additional that you could call out? Thanks.

[Douglas Swirsky, CFO at MaxCyte]

Sure, in terms of variability between Q3 and Q4, we do expect to be slightly weighted towards Q4, but not materially. So a slight weight to Q4 in terms of the midpoint of the revised range. I think when we start looking at sort of cases or down cases from that midpoint, I think it's going to be Q4 dependent.

[Rohan Walcott, Equity Research Associate at Stifel Financial Corp]

Thank you. And one more follow-up, you know, on instruments that seems to be, you know, a bright spot in the business up 22% year over year, you set some light on like, what you guys were hearing from, you know, your cell and gene therapy customers and how those conversations are going, and also what you're expecting performance wise for the rest of the year from instrumentation sales? Thank you.

[Maher Masoud, President, CEO & Director at MaxCyte]

Sure. Let me take that and Doug, feel free to add as well. As we mentioned in previous calls, obviously we've seen some CapEx constraints from customers. However, we are seeding the market more. We're seeing more of our lower price systems that we're able to sell into our customer base.

[Maher Masoud, President, CEO & Director at MaxCyte]

And as we speak with customers as well, we're starting to see those short term headwinds dissipate. Obviously, we had early in the year some concerns from customers on the NIH funding, or I should say, the funding. But we're starting to see that kind of baseline from here. And what we saw on the instrument side for the first half obviously is a testament to our execution as well in this tough environment. But it's of our strategy of ensuring that we can get in earlier with customers as well as to sell a few more of our lower priced systems and our higher end systems. Mean, Doug, anything else to add?

[Douglas Swirsky, CFO at MaxCyte]

Yes, mean, we're really focused on making sure we've got a global platform here. I think revenue outside ex US has been an increasing part of things as there's definitely some variability in terms of where folks are in the cycle, if you will. And so I think ex US, particularly Asia Pacific, has been strong for us.

[Rohan Walcott, Equity Research Associate at Stifel Financial Corp]

All right, thanks, guys. I'll jump back in the queue.

[Maher Masoud, President, CEO & Director at MaxCyte]

Yes. Thank you.

[Operator]

Thank you. One moment for our next question. Our next question comes from the line of Brandon Smith of TD Cowen. Your line is now open.

[Brendan Smith, Director & Senior Analyst at TD Cowen]

Great. Thanks for taking the questions, guys. Maybe kind of just a follow-up to a couple of things that have been discussed already here. But I guess just within your SPLs and the partnerships there, guess, and maybe more specifically the assets that are still advancing to the clinic. Can you maybe give us a little bit of a sense like are some of those programs skewed towards some more traditional use cases for cell therapies, like maybe CAR T or I guess, I'm really just wondering like where you're seeing some of your partners kind of drawing the line within their own pipelines as they're thinking about prioritizing their respective programs?

[Maher Masoud, President, CEO & Director at MaxCyte]

Yeah, great question. Actually, if you look at the ones on the corporate deck that we updated there, Brandon, I hope everyone looks at this. If you look at we're seeing a lot more customers now go allogeneic as well. So off the shelf is what we're seeing. If you look at the ones that we can publicly disclose, that's CRISPR CTX-one hundred twelve that we hope to get data on later on in the second half of the year.

[Maher Masoud, President, CEO & Director at MaxCyte]

You have version with CAR T7, imaging with azure cell, Caribou, CB10. These are all allogeneic B cell hematologic malignancies. We have one undisclosed program that we can't speak to whether it's autologous or allogeneic, but we are seeing more towards that shift of allogeneic therapies. Which bodes very well, Brandon, for our system. If you look at the scale we provide, we are highly differentiated from any system out there.

[Maher Masoud, President, CEO & Director at MaxCyte]

That's really the beauty of our models. You can work with us early in research, and as you scale up into those larger platforms, you know, where you're using a system that can transfect up to 20,000,000,000 cells, you're using a Mac sized system with the support that we provide as well.

[Brendan Smith, Director & Senior Analyst at TD Cowen]

Okay, got it. Thanks. That's very helpful.

[Operator]

Thank you. One moment for our next question. And our next question comes from the line of Hannah Hefley of Stephens. Your line is now open.

[Hannah Hefley, Senior Research Associate at Stephens Inc.]

Hi. Thanks for taking the questions. It sounds like PA revenue benefited from maybe a pull forward ahead of tariffs during the quarter. Could you frame up how large this benefit was? And does that mean you're expecting PA revenue to step down further next quarter?

[Douglas Swirsky, CFO at MaxCyte]

So, yes, it was a single order from a distributor. And we don't actually think that that's had a tremendous influence. So we get, you know, you think of it as a pull through, but we're seeing good order flow from those customers. And I don't think that it's something that's already built into the guide. And we're not tipping our hat to any particular breakdown of the core revenue that's been guided to with respect to either, you know, to what the breakdown is between instruments and PAs. But don't I think that's going to have a material impact. Where it did impact if you do, if you look at the slide of historical core business disclosures in the deck that we just posted the update of, you know, core revenue generated by SPL clients, you know, dipped.

[Douglas Swirsky, CFO at MaxCyte]

Really, that's two things. One is this, you know, reasonably reasonable order, that was sort of tariff motivated to get ahead of those. And then another was just a decline in expectations from a large customer. Think you take those out that 42% starts to creep back up into sort of the low 50s and consistent with where we expect to be in the business.

[Hannah Hefley, Senior Research Associate at Stephens Inc.]

Great, thanks. And then it seems like SPL customers were a little bit more insulated from some of these macro headwinds, at least like what we talked about last quarter, and now that seems to have changed a little bit. Is this more like focused on a few customers or are you seeing any impact to the SPL pipeline given these headwinds?

[Maher Masoud, President, CEO & Director at MaxCyte]

Great question, Hannah. No, we're not seeing impacts to the pipeline. In fact, as you can tell, you know, obviously, we signed three so far this year, I feel confident to sign three to five, you know, each year for the foreseeable future. If anything, some of those impacts were really short term. Saw that one customer just go completely in vivo.

[Maher Masoud, President, CEO & Director at MaxCyte]

We saw one customer shift focus from cell therapy to another modality. But overall, we have a very we have a very keen eye as to all of our scale customers. On occasion, we're going to have one or two customers here and there shift focus, but that's built into our model. That's why we signed three to five per year. It builds it builds for us.

[Maher Masoud, President, CEO & Director at MaxCyte]

I mean, there's a reason why four programs went off, but yet we added four more. So we still have 18 clinical programs using our system in the clinic. You have five going into pivotal in the next six to eighteen months, that all bode well for us in twenty twenty seven-twenty eight with potential approvals. So really, I see this as these are just short term, the nature it's built into our business model. That's what we signed three to five, we're going to have some drop off, but we're going to have more come in and then drop off. That's, that's what we built it into.

[Douglas Swirsky, CFO at MaxCyte]

The revised guide contemplates some decrease in license revenue associated with a couple of decisions. But the goal here, and I think it's proved out is that we're going to have more SPL customers coming into the fold, while you will see a smaller number of customers that are rationalizing their programs, or in some cases, know, trying to out license those programs and some of those have come back as a result.

[Maher Masoud, President, CEO & Director at MaxCyte]

That's right. And let me add a little bit more on this one. So we signed six SPALs last year, we've signed three so far this year, many of those will have programs going to the clinic. A lot of these customers that we signed were preclinical. We anticipate many of them going to the clinic in near future.

[Hannah Hefley, Senior Research Associate at Stephens Inc.]

Great, thanks. I'll leave it there.

[Maher Masoud, President, CEO & Director at MaxCyte]

Yeah, thanks, Sam.

[Operator]

Thank you. I'm showing no further questions at this time. I'll now turn it back to Maher for closing remarks.

[Maher Masoud, President, CEO & Director at MaxCyte]

Yeah, thank you, operator. Thank you, everyone, for joining us today. And I look forward and we all look forward to speaking to you again on our next earnings call in a few months.

[Operator]

Thank you for your participation in today's conference. This does conclude the program. You may now disconnect.

Participants

Executives

• Erik Abdow, Investor Relations
• Maher Masoud, President, CEO & Director
• Douglas Swirsky, CFO

Analysts

• Matt Larew, Research Analyst - Healthcare at William Blair
• Rohan Walcott, Equity Research Associate at Stifel Financial Corp
• Brendan Smith, Director & Senior Analyst at TD Cowen
• Hannah Hefley, Senior Research Associate at Stephens Inc.