| 2/20/2020 | Geode Capital Management LLC | 98,007 | $0.12M | 0.0% | +53.1% | 0.094% | |
| 2/18/2020 | Man Group plc | 1,084,803 | $1.30M | 0.0% | -47.1% | 1.036% | |
| 2/14/2020 | Marshall Wace LLP | 29,102 | $35K | 0.0% | -63.3% | 0.028% | |
| 2/13/2020 | Renaissance Technologies LLC | 1,465,143 | $1.76M | 0.0% | +66.7% | 1.399% | |
| 2/12/2020 | Polygon Management Ltd. | 857,311 | $1.03M | 0.2% | +71.5% | 0.819% | |
| 2/12/2020 | Raymond James & Associates | 29,411 | $35K | 0.0% | +13.7% | 0.028% | |
| 2/10/2020 | Baillie Gifford & Co. | 4,287,545 | $5.15M | 0.0% | +2.9% | 4.095% | |
| 2/4/2020 | Partnervest Advisory Services LLC | 35,000 | $42K | 0.0% | N/A | 0.033% | |
| 11/27/2019 | Millennium Management LLC | 914,416 | $1.38M | 0.0% | +5.2% | 0.873% | |
| 11/27/2019 | Man Group plc | 2,049,668 | $3.10M | 0.0% | +11.4% | 1.958% | |
| 11/5/2019 | Tower Research Capital LLC TRC | 21,472 | $32K | 0.0% | +21,372.0% | 0.021% | |
| 8/15/2019 | Bamco Inc. NY | 172,669 | $0.69M | 0.0% | +6.1% | 0.165% | |
| 8/14/2019 | D. E. Shaw & Co. Inc. | 77,990 | $0.31M | 0.0% | -73.5% | 0.074% | |
| 8/14/2019 | Morgan Stanley | 157,938 | $0.64M | 0.0% | -33.3% | 0.151% | |
| 8/14/2019 | Man Group plc | 1,839,225 | $7.39M | 0.0% | +37.4% | 1.757% | |
| 8/14/2019 | Rock Springs Capital Management LP | 875,000 | $3.52M | 0.1% | +9.4% | 0.836% | |
| 8/13/2019 | WS Management Lllp | 165,947 | $0.67M | 0.0% | -10.6% | 0.159% | |
| 8/12/2019 | Renaissance Technologies LLC | 497,100 | $2M | 0.0% | -37.4% | 0.475% | |
| 8/12/2019 | Rathbone Brothers plc | 704,472 | $2.83M | 0.1% | +146.6% | 0.673% | |
| 8/8/2019 | Baillie Gifford & Co. | 4,143,840 | $16.66M | 0.0% | +7.9% | 3.958% | |
| 8/8/2019 | Acadian Asset Management LLC | 42,517 | $0.17M | 0.0% | +119.5% | 0.041% | |
| 8/7/2019 | JPMorgan Chase & Co. | 278,120 | $1.11M | 0.0% | -30.9% | 0.266% | |
| 8/6/2019 | GSA Capital Partners LLP | 57,645 | $0.23M | 0.0% | -16.6% | 0.055% | |
| 8/1/2019 | DekaBank Deutsche Girozentrale | 89,000 | $0.36M | 0.0% | +263.3% | 0.085% | |
| 7/30/2019 | Aperio Group LLC | 21,992 | $88K | 0.0% | N/A | 0.021% | |
| 6/30/2019 | SG Americas Securities LLC | 23,259 | $94K | 0.0% | +25.7% | 0.022% | |
| 5/13/2019 | WS Management Lllp | 185,537 | $0.80M | 0.0% | -11.8% | 0.177% | |
| 5/10/2019 | DekaBank Deutsche Girozentrale | 24,500 | $0.27M | 0.0% | -44.9% | 0.023% | |
| 5/9/2019 | Rathbone Brothers plc | 285,722 | $1.23M | 0.0% | +27.9% | 0.273% | |
| 5/1/2019 | Baillie Gifford & Co. | 3,839,190 | $16.51M | 0.0% | +3.8% | 3.667% | |
| 4/26/2019 | Mitsubishi UFJ Kokusai Asset Management Co. Ltd. | 28,621 | $0.12M | 0.0% | +8.7% | 0.027% | |
| 4/24/2019 | Creative Planning | 101,698 | $0.44M | 0.0% | -16.4% | 0.097% | |
| 4/1/2019 | Deutsche Bank AG | 117,700 | $0.68M | 0.0% | +1,681,328.6% | 0.112% | |
| 2/26/2019 | FMR LLC | 1,578,783 | $9.08M | 0.0% | -29.6% | 1.672% | |
| 2/14/2019 | Squarepoint Ops LLC | 108,100 | $0.62M | 0.0% | N/A | 0.114% | |
| 2/14/2019 | Orbimed Advisors LLC | 1,350,655 | $7.77M | 0.1% | +102.6% | 1.431% | |
| 2/14/2019 | D. E. Shaw & Co. Inc. | 214,161 | $1.23M | 0.0% | N/A | 0.227% | |
| 2/14/2019 | Weiss Multi Strategy Advisers LLC | 65,000 | $0.37M | 0.0% | -7.1% | 0.069% | |
| 2/14/2019 | Baillie Gifford & Co. | 3,699,521 | $21.27M | 0.0% | +8.2% | 3.918% | |
| 2/13/2019 | Tekla Capital Management LLC | 228,496 | $1.31M | 0.1% | -35.0% | 0.242% | |
| 2/13/2019 | Foresite Capital Management II LLC | 700,000 | $4.03M | 2.1% | +40.0% | 0.741% | |
| 2/12/2019 | WS Management Lllp | 210,459 | $1.21M | 0.1% | -29.1% | 0.223% | |
| 2/12/2019 | Bellevue Group AG | 131,135 | $0.75M | 0.0% | +124.0% | 0.139% | |
| 2/11/2019 | Raymond James & Associates | 22,906 | $0.13M | 0.0% | +59.0% | 0.024% | |
| 2/8/2019 | BlackRock Inc. | 856,415 | $4.92M | 0.0% | +10.4% | 0.907% | |
| 2/8/2019 | Mitsubishi UFJ Kokusai Asset Management Co. Ltd. | 26,341 | $0.14M | 0.0% | +139.9% | 0.028% | |
| 2/7/2019 | Acadian Asset Management LLC | 38,078 | $0.22M | 0.0% | N/A | 0.040% | |
| 2/7/2019 | Henry James International Management Inc. | 25,027 | $0.14M | 0.1% | N/A | 0.027% | |
| 2/5/2019 | Virtus ETF Advisers LLC | 58,223 | $0.34M | 0.1% | +54.8% | 0.062% | |
| 2/1/2019 | SG Americas Securities LLC | 20,004 | $0.12M | 0.0% | +157.3% | 0.021% | |
| 1/29/2019 | D.A. Davidson & CO. | 11,199 | $64K | 0.0% | -53.1% | 0.012% | |
| 11/16/2018 | B. Riley Wealth Management Inc. | 10,900 | $0.15M | 0.0% | N/A | 0.012% | |
| 11/15/2018 | Nexthera Capital LP | 74,132 | $1.01M | 0.2% | N/A | 0.079% | |
| 11/15/2018 | Point72 Asset Management L.P. | 300,000 | $4.07M | 0.0% | N/A | 0.318% | |
| 11/15/2018 | Sofinnova Ventures Inc | 89,919 | $1.22M | 0.1% | N/A | 0.095% | |
| 11/15/2018 | Man Group plc | 398,902 | $5.41M | 0.0% | N/A | 0.422% | |
| 11/15/2018 | Oracle Investment Management Inc. | 897,494 | $12.17M | 2.7% | -35.6% | 0.951% | |
| 11/15/2018 | Vident Investment Advisory LLC | 192,251 | $2.61M | 0.1% | -6.5% | 0.204% | |
| 11/14/2018 | Virtus ETF Advisers LLC | 37,603 | $0.51M | 0.1% | -42.3% | 0.040% | |
| 11/14/2018 | Capital World Investors | 6,792,700 | $92.11M | 0.0% | -5.5% | 7.194% | |
| 11/14/2018 | Capital International Investors | 394,000 | $5.34M | 0.0% | N/A | 0.417% | |
| 11/14/2018 | Bamco Inc. NY | 607,699 | $8.24M | 0.0% | +76.0% | 0.644% | |
| 11/13/2018 | Tocqueville Asset Management L.P. | 11,175 | $0.15M | 0.0% | -57.3% | 0.012% | |
| 11/13/2018 | Renaissance Technologies LLC | 1,033,800 | $14.02M | 0.0% | -20.6% | 1.095% | |
| 11/13/2018 | Tekla Capital Management LLC | 351,618 | $4.77M | 0.2% | -58.9% | 0.372% | |
| 11/13/2018 | Foresite Capital Management II LLC | 500,000 | $6.78M | 2.5% | -28.6% | 0.530% | |
| 11/13/2018 | JPMorgan Chase & Co. | 148,525 | $2.01M | 0.0% | -29.9% | 0.157% | |
| 11/13/2018 | NEA Management Company LLC | 15,832,611 | $214.69M | 9.3% | +18.8% | 16.768% | |
| 11/13/2018 | Baillie Gifford & Co. | 3,417,627 | $46.34M | 0.1% | +12.7% | 3.620% | |
| 11/13/2018 | FDx Advisors Inc. | 10,445 | $0.14M | 0.0% | N/A | 0.011% | |
| 11/13/2018 | D.A. Davidson & CO. | 23,874 | $0.32M | 0.0% | -51.6% | 0.025% | |
| 11/9/2018 | FMR LLC | 2,243,825 | $30.43M | 0.0% | -34.5% | 2.376% | |
| 11/9/2018 | BlackRock Inc. | 775,405 | $10.51M | 0.0% | +1.6% | 0.821% | |
| 11/7/2018 | JPMorgan Chase & Co. | 148,525 | $2.01M | 0.0% | -29.9% | 0.157% | |
| 11/6/2018 | SG Americas Securities LLC | 7,775 | $0.11M | 0.0% | -62.8% | 0.008% | |
| 10/30/2018 | Stanley Laman Group Ltd. | 565,271 | $7.67M | 1.9% | N/A | 0.599% | |
| 10/30/2018 | Frontier Capital Management Co. LLC | 698,694 | $9.47M | 0.1% | +351.1% | 0.740% | |
| 10/25/2018 | Creative Planning | 120,900 | $1.64M | 0.0% | +17.5% | 0.128% | |
| 10/12/2018 | Dorsey Wright & Associates | 381,348 | $5.17M | 0.9% | -34.8% | 0.404% | |
| 10/12/2018 | Rathbone Brothers plc | 223,430 | $3.03M | 0.1% | -8.2% | 0.237% | |
| 8/15/2018 | California Public Employees Retirement System | 37,796 | $0.45M | 0.0% | N/A | 0.040% | |
| 8/15/2018 | Orbimed Advisors LLC | 666,593 | $7.91M | 0.1% | -23.1% | 0.708% | |
| 8/14/2018 | Vident Investment Advisory LLC | 205,701 | $2.44M | 0.1% | -11.1% | 0.219% | |
| 8/14/2018 | Raymond James & Associates | 15,596 | $0.19M | 0.0% | -38.0% | 0.017% | |
| 8/13/2018 | Tocqueville Asset Management L.P. | 26,175 | $0.31M | 0.0% | N/A | 0.028% | |
| 8/13/2018 | BB&T Securities LLC | 10,867 | $0.13M | 0.0% | N/A | 0.012% | |
| 8/10/2018 | FMR LLC | 3,424,373 | $40.65M | 0.0% | -10.5% | 3.627% | |
| 8/9/2018 | BlackRock Inc. | 763,292 | $9.06M | 0.0% | -5.4% | 0.811% | |
| 8/7/2018 | Trexquant Investment LP | 15,021 | $0.18M | 0.0% | N/A | 0.016% | |
| 8/7/2018 | Bellevue Group AG | 59,935 | $0.71M | 0.1% | N/A | 0.064% | |
| 8/3/2018 | Frontier Capital Management Co. LLC | 154,885 | $1.84M | 0.0% | N/A | 0.165% | |
| 8/2/2018 | Alps Advisors Inc. | 103,816 | $0.69M | 0.0% | -17.4% | 0.110% | |
| 7/31/2018 | Alps Advisors Inc. | 103,816 | $0.69M | 0.0% | -17.4% | 0.110% | |
| 7/30/2018 | Raymond James Financial Services Advisors Inc. | 31,951 | $0.38M | 0.0% | +70.0% | 0.034% | |
| 7/25/2018 | Alps Advisors Inc. | 103,816 | $0.69M | 0.0% | -17.4% | 0.110% | |
| 7/25/2018 | BNP Paribas Arbitrage SA | 10,302 | $0.12M | 0.0% | N/A | 0.011% | |
| 7/25/2018 | Trellus Management Company LLC | 16,464 | $0.20M | 0.3% | N/A | 0.017% | |
| 7/19/2018 | Fred Alger Management Inc. | 25,000 | $0.30M | 0.0% | N/A | 0.027% | |
| 7/17/2018 | Essex Investment Management Co. LLC | 168,187 | $2M | 0.2% | -55.0% | 0.179% | |
| 7/17/2018 | Baillie Gifford & Co. | 3,033,261 | $36.01M | 0.0% | +18.2% | 3.222% | |
