| 8/15/2025 | Adage Capital Partners GP L.L.C. | 140,000 | $1.01M | 0.0% | -69.9% | 2.291% | |
| 8/13/2025 | Sio Capital Management LLC | 335,937 | $2.42M | 0.9% | +85.9% | 5.498% | |
| 8/12/2025 | XTX Topco Ltd | 13,849 | $100K | 0.0% | N/A | 0.227% | |
| 8/8/2025 | Geode Capital Management LLC | 34,048 | $246K | 0.0% | +21.3% | 0.557% | |
| 7/31/2025 | AlphaQuest LLC | 5,943 | $43K | 0.0% | -62.3% | 0.097% | |
| 5/16/2025 | Woodline Partners LP | 315,383 | $2.60M | 0.0% | N/A | 5.158% | |
| 5/16/2025 | EcoR1 Capital LLC | 88,569 | $731K | 0.0% | -65.3% | 1.449% | |
| 5/16/2025 | Alyeska Investment Group L.P. | 412,000 | $3.40M | 0.0% | N/A | 6.739% | |
| 5/16/2025 | Adage Capital Partners GP L.L.C. | 465,000 | $3.84M | 0.0% | +43.1% | 7.605% | |
| 5/15/2025 | Trexquant Investment LP | 38,254 | $316K | 0.0% | -44.6% | 0.626% | |
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| 5/15/2025 | Heights Capital Management Inc. | 241,500 | $1.99M | 1.0% | N/A | 3.950% | |
| 5/14/2025 | AlphaQuest LLC | 15,760 | $130K | 0.0% | N/A | 0.258% | |
| 5/12/2025 | Vivo Capital LLC | 10,199 | $84K | 0.0% | -92.8% | 0.167% | |
| 5/6/2025 | Readystate Asset Management LP | 45,400 | $375K | 0.0% | N/A | 0.743% | |
| 4/23/2025 | Golden State Wealth Management LLC | 5,348 | $44K | 0.0% | +100.0% | 0.087% | |
| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 40,096 | $1.60M | 0.1% | -40.2% | 1.117% | |
| 2/14/2025 | Northern Trust Corp | 5,157 | $205K | 0.0% | N/A | 0.144% | |
| 2/14/2025 | Boothbay Fund Management LLC | 18,543 | $739K | 0.0% | N/A | 0.517% | |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 325,000 | $12.95M | 0.0% | +48.5% | 9.053% | |
| 2/14/2025 | Tower Research Capital LLC TRC | 652 | $26K | 0.0% | +2,073.3% | 0.018% | |
| 2/13/2025 | Renaissance Technologies LLC | 11,443 | $456K | 0.0% | -14.9% | 0.319% | |
| 2/13/2025 | Wells Fargo & Company MN | 21,800 | $869K | 0.0% | N/A | 0.607% | |
| 2/12/2025 | Trexquant Investment LP | 69,050 | $2.75M | 0.0% | N/A | 1.923% | |
| 2/12/2025 | Geode Capital Management LLC | 27,253 | $1.09M | 0.0% | +13.3% | 0.759% | |
| 2/10/2025 | Avantax Advisory Services Inc. | 30,570 | $1.22M | 0.0% | N/A | 0.852% | |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 14,286 | $569K | 0.0% | +19.2% | 0.398% | |
| 1/28/2025 | Golden State Wealth Management LLC | 2,674 | $107K | 0.0% | N/A | 0.074% | |
| 1/22/2025 | Drive Wealth Management LLC | 23,000 | $916K | 0.2% | N/A | 0.641% | |
| 1/21/2025 | AlphaMark Advisors LLC | 1,100 | $44K | 0.0% | +1,000.0% | 0.031% | |
| 11/15/2024 | Baker BROS. Advisors LP | 83,055 | $719K | 0.0% | -96.0% | 2.599% | |
| 11/14/2024 | Hhlr Advisors LTD. | 76,247 | $660K | 0.0% | -97.6% | 2.383% | |
| 11/12/2024 | Charles Schwab Investment Management Inc. | 11,980 | $104K | 0.0% | -61.8% | 0.374% | |
| 8/15/2024 | Armistice Capital LLC | 7,256,410 | $2.54M | 0.0% | +5.3% | 9.290% | |
| 8/9/2024 | Renaissance Technologies LLC | 768,839 | $269K | 0.0% | -4.9% | 0.984% | |
| 8/8/2024 | Versant Venture Management LLC | 1,457,937 | $510K | 0.7% | -37.2% | 1.867% | |
| 8/6/2024 | Acadian Asset Management LLC | 829,485 | $289K | 0.0% | +26.1% | 1.062% | |
| 5/29/2024 | Opaleye Management Inc. | 1,630,000 | $1.60M | 0.3% | +25.7% | 2.087% | |
| 5/10/2024 | Acadian Asset Management LLC | 657,995 | $644K | 0.0% | +17.6% | 0.870% | |
| 2/15/2024 | Opaleye Management Inc. | 1,297,000 | $861K | 0.2% | N/A | 1.731% | |
| 2/14/2024 | Hhlr Advisors LTD. | 1,906,191 | $1.27M | 0.0% | -17.5% | 2.544% | |
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| 2/14/2024 | Altitude Crest Partners Inc. | 2,844,681 | $1.89M | 1.3% | N/A | 3.796% | |
| 2/13/2024 | Armistice Capital LLC | 6,833,875 | $4.54M | 0.1% | N/A | 9.120% | |
| 1/1/2024 | Vanguard Group Inc. | 1,010,617 | $755K | 0.0% | +1.6% | 1.349% | |
| 11/14/2023 | Newtyn Management LLC | 920,000 | $687K | 0.2% | +2.2% | 1.228% | |
| 5/15/2023 | Logos Global Management LP | 1,000,000 | $874K | 0.1% | N/A | 2.329% | |
| 5/11/2023 | Acadian Asset Management LLC | 564,715 | $492K | 0.0% | +68.7% | 1.315% | |
| 2/15/2023 | Tang Capital Management LLC | 2,816,391 | $2.68M | 0.4% | +68.2% | 6.577% | |
| 2/10/2023 | New York Life Investment Management LLC | 263,832 | $251K | 0.0% | +12.7% | 0.616% | |
| 11/15/2022 | Tang Capital Management LLC | 1,674,166 | $1.84M | 0.2% | +8.2% | 3.910% | |
| 11/14/2022 | Point72 Asset Management L.P. | 917,036 | $1.01M | 0.0% | +14.6% | 2.142% | |
| 11/14/2022 | Ergoteles LLC | 52,889 | $58K | 0.0% | -49.0% | 0.124% | |
| 11/2/2022 | Rockefeller Capital Management L.P. | 77,499 | $85K | 0.0% | N/A | 0.181% | |
| 8/15/2022 | Pivotal bioVenture Partners Investment Advisor LLC | 743,215 | $899K | 0.5% | -15.2% | 1.736% | |
| 7/25/2022 | Silverarc Capital Management LLC | 58,392 | $71K | 0.0% | +447.8% | 0.137% | |
| 7/18/2022 | Brinker Capital Investments LLC | 44,649 | $54K | 0.0% | N/A | 0.105% | |
| 7/11/2022 | Wedmont Private Capital | 20,741 | $25K | 0.0% | N/A | 0.049% | |
| 5/6/2022 | IndexIQ Advisors LLC | 192,976 | $415K | 0.0% | N/A | 0.452% | |
| 4/19/2022 | Denali Advisors LLC | 16,000 | $34K | 0.0% | N/A | 0.037% | |
| 2/14/2022 | Virtus ETF Advisers LLC | 14,209 | $169K | 0.1% | +108.5% | 0.033% | |
| 2/14/2022 | Point72 Asset Management L.P. | 110,488 | $1.31M | 0.0% | +13.6% | 0.259% | |
| 2/11/2022 | Ensign Peak Advisors Inc | 7,320 | $87K | 0.0% | N/A | 0.017% | |
| 2/8/2022 | Bank of America Corp DE | 1,164,300 | $13.82M | 0.0% | +3,351.9% | 2.733% | |
| 2/8/2022 | ProShare Advisors LLC | 10,177 | $121K | 0.0% | N/A | 0.024% | |
| 2/8/2022 | Northern Trust Corp | 203,799 | $2.42M | 0.0% | +2.8% | 0.478% | |
| 11/17/2021 | Altium Capital Management LP | 33,492 | $519K | 0.1% | N/A | 0.079% | |
| 11/16/2021 | Janus Henderson Group PLC | 2,440,476 | $37.66M | 0.0% | +8.0% | 5.728% | |
| 11/16/2021 | Two Sigma Investments LP | 89,863 | $1.39M | 0.0% | N/A | 0.211% | |
| 11/16/2021 | Wellington Management Group LLP | 3,829,383 | $59.39M | 0.0% | -8.3% | 8.987% | |
| 11/15/2021 | Point72 Asset Management L.P. | 97,300 | $1.51M | 0.0% | N/A | 0.228% | |
| 11/15/2021 | California State Teachers Retirement System | 32,126 | $498K | 0.0% | +24.1% | 0.075% | |
| 11/15/2021 | Sphera Funds Management LTD. | 249,197 | $3.87M | 0.3% | N/A | 0.585% | |
| 11/12/2021 | Renaissance Technologies LLC | 53,200 | $825K | 0.0% | N/A | 0.125% | |
| 11/12/2021 | Jump Financial LLC | 16,100 | $250K | 0.0% | N/A | 0.038% | |
| 11/12/2021 | Macquarie Group Ltd. | 5,786 | $90K | 0.0% | N/A | 0.014% | |
| 11/12/2021 | The Manufacturers Life Insurance Company | 12,276 | $190K | 0.0% | +10.8% | 0.029% | |
| 11/12/2021 | Credit Suisse AG | 13,624 | $211K | 0.0% | N/A | 0.032% | |
| 11/12/2021 | Geode Capital Management LLC | 313,655 | $4.86M | 0.0% | +22.8% | 0.736% | |
| 11/10/2021 | Goldman Sachs Group Inc. | 23,737 | $368K | 0.0% | -37.5% | 0.056% | |
| 11/10/2021 | Citigroup Inc. | 3,122 | $48K | 0.0% | +49.7% | 0.007% | |
| 11/10/2021 | O Shaughnessy Asset Management LLC | 3,261 | $51K | 0.0% | N/A | 0.008% | |
| 11/9/2021 | BlackRock Inc. | 1,239,562 | $19.23M | 0.0% | +14.3% | 2.909% | |
| 11/8/2021 | Swiss National Bank | 56,200 | $872K | 0.0% | +67.3% | 0.132% | |
| 11/5/2021 | Advisor Group Holdings Inc. | 4,500 | $70K | 0.0% | N/A | 0.011% | |
| 11/4/2021 | Deutsche Bank AG | 83,752 | $1.30M | 0.0% | -13.2% | 0.197% | |
| 11/1/2021 | SG Americas Securities LLC | 8,383 | $130K | 0.0% | N/A | 0.020% | |
| 8/17/2021 | Logos Global Management LP | 212,785 | $4.34M | 0.4% | -55.3% | 0.499% | |
| 8/17/2021 | Metropolitan Life Insurance Co NY | 6,361 | $130K | 0.0% | N/A | 0.015% | |
| 8/17/2021 | MetLife Investment Management LLC | 8,308 | $169K | 0.0% | N/A | 0.019% | |
| 8/17/2021 | Price T Rowe Associates Inc. MD | 27,230 | $555K | 0.0% | N/A | 0.064% | |
| 8/17/2021 | Acuta Capital Partners LLC | 214,254 | $4.37M | 1.7% | N/A | 0.503% | |
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| 8/16/2021 | California State Teachers Retirement System | 25,890 | $528K | 0.0% | +61.3% | 0.061% | |
| 8/16/2021 | Charles Schwab Investment Management Inc. | 89,039 | $1.82M | 0.0% | +24.4% | 0.209% | |
| 8/16/2021 | State Street Corp | 298,587 | $6.09M | 0.0% | +73.5% | 0.701% | |
| 8/16/2021 | Nuveen Asset Management LLC | 64,216 | $1.31M | 0.0% | +163.8% | 0.151% | |
| 8/16/2021 | Goldman Sachs Group Inc. | 37,968 | $774K | 0.0% | -9.1% | 0.089% | |
| 8/13/2021 | HarbourVest Partners LLC | 18,783 | $383K | 0.0% | N/A | 0.049% | |
| 8/13/2021 | Northern Trust Corp | 178,014 | $3.63M | 0.0% | +56.6% | 0.467% | |
| 8/13/2021 | Geode Capital Management LLC | 255,348 | $5.21M | 0.0% | +42.9% | 0.669% | |
| 8/13/2021 | Vanguard Group Inc. | 983,296 | $20.05M | 0.0% | +59.9% | 2.577% | |
| 8/12/2021 | Versant Venture Management LLC | 2,320,381 | $47.30M | 15.7% | -29.5% | 6.082% | |
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