| 5/23/2025 | Siren L.L.C. | 690,170 | $2.34M | 0.1% | N/A | 1.153% | |
| 5/19/2025 | Jane Street Group LLC | 224,600 | $761K | 0.0% | +83.7% | 0.375% | |
| 5/16/2025 | Zimmer Partners LP | 754,970 | $2.56M | 0.0% | +0.7% | 1.261% | |
| 5/16/2025 | Exome Asset Management LLC | 114,145 | $387K | 0.3% | -55.5% | 0.191% | |
| 5/16/2025 | Goldman Sachs Group Inc. | 258,106 | $875K | 0.0% | +78.2% | 0.431% | |
| 5/15/2025 | Nantahala Capital Management LLC | 1,141,237 | $3.87M | 0.2% | -0.6% | 1.906% | |
| 5/15/2025 | Siren L.L.C. | 690,170 | $2.34M | 0.1% | N/A | 1.153% | |
| 5/15/2025 | OMERS ADMINISTRATION Corp | 56,500 | $192K | 0.0% | -10.0% | 0.094% | |
| 5/14/2025 | 22NW LP | 636,364 | $2.16M | 1.6% | N/A | 1.063% | |
| 5/14/2025 | CW Advisors LLC | 10,000 | $34K | 0.0% | N/A | 0.017% | |
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| 5/14/2025 | Wellington Management Group LLP | 188,485 | $639K | 0.0% | N/A | 0.315% | |
| 5/6/2025 | Y Intercept Hong Kong Ltd | 12,065 | $41K | 0.0% | N/A | 0.020% | |
| 4/30/2025 | Alps Advisors Inc. | 44,436 | $151K | 0.0% | -8.0% | 0.074% | |
| 2/27/2025 | Jefferies Financial Group Inc. | 22,000 | $91K | 0.0% | N/A | 0.037% | |
| 2/18/2025 | Alpine Global Management LLC | 13,471 | $56K | 0.0% | N/A | 0.023% | |
| 2/18/2025 | AWM Investment Company Inc. | 1,100,473 | $4.53M | 0.6% | N/A | 1.842% | |
| 2/18/2025 | Frazier Life Sciences Management L.P. | 1,176,735 | $4.85M | 0.2% | N/A | 1.970% | |
| 2/17/2025 | Woodline Partners LP | 1,671,822 | $6.89M | 0.0% | +98.3% | 2.798% | |
| 2/17/2025 | Zimmer Partners LP | 750,000 | $3.09M | 0.1% | -47.7% | 1.255% | |
| 2/17/2025 | Velan Capital Investment Management LP | 323,973 | $1.34M | 1.2% | N/A | 0.542% | |
| 2/17/2025 | Sphera Funds Management LTD. | 2,551,619 | $10.51M | 1.9% | +96.7% | 4.271% | |
| 2/17/2025 | Point72 Asia Singapore Pte. Ltd. | 18,379 | $76K | 0.0% | N/A | 0.031% | |
| 2/17/2025 | Point72 Asset Management L.P. | 1,095,000 | $4.51M | 0.0% | N/A | 1.833% | |
| 2/17/2025 | OMERS ADMINISTRATION Corp | 62,800 | $259K | 0.0% | N/A | 0.105% | |
| 2/17/2025 | Millennium Management LLC | 118,861 | $490K | 0.0% | N/A | 0.199% | |
| 2/17/2025 | Jefferies Financial Group Inc. | 22,000 | $91K | 0.0% | N/A | 0.037% | |
| 2/17/2025 | Ensign Peak Advisors Inc | 1,264,919 | $5.21M | 0.0% | +185.5% | 2.117% | |
| 2/17/2025 | Cubist Systematic Strategies LLC | 24,568 | $101K | 0.0% | N/A | 0.041% | |
| 2/17/2025 | Balyasny Asset Management L.P. | 32,623 | $134K | 0.0% | N/A | 0.055% | |
| 2/17/2025 | Bank of America Corp DE | 95,142 | $392K | 0.0% | +1,295.9% | 0.159% | |
| 2/17/2025 | Alyeska Investment Group L.P. | 933,475 | $3.85M | 0.0% | +86.7% | 1.563% | |
| 2/17/2025 | Allostery Investments LP | 100,000 | $412K | 0.4% | N/A | 0.167% | |
| 2/17/2025 | 683 Capital Management LLC | 154,960 | $638K | 0.0% | N/A | 0.259% | |
| 2/17/2025 | Acuta Capital Partners LLC | 235,750 | $971K | 1.0% | N/A | 0.395% | |
| 2/14/2025 | RA Capital Management L.P. | 3,566,338 | $14.69M | 0.2% | N/A | 5.970% | |
| 2/14/2025 | Jane Street Group LLC | 122,275 | $504K | 0.0% | N/A | 0.205% | |
| 2/14/2025 | Schonfeld Strategic Advisors LLC | 1,515,750 | $6.25M | 0.0% | +1.1% | 2.537% | |
| 2/14/2025 | Nantahala Capital Management LLC | 1,147,946 | $4.73M | 0.2% | +91.3% | 1.922% | |
| 2/14/2025 | First Light Asset Management LLC | 2,328,768 | $9.60M | 0.9% | N/A | 3.898% | |
| 2/14/2025 | Northern Trust Corp | 126,885 | $523K | 0.0% | +38.1% | 0.212% | |
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| 2/14/2025 | Boothbay Fund Management LLC | 341,923 | $1.41M | 0.0% | N/A | 0.572% | |
| 2/14/2025 | Blue Owl Capital Holdings LP | 1,959,912 | $8.08M | 1.9% | N/A | 3.281% | |
| 2/14/2025 | Diadema Partners LP | 75,794 | $312K | 0.1% | N/A | 0.127% | |
| 2/14/2025 | Alpine Global Management LLC | 13,471 | $56K | 0.0% | N/A | 0.023% | |
| 2/14/2025 | Tower Research Capital LLC TRC | 7,944 | $33K | 0.0% | +418.5% | 0.013% | |
| 2/14/2025 | Dimensional Fund Advisors LP | 23,033 | $95K | 0.0% | -32.7% | 0.039% | |
| 2/13/2025 | Marshall Wace LLP | 80,431 | $331K | 0.0% | N/A | 0.135% | |
| 2/13/2025 | EAM Investors LLC | 109,555 | $451K | 0.1% | N/A | 0.183% | |
| 2/13/2025 | Barclays PLC | 70,000 | $288K | 0.0% | N/A | 0.117% | |
| 2/13/2025 | Renaissance Technologies LLC | 147,173 | $606K | 0.0% | +8.3% | 0.246% | |
| 2/13/2025 | ADAR1 Capital Management LLC | 16,000 | $66K | 0.0% | N/A | 0.027% | |
| 2/12/2025 | Geode Capital Management LLC | 663,101 | $2.73M | 0.0% | +75.4% | 1.110% | |
| 2/11/2025 | Virtu Financial LLC | 20,016 | $82K | 0.0% | N/A | 0.034% | |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 29,987 | $124K | 0.0% | +100.1% | 0.050% | |
| 1/17/2025 | Inspire Investing LLC | 194,688 | $802K | 0.1% | N/A | 0.326% | |
| 1/15/2025 | Kera Capital Partners Inc. | 25,770 | $106K | 0.0% | N/A | 0.043% | |
| 11/16/2024 | Geode Capital Management LLC | 378,058 | $942K | 0.0% | +9.7% | 0.953% | |
| 11/15/2024 | Zimmer Partners LP | 1,434,727 | $3.57M | 0.1% | -32.0% | 3.618% | |
| 10/30/2024 | Clarity Capital Partners LLC | 11,500 | $29K | 0.0% | N/A | 0.029% | |
| 8/20/2024 | Nantahala Capital Management LLC | 600,000 | $1.58M | 0.1% | N/A | 2.418% | |
| 8/15/2024 | Armistice Capital LLC | 2,336,000 | $6.17M | 0.1% | +1.7% | 9.414% | |
| 8/9/2024 | Renaissance Technologies LLC | 136,773 | $361K | 0.0% | +57.1% | 0.551% | |
| 8/9/2024 | Dimensional Fund Advisors LP | 30,233 | $80K | 0.0% | N/A | 0.122% | |
| 8/8/2024 | Marco Investment Management LLC | 30,344 | $80K | 0.0% | +22.3% | 0.122% | |
| 5/14/2024 | CM Management LLC | 160,000 | $330K | 0.3% | +14.3% | 0.645% | |
| 5/10/2024 | Vanguard Group Inc. | 969,121 | $2.00M | 0.0% | +39.4% | 3.906% | |
| 2/13/2024 | Armistice Capital LLC | 2,189,000 | $3.94M | 0.1% | +20.0% | 9.045% | |
| 11/15/2023 | Armistice Capital LLC | 1,824,000 | $2.50M | 0.0% | -1.0% | 7.538% | |
| 10/19/2023 | Jmac Enterprises LLC | 58,041 | $80K | 0.0% | -27.5% | 0.246% | |
| 8/15/2023 | BVF Inc. IL | 4,326,710 | $5.93M | 0.2% | +86.0% | 18.372% | |
| 8/11/2023 | SVB Financial Group | 18,025 | $25K | 0.0% | -33.1% | 0.080% | |
| 7/20/2023 | Jmac Enterprises LLC | 80,041 | $110K | 0.0% | +46.8% | 0.356% | |
| 2/9/2023 | CM Management LLC | 234,800 | $535K | 0.6% | -4.2% | 1.706% | |
| 11/14/2022 | Cormorant Asset Management LP | 1,223,500 | $3.38M | 0.2% | -6.3% | 8.894% | |
| 11/14/2022 | Point72 Asset Management L.P. | 375,000 | $1.04M | 0.0% | -12.5% | 2.726% | |
| 11/14/2022 | Boothbay Fund Management LLC | 22,050 | $61K | 0.0% | -36.3% | 0.160% | |
| 11/4/2022 | CM Management LLC | 245,000 | $676K | 0.8% | +8.9% | 1.781% | |
| 8/16/2022 | Woodline Partners LP | 516,675 | $1.26M | 0.0% | -23.2% | 3.755% | |
| 5/9/2022 | CM Management LLC | 225,000 | $887K | 0.7% | +95.7% | 1.636% | |
| 4/25/2022 | Bailard Inc. | 27,600 | $109K | 0.0% | N/A | 0.193% | |
| 2/14/2022 | Point72 Asset Management L.P. | 431,435 | $1.90M | 0.0% | +105.9% | 3.016% | |
| 2/11/2022 | Ensign Peak Advisors Inc | 77,100 | $340K | 0.0% | +966.7% | 0.539% | |
| 2/7/2022 | Ameritas Advisory Services LLC | 24,219 | $107K | 0.0% | N/A | 0.169% | |
| 2/2/2022 | CM Management LLC | 115,000 | $507K | 0.4% | +53.3% | 0.804% | |
| 11/16/2021 | Two Sigma Advisers LP | 115,900 | $716K | 0.0% | +48.0% | 0.810% | |
| 11/16/2021 | Two Sigma Investments LP | 115,324 | $713K | 0.0% | +100.5% | 0.806% | |
| 11/16/2021 | BVF Inc. IL | 1,363,435 | $8.43M | 0.3% | +22.5% | 9.530% | |
| 11/15/2021 | Point72 Asset Management L.P. | 209,490 | $1.30M | 0.0% | +11.0% | 1.464% | |
| 11/15/2021 | Eversept Partners LP | 114,008 | $705K | 0.1% | N/A | 0.797% | |
| 11/15/2021 | Ensign Peak Advisors Inc | 7,228 | $45K | 0.0% | -80.0% | 0.051% | |
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| 11/10/2021 | Mercer Global Advisors Inc. ADV | 16,726 | $103K | 0.0% | N/A | 0.117% | |
| 8/18/2021 | Ikarian Capital LLC | 350,000 | $2.77M | 0.2% | +40.0% | 2.446% | |
| 8/17/2021 | Woodline Partners LP | 857,445 | $6.78M | 0.1% | -3.8% | 5.993% | |
| 8/17/2021 | Boothbay Fund Management LLC | 40,052 | $317K | 0.0% | +39.6% | 0.280% | |
| 8/16/2021 | Point72 Asset Management L.P. | 188,690 | $1.49M | 0.0% | +51.0% | 1.319% | |
| 8/16/2021 | Morgan Stanley | 851,004 | $6.73M | 0.0% | +7,235.6% | 5.948% | |
| 8/16/2021 | State Street Corp | 32,935 | $261K | 0.0% | N/A | 0.230% | |
| 8/13/2021 | Renaissance Technologies LLC | 21,107 | $167K | 0.0% | -22.0% | 0.148% | |
| 8/13/2021 | Northern Trust Corp | 32,116 | $254K | 0.0% | +106.8% | 0.224% | |
| 8/13/2021 | Geode Capital Management LLC | 124,614 | $985K | 0.0% | +25.7% | 0.871% | |
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