| 5/16/2025 | Cormorant Asset Management LP | 2,009,482 | $22.17M | 1.7% | +238.8% | 3.862% | |
| 5/16/2025 | BVF Inc. IL | 8,827,712 | $97.37M | 4.0% | -15.1% | 16.967% | |
| 5/16/2025 | Alyeska Investment Group L.P. | 454,975 | $5.02M | 0.0% | N/A | 0.874% | |
| 5/15/2025 | RA Capital Management L.P. | 6,944,648 | $76.60M | 1.3% | +3.9% | 13.348% | |
| 5/15/2025 | Troluce Capital Advisors LLC | 155,597 | $1.72M | 0.5% | N/A | 0.299% | |
| 5/14/2025 | Walleye Capital LLC | 52,940 | $584K | 0.0% | N/A | 0.102% | |
| 5/8/2025 | Jefferies Financial Group Inc. | 750,000 | $8.27M | 0.1% | N/A | 1.442% | |
| 5/8/2025 | XTX Topco Ltd | 15,354 | $169K | 0.0% | N/A | 0.030% | |
| 4/22/2025 | Palumbo Wealth Management LLC | 12,869 | $142K | 0.0% | N/A | 0.025% | |
| 2/17/2025 | Woodline Partners LP | 78,949 | $553K | 0.0% | +112.0% | 0.152% | |
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| 2/17/2025 | Two Sigma Investments LP | 16,761 | $117K | 0.0% | N/A | 0.032% | |
| 2/17/2025 | Millennium Management LLC | 20,761 | $145K | 0.0% | N/A | 0.040% | |
| 2/17/2025 | BNP Paribas Financial Markets | 6,310 | $44K | 0.0% | N/A | 0.012% | |
| 2/14/2025 | AdvisorShares Investments LLC | 36,011 | $252K | 0.0% | +15.4% | 0.069% | |
| 2/14/2025 | Northern Trust Corp | 40,834 | $286K | 0.0% | +26.8% | 0.078% | |
| 2/14/2025 | Lynx1 Capital Management LP | 4,858,994 | $34.01M | 12.8% | +15.8% | 9.339% | |
| 2/14/2025 | Diadema Partners LP | 101,502 | $711K | 0.3% | N/A | 0.195% | |
| 2/12/2025 | Geode Capital Management LLC | 72,513 | $508K | 0.0% | +4.5% | 0.139% | |
| 11/19/2024 | Barclays PLC | 5,984 | $40K | 0.0% | -69.9% | 0.012% | |
| 11/15/2024 | Barclays PLC | 5,984 | $40K | 0.0% | -69.9% | 0.012% | |
| 11/15/2024 | RA Capital Management L.P. | 6,686,689 | $44.73M | 0.5% | +1.3% | 12.852% | |
| 11/14/2024 | Verition Fund Management LLC | 1,057,782 | $7.08M | 0.0% | -7.3% | 2.033% | |
| 11/13/2024 | FMR LLC | 2,745,445 | $18.37M | 0.0% | -7.4% | 5.277% | |
| 8/15/2024 | Lynx1 Capital Management LP | 3,966,726 | $46.25M | 16.7% | +19.8% | 7.624% | |
| 8/8/2024 | AdvisorShares Investments LLC | 22,605 | $266K | 0.0% | -24.8% | 0.043% | |
| 5/30/2024 | Lynx1 Capital Management LP | 3,310,563 | $35.29M | 9.1% | +80.1% | 6.363% | |
| 5/17/2024 | RA Capital Management L.P. | 6,251,714 | $66.64M | 0.8% | +11.9% | 12.016% | |
| 2/15/2024 | BVF Inc. IL | 10,400,158 | $60.32M | 1.5% | +12.1% | 20.586% | |
| 2/14/2024 | Verition Fund Management LLC | 1,162,485 | $6.74M | 0.1% | -1.9% | 0.000% | |
| 2/14/2024 | AdvisorShares Investments LLC | 48,300 | $280K | 0.1% | +4.3% | 0.000% | |
| 1/24/2024 | Mirae Asset Global Investments Co. Ltd. | 106,363 | $617K | 0.0% | +14.6% | 0.000% | |
| 11/15/2023 | RTW Investments LP | 3,327,129 | $33.44M | 0.7% | +53.4% | 0.000% | |
| 11/14/2023 | Lynx1 Capital Management LP | 1,103,178 | $11.09M | 7.3% | +13.8% | 0.000% | |
| 11/14/2023 | PEAK6 Investments LLC | 40,308 | $405K | 0.0% | +72.9% | 0.000% | |
| 11/13/2023 | FMR LLC | 3,235,469 | $32.52M | 0.0% | -21.6% | 0.000% | |
| 11/7/2023 | Barclays PLC | 63,590 | $640K | 0.0% | +98.2% | 0.000% | |
| 10/26/2023 | Mirae Asset Global Investments Co. Ltd. | 92,784 | $932K | 0.0% | +16.2% | 0.184% | |
| 8/15/2023 | RA Capital Management L.P. | 5,587,333 | $66.29M | 1.3% | +0.1% | 11.060% | |
| 8/11/2023 | PEAK6 Investments LLC | 23,317 | $277K | 0.0% | +11.2% | 0.000% | |
| 8/10/2023 | Mirae Asset Global Investments Co. Ltd. | 79,873 | $948K | 0.0% | -18.4% | 0.158% | |
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| 8/9/2023 | AdvisorShares Investments LLC | 45,129 | $535K | 0.2% | -2.7% | 0.000% | |
| 8/2/2023 | Bank of Montreal Can | 10,641 | $133K | 0.0% | N/A | 0.000% | |
| 5/9/2023 | AdvisorShares Investments LLC | 46,360 | $370K | 0.1% | +58.5% | 0.092% | |
| 5/4/2023 | Mirae Asset Global Investments Co. Ltd. | 97,873 | $782K | 0.0% | -7.5% | 0.194% | |
| 2/14/2023 | VR Adviser LLC | 3,517,125 | $34.19M | 5.5% | +5.5% | 6.962% | |
| 2/14/2023 | Verition Fund Management LLC | 897,860 | $8.68M | 0.1% | +47.6% | 1.777% | |
| 2/9/2023 | Mirae Asset Global Investments Co. Ltd. | 105,758 | $1.03M | 0.0% | -16.0% | 0.209% | |
| 2/1/2023 | Cornerstone Investment Partners LLC | 14,800 | $144K | 0.0% | N/A | 0.029% | |
| 1/27/2023 | Exchange Traded Concepts LLC | 11,510 | $111K | 0.0% | +126.8% | 0.023% | |
| 1/18/2023 | Exchange Traded Concepts LLC | 11,510 | $111K | 0.0% | +126.8% | 0.023% | |
| 11/15/2022 | Pura Vida Investments LLC | 158,327 | $1.84M | 0.1% | -24.1% | 0.313% | |
| 11/15/2022 | Citadel Advisors LLC | 1,288,102 | $14.97M | 0.0% | -1.2% | 2.550% | |
| 11/14/2022 | Cormorant Asset Management LP | 593,043 | $6.89M | 0.5% | -2.5% | 1.174% | |
| 11/14/2022 | Point72 Asset Management L.P. | 202,600 | $2.35M | 0.0% | -12.4% | 0.401% | |
| 11/14/2022 | VR Adviser LLC | 3,333,154 | $38.73M | 5.7% | +4.6% | 6.598% | |
| 8/30/2022 | Verition Fund Management LLC | 608,124 | $6.07M | 0.1% | -41.7% | 1.204% | |
| 8/15/2022 | Acuta Capital Partners LLC | 243,250 | $2.43M | 1.4% | -42.0% | 0.481% | |
| 8/12/2022 | Virtus ETF Advisers LLC | 9,952 | $99K | 0.0% | +48.8% | 0.020% | |
| 8/12/2022 | FMR LLC | 4,937,196 | $49.27M | 0.0% | -5.1% | 9.773% | |
| 8/8/2022 | AdvisorShares Investments LLC | 24,835 | $248K | 0.1% | +28.2% | 0.049% | |
| 8/5/2022 | TimesSquare Capital Management LLC | 481,809 | $4.81M | 0.1% | -0.3% | 0.954% | |
| 8/3/2022 | Tortoise Investment Management LLC | 4,081 | $41K | 0.0% | N/A | 0.008% | |
| 7/26/2022 | Mirae Asset Global Investments Co. Ltd. | 159,001 | $1.59M | 0.0% | +16.4% | 0.315% | |
| 7/20/2022 | Exchange Traded Concepts LLC | 4,885 | $49K | 0.0% | +373.4% | 0.010% | |
| 7/13/2022 | Private Advisor Group LLC | 10,236 | $102K | 0.0% | N/A | 0.020% | |
| 5/17/2022 | RA Capital Management L.P. | 4,827,330 | $88.29M | 1.9% | +69.8% | 9.555% | |
| 5/9/2022 | AdvisorShares Investments LLC | 19,374 | $354K | 0.1% | +36.0% | 0.038% | |
| 5/6/2022 | TimesSquare Capital Management LLC | 483,409 | $8.84M | 0.1% | -3.0% | 0.957% | |
| 2/16/2022 | Ghost Tree Capital LLC | 100,000 | $2.33M | 0.8% | -75.0% | 0.198% | |
| 2/15/2022 | Laurion Capital Management LP | 334,592 | $7.81M | 0.1% | -3.0% | 0.662% | |
| 2/15/2022 | Adage Capital Partners GP L.L.C. | 150,000 | $3.50M | 0.0% | -62.5% | 0.297% | |
| 2/14/2022 | Citadel Advisors LLC | 1,275,732 | $29.76M | 0.0% | -2.8% | 2.525% | |
| 2/14/2022 | Virtus ETF Advisers LLC | 7,086 | $165K | 0.1% | N/A | 0.014% | |
| 2/14/2022 | Point72 Asset Management L.P. | 311,000 | $7.26M | 0.0% | N/A | 0.616% | |
| 2/14/2022 | Deep Track Capital LP | 499,400 | $11.65M | 0.8% | N/A | 0.988% | |
| 2/8/2022 | Mirae Asset Global Investments Co. Ltd. | 135,800 | $3.17M | 0.0% | N/A | 0.269% | |
| 2/4/2022 | TimesSquare Capital Management LLC | 498,299 | $11.63M | 0.1% | -0.5% | 0.986% | |
| 1/31/2022 | AdvisorShares Investments LLC | 14,242 | $332K | 0.0% | +278.0% | 0.028% | |
| 11/16/2021 | Schonfeld Strategic Advisors LLC | 17,223 | $380K | 0.0% | N/A | 0.034% | |
| 11/16/2021 | VR Adviser LLC | 1,642,296 | $36.23M | 4.7% | +28.7% | 3.251% | |
| 11/16/2021 | Verition Fund Management LLC | 1,263,124 | $27.87M | 0.2% | -5.6% | 2.500% | |
| 11/16/2021 | Laurion Capital Management LP | 345,000 | $7.61M | 0.0% | -4.2% | 0.683% | |
| 11/16/2021 | Citadel Advisors LLC | 1,312,646 | $28.30M | 0.0% | +2.2% | 2.598% | |
| 11/15/2021 | Deerfield Management Company L.P. Series C | 405,416 | $8.94M | 0.2% | -27.0% | 0.802% | |
| 11/15/2021 | Pura Vida Investments LLC | 380,045 | $8.38M | 0.3% | -5.0% | 0.752% | |
| 11/15/2021 | RA Capital Management L.P. | 3,013,957 | $66.49M | 0.9% | +1.2% | 5.966% | |
| 11/15/2021 | Penserra Capital Management LLC | 25,366 | $559K | 0.0% | N/A | 0.050% | |
| 11/8/2021 | TimesSquare Capital Management LLC | 500,599 | $11.04M | 0.1% | +18.5% | 0.991% | |
| 11/4/2021 | AdvisorShares Investments LLC | 3,768 | $83K | 0.0% | N/A | 0.007% | |
| 8/17/2021 | Walleye Capital LLC | 85,100 | $1.85M | 0.1% | N/A | 0.168% | |
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| 8/17/2021 | Woodline Partners LP | 138,897 | $3.02M | 0.1% | N/A | 0.275% | |
| 8/17/2021 | Logos Global Management LP | 724,333 | $15.74M | 1.3% | N/A | 1.434% | |
| 8/17/2021 | Millennium Management LLC | 45,866 | $997K | 0.0% | N/A | 0.091% | |
| 8/17/2021 | Acuta Capital Partners LLC | 150,000 | $3.26M | 1.3% | N/A | 0.297% | |
| 8/17/2021 | BVF Inc. IL | 9,275,156 | $201.55M | 7.6% | N/A | 18.359% | |
| 8/17/2021 | Boxer Capital LLC | 1,013,399 | $22.02M | 0.8% | N/A | 2.006% | |
| 8/17/2021 | Citadel Advisors LLC | 1,283,790 | $27.14M | 0.0% | N/A | 2.541% | |
| 8/16/2021 | Squarepoint Ops LLC | 18,000 | $391K | 0.0% | N/A | 0.036% | |
| 8/16/2021 | RA Capital Management L.P. | 2,978,955 | $64.73M | 1.0% | N/A | 5.896% | |
| 8/16/2021 | Alyeska Investment Group L.P. | 100,000 | $2.17M | 0.0% | N/A | 0.198% | |
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