| 5/14/2019 | Elo Mutual Pension Insurance Co | 121,964 | $3.09M | 0.1% | N/A | 0.434% |  |
| 5/13/2019 | Citigroup Inc. | 165,900 | $4.21M | 0.0% | N/A | 0.590% | |
| 5/10/2019 | GAM Holding AG | 27,589 | $0.70M | 0.0% | N/A | 0.098% | |
| 5/9/2019 | Alpine Associates Management Inc. | 615,680 | $15.62M | 0.5% | N/A | 2.191% | |
| 5/9/2019 | S. Muoio & CO. LLC | 10,000 | $0.25M | 0.2% | N/A | 0.036% | |
| 5/8/2019 | NEA Management Company LLC | 1,214,285 | $30.81M | 1.6% | +70.0% | 4.321% | |
| 5/7/2019 | Water Island Capital LLC | 490,993 | $12.46M | 0.6% | N/A | 1.747% | |
| 5/3/2019 | Water Island Capital LLC | 490,993 | $12.46M | 0.7% | N/A | 1.747% | |
| 5/2/2019 | Gamco Investors INC. ET AL | 47,403 | $1.20M | 0.0% | N/A | 0.169% | |
| 5/2/2019 | GABELLI & Co INVESTMENT ADVISERS INC. | 292,353 | $7.42M | 1.0% | N/A | 1.040% | |
| 5/2/2019 | Gabelli Funds LLC | 711,203 | $18.04M | 0.1% | N/A | 2.531% | |
| 5/2/2019 | Candriam Luxembourg S.C.A. | 97,043 | $2.46M | 0.0% | N/A | 0.345% | |
| 4/29/2019 | SG Americas Securities LLC | 148,559 | $3.77M | 0.0% | N/A | 0.529% | |
| 4/26/2019 | Mitsubishi UFJ Kokusai Asset Management Co. Ltd. | 11,629 | $0.30M | 0.0% | +11.6% | 0.041% | |
| 4/24/2019 | Harvest Management LLC | 27,000 | $0.69M | 1.0% | N/A | 0.096% | |
| 4/15/2019 | Havens Advisors LLC | 57,000 | $1.45M | 1.4% | N/A | 0.203% | |
| 2/15/2019 | Millennium Management LLC | 36,000 | $0.42M | 0.0% | -67.0% | 0.128% | |
| 2/14/2019 | Squarepoint Ops LLC | 43,886 | $0.51M | 0.0% | +106.7% | 0.156% | |
| 2/13/2019 | Tekla Capital Management LLC | 98,929 | $1.14M | 0.0% | -34.0% | 0.352% | |
| 2/13/2019 | United Services Automobile Association | 62,758 | $0.72M | 0.0% | -7.0% | 0.223% | |
| 2/12/2019 | Sectoral Asset Management Inc | 233,711 | $2.69M | 0.4% | -1.9% | 0.832% | |
| 2/8/2019 | Mitsubishi UFJ Kokusai Asset Management Co. Ltd. | 10,417 | $0.13M | 0.0% | N/A | 0.037% | |
| 2/5/2019 | Virtus ETF Advisers LLC | 27,277 | $0.31M | 0.1% | N/A | 0.097% | |
| 12/6/2018 | Marshall Wace LLP | 58,996 | $1.21M | 0.0% | N/A | 0.210% | |
| 11/15/2018 | Point72 Asset Management L.P. | 1,527,229 | $31.20M | 0.1% | N/A | 5.435% | |
| 11/15/2018 | Redmile Group LLC | 2,080,846 | $42.51M | 1.3% | +16.5% | 7.405% | |
| 11/13/2018 | Renaissance Technologies LLC | 81,700 | $1.67M | 0.0% | N/A | 0.291% | |
| 11/13/2018 | Citadel Advisors LLC | 66,965 | $1.37M | 0.0% | N/A | 0.238% | |
| 11/13/2018 | Tekla Capital Management LLC | 150,000 | $3.07M | 0.1% | N/A | 0.534% | |
| 11/13/2018 | Monashee Investment Management LLC | 70,000 | $1.43M | 0.3% | N/A | 0.249% | |
| 11/7/2018 | JPMorgan Chase & Co. | 10,463 | $0.21M | 0.0% | N/A | 0.037% | |
| 11/5/2018 | Janney Montgomery Scott LLC | 10,000 | $0.20M | 0.0% | N/A | 0.036% | |
| 10/29/2018 | Harel Insurance Investments & Financial Services Ltd. | 8,261 | $0.17M | 0.0% | N/A | 0.029% | |
| 10/16/2018 | Essex Investment Management Co. LLC | 62,860 | $1.28M | 0.2% | -48.5% | 0.224% | |
| 8/15/2018 | Partner Fund Management L.P. | 1,016,980 | $16.27M | 0.3% | +0.7% | 3.619% | |
| 8/14/2018 | Redmile Group LLC | 1,785,446 | $28.57M | 1.0% | +0.9% | 6.354% | |
| 8/14/2018 | Bank of America Corp DE | 8,235 | $0.13M | 0.0% | N/A | 0.029% | |
| 8/9/2018 | Woodford Investment Management Ltd | 314,000 | $5.02M | 0.6% | N/A | 1.117% | |
| 8/9/2018 | Chartwell Investment Partners LLC | 45,544 | $0.73M | 0.0% | -8.3% | 0.162% | |
| 8/9/2018 | Stanley Laman Group Ltd. | 12,181 | $0.20M | 0.0% | N/A | 0.043% | |
| 5/16/2018 | Millennium Management LLC | 35,308 | $0.51M | 0.0% | N/A | 0.126% | |
| 5/15/2018 | Redmile Group LLC | 1,768,946 | $25.42M | 1.0% | -0.2% | 6.295% | |
| 5/10/2018 | Franklin Resources Inc. | 136,387 | $1.96M | 0.0% | -58.0% | 0.485% | |
| 2/8/2018 | Chartwell Investment Partners LLC | 111,571 | $1.46M | 0.0% | -46.4% | 0.397% | |
| 2/5/2018 | Essex Investment Management Co. LLC | 134,965 | $1.77M | 0.2% | N/A | 0.480% | |
| 11/14/2017 | Alyeska Investment Group L.P. | 100,000 | $1.92M | 0.0% | N/A | 0.356% | |
| 11/9/2017 | Citadel Advisors LLC | 12,500 | $0.24M | 0.0% | N/A | 0.044% | |
| 11/9/2017 | Sphera Funds Management LTD. | 90,000 | $1.73M | 0.2% | N/A | 0.320% | |
| 11/8/2017 | Chartwell Investment Partners LLC | 208,089 | $4M | 0.1% | N/A | 0.741% | |
| 11/7/2017 | Ameriprise Financial Inc. | 300,000 | $5.76M | 0.0% | N/A | 1.068% | |
| 10/23/2017 | Nationwide Fund Advisors | 62,300 | $1.20M | 0.0% | N/A | 0.222% | |
