| 2/25/2021 | Dimensional Fund Advisors LP | 1,174,026 | $7.60M | 0.0% | +0.5% | 2.430% | |
| 2/18/2021 | Ghost Tree Capital LLC | 200,000 | $1.29M | 0.3% | N/A | 0.414% | |
| 2/16/2021 | One68 Global Capital LLC | 21,599 | $0.14M | 0.3% | N/A | 0.045% | |
| 2/16/2021 | Silverarc Capital Management LLC | 263,951 | $1.71M | 1.0% | N/A | 0.547% | |
| 2/16/2021 | Captrust Financial Advisors | 10,000 | $65K | 0.0% | N/A | 0.021% | |
| 2/16/2021 | Price T Rowe Associates Inc. MD | 21,700 | $0.14M | 0.0% | N/A | 0.045% | |
| 2/16/2021 | Engineers Gate Manager LP | 60,478 | $0.39M | 0.0% | N/A | 0.125% | |
| 2/16/2021 | Gyon Technologies Capital Management LP | 46,657 | $0.30M | 0.1% | +54.3% | 0.097% | |
| 2/16/2021 | ExodusPoint Capital Management LP | 345,402 | $2.24M | 0.0% | N/A | 0.716% | |
| 2/16/2021 | Charles Schwab Investment Management Inc. | 16,843 | $0.11M | 0.0% | -47.1% | 0.035% | |
|
| 2/12/2021 | Ikarian Capital LLC | 259,337 | $1.68M | 0.1% | -40.4% | 0.538% | |
| 2/12/2021 | Mercer Global Advisors Inc. ADV | 176,447 | $1.14M | 0.0% | +2.9% | 0.366% | |
| 2/11/2021 | Northern Trust Corp | 124,577 | $0.81M | 0.0% | -5.7% | 0.258% | |
| 2/11/2021 | Citigroup Inc. | 61,584 | $0.40M | 0.0% | N/A | 0.128% | |
| 2/10/2021 | Renaissance Technologies LLC | 1,402,565 | $9.08M | 0.0% | -15.3% | 2.908% | |
| 2/9/2021 | Wells Fargo & Company MN | 49,856 | $0.32M | 0.0% | +45.2% | 0.103% | |
| 2/9/2021 | Bank of New York Mellon Corp | 85,306 | $0.55M | 0.0% | +101.2% | 0.177% | |
| 2/5/2021 | BlackRock Inc. | 876,567 | $5.67M | 0.0% | +0.8% | 1.818% | |
| 2/4/2021 | Cambridge Investment Research Advisors Inc. | 82,720 | $0.54M | 0.0% | +103.5% | 0.172% | |
| 2/4/2021 | GSA Capital Partners LLP | 24,911 | $0.16M | 0.0% | -68.2% | 0.052% | |
| 12/10/2020 | Mercer Global Advisors Inc. ADV | 171,447 | $0.69M | 0.0% | +3.0% | 0.355% | |
| 11/17/2020 | Jane Street Group LLC | 34,956 | $0.14M | 0.0% | N/A | 0.072% | |
| 11/17/2020 | Schonfeld Strategic Advisors LLC | 399,087 | $1.62M | 0.0% | +134.8% | 0.828% | |
| 11/16/2020 | Point72 Asset Management L.P. | 3,184,497 | $12.90M | 0.1% | +226.9% | 6.603% | |
| 11/16/2020 | Squarepoint Ops LLC | 33,642 | $0.14M | 0.0% | N/A | 0.070% | |
| 11/16/2020 | J. Goldman & Co LP | 924,645 | $3.75M | 0.3% | +81.6% | 1.917% | |
| 11/16/2020 | Boothbay Fund Management LLC | 71,485 | $0.29M | 0.0% | -58.9% | 0.148% | |
| 11/16/2020 | Gyon Technologies Capital Management LP | 30,232 | $0.12M | 0.1% | +80.9% | 0.063% | |
| 11/13/2020 | Morgan Stanley | 59,852 | $0.24M | 0.0% | +66.0% | 0.124% | |
| 11/13/2020 | Sofinnova Investments Inc. | 2,111,596 | $8.55M | 0.6% | +27.9% | 4.378% | |
| 11/12/2020 | Connor Clark & Lunn Investment Management Ltd. | 13,625 | $55K | 0.0% | -38.9% | 0.028% | |
| 11/12/2020 | Federated Hermes Inc. | 3,930,769 | $15.92M | 0.0% | N/A | 8.150% | |
| 11/9/2020 | Acadian Asset Management LLC | 90,617 | $0.37M | 0.0% | -46.2% | 0.188% | |
| 11/9/2020 | LPL Financial LLC | 10,870 | $44K | 0.0% | N/A | 0.023% | |
| 11/6/2020 | BlackRock Inc. | 869,406 | $3.52M | 0.0% | +8.2% | 1.803% | |
| 11/6/2020 | GSA Capital Partners LLP | 78,237 | $0.32M | 0.1% | N/A | 0.162% | |
| 10/29/2020 | Cambridge Investment Research Advisors Inc. | 40,640 | $0.17M | 0.0% | +168.4% | 0.084% | |
| 9/15/2020 | Schonfeld Strategic Advisors LLC | 169,971 | $0.62M | 0.0% | +503.4% | 0.352% | |
| 8/17/2020 | Jacobs Levy Equity Management Inc. | 57,825 | $0.21M | 0.0% | +91.1% | 0.120% | |
| 8/14/2020 | Man Group plc | 69,069 | $0.25M | 0.0% | -6.2% | 0.224% | |
| 8/14/2020 | Point72 Asset Management L.P. | 974,259 | $3.53M | 0.0% | +387.1% | 3.156% | |
| 8/14/2020 | Gyon Technologies Capital Management LP | 16,710 | $60K | 0.1% | N/A | 0.054% | |
| 8/13/2020 | Sofinnova Investments Inc. | 1,651,411 | $5.98M | 0.4% | +9.0% | 5.350% | |
| 7/27/2020 | Cambridge Investment Research Advisors Inc. | 15,140 | $55K | 0.0% | +30.1% | 0.049% | |
| 5/18/2020 | Mercer Global Advisors Inc. ADV | 90,485 | $0.18M | 0.0% | -34.3% | 0.293% | |
| 5/15/2020 | Orbimed Advisors LLC | 71,994 | $0.14M | 0.0% | -79.5% | 0.233% | |
| 5/13/2020 | Connor Clark & Lunn Investment Management Ltd. | 30,776 | $61K | 0.0% | N/A | 0.100% | |
| 5/12/2020 | Granahan Investment Management Inc. MA | 165,482 | $0.33M | 0.0% | N/A | 0.536% | |
| 5/12/2020 | JPMorgan Chase & Co. | 31,106 | $61K | 0.0% | +156.8% | 0.101% | |
| 5/11/2020 | Ensign Peak Advisors Inc | 22,427 | $44K | 0.0% | N/A | 0.073% | |
| 5/11/2020 | Acadian Asset Management LLC | 160,691 | $0.32M | 0.0% | +28.5% | 0.521% | |
| 5/6/2020 | First Manhattan Co. | 1,003,933 | $1.98M | 0.0% | -36.2% | 3.258% | |
| 5/1/2020 | BlackRock Inc. | 793,856 | $1.56M | 0.0% | -3.7% | 2.576% | |
| 2/14/2020 | Bank of America Corp DE | 134,649 | $0.52M | 0.0% | -6.9% | 0.438% | |
| 2/14/2020 | Jacobs Levy Equity Management Inc. | 68,641 | $0.26M | 0.0% | -16.8% | 0.223% | |
| 2/14/2020 | Sofinnova Investments Inc. | 1,515,629 | $5.80M | 0.4% | +5.4% | 4.929% | |
| 2/13/2020 | Mercer Global Advisors Inc. ADV | 137,746 | $0.53M | 0.0% | +222.2% | 0.448% | |
| 2/13/2020 | Renaissance Technologies LLC | 1,939,965 | $7.43M | 0.0% | +12.7% | 6.309% | |
| 1/31/2020 | Ikarian Capital LLC | 1,067,271 | $4.09M | 0.7% | N/A | 3.471% | |
| 11/27/2019 | Man Group plc | 111,140 | $0.27M | 0.0% | -26.2% | 0.361% | |
| 8/16/2019 | First Manhattan Co. | 2,938,633 | $8.08M | 0.0% | -1.4% | 9.557% | |
| 8/14/2019 | D. E. Shaw & Co. Inc. | 830,754 | $2.29M | 0.0% | -1.2% | 2.702% | |
| 8/14/2019 | Morgan Stanley | 21,355 | $58K | 0.0% | -17.7% | 0.069% | |
| 8/14/2019 | Man Group plc | 150,640 | $0.41M | 0.0% | +4.5% | 0.490% | |
| 8/14/2019 | Vanguard Group Inc. | 1,176,798 | $3.24M | 0.0% | +0.5% | 3.827% | |
| 8/13/2019 | Jacobs Levy Equity Management Inc. | 90,798 | $0.25M | 0.0% | -14.6% | 0.295% | |
| 8/13/2019 | Eversept Partners LP | 194,429 | $0.54M | 0.2% | +8.0% | 0.632% | |
| 8/13/2019 | BlackRock Inc. | 844,466 | $2.32M | 0.0% | +1.0% | 2.746% | |
| 8/13/2019 | Parametric Portfolio Associates LLC | 12,627 | $35K | 0.0% | -48.2% | 0.041% | |
| 8/13/2019 | Sofinnova Investments Inc. | 1,337,568 | $3.68M | 0.3% | +30.6% | 4.350% | |
| 8/12/2019 | Renaissance Technologies LLC | 1,722,917 | $4.74M | 0.0% | +5.2% | 5.603% | |
| 8/8/2019 | Acadian Asset Management LLC | 125,088 | $0.35M | 0.0% | +5.1% | 0.407% | |
| 8/7/2019 | Connor Clark & Lunn Investment Management Ltd. | 14,400 | $40K | 0.0% | -43.3% | 0.047% | |
| 8/7/2019 | JPMorgan Chase & Co. | 111,097 | $0.28M | 0.0% | -42.1% | 0.361% | |
| 5/9/2019 | Acadian Asset Management LLC | 119,044 | $0.31M | 0.0% | +31.6% | 0.388% | |
| 5/8/2019 | Connor Clark & Lunn Investment Management Ltd. | 25,400 | $67K | 0.0% | -26.6% | 0.083% | |
| 5/7/2019 | Spark Investment Management LLC | 46,207 | $0.12M | 0.0% | +59.5% | 0.151% | |
| 4/23/2019 | Mercer Global Advisors Inc. ADV | 85,701 | $0.23M | 0.0% | N/A | 0.279% | |
| 4/12/2019 | First Manhattan Co. | 2,981,633 | $7.84M | 0.0% | -2.0% | 9.717% | |
| 4/1/2019 | Deutsche Bank AG | 31,050 | $57K | 0.0% | -66.5% | 0.101% | |
| 2/22/2019 | Sofinnova Investments Inc. | 1,023,865 | $1.89M | 0.2% | +3.7% | 3.343% | |
| 2/15/2019 | 683 Capital Management LLC | 1,100,000 | $2.04M | 0.1% | +37.5% | 3.591% | |
| 2/15/2019 | Millennium Management LLC | 90,794 | $0.17M | 0.0% | -78.1% | 0.296% | |
| 2/14/2019 | D. E. Shaw & Co. Inc. | 859,838 | $1.59M | 0.0% | -4.3% | 2.807% | |
| 2/14/2019 | Bank of America Corp DE | 87,702 | $0.16M | 0.0% | -8.1% | 0.286% | |
| 2/14/2019 | Barclays PLC | 22,317 | $41K | 0.0% | -78.5% | 0.073% | |
| 2/14/2019 | Pura Vida Investments LLC | 896,387 | $1.66M | 1.0% | +211.6% | 2.927% | |
| 2/12/2019 | Connor Clark & Lunn Investment Management Ltd. | 34,600 | $64K | 0.0% | -27.0% | 0.113% | |
| 2/11/2019 | Bank of New York Mellon Corp | 44,164 | $82K | 0.0% | -91.1% | 0.144% | |
| 2/8/2019 | BlackRock Inc. | 841,216 | $1.56M | 0.0% | +4.4% | 2.746% | |
| 2/7/2019 | Acadian Asset Management LLC | 90,493 | $0.17M | 0.0% | +14.9% | 0.295% | |
| 1/30/2019 | First Manhattan Co. | 3,041,794 | $5.63M | 0.0% | +71.7% | 9.931% | |
| 12/13/2018 | Vanguard Group Inc | 1,127,033 | $3.10M | 0.0% | +11.2% | 3.680% | |
| 11/23/2018 | Vanguard Group Inc. | 1,127,033 | $3.10M | 0.0% | +11.2% | 3.680% | |
| 11/15/2018 | Man Group plc | 346,763 | $0.95M | 0.0% | -17.7% | 1.132% | |
| 11/13/2018 | Renaissance Technologies LLC | 1,439,700 | $3.96M | 0.0% | +6.3% | 4.700% | |
| 11/13/2018 | Dimensional Fund Advisors LP | 1,486,012 | $4.09M | 0.0% | +5.7% | 4.851% | |
| 11/7/2018 | JPMorgan Chase & Co. | 189,033 | $0.52M | 0.0% | -23.9% | 0.617% | |
| 10/15/2018 | First Manhattan Co. | 1,771,873 | $4.87M | 0.0% | -6.8% | 5.785% | |
| 9/18/2018 | Northern Trust Corp | 92,419 | $0.36M | 0.0% | -71.0% | 0.302% | |
