| 5/21/2025 | Acadian Asset Management LLC | 2,088,046 | $650K | 0.0% | +12.8% | 2.936% | |
| 5/16/2025 | Goldman Sachs Group Inc. | 104,435 | $33K | 0.0% | -47.3% | 0.147% | |
| 5/16/2025 | Jacobs Levy Equity Management Inc. | 200,593 | $63K | 0.0% | -31.2% | 0.282% | |
| 5/16/2025 | Adage Capital Partners GP L.L.C. | 1,150,000 | $359K | 0.0% | +15.0% | 1.617% | |
| 5/14/2025 | Affinity Asset Advisors LLC | 667,516 | $208K | 0.0% | N/A | 0.939% | |
| 5/12/2025 | Nuveen LLC | 119,113 | $37K | 0.0% | N/A | 0.168% | |
| 5/8/2025 | XTX Topco Ltd | 93,154 | $29K | 0.0% | N/A | 0.131% | |
| 4/15/2025 | Assenagon Asset Management S.A. | 560,830 | $175K | 0.0% | +699.9% | 0.789% | |
| 2/17/2025 | Velan Capital Investment Management LP | 70,000 | $65K | 0.1% | N/A | 0.099% | |
| 2/17/2025 | Madison Avenue Partners LP | 3,722,627 | $3.48M | 0.4% | -9.6% | 5.242% | |
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| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 943,416 | $881K | 0.1% | +50.2% | 1.329% | |
| 2/17/2025 | Jacobs Levy Equity Management Inc. | 291,701 | $272K | 0.0% | N/A | 0.411% | |
| 2/17/2025 | Bridgeway Capital Management LLC | 229,115 | $214K | 0.0% | -26.0% | 0.323% | |
| 2/17/2025 | Bank of America Corp DE | 56,733 | $53K | 0.0% | +49.7% | 0.080% | |
| 2/17/2025 | BNP Paribas Financial Markets | 104,712 | $98K | 0.0% | -52.5% | 0.147% | |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 1,000,000 | $934K | 0.0% | N/A | 1.408% | |
| 2/13/2025 | Kennedy Capital Management LLC | 1,545,387 | $1.44M | 0.0% | +1.1% | 2.176% | |
| 2/13/2025 | Renaissance Technologies LLC | 107,700 | $101K | 0.0% | +142.0% | 0.152% | |
| 2/13/2025 | ADAR1 Capital Management LLC | 130,532 | $122K | 0.0% | +245.8% | 0.184% | |
| 2/12/2025 | TLS Advisors LLC | 680,967 | $636K | 1.5% | -11.7% | 0.959% | |
| 2/12/2025 | Takeda Pharmaceutical Co. Ltd. | 7,531,996 | $7.01M | 26.4% | N/A | 10.607% | |
| 2/12/2025 | JPMorgan Chase & Co. | 1,418,306 | $1.32M | 0.0% | -3.1% | 1.997% | |
| 2/10/2025 | Monimus Capital Management LP | 138,266 | $129K | 0.1% | N/A | 0.195% | |
| 1/30/2025 | Rhumbline Advisers | 84,078 | $79K | 0.0% | +22.3% | 0.118% | |
| 1/17/2025 | SG Americas Securities LLC | 37,636 | $35K | 0.0% | +83.9% | 0.053% | |
| 1/14/2025 | Assenagon Asset Management S.A. | 70,114 | $65K | 0.0% | -18.7% | 0.099% | |
| 11/19/2024 | Barclays PLC | 84,175 | $98K | 0.0% | +311.2% | 0.119% | |
| 11/16/2024 | Geode Capital Management LLC | 1,317,330 | $1.56M | 0.0% | +1.1% | 1.855% | |
| 11/15/2024 | Barclays PLC | 84,175 | $98K | 0.0% | +311.2% | 0.119% | |
| 11/15/2024 | XTX Topco Ltd | 38,230 | $45K | 0.0% | +46.2% | 0.054% | |
| 11/15/2024 | Jane Street Group LLC | 38,399 | $45K | 0.0% | -61.1% | 0.054% | |
| 11/14/2024 | Verition Fund Management LLC | 74,875 | $88K | 0.0% | N/A | 0.105% | |
| 11/13/2024 | BNP Paribas Financial Markets | 220,401 | $260K | 0.0% | +4,128.7% | 0.311% | |
| 11/13/2024 | FMR LLC | 50,225 | $59K | 0.0% | +1,907.4% | 0.071% | |
| 11/5/2024 | GSA Capital Partners LLP | 260,509 | $307K | 0.0% | +118.0% | 0.367% | |
| 10/23/2024 | Assenagon Asset Management S.A. | 86,289 | $102K | 0.0% | N/A | 0.122% | |
| 8/16/2024 | Driehaus Capital Management LLC | 1,400,191 | $1.08M | 0.0% | N/A | 1.974% | |
| 8/13/2024 | DCF Advisers LLC | 41,750 | $32K | 0.0% | +111.6% | 0.059% | |
| 8/9/2024 | Renaissance Technologies LLC | 141,200 | $109K | 0.0% | -9.9% | 0.199% | |
| 8/9/2024 | Dimensional Fund Advisors LP | 274,982 | $211K | 0.0% | -19.6% | 0.388% | |
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| 8/1/2024 | Rhumbline Advisers | 69,733 | $54K | 0.0% | -15.6% | 0.098% | |
| 8/1/2024 | FFT Wealth Management LLC | 489,552 | $377K | 0.0% | +18.2% | 0.690% | |
| 7/26/2024 | Bank of New York Mellon Corp | 218,163 | $168K | 0.0% | -5.0% | 0.308% | |
| 5/16/2024 | BVF Inc. IL | 3,853,818 | $11.75M | 0.3% | -43.7% | 5.442% | |
| 5/15/2024 | Price T Rowe Associates Inc. MD | 17,396 | $54K | 0.0% | +22.1% | 0.025% | |
| 5/10/2024 | Vanguard Group Inc. | 2,976,308 | $9.08M | 0.0% | -0.5% | 4.203% | |
| 5/7/2024 | SG Americas Securities LLC | 35,938 | $110K | 0.0% | -9.7% | 0.051% | |
| 5/7/2024 | Empowered Funds LLC | 128,070 | $391K | 0.0% | +8.1% | 0.181% | |
| 5/1/2024 | BNP Paribas Financial Markets | 32,162 | $98K | 0.0% | +74.7% | 0.045% | |
| 4/29/2024 | China Universal Asset Management Co. Ltd. | 13,579 | $41K | 0.0% | +66.0% | 0.019% | |
| 4/24/2024 | Assenagon Asset Management S.A. | 114,265 | $349K | 0.0% | +45.6% | 0.162% | |
| 2/14/2024 | Rubric Capital Management LP | 5,315,969 | $17.12M | 0.4% | -2.4% | 7.521% | |
| 2/14/2024 | Vestal Point Capital LP | 85,429 | $275K | 0.0% | N/A | 0.121% | |
| 2/13/2024 | DCF Advisers LLC | 18,730 | $60K | 0.0% | -38.4% | 0.026% | |
| 2/6/2024 | FFT Wealth Management LLC | 395,774 | $1.27M | 0.1% | N/A | 0.560% | |
| 1/24/2024 | China Universal Asset Management Co. Ltd. | 8,178 | $26K | 0.0% | N/A | 0.012% | |
| 1/17/2024 | Assenagon Asset Management S.A. | 78,479 | $253K | 0.0% | N/A | 0.111% | |
| 1/12/2024 | SG Americas Securities LLC | 39,792 | $128K | 0.0% | +52.7% | 0.056% | |
| 11/13/2023 | Connor Clark & Lunn Investment Management Ltd. | 81,173 | $312K | 0.0% | +17.2% | 0.115% | |
| 11/13/2023 | Acadian Asset Management LLC | 1,701,228 | $6.53M | 0.0% | -4.5% | 2.407% | |
| 11/7/2023 | New York State Common Retirement Fund | 19,110 | $73K | 0.0% | -28.7% | 0.027% | |
| 11/7/2023 | Jump Financial LLC | 15,811 | $61K | 0.0% | N/A | 0.022% | |
| 10/13/2023 | SG Americas Securities LLC | 26,064 | $100K | 0.0% | N/A | 0.037% | |
| 9/21/2023 | Barclays PLC | 11,955 | $40K | 0.0% | N/A | 0.017% | |
| 8/11/2023 | Rubric Capital Management LP | 5,445,910 | $17.86M | 0.8% | -22.2% | 7.714% | |
| 8/11/2023 | Tejara Capital Ltd | 112,591 | $369K | 0.2% | -5.2% | 0.159% | |
| 8/9/2023 | DCF Advisers LLC | 64,764 | $212K | 0.1% | -5.1% | 0.092% | |
| 8/4/2023 | American International Group Inc. | 28,701 | $94K | 0.0% | N/A | 0.041% | |
| 7/27/2023 | EA Series Trust | 98,952 | $325K | 0.0% | N/A | 0.140% | |
| 7/25/2023 | Raymond James & Associates | 25,000 | $82K | 0.0% | N/A | 0.035% | |
| 5/15/2023 | Madison Avenue Partners LP | 3,104,603 | $8.01M | 1.7% | +14.1% | 4.402% | |
| 5/15/2023 | Rubric Capital Management LP | 7,001,124 | $18.06M | 0.5% | +2.5% | 9.928% | |
| 5/12/2023 | Tejara Capital Ltd | 118,791 | $306K | 0.2% | +10.5% | 0.168% | |
| 5/11/2023 | Acadian Asset Management LLC | 1,780,873 | $4.59M | 0.0% | -1.9% | 2.525% | |
| 5/10/2023 | Connor Clark & Lunn Investment Management Ltd. | 30,858 | $80K | 0.0% | -22.7% | 0.044% | |
| 5/9/2023 | Y Intercept Hong Kong Ltd | 35,116 | $91K | 0.0% | N/A | 0.050% | |
| 5/1/2023 | Virtu Financial LLC | 17,892 | $46K | 0.0% | N/A | 0.025% | |
| 2/10/2023 | Blair William & Co. IL | 24,328 | $45K | 0.0% | -22.1% | 0.035% | |
| 11/14/2022 | Rubric Capital Management LP | 4,516,300 | $8.31M | 0.4% | +56.7% | 6.409% | |
| 11/10/2022 | Stonepine Capital Management LLC | 1,540,671 | $2.84M | 1.3% | -55.8% | 2.188% | |
| 10/18/2022 | Newman Dignan & Sheerar Inc. | 15,522 | $29K | 0.0% | N/A | 0.022% | |
| 8/16/2022 | Driehaus Capital Management LLC | 1,343,325 | $2.89M | 0.0% | +273.2% | 1.908% | |
| 8/12/2022 | Ikarian Capital LLC | 26,831 | $59K | 0.0% | -96.4% | 0.038% | |
| 8/5/2022 | Connor Clark & Lunn Investment Management Ltd. | 36,748 | $79K | 0.0% | -57.7% | 0.052% | |
| 7/29/2022 | Walker Asset Management LLC | 43,400 | $105K | 0.0% | N/A | 0.062% | |
| 7/29/2022 | Russell Investments Group Ltd. | 267,868 | $574K | 0.0% | -2.9% | 0.380% | |
| 7/27/2022 | Assenagon Asset Management S.A. | 26,362 | $57K | 0.0% | N/A | 0.037% | |
| 7/25/2022 | Walker Asset Management LLC | 43,400 | $105K | 0.0% | N/A | 0.062% | |
| 5/12/2022 | Acadian Asset Management LLC | 2,139,290 | $6.72M | 0.0% | +4.9% | 3.038% | |
| 5/12/2022 | Connor Clark & Lunn Investment Management Ltd. | 86,888 | $273K | 0.0% | -27.3% | 0.123% | |
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| 5/9/2022 | Bank of Nova Scotia | 47,350 | $149K | 0.0% | +12.1% | 0.067% | |
| 5/5/2022 | Royce & Associates LP | 11,811 | $37K | 0.0% | N/A | 0.017% | |
| 5/5/2022 | Russell Investments Group Ltd. | 275,973 | $865K | 0.0% | -10.0% | 0.392% | |
| 2/15/2022 | Stonepine Capital Management LLC | 4,006,185 | $12.86M | 5.9% | +23.2% | 5.883% | |
| 2/14/2022 | Blair William & Co. IL | 90,852 | $292K | 0.0% | -6.3% | 0.133% | |
| 2/10/2022 | Bailard Inc. | 47,948 | $154K | 0.0% | N/A | 0.070% | |
| 2/10/2022 | Qube Research & Technologies Ltd | 13,989 | $45K | 0.0% | N/A | 0.021% | |
| 2/10/2022 | Acadian Asset Management LLC | 2,040,084 | $6.54M | 0.0% | +7.2% | 2.996% | |
| 2/10/2022 | WINTON GROUP Ltd | 11,829 | $38K | 0.0% | -78.1% | 0.017% | |
| 2/10/2022 | Connor Clark & Lunn Investment Management Ltd. | 119,573 | $384K | 0.0% | -40.1% | 0.176% | |
