Syros Pharmaceuticals (SYRS) Short Interest Ratio & Short Volume $0.0001 0.00 (0.00%) As of 02:34 PM Eastern Add Compare Share Share Short Interest Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Syros Pharmaceuticals Short Interest DataSyros Pharmaceuticals (SYRS) has a short interest of 45,500 shares, representing 0.19% of the float (the number of shares available for trading by the public). This marks a -35.64% decrease in short interest from the previous month. The short interest ratio (days to cover) is 1.1, indicating that it would take 1.1 days of the average trading volume of 157,358 shares to cover all short positions.Current Short Interest45,500 sharesPrevious Short Interest70,700 sharesChange Vs. Previous Month-35.64%Dollar Volume Sold Short$91.00Short Interest Ratio1.1 Days to CoverLast Record DateAugust 31, 2025Outstanding Shares26,832,000 sharesShort Percent of Float0.19%Today's Trading Volume72,404 sharesAverage Trading Volume157,358 sharesToday's Volume Vs. Average46% Short Selling Syros Pharmaceuticals? Sign up to receive the latest short interest report for Syros Pharmaceuticals and its competitors with MarketBeat's FREE newsletter. Email Address Get Report View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. 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Skip Charts & View Short Interest HistoryShort Interest ChartDays to Cover ChartShort Percent of Float ChartSYRS Short Interest Over TimeSYRS Days to Cover Over TimeSYRS Percentage of Float Shorted Over Time Syros Pharmaceuticals Short Interest History Export to ExcelReport DateTotal Shares Sold ShortDollar Volume Sold ShortChange from Previous ReportPercentage of Float ShortedDays to CoverPrice on Report Date 8/31/202545,500 shares $91.00 -35.6%0.2%1.1 $0.00 8/15/202570,700 shares $113.12 -3.8%N/A2.4 $0.00 7/31/202573,500 shares $88.20 -32.3%0.3%0.8 $0.00 7/15/2025108,500 shares $282.10 -9.1%N/A0.5 $0.00 6/30/2025119,400 shares $2.65 thousand -1.0%0.5%0.4 $0.02 6/15/2025120,600 shares $2.69 thousand -6.7%0.5%0.5 $0.02 5/31/2025129,200 shares $3.48 thousand No Change0.5%0.4 $0.03 5/15/2025129,200 shares $4.07 thousand -60.7%N/A0.4 $0.03 4/30/2025329,100 shares $10.00 thousand -41.6%N/A0.8 $0.03 4/15/2025563,700 shares $14.09 thousand -3.7%N/A1 $0.03 Get the Latest News and Ratings for SYRS and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Syros Pharmaceuticals and its competitors with MarketBeat's FREE daily newsletter. 3/15/20254,190,000 shares $387.16 thousand +345.9%17.7%0.2 $0.09 2/28/2025939,600 shares $134.55 thousand +2.9%4.0%0.1 $0.14 2/15/2025913,100 shares $168.92 thousand +26.3%3.9%0.4 $0.19 1/31/2025723,200 shares $126.70 thousand -47.2%4.2%0.1 $0.18 1/15/20251,370,000 shares $326.20 thousand +24.6%7.9%0.1 $0.24 12/31/20241,100,000 shares $252.78 thousand -29.9%6.3%0.1 $0.23 12/15/20241,570,000 shares $325.30 thousand -29.6%9.0%0.2 $0.21 11/30/20242,230,000 shares $605.45 thousand -53.3%12.8%0.3 $0.27 11/15/20244,770,000 shares $1.24 million +281.6%27.7%0.6 $0.26 10/31/20241,250,000 shares $3.15 million +31.2%6.4%2.8 $2.52 10/15/2024952,600 shares $1.90 million -4.7%4.8%2.5 $1.99 9/30/2024999,900 shares $2.15 million -9.1%5.1%3.1 $2.15 9/15/20241,100,000 shares $2.15 million +14.9%5.6%3.6 $1.95 8/31/2024957,500 shares $1.57 million -22.8%4.8%4 $1.64 8/15/20241,240,000 shares $1.90 million -6.8%6.2%5.3 $1.53 7/31/20241,330,000 shares $7.98 million +4.7%6.7%12.9 $6.00 7/15/20241,270,000 shares $7.80 million -3.1%6.4%12.5 $6.14 6/30/20241,310,000 shares $6.76 million +4.0%6.6%9.8 $5.16 6/15/20241,260,000 shares $7.56 million -4.6%6.4%7.8 $6.00 5/31/20241,320,000 shares $6.73 million -13.2%6.6%8 $5.10 5/15/20241,520,000 shares $8.38 million +4.8%7.6%8 $5.51 4/30/20241,450,000 shares $7.83 million -22.0%7.8%7.4 $5.40 4/15/20241,860,000 shares $9.95 million +2.2%10.1%8.5 $5.35 3/31/20241,820,000 shares $9.74 million +4.6%9.9%8.4 $5.35 3/15/20241,740,000 shares $10.46 million +31.8%9.6%8.2 $6.01 2/29/20241,320,000 shares $9.58 million +29.4%7.3%4.1 $7.26 2/15/20241,020,000 shares $7.22 million +38.1%5.6%3.4 $7.08 1/31/2024738,800 shares $5.28 million +27.1%3.6%2.6 $7.14 1/15/2024581,200 shares $4.21 million +18.5%2.8%2.2 $7.24 12/31/2023490,600 shares $3.82 million -2.6%2.5%2.1 $7.79 12/15/2023503,500 shares $2.09 million +2.1%2.5%2.5 $4.16 11/30/2023493,400 shares $1.36 million +0.3%3.0%3.2 $2.75 11/15/2023491,800 shares $1.50 million -11.1%3.0%8.5 $3.04 10/31/2023553,100 shares $1.38 million -9.5%3.4%9.3 $2.49 10/15/2023611,200 shares $1.58 million -5.6%3.8%10.5 $2.59 9/30/2023647,300 shares $2.56 million +8.7%4.0%10.7 $3.95 9/15/2023595,500 shares $2.34 million -4.2%3.7%9.7 $3.93 8/31/2023621,800 shares $2.43 million -0.1%3.8%9.9 $3.90 8/15/2023622,600 shares $2.37 million -6.4%3.8%9.3 $3.81 7/31/2023665,000 shares $2.65 million +0.8%3.6%9 $3.98 7/15/2023660,000 shares $2.21 million +2.9%3.6%8.5 $3.35 6/30/2023641,500 shares $2.02 million +1.9%3.5%8.2 $3.15 6/15/2023629,700 shares $2.04 million +0.6%3.5%7.7 $3.24 5/31/2023625,800 shares $2.41 million -0.7%4.0%6.2 $3.85 5/15/2023630,200 shares $2.37 million -4.9%4.0%5.8 $3.76 4/30/2023662,700 shares $2.11 million -6.2%4.4%6.3 $3.18 4/15/2023706,700 shares $1.91 million -2.4%4.7%5.5 $2.70 3/31/2023724,200 shares $1.93 million +11.5%4.8%5.5 $2.67 3/15/2023649,500 shares $2.01 million +21.6%4.3%4.9 $3.09 2/28/2023534,300 shares $2.01 million -5.9%3.6%4.4 $3.76 2/15/2023567,600 shares $2.35 million -7.7%3.8%4.8 $4.14 1/31/2023615,100 shares $3.14 million +5.2%3.8%4.9 $5.11 1/15/2023584,700 shares $2.79 million -39.4%3.7%5.4 $4.77 12/30/2022964,400 shares $3.46 million +1.9%6.0%8.3 $3.59 12/15/2022946,500 shares $3.43 million +13.2%5.9%7.6 $3.62 11/30/2022836,400 shares $3.31 million +1.6%5.2%3.3 $3.96 11/15/2022823,300 shares $3.30 million +21.8%5.1%3.4 $4.01 10/31/2022676,000 shares $3.39 million +11.1%3.4%2.9 $5.02 10/15/2022608,700 shares $3.51 million -13.7%3.1%2.6 $5.77 9/30/2022705,200 shares $4.54 million -9.1%8.9%3.2 $6.44 9/15/2022775,700 shares $5.66 million -79.9%12.6%3.6 $7.29 8/31/20223,850,000 shares $3.08 million +5.2%14.3%5.3 $0.80 8/15/20223,660,000 shares $3.70 million +78.5%13.6%4.5 $1.01 7/31/20222,050,000 shares $1.61 million No Change7.6%2.4 $0.79 7/15/20222,050,000 shares $1.92 million +31.4%7.6%2.4 $0.94 6/30/20221,560,000 shares $1.50 million -53.3%3.5%1.7 $0.96 6/15/20223,340,000 shares $3.57 million -4.8%7.5%3.3 $1.07 5/31/20223,510,000 shares $2.89 million -14.8%8.0%3.9 $0.82 5/15/20224,120,000 shares $3.70 million +9.6%9.4%5 $0.90 4/30/20223,760,000 shares $3.17 million +29.7%9.0%4.9 $0.84 4/15/20222,900,000 shares $2.63 million -9.4%7.0%3.9 $0.91 3/31/20223,200,000 shares $3.81 million -4.8%7.8%5.4 $1.19 3/15/20223,360,000 shares $3.73 million -18.8%8.2%7 $1.11 2/28/20224,140,000 shares $5.34 million +1.7%10.1%9.3 $1.29 2/15/20224,070,000 shares $6.47 million -4.7%9.9%9.4 $1.59 1/31/20224,270,000 shares $8.45 million +4.4%10.9%10 $1.98 1/15/20224,090,000 shares $11.00 million +19.6%10.5%11.6 $2.69 12/31/20213,420,000 shares $11.15 million No Change8.8%10.2 $3.26 12/15/20213,420,000 shares $11.97 million -7.6%8.8%9.4 $3.50 11/30/20213,700,000 shares $14.65 million +3.6%9.5%8.2 $3.96 11/15/20213,570,000 shares $15.21 million -7.0%9.2%7.6 $4.26 10/29/20213,840,000 shares $15.86 million -6.8%9.8%8.1 $4.13 10/15/20214,120,000 shares $18.66 million +1.7%10.5%8.1 $4.53 9/30/20214,050,000 shares $18.10 million -6.0%10.3%7 $4.47 9/15/20214,310,000 shares $22.58 million -2.9%11.0%6.5 $5.24 8/31/20214,440,000 shares $23.53 million No Change11.3%6 $5.30 8/13/20214,440,000 shares $20.34 million +2.1%11.3%3.6 $4.58 7/30/20214,350,000 shares $20.10 million +9.9%10.8%3.2 $4.62 7/15/20213,960,000 shares $18.14 million -17.2%9.4%2.9 $4.58 6/30/20214,780,000 shares $26.05 million -2.3%11.4%3.5 $5.45 6/15/20214,890,000 shares $28.07 million -14.4%11.7%3.6 $5.74 5/28/20215,710,000 shares $36.83 million -6.6%13.7%4.6 $6.45 5/14/20216,110,000 shares $31.10 million +15.7%14.6%6.8 $5.09 4/30/20215,280,000 shares $32.95 million +7.8%12.5%7.4 $6.24 4/15/20214,900,000 shares $32.49 million -9.4%11.6%6.9 $6.63 3/31/20215,410,000 shares $39.20 million +10.9%12.8%7.1 $7.25 3/15/20214,880,000 shares $43.82 million +21.1%11.6%6.2 $8.98 2/26/20214,030,000 shares $35.79 million +10.7%9.6%5 $8.88 2/12/20213,640,000 shares $42.77 million -4.0%8.7%4.9 $11.75 1/29/20213,790,000 shares $40.36 million +7.7%N/A5.4 $10.65 1/15/20213,520,000 shares $48.68 million No ChangeN/A4.9 $13.83 12/31/20203,520,000 shares $41.78 million -22.8%8.8%5.6 $11.87 12/15/20204,560,000 shares $53.12 million +2.0%14.0%7.8 $11.65 11/30/20204,470,000 shares $36.43 million -3.7%11.3%8.8 $8.15 11/15/20204,640,000 shares $40.74 million -20.6%11.7%10 $8.78 10/30/20205,840,000 shares $40.18 million +4.1%14.7%12 $6.88 10/15/20205,610,000 shares $50.01 million +15.7%14.2%13.5 $8.92 9/30/20204,850,000 shares $42.87 million +31.1%12.2%13 $8.84 SYRS Short Interest - Frequently Asked Questions What is Syros Pharmaceuticals' current short interest? Short interest is the volume of Syros Pharmaceuticals shares that have been sold short but have not yet been covered or closed out. As of August 31st, investors have sold 45,500 shares of SYRS short. 0.19% of Syros Pharmaceuticals' shares are currently sold short. Learn More on Syros Pharmaceuticals' current short interest. What is a good short interest ratio for Syros Pharmaceuticals? The short interest ratio, also known as the "days to cover ratio", is calculated by dividing the number of shares of a stock sold short divided by its average trading volume. A short interest ratio ranging between 1 and 4 generally indicates strong positive sentiment about a stock and a lack of short sellers. A short interest ratio of 10 or greater indicates strong pessimism about a stock. SYRS shares currently have a short interest ratio of 1.0. Learn More on Syros Pharmaceuticals's short interest ratio. Which institutional investors are shorting Syros Pharmaceuticals? As of the most recent reporting period, the following institutional investors, funds, and major shareholders have reported short positions of Syros Pharmaceuticals: FNY Investment Advisers LLC. These positions are disclosed in Form 13F filings with the Securities and Exchange Commission. What is a good short interest percentage for Syros Pharmaceuticals? Companies that have a short interest as a percentage of float below 10% indicates positive investor sentiment and few short sellers. Stocks with a short interest percentage above 10% is considered high, suggesting some investors are pessimistic about the stock. Companies with a short interest percentage of 20% or more indicates widespread negative sentiment. 0.19% of Syros Pharmaceuticals' floating shares are currently sold short. Is Syros Pharmaceuticals' short interest increasing or decreasing? Syros Pharmaceuticals saw a drop in short interest during the month of August. As of August 31st, there was short interest totaling 45,500 shares, a drop of 35.6% from the previous total of 70,700 shares. Changes in short volume can be used to identify positive and negative investor sentiment. Investors that short sell a stock are betting that its price will decline in the future. An increase in short sale volume suggests bearish (negative) sentiment among investors. A decrease on short sale volume suggests bullish (positive) sentiment. How does Syros Pharmaceuticals' short interest compare to its competitors? 0.19% of Syros Pharmaceuticals' shares are currently sold short. Here is how the short interest of companies in the industry of "pharmaceutical products" compare to Syros Pharmaceuticals: CERo Therapeutics Holdings, Inc. (3.33%), Ensysce Biosciences, Inc. (13.70%), China Pharma Holdings, Inc. (0.43%), NKGen Biotech, Inc. (1.86%), 60 Degrees Pharmaceuticals Inc. (2.87%), Pasithea Therapeutics Corp. (1.46%), Titan Pharmaceuticals, Inc. (6.20%), Xenetic Biosciences, Inc. (1.76%), Spruce Biosciences, Inc. (0.22%), Calidi Biotherapeutics, Inc. (14.69%), Which stocks are the most shorted right now? As of the most recent reporting period, the following stocks had the largest short interest positions: SPDR S&P 500 ETF Trust ($73.23 billion), Invesco QQQ ($29.52 billion), iShares Russell 2000 ETF ($20.82 billion), iShares 20+ Year Treasury Bond ETF ($10.76 billion), Palo Alto Networks, Inc. ($9.37 billion), Strategy Inc ($7.58 billion), Invesco S&P 500 Equal Weight ETF ($6.78 billion), SPDR S&P Biotech ETF ($6.72 billion), AppLovin Corporation ($6.37 billion), and iShares iBoxx $ Investment Grade Corporate Bond ETF ($6.29 billion). View all of the most shorted stocks. What does it mean to sell short Syros Pharmaceuticals stock? Short selling SYRS is an investing strategy that aims to generate trading profit from Syros Pharmaceuticals as its price is falling. SYRS shares are trading up $0.00 today. To short a stock, an investor borrows shares, sells them and buys the shares back on the public market later to return it to the lender. Short sellers are betting that a stock will decline in price. If the stock does drop after selling, the short seller buys it back at a lower price and returns it to the lender. The difference between the sell price and the buy price is the trader's profit. How does a short squeeze work against Syros Pharmaceuticals? A short squeeze for Syros Pharmaceuticals occurs when it has a large amount of short interest and its stock appreciates in price. This forces short sellers to cover their short interest positions by buying actual shares of SYRS, which in turn drives the price of the stock up even further. How often is Syros Pharmaceuticals' short interest reported? Short interest is typically published by a stock exchange once per month. However, NASDAQ publishes a report for U.S. stocks, including SYRS, twice per month. The most recent reporting period available is August, 31 2025. More Short Interest Resources from MarketBeat Related Companies CERO Short Interest Data ENSC Short Interest Data CPHI Short Interest Data NKGN Short Interest Data SXTP Short Interest Data KTTA Short Interest Data TTNP Short Interest Data XBIO Short Interest Data SPRB Short Interest Data CLDI Short Interest Data Short Interest Tools Stocks to Short Largest Short Interest Positions Short Interest Increases Short Interest Decreases Short Interest Reporting Dates This page (NASDAQ:SYRS) was last updated on 9/26/2025 by MarketBeat.com Staff From Our PartnersWhy More Investors Are Using Family Trusts to Protect Their WealthFor many investors, a family trust can be an essential tool for protecting assets, avoiding probate, and ensur...SmartAsset | SponsoredYour Bank Account Is No Longer SafeWhat If Washington Declared That: YOUR Money ISN'T Actually Yours? 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