Syros Pharmaceuticals (SYRS) Short Interest Ratio & Short Volume $0.0017 +0.00 (+54.55%) As of 03:54 PM Eastern Add Compare Share Share Short Interest Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Syros Pharmaceuticals Short Interest DataSyros Pharmaceuticals (SYRS) has a short interest of 70,700 shares. This marks a -3.81% decrease in short interest from the previous month. The short interest ratio (days to cover) is 2.4, indicating that it would take 2.4 days of the average trading volume of 173,740 shares to cover all short positions.Current Short Interest70,700 sharesPrevious Short Interest73,500 sharesChange Vs. Previous Month-3.81%Dollar Volume Sold Short$113.12Short Interest Ratio2.4 Days to CoverLast Record DateAugust 15, 2025Outstanding Shares26,832,000 sharesPercentage of Shares Shorted0.26%Today's Trading Volume12,268 sharesAverage Trading Volume173,740 sharesToday's Volume Vs. Average7% Short Selling Syros Pharmaceuticals? Sign up to receive the latest short interest report for Syros Pharmaceuticals and its competitors with MarketBeat's FREE newsletter. Email Address Get Report View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. 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Skip Charts & View Short Interest HistoryShort Interest ChartDays to Cover ChartShort Percent of Float ChartSYRS Short Interest Over TimeSYRS Days to Cover Over TimeSYRS Percentage of Float Shorted Over Time Syros Pharmaceuticals Short Interest History Export to ExcelReport DateTotal Shares Sold ShortDollar Volume Sold ShortChange from Previous ReportPercentage of Float ShortedDays to CoverPrice on Report Date 8/15/202570,700 shares $113.12 -3.8%N/A2.4 $0.00 7/31/202573,500 shares $88.20 -32.3%0.3%0.8 $0.00 7/15/2025108,500 shares $282.10 -9.1%N/A0.5 $0.00 6/30/2025119,400 shares $2.65 thousand -1.0%0.5%0.4 $0.02 6/15/2025120,600 shares $2.69 thousand -6.7%0.5%0.5 $0.02 5/31/2025129,200 shares $3.48 thousand No Change0.5%0.4 $0.03 5/15/2025129,200 shares $4.07 thousand -60.7%N/A0.4 $0.03 4/30/2025329,100 shares $10.00 thousand -41.6%N/A0.8 $0.03 4/15/2025563,700 shares $14.09 thousand -3.7%N/A1 $0.03 3/15/20254,190,000 shares $387.16 thousand +345.9%17.7%0.2 $0.09 Get the Latest News and Ratings for SYRS and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Syros Pharmaceuticals and its competitors with MarketBeat's FREE daily newsletter. 2/28/2025939,600 shares $134.55 thousand +2.9%4.0%0.1 $0.14 2/15/2025913,100 shares $168.92 thousand +26.3%3.9%0.4 $0.19 1/31/2025723,200 shares $126.70 thousand -47.2%4.2%0.1 $0.18 1/15/20251,370,000 shares $326.20 thousand +24.6%7.9%0.1 $0.24 12/31/20241,100,000 shares $252.78 thousand -29.9%6.3%0.1 $0.23 12/15/20241,570,000 shares $325.30 thousand -29.6%9.0%0.2 $0.21 11/30/20242,230,000 shares $605.45 thousand -53.3%12.8%0.3 $0.27 11/15/20244,770,000 shares $1.24 million +281.6%27.7%0.6 $0.26 10/31/20241,250,000 shares $3.15 million +31.2%6.4%2.8 $2.52 10/15/2024952,600 shares $1.90 million -4.7%4.8%2.5 $1.99 9/30/2024999,900 shares $2.15 million -9.1%5.1%3.1 $2.15 9/15/20241,100,000 shares $2.15 million +14.9%5.6%3.6 $1.95 8/31/2024957,500 shares $1.57 million -22.8%4.8%4 $1.64 8/15/20241,240,000 shares $1.90 million -6.8%6.2%5.3 $1.53 7/31/20241,330,000 shares $7.98 million +4.7%6.7%12.9 $6.00 7/15/20241,270,000 shares $7.80 million -3.1%6.4%12.5 $6.14 6/30/20241,310,000 shares $6.76 million +4.0%6.6%9.8 $5.16 6/15/20241,260,000 shares $7.56 million -4.6%6.4%7.8 $6.00 5/31/20241,320,000 shares $6.73 million -13.2%6.6%8 $5.10 5/15/20241,520,000 shares $8.38 million +4.8%7.6%8 $5.51 4/30/20241,450,000 shares $7.83 million -22.0%7.8%7.4 $5.40 4/15/20241,860,000 shares $9.95 million +2.2%10.1%8.5 $5.35 3/31/20241,820,000 shares $9.74 million +4.6%9.9%8.4 $5.35 3/15/20241,740,000 shares $10.46 million +31.8%9.6%8.2 $6.01 2/29/20241,320,000 shares $9.58 million +29.4%7.3%4.1 $7.26 2/15/20241,020,000 shares $7.22 million +38.1%5.6%3.4 $7.08 1/31/2024738,800 shares $5.28 million +27.1%3.6%2.6 $7.14 1/15/2024581,200 shares $4.21 million +18.5%2.8%2.2 $7.24 12/31/2023490,600 shares $3.82 million -2.6%2.5%2.1 $7.79 12/15/2023503,500 shares $2.09 million +2.1%2.5%2.5 $4.16 11/30/2023493,400 shares $1.36 million +0.3%3.0%3.2 $2.75 11/15/2023491,800 shares $1.50 million -11.1%3.0%8.5 $3.04 10/31/2023553,100 shares $1.38 million -9.5%3.4%9.3 $2.49 10/15/2023611,200 shares $1.58 million -5.6%3.8%10.5 $2.59 9/30/2023647,300 shares $2.56 million +8.7%4.0%10.7 $3.95 9/15/2023595,500 shares $2.34 million -4.2%3.7%9.7 $3.93 8/31/2023621,800 shares $2.43 million -0.1%3.8%9.9 $3.90 8/15/2023622,600 shares $2.37 million -6.4%3.8%9.3 $3.81 7/31/2023665,000 shares $2.65 million +0.8%3.6%9 $3.98 7/15/2023660,000 shares $2.21 million +2.9%3.6%8.5 $3.35 6/30/2023641,500 shares $2.02 million +1.9%3.5%8.2 $3.15 6/15/2023629,700 shares $2.04 million +0.6%3.5%7.7 $3.24 5/31/2023625,800 shares $2.41 million -0.7%4.0%6.2 $3.85 5/15/2023630,200 shares $2.37 million -4.9%4.0%5.8 $3.76 4/30/2023662,700 shares $2.11 million -6.2%4.4%6.3 $3.18 4/15/2023706,700 shares $1.91 million -2.4%4.7%5.5 $2.70 3/31/2023724,200 shares $1.93 million +11.5%4.8%5.5 $2.67 3/15/2023649,500 shares $2.01 million +21.6%4.3%4.9 $3.09 2/28/2023534,300 shares $2.01 million -5.9%3.6%4.4 $3.76 2/15/2023567,600 shares $2.35 million -7.7%3.8%4.8 $4.14 1/31/2023615,100 shares $3.14 million +5.2%3.8%4.9 $5.11 1/15/2023584,700 shares $2.79 million -39.4%3.7%5.4 $4.77 12/30/2022964,400 shares $3.46 million +1.9%6.0%8.3 $3.59 12/15/2022946,500 shares $3.43 million +13.2%5.9%7.6 $3.62 11/30/2022836,400 shares $3.31 million +1.6%5.2%3.3 $3.96 11/15/2022823,300 shares $3.30 million +21.8%5.1%3.4 $4.01 10/31/2022676,000 shares $3.39 million +11.1%3.4%2.9 $5.02 10/15/2022608,700 shares $3.51 million -13.7%3.1%2.6 $5.77 9/30/2022705,200 shares $4.54 million -9.1%8.9%3.2 $6.44 9/15/2022775,700 shares $5.66 million -79.9%12.6%3.6 $7.29 8/31/20223,850,000 shares $3.08 million +5.2%14.3%5.3 $0.80 8/15/20223,660,000 shares $3.70 million +78.5%13.6%4.5 $1.01 7/31/20222,050,000 shares $1.61 million No Change7.6%2.4 $0.79 7/15/20222,050,000 shares $1.92 million +31.4%7.6%2.4 $0.94 6/30/20221,560,000 shares $1.50 million -53.3%3.5%1.7 $0.96 6/15/20223,340,000 shares $3.57 million -4.8%7.5%3.3 $1.07 5/31/20223,510,000 shares $2.89 million -14.8%8.0%3.9 $0.82 5/15/20224,120,000 shares $3.70 million +9.6%9.4%5 $0.90 4/30/20223,760,000 shares $3.17 million +29.7%9.0%4.9 $0.84 4/15/20222,900,000 shares $2.63 million -9.4%7.0%3.9 $0.91 3/31/20223,200,000 shares $3.81 million -4.8%7.8%5.4 $1.19 3/15/20223,360,000 shares $3.73 million -18.8%8.2%7 $1.11 2/28/20224,140,000 shares $5.34 million +1.7%10.1%9.3 $1.29 2/15/20224,070,000 shares $6.47 million -4.7%9.9%9.4 $1.59 1/31/20224,270,000 shares $8.45 million +4.4%10.9%10 $1.98 1/15/20224,090,000 shares $11.00 million +19.6%10.5%11.6 $2.69 12/31/20213,420,000 shares $11.15 million No Change8.8%10.2 $3.26 12/15/20213,420,000 shares $11.97 million -7.6%8.8%9.4 $3.50 11/30/20213,700,000 shares $14.65 million +3.6%9.5%8.2 $3.96 11/15/20213,570,000 shares $15.21 million -7.0%9.2%7.6 $4.26 10/29/20213,840,000 shares $15.86 million -6.8%9.8%8.1 $4.13 10/15/20214,120,000 shares $18.66 million +1.7%10.5%8.1 $4.53 9/30/20214,050,000 shares $18.10 million -6.0%10.3%7 $4.47 9/15/20214,310,000 shares $22.58 million -2.9%11.0%6.5 $5.24 8/31/20214,440,000 shares $23.53 million No Change11.3%6 $5.30 8/13/20214,440,000 shares $20.34 million +2.1%11.3%3.6 $4.58 7/30/20214,350,000 shares $20.10 million +9.9%10.8%3.2 $4.62 7/15/20213,960,000 shares $18.14 million -17.2%9.4%2.9 $4.58 6/30/20214,780,000 shares $26.05 million -2.3%11.4%3.5 $5.45 6/15/20214,890,000 shares $28.07 million -14.4%11.7%3.6 $5.74 5/28/20215,710,000 shares $36.83 million -6.6%13.7%4.6 $6.45 5/14/20216,110,000 shares $31.10 million +15.7%14.6%6.8 $5.09 4/30/20215,280,000 shares $32.95 million +7.8%12.5%7.4 $6.24 4/15/20214,900,000 shares $32.49 million -9.4%11.6%6.9 $6.63 3/31/20215,410,000 shares $39.20 million +10.9%12.8%7.1 $7.25 3/15/20214,880,000 shares $43.82 million +21.1%11.6%6.2 $8.98 2/26/20214,030,000 shares $35.79 million +10.7%9.6%5 $8.88 2/12/20213,640,000 shares $42.77 million -4.0%8.7%4.9 $11.75 1/29/20213,790,000 shares $40.36 million +7.7%N/A5.4 $10.65 1/15/20213,520,000 shares $48.68 million No ChangeN/A4.9 $13.83 12/31/20203,520,000 shares $41.78 million -22.8%8.8%5.6 $11.87 12/15/20204,560,000 shares $53.12 million +2.0%14.0%7.8 $11.65 11/30/20204,470,000 shares $36.43 million -3.7%11.3%8.8 $8.15 11/15/20204,640,000 shares $40.74 million -20.6%11.7%10 $8.78 10/30/20205,840,000 shares $40.18 million +4.1%14.7%12 $6.88 10/15/20205,610,000 shares $50.01 million +15.7%14.2%13.5 $8.92 9/30/20204,850,000 shares $42.87 million +31.1%12.2%13 $8.84 9/15/20203,700,000 shares $38.48 million +2.2%9.3%9.9 $10.40 SYRS Short Interest - Frequently Asked Questions What is Syros Pharmaceuticals' current short interest? Short interest is the volume of Syros Pharmaceuticals shares that have been sold short but have not yet been closed out or covered. As of August 15th, traders have sold 70,700 shares of SYRS short. Learn More on Syros Pharmaceuticals' current short interest. What is a good short interest ratio for Syros Pharmaceuticals? The short interest ratio, also known as the "days to cover ratio", is calculated by dividing the number of shares of a stock sold short divided by its average trading volume. A short interest ratio ranging between 1 and 4 generally indicates strong positive sentiment about a stock and a lack of short sellers. A short interest ratio of 10 or greater indicates strong pessimism about a stock. SYRS shares currently have a short interest ratio of 2.0. Learn More on Syros Pharmaceuticals's short interest ratio. Which institutional investors are shorting Syros Pharmaceuticals? As of the most recent reporting period, the following institutional investors, funds, and major shareholders have reported short positions of Syros Pharmaceuticals: FNY Investment Advisers LLC. These positions are disclosed in Form 13F filings with the Securities and Exchange Commission. Is Syros Pharmaceuticals' short interest increasing or decreasing? Syros Pharmaceuticals saw a drop in short interest during the month of August. As of August 15th, there was short interest totaling 70,700 shares, a drop of 3.8% from the previous total of 73,500 shares. Changes in short volume can be used to identify positive and negative investor sentiment. Investors that short sell a stock are betting that its price will decline in the future. An increase in short sale volume suggests bearish (negative) sentiment among investors. A decrease on short sale volume suggests bullish (positive) sentiment. How does Syros Pharmaceuticals' short interest compare to its competitors? Here is how the short interest of companies in the industry of "pharmaceutical products" compare to Syros Pharmaceuticals: NuCana PLC Sponsored ADR (20.40%), Navidea Biopharmaceuticals, Inc. (0.00%), Smart for Life, Inc. (0.01%), Scopus BioPharma Inc. (0.02%), Virpax Pharmaceuticals, Inc. (0.96%), Statera Biopharma, Inc. (0.15%), Evelo Biosciences, Inc. (0.04%), Comera Life Sciences Holdings, Inc. (0.01%), Genocea Biosciences, Inc. (0.33%), Aridis Pharmaceuticals, Inc. (0.05%), Which stocks are the most shorted right now? As of the most recent reporting period, the following stocks had the largest short interest positions: Lucid Group, Inc. ($8.00 billion), Spotify Technology ($5.48 billion), AppLovin Corporation ($5.11 billion), Reddit Inc. ($5.02 billion), Coinbase Global, Inc. ($3.99 billion), Charter Communications, Inc. ($3.89 billion), Live Nation Entertainment, Inc. ($3.18 billion), Seagate Technology Holdings PLC ($2.59 billion), ResMed Inc. ($2.55 billion), and Rocket Lab Corporation ($2.52 billion). View all of the most shorted stocks. What does it mean to sell short Syros Pharmaceuticals stock? Short selling SYRS is an investing strategy that aims to generate trading profit from Syros Pharmaceuticals as its price is falling. SYRS shares are trading up $0.00 today. To short a stock, an investor borrows shares, sells them and buys the shares back on the public market later to return it to the lender. Short sellers are betting that a stock will decline in price. If the stock does drop after selling, the short seller buys it back at a lower price and returns it to the lender. The difference between the sell price and the buy price is the trader's profit. How does a short squeeze work against Syros Pharmaceuticals? A short squeeze for Syros Pharmaceuticals occurs when it has a large amount of short interest and its stock appreciates in price. This forces short sellers to cover their short interest positions by buying actual shares of SYRS, which in turn drives the price of the stock up even further. How often is Syros Pharmaceuticals' short interest reported? Short interest is typically published by a stock exchange once per month. However, NASDAQ publishes a report for U.S. stocks, including SYRS, twice per month. The most recent reporting period available is August, 15 2025. More Short Interest Resources from MarketBeat Related Companies NCNA Short Interest Data NAVB Short Interest Data SMFL Short Interest Data SCPS Short Interest Data VRPX Short Interest Data STAB Short Interest Data EVLO Short Interest Data CMRA Short Interest Data GNCAQ Short Interest Data ARDS Short Interest Data Short Interest Tools Stocks to Short Largest Short Interest Positions Short Interest Increases Short Interest Decreases Short Interest Reporting Dates This page (NASDAQ:SYRS) was last updated on 9/4/2025 by MarketBeat.com Staff From Our PartnersCapital Gains Tax Strategies for SeniorsCapital gains taxes can take a bite out of your retirement income—unless you have a smart strategy. 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