| 5/11/2021 | Acadian Asset Management LLC | 23,997 | $0.20M | 0.0% | N/A | 0.155% | |
| 5/10/2021 | GSA Capital Partners LLP | 25,650 | $0.21M | 0.0% | -44.7% | 0.165% | |
| 5/5/2021 | Total Clarity Wealth Management Inc. | 6,825 | $56K | 0.0% | N/A | 0.044% | |
| 4/29/2021 | We Are One Seven LLC | 11,780 | $96K | 0.0% | -26.4% | 0.076% | |
| 4/29/2021 | Dowling & Yahnke LLC | 40,455 | $0.33M | 0.0% | +32.8% | 0.261% | |
| 4/28/2021 | Lindbrook Capital LLC | 6,500 | $53K | 0.0% | N/A | 0.042% | |
| 2/17/2021 | Jane Street Group LLC | 11,041 | $0.13M | 0.0% | -71.5% | 0.081% | |
| 2/16/2021 | Price T Rowe Associates Inc. MD | 13,900 | $0.16M | 0.0% | N/A | 0.102% | |
| 2/12/2021 | Opaleye Management Inc. | 2,518,371 | $29.47M | 3.8% | +25.1% | 18.402% | |
| 2/12/2021 | Ikarian Capital LLC | 2,716,840 | $31.79M | 1.4% | +25.6% | 19.853% | |
|
| 2/10/2021 | Renaissance Technologies LLC | 169,100 | $1.98M | 0.0% | +107.5% | 1.236% | |
| 2/9/2021 | Wells Fargo & Company MN | 7,329 | $86K | 0.0% | +166.1% | 0.054% | |
| 2/9/2021 | Bank of New York Mellon Corp | 62,421 | $0.73M | 0.0% | N/A | 0.456% | |
| 2/5/2021 | BlackRock Inc. | 325,970 | $3.81M | 0.0% | +5,758.6% | 2.382% | |
| 2/4/2021 | GSA Capital Partners LLP | 46,375 | $0.54M | 0.1% | -43.2% | 0.339% | |
| 1/14/2021 | Vigilare Wealth Management | 14,000 | $0.16M | 0.2% | -17.6% | 0.102% | |
| 12/11/2020 | Virtu Financial LLC | 61,180 | $0.32M | 0.1% | +58.3% | 0.447% | |
| 11/17/2020 | Jane Street Group LLC | 38,749 | $0.20M | 0.0% | N/A | 0.283% | |
| 11/16/2020 | Boothbay Fund Management LLC | 236,301 | $1.22M | 0.1% | N/A | 1.727% | |
| 11/6/2020 | GSA Capital Partners LLP | 81,675 | $0.42M | 0.1% | N/A | 0.597% | |
| 11/3/2020 | Lindbrook Capital LLC | 10,000 | $52K | 0.0% | N/A | 0.085% | |
| 10/30/2020 | We Are One Seven LLC | 16,000 | $83K | 0.0% | N/A | 0.137% | |
| 10/19/2020 | Dowling & Yahnke LLC | 30,455 | $0.16M | 0.0% | +48.9% | 0.260% | |
| 10/15/2020 | Vigilare Wealth Management | 17,000 | $88K | 0.1% | N/A | 0.145% | |
| 9/15/2020 | Two Sigma Advisers LP | 55,400 | $0.11M | 0.0% | +326.2% | 0.473% | |
| 8/14/2020 | Telemetry Investments L.L.C. | 125,401 | $0.25M | 0.7% | +88.9% | 2.280% | |
| 8/7/2020 | Virtu Financial LLC | 38,650 | $76K | 0.0% | N/A | 0.703% | |
| 7/16/2020 | Wedbush Securities Inc. | 25,704 | $50K | 0.0% | N/A | 0.467% | |
| 5/15/2020 | Dowling & Yahnke LLC | 15,000 | $26K | 0.0% | N/A | 0.273% | |
| 5/15/2020 | Two Sigma Investments LP | 35,686 | $61K | 0.0% | N/A | 0.649% | |
| 5/12/2020 | JPMorgan Chase & Co. | 34,080 | $57K | 0.0% | N/A | 0.620% | |
| 2/14/2020 | Puissance Capital Management LP | 76,048 | $0.18M | 0.4% | -98.3% | 2.423% | |
| 2/13/2020 | Renaissance Technologies LLC | 151,529 | $0.36M | 0.0% | -88.2% | 4.827% | |
| 1/24/2020 | NEA Management Company LLC | 346,718 | $0.81M | 0.0% | -90.0% | 11.042% | |
| 10/17/2019 | Wedbush Securities Inc. | 146,000 | $65K | 0.0% | +207.4% | 0.488% | |
| 8/16/2019 | Susquehanna International Group LLP | 38,323 | $26K | 0.0% | N/A | 0.128% | |
| 8/14/2019 | Vanguard Group Inc. | 879,885 | $0.60M | 0.0% | -19.0% | 2.939% | |
| 8/13/2019 | BlackRock Inc. | 55,056 | $38K | 0.0% | -46.0% | 0.184% | |
| 8/12/2019 | Renaissance Technologies LLC | 1,209,203 | $0.82M | 0.0% | +17.5% | 4.039% | |
| 8/1/2019 | Wedbush Securities Inc. | 47,500 | $32K | 0.0% | N/A | 0.159% | |
| 5/10/2019 | Nicolet Advisory Services LLC | 35,701 | $49K | 0.0% | N/A | 0.119% | |
| 2/14/2019 | Telemetry Investments L.L.C. | 966,975 | $0.61M | 0.4% | +153.5% | 3.237% | |
| 11/13/2018 | Renaissance Technologies LLC | 808,100 | $1.66M | 0.0% | +12.3% | 2.705% | |
| 11/13/2018 | Bridgeway Capital Management Inc. | 100,000 | $0.21M | 0.0% | +100.0% | 0.335% | |
| 9/17/2018 | 683 Capital Management LLC | 2,738,938 | $7.07M | 0.5% | +82.6% | 9.179% | |
| 8/13/2018 | Renaissance Technologies LLC | 719,900 | $1.94M | 0.0% | +40.7% | 4.056% | |
| 8/10/2018 | Dimensional Fund Advisors LP | 76,999 | $0.21M | 0.0% | +368.8% | 0.434% | |
| 5/11/2018 | X Square Capital LLC | 79,198 | $0.18M | 0.2% | -39.2% | 0.446% | |
| 5/10/2018 | NEA Management Company LLC | 3,467,181 | $7.98M | 0.4% | +25.7% | 19.533% | |
| 5/8/2018 | Alambic Investment Management L.P. | 92,611 | $0.21M | 0.0% | N/A | 0.522% | |
| 2/15/2018 | 683 Capital Management LLC | 1,490,000 | $4.99M | 0.4% | +49.7% | 8.509% | |
| 2/14/2018 | QVT Financial LP | 124,966 | $0.40M | 0.0% | -59.5% | 0.714% | |
| 2/13/2018 | Renaissance Technologies LLC | 264,700 | $0.89M | 0.0% | +73.0% | 1.512% | |
| 2/12/2018 | X Square Capital LLC | 130,204 | $0.44M | 0.5% | N/A | 0.744% | |
| 12/7/2017 | 683 Capital Management LLC | 995,000 | $3.13M | 0.3% | N/A | 5.682% | |
| 11/3/2017 | Candriam Luxembourg S.C.A. | 143,000 | $0.45M | 0.0% | N/A | 0.861% | |
| 8/10/2017 | Franklin Resources Inc. | 453,264 | $1.09M | 0.0% | -47.9% | 2.729% | |
| 7/26/2017 | NEA Management Company LLC | 2,759,217 | $6.62M | 0.2% | No Change | 16.613% | |
| 5/15/2017 | Eventide Asset Management LLC | 900,000 | $3.38M | 0.2% | +4.0% | 5.568% | |
| 5/12/2017 | Renaissance Technologies LLC | 63,200 | $0.24M | 0.0% | +56.8% | 0.391% | |
| 5/10/2017 | NEA Management Company LLC | 2,759,217 | $10.35M | 0.4% | No Change | 17.071% | |
| 5/10/2017 | Stifel Financial Corp | 30,200 | $0.11M | 0.0% | +1.5% | 0.187% | |
| 4/21/2017 | Candriam Luxembourg S.C.A. | 143,000 | $0.54M | 0.0% | No Change | 0.885% | |
| 2/14/2017 | Perceptive Advisors LLC | 100,000 | $0.49M | 0.0% | N/A | 0.765% | |
| 2/14/2017 | Eventide Asset Management LLC | 865,526 | $4.24M | 0.3% | +67.2% | 6.625% | |
| 2/14/2017 | Alyeska Investment Group L.P. | 100,000 | $0.49M | 0.0% | N/A | 0.765% | |
| 2/14/2017 | Franklin Resources Inc. | 869,565 | $4.26M | 0.0% | N/A | 6.656% | |
| 2/13/2017 | Renaissance Technologies LLC | 40,300 | $0.20M | 0.0% | +181.8% | 0.308% | |
| 2/13/2017 | Sii Investments Inc. WI | 29,406 | $0.14M | 0.0% | -17.6% | 0.225% | |
| 1/18/2017 | Wall Street Associates | 241,536 | $1.18M | 0.8% | No Change | 1.849% | |
| 11/10/2016 | NEA Management Company LLC | 1,889,652 | $12.60M | 0.6% | No Change | 15.485% | |
| 8/15/2016 | Deerfield Management Co. | 67,567 | $0.30M | 0.0% | -83.0% | 0.554% | |
| 7/28/2016 | ClariVest Asset Management LLC | 56,500 | $0.25M | 0.0% | +56.9% | 0.463% | |
| 7/26/2016 | Candriam Luxembourg S.C.A. | 143,000 | $0.63M | 0.0% | -12.3% | 1.172% | |
| 5/16/2016 | Deerfield Management Co. | 397,085 | $2.78M | 0.1% | -18.1% | 3.259% | |
| 5/13/2016 | Geode Capital Management LLC | 24,420 | $0.17M | 0.0% | -0.2% | 0.200% | |
| 2/12/2016 | Visium Asset Management LP | 436,336 | $4.03M | 0.1% | No Change | 3.584% | |
| 1/26/2016 | Candriam Luxembourg S.C.A. | 180,000 | $1.66M | 0.0% | +33.0% | 1.478% | |
| 1/24/2016 | NEA Management Company LLC | 1,889,652 | $17.46M | 1.1% | No Change | 0.000% | |
| 9/30/2015 | J. Goldman & Company | 170,000 | $1.66M | 0.1% | N/A | 1.396% | |
