TriSalus Life Sciences (NASDAQ:TLSIW) is a clinical-stage biotechnology company focused on developing combination immuno-radiotherapeutic solutions for solid tumor cancers. The company’s approach leverages the synergistic potential of targeted radiotherapy to prime the tumor microenvironment and enhance the efficacy of immunomodulatory agents. TriSalus aims to address treatment resistance in cancers such as colorectal, pancreatic and other gastrointestinal malignancies by integrating proprietary drug candidates with precision radiation regimens.
The company’s lead investigational product, TRSL-201, is designed to be administered alongside radiotherapy in patients with microsatellite-stable colorectal cancer, a group that historically shows limited response to existing immunotherapies. In addition to TRSL-201, TriSalus is advancing multiple preclinical and early-stage clinical programs—such as TRSL-501 and TRSL-301—that explore novel combinations of immune checkpoint inhibitors and radiopharmaceuticals. These programs are supported by a translational research platform that includes biomarker analysis and advanced imaging techniques to optimize dosing schedules and patient selection.
Founded in 2019 and headquartered in Ann Arbor, Michigan, TriSalus conducts its clinical trials at leading oncology centers across the United States, with plans to expand into select international markets. The company collaborates with academic institutions and contract research organizations to accelerate its development timelines and to ensure broad access to cutting-edge radiotherapy technologies. TriSalus’s research strategy emphasizes adaptive trial designs and real-time data integration to streamline regulatory interactions and facilitate rapid proof-of-concept evaluations.
Under the leadership of Founder and Chief Executive Officer Edward C. Fabiano, TriSalus has assembled a management team with deep expertise in oncology drug development, radiopharmaceutical sciences and regulatory affairs. The board includes seasoned executives from the pharmaceutical and medical device industries, guiding the company through its public listing on the NASDAQ. TriSalus Life Sciences remains committed to transforming the standard of care for patients with challenging solid tumors by advancing innovative combination therapies that harness the full potential of the body’s own immune response.
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