| 5/29/2025 | Rhumbline Advisers | 82,738 | $985K | 0.0% | -20.3% | 0.119% | |
| 5/19/2025 | Jane Street Group LLC | 135,763 | $1.62M | 0.0% | +487.0% | 0.195% | |
| 5/19/2025 | UBS AM A Distinct Business Unit of UBS Asset Management Americas LLC | 3,879,945 | $46.21M | 0.0% | +184.2% | 5.576% | |
| 5/16/2025 | Empowered Funds LLC | 360,044 | $4.29M | 0.1% | +2.1% | 0.517% | |
| 5/16/2025 | Goldman Sachs Group Inc. | 200,047 | $2.38M | 0.0% | -20.0% | 0.288% | |
| 5/16/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,385 | $386K | 0.0% | +4.6% | 0.047% | |
| 5/16/2025 | Jacobs Levy Equity Management Inc. | 12,040 | $143K | 0.0% | -96.6% | 0.017% | |
| 5/16/2025 | Granahan Investment Management LLC | 407,589 | $4.85M | 0.2% | -0.9% | 0.586% | |
| 5/16/2025 | EcoR1 Capital LLC | 17,259,548 | $205.56M | 12.2% | +14.8% | 24.806% | |
| 5/16/2025 | Bridgeway Capital Management LLC | 766,944 | $9.13M | 0.2% | +1.0% | 1.102% | |
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| 5/16/2025 | AQR Capital Management LLC | 48,485 | $577K | 0.0% | +86.0% | 0.070% | |
| 5/16/2025 | ADAR1 Capital Management LLC | 50,000 | $596K | 0.1% | N/A | 0.072% | |
| 5/15/2025 | Redmile Group LLC | 4,788,945 | $57.04M | 5.4% | -1.1% | 6.883% | |
| 5/15/2025 | Vestal Point Capital LP | 500,000 | $5.96M | 0.4% | +170.3% | 0.719% | |
| 5/15/2025 | Royal Bank of Canada | 56,771 | $676K | 0.0% | -6.8% | 0.082% | |
| 5/15/2025 | Magnetar Financial LLC | 12,448 | $148K | 0.0% | N/A | 0.018% | |
| 5/15/2025 | Tema Etfs LLC | 33,001 | $393K | 0.1% | N/A | 0.047% | |
| 5/15/2025 | Trexquant Investment LP | 220,809 | $2.63M | 0.0% | +116.5% | 0.317% | |
| 5/14/2025 | Walleye Capital LLC | 247,959 | $2.95M | 0.0% | -45.2% | 0.356% | |
| 5/14/2025 | AlphaQuest LLC | 31,676 | $377K | 0.0% | +1,028.1% | 0.046% | |
| 5/14/2025 | Wellington Management Group LLP | 182,246 | $2.17M | 0.0% | -16.8% | 0.262% | |
| 5/13/2025 | Northwest & Ethical Investments L.P. | 10,030 | $119K | 0.0% | +83.3% | 0.014% | |
| 5/13/2025 | Cresset Asset Management LLC | 21,320 | $254K | 0.0% | -30.8% | 0.031% | |
| 5/13/2025 | American Century Companies Inc. | 31,147 | $371K | 0.0% | -22.0% | 0.045% | |
| 5/13/2025 | Tejara Capital Ltd | 189,409 | $2.26M | 0.9% | +391.5% | 0.272% | |
| 5/12/2025 | Nuveen LLC | 198,812 | $2.37M | 0.0% | N/A | 0.286% | |
| 5/12/2025 | Invesco Ltd. | 78,206 | $931K | 0.0% | +12.7% | 0.112% | |
| 5/12/2025 | Swiss National Bank | 80,100 | $954K | 0.0% | -11.2% | 0.115% | |
| 5/9/2025 | Deutsche Bank AG | 1,552,612 | $18.49M | 0.0% | +0.4% | 2.232% | |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 133,639 | $1.59M | 0.0% | +1.8% | 0.192% | |
| 5/9/2025 | Vanguard Group Inc. | 1,767,041 | $21.05M | 0.0% | -29.1% | 2.540% | |
| 5/8/2025 | XTX Topco Ltd | 20,205 | $241K | 0.0% | -40.0% | 0.029% | |
| 5/7/2025 | Picton Mahoney Asset Management | 208,029 | $2.48M | 0.0% | +0.7% | 0.299% | |
| 5/7/2025 | Zurcher Kantonalbank Zurich Cantonalbank | 24,531 | $292K | 0.0% | +25.1% | 0.035% | |
| 5/6/2025 | One Wealth Advisors LLC | 10,404 | $124K | 0.0% | -25.6% | 0.015% | |
| 5/2/2025 | Victory Capital Management Inc. | 44,270 | $527K | 0.0% | -14.2% | 0.064% | |
| 5/1/2025 | CWM LLC | 2,299 | $27K | 0.0% | +1,091.2% | 0.003% | |
| 5/1/2025 | Arizona State Retirement System | 11,846 | $141K | 0.0% | -11.7% | 0.017% | |
| 4/30/2025 | China Universal Asset Management Co. Ltd. | 13,816 | $165K | 0.0% | -5.4% | 0.020% | |
| 4/29/2025 | Envestnet Asset Management Inc. | 49,512 | $590K | 0.0% | -8.5% | 0.071% | |
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| 4/28/2025 | Teacher Retirement System of Texas | 11,168 | $133K | 0.0% | -18.7% | 0.016% | |
| 4/21/2025 | Duncan Williams Asset Management LLC | 22,095 | $263K | 0.1% | N/A | 0.032% | |
| 4/17/2025 | Janney Montgomery Scott LLC | 11,567 | $138K | 0.0% | +12.7% | 0.017% | |
| 4/17/2025 | Exchange Traded Concepts LLC | 10,126 | $121K | 0.0% | -24.4% | 0.015% | |
| 4/17/2025 | Ritholtz Wealth Management | 60,494 | $720K | 0.0% | -18.8% | 0.087% | |
| 4/15/2025 | Assenagon Asset Management S.A. | 495,067 | $5.90M | 0.0% | -22.9% | 0.712% | |
| 4/15/2025 | SG Americas Securities LLC | 98,165 | $1.17M | 0.0% | +266.5% | 0.141% | |
| 4/8/2025 | Rhumbline Advisers | 82,738 | $985K | 0.0% | -20.3% | 0.119% | |
| 4/7/2025 | GAMMA Investing LLC | 6,467 | $77K | 0.0% | +1,113.3% | 0.009% | |
| 3/24/2025 | Wellington Management Group LLP | 219,098 | $3.21M | 0.0% | -9.9% | 0.315% | |
| 2/25/2025 | Polar Asset Management Partners Inc. | 36,000 | $527K | 0.0% | N/A | 0.052% | |
| 2/19/2025 | Public Employees Retirement System of Ohio | 50,583 | $741K | 0.0% | -17.1% | 0.073% | |
| 2/17/2025 | UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,365,111 | $19.99M | 0.0% | -10.4% | 1.982% | |
| 2/17/2025 | Voloridge Investment Management LLC | 43,708 | $640K | 0.0% | N/A | 0.063% | |
| 2/17/2025 | Vestal Point Capital LP | 185,000 | $2.71M | 0.2% | -69.9% | 0.269% | |
| 2/17/2025 | Silvercrest Asset Management Group LLC | 282,345 | $4.13M | 0.0% | -1.0% | 0.410% | |
| 2/17/2025 | Redmile Group LLC | 4,840,463 | $70.86M | 4.9% | -5.1% | 7.027% | |
| 2/17/2025 | Point72 Asset Management L.P. | 330,127 | $4.83M | 0.0% | +565.8% | 0.479% | |
| 2/17/2025 | Polar Asset Management Partners Inc. | 36,000 | $527K | 0.0% | N/A | 0.052% | |
| 2/17/2025 | ProShare Advisors LLC | 18,623 | $273K | 0.0% | -36.9% | 0.027% | |
| 2/17/2025 | Prosight Management LP | 820,000 | $12.01M | 3.3% | -10.6% | 1.190% | |
| 2/17/2025 | Nuveen Asset Management LLC | 207,023 | $3.03M | 0.0% | +0.4% | 0.301% | |
| 2/17/2025 | Jacobs Levy Equity Management Inc. | 356,168 | $5.21M | 0.0% | -31.9% | 0.517% | |
| 2/17/2025 | Granahan Investment Management LLC | 411,120 | $6.02M | 0.3% | -33.0% | 0.597% | |
| 2/17/2025 | Farallon Capital Management LLC | 1,329,974 | $19.47M | 0.1% | -2.3% | 1.931% | |
| 2/17/2025 | D. E. Shaw & Co. Inc. | 20,840 | $305K | 0.0% | -4.3% | 0.030% | |
| 2/17/2025 | Deutsche Bank AG | 1,546,772 | $22.65M | 0.0% | +1.2% | 2.246% | |
| 2/17/2025 | Cresset Asset Management LLC | 30,806 | $451K | 0.0% | -21.8% | 0.045% | |
| 2/17/2025 | Bridgeway Capital Management LLC | 759,653 | $11.12M | 0.2% | +2.3% | 1.103% | |
| 2/17/2025 | Blackstone Inc. | 569,715 | $8.34M | 0.0% | +2,171.4% | 0.827% | |
| 2/17/2025 | BVF Inc. IL | 4,308,935 | $63.08M | 2.1% | -6.5% | 6.256% | |
| 2/17/2025 | Bank of America Corp DE | 31,700 | $464K | 0.0% | -54.5% | 0.046% | |
| 2/17/2025 | BNP Paribas Financial Markets | 7,363 | $108K | 0.0% | N/A | 0.011% | |
| 2/17/2025 | Ameriprise Financial Inc. | 121,526 | $1.78M | 0.0% | -11.5% | 0.176% | |
| 2/17/2025 | Acuta Capital Partners LLC | 67,240 | $984K | 1.0% | N/A | 0.098% | |
| 2/14/2025 | Jane Street Group LLC | 23,127 | $339K | 0.0% | -71.2% | 0.034% | |
| 2/14/2025 | Schonfeld Strategic Advisors LLC | 22,800 | $334K | 0.0% | N/A | 0.033% | |
| 2/14/2025 | Northern Trust Corp | 394,830 | $5.78M | 0.0% | +6.4% | 0.573% | |
| 2/14/2025 | The Manufacturers Life Insurance Company | 20,958 | $307K | 0.0% | -4.9% | 0.030% | |
| 2/14/2025 | Susquehanna Fundamental Investments LLC | 97,553 | $1.43M | 0.0% | N/A | 0.142% | |
| 2/14/2025 | Virtus ETF Advisers LLC | 5,633 | $82K | 0.0% | -44.3% | 0.008% | |
| 2/14/2025 | Voya Investment Management LLC | 59,514 | $871K | 0.0% | +207.7% | 0.086% | |
| 2/14/2025 | Price T Rowe Associates Inc. MD | 21,583 | $316K | 0.0% | +17.6% | 0.031% | |
| 2/14/2025 | Stifel Financial Corp | 64,330 | $942K | 0.0% | -12.7% | 0.093% | |
| 2/14/2025 | Tower Research Capital LLC TRC | 9,704 | $142K | 0.0% | +343.9% | 0.014% | |
| 2/14/2025 | MetLife Investment Management LLC | 33,946 | $497K | 0.0% | +6.4% | 0.049% | |
| 2/14/2025 | Dimensional Fund Advisors LP | 972,742 | $14.24M | 0.0% | +14.5% | 1.412% | |
| 2/13/2025 | Jump Financial LLC | 48,612 | $712K | 0.0% | N/A | 0.071% | |
| 2/13/2025 | Walleye Capital LLC | 452,804 | $6.63M | 0.0% | N/A | 0.657% | |
| 2/13/2025 | XTX Topco Ltd | 33,702 | $493K | 0.0% | N/A | 0.049% | |
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| 2/13/2025 | Barclays PLC | 220,890 | $3.23M | 0.0% | +43.1% | 0.321% | |
| 2/13/2025 | Sterling Capital Management LLC | 1,719 | $25K | 0.0% | +781.5% | 0.002% | |
| 2/13/2025 | Kennedy Capital Management LLC | 139,953 | $2.05M | 0.0% | -2.5% | 0.203% | |
| 2/13/2025 | Raymond James Financial Inc. | 60,642 | $888K | 0.0% | N/A | 0.088% | |
| 2/13/2025 | Renaissance Technologies LLC | 285,700 | $4.18M | 0.0% | +54.8% | 0.415% | |
| 2/13/2025 | Legal & General Group Plc | 47,082 | $689K | 0.0% | +5.8% | 0.068% | |
| 2/13/2025 | Invesco Ltd. | 69,382 | $1.02M | 0.0% | -57.4% | 0.101% | |
| 2/13/2025 | Bank of Montreal Can | 25,948 | $380K | 0.0% | -9.2% | 0.038% | |
| 2/13/2025 | Federated Hermes Inc. | 181,626 | $2.66M | 0.0% | +1.9% | 0.264% | |
| 2/13/2025 | Russell Investments Group Ltd. | 44,945 | $658K | 0.0% | -9.7% | 0.065% | |
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