Pressure BioSciences, Inc. (OTCMKTS:PBIO) is a life sciences instrumentation company specializing in pressure-based technologies for biological sample preparation. Headquartered in South Easton, Massachusetts, the company leverages its proprietary pressure cycling technology (PCT) to develop instruments and consumables that enable rapid and reproducible processing of cells, tissues, viruses and other biological materials. Pressure BioSciences serves a diverse customer base, including biopharmaceutical firms, academic research institutions and government laboratories, across North America, Europe and Asia.
At the core of the company’s product line is the Barocycler® family of instruments, which uses alternating cycles of hydrostatic pressure to disrupt cellular structures and facilitate extraction of proteins, nucleic acids and metabolites. These systems are designed to improve the efficiency and consistency of sample preparation workflows for proteomics, genomics and lipidomics applications. In parallel, Pressure BioSciences offers consumables such as PULSE® tubes and MicroPestles™ that are optimized to work in concert with its PCT platforms, ensuring reliable results from small to large sample volumes.
Beyond proteomic and genomic sample preparation, Pressure BioSciences has extended its technology to pathogen inactivation and vaccine development, providing a chemical-free approach for rendering viruses non‐infectious while preserving antigenic structures. This application has attracted interest from vaccine manufacturers and diagnostic companies seeking advanced tools for safe handling of high‐risk pathogens. The company also supports emerging fields such as soil remediation and forensics, where PCT can improve extraction of trace compounds or DNA from challenging matrices.
Founded in 2005, Pressure BioSciences has built an intellectual property portfolio encompassing multiple patents covering high‐pressure processing methods and apparatus. Under the leadership of President and Chief Executive Officer Neil J. Gottlieb, the company continues to pursue strategic collaborations and expand its global distribution network. With a focus on innovation and quality, Pressure BioSciences aims to advance sample preparation standards and support scientific discoveries in both research and applied markets.
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