Tcg Crossover Management, LLC Top Holdings and 13F Report (2026)

About Tcg Crossover Management, LLC

Investment Activity

Tcg Crossover Management, LLC has $3.50 billion in total holdings as of March 31, 2026.
Tcg Crossover Management, LLC owns shares of 49 different stocks, but just 19 companies or ETFs make up 80% of its holdings.
Approximately 20.25% of the portfolio was purchased this quarter.
About 13.82% of the portfolio was sold this quarter.
This quarter, Tcg Crossover Management, LLC has purchased 43 new stocks and bought additional shares in 8 stocks.
Tcg Crossover Management, LLC sold shares of 10 stocks and completely divested from 5 stocks this quarter.

Largest Holdings

ABIVAX SA AMERICAN DEPOSITARY SHARES: $721,668,815
CG ONCOLOGY INC: $248,399,542
Tango Therapeutics: $220,310,005
Cogent Biosciences: $190,405,950
Centessa Pharmaceuticals: $170,258,986

Largest New Holdings this Quarter

09058V103 - BioCryst Pharmaceuticals: $104,919,615 Holding
929033207 - VOR BIOPHARMA INC: $96,499,052 Holding
254604101 - Disc Medicine: $85,798,656 Holding
86889P208 - SURROZEN INC: $42,911,432 Holding
15673T100 - Century Therapeutics: $39,021,574 Holding

Largest Purchases this Quarter

BioCryst Pharmaceuticals: 11,020,968 shares (about $104.92M)
VOR BIOPHARMA INC: 5,673,078 shares (about $96.50M)
Mirum Pharmaceuticals: 1,000,000 shares (about $92.38M)
Disc Medicine: 1,341,862 shares (about $85.80M)
Immunovant: 2,797,055 shares (about $69.48M)

Largest Sales this Quarter

ABIVAX SA AMERICAN DEPOSITARY SHARES: 630,511 shares (about $70.21M)
Liquidia: 1,307,036 shares (about $49.33M)
Tango Therapeutics: 2,231,023 shares (about $46.67M)
Structure Therapeutics: 780,446 shares (about $37.62M)
Cogent Biosciences: 921,268 shares (about $35.46M)

Sector Allocation Over Time

Selling

Neutral

Buying

Latest 13F Holdings and Changes Since Previous Quarterly Filing

Issuer Name	Holdings Value	Approximate Purchase/Sale	Change in Shares	Shares Held	% of Portfolio	Sector
ABIVAX SA AMERICAN DEPOSITARY SHARES	$721,668,815	$70,207,400 â–¼	-8.9%	6,481,085	20.6%	ADRS
CG ONCOLOGY INC	$248,399,542		0.0%	3,670,206	7.1%	COMM
TNGX Tango Therapeutics	$220,310,005	$46,673,001 â–¼	-17.5%	10,531,071	6.3%	Medical
COGT Cogent Biosciences	$190,405,950	$35,459,605 â–¼	-15.7%	4,946,894	5.4%	Medical
CNTA Centessa Pharmaceuticals	$170,258,986		0.0%	4,286,480	4.9%	Medical
DIANTHUS THERAPEUTICS INC	$140,702,286		0.0%	1,676,624	4.0%	COMM
TYRA Tyra Biosciences	$124,435,934	$13,438,589 â–²	12.1%	3,248,980	3.6%	Medical
IMVT Immunovant	$110,736,422	$69,478,846 â–²	168.4%	4,457,988	3.2%	Medical
BCRX BioCryst Pharmaceuticals	$104,919,615	$104,919,615 â–²	New Holding	11,020,968	3.0%	Medical
MIRM Mirum Pharmaceuticals	$98,112,087	$92,380,000 â–²	1,611.6%	1,062,049	2.8%	Medical
VOR BIOPHARMA INC	$96,499,052	$96,499,052 â–²	New Holding	5,673,078	2.8%	COMM
SPYRE THERAPEUTICS INC	$95,865,356		0.0%	1,900,582	2.7%	COMM
AMLX Amylyx Pharmaceuticals	$86,788,987		0.0%	6,243,812	2.5%	Medical
IRON Disc Medicine	$85,798,656	$85,798,656 â–²	New Holding	1,341,862	2.5%	Medical
DYNE THERAPEUTICS INC	$83,672,561		0.0%	4,615,144	2.4%	COMM
GLUE Monte Rosa Therapeutics	$76,034,384		0.0%	4,622,151	2.2%	Medical
SVRA Savara	$67,497,639		0.0%	12,362,205	1.9%	Medical
RVMD Revolution Medicines	$56,061,999	$13,615,000 â–²	32.1%	576,473	1.6%	Medical
KOD Kodiak Sciences	$55,103,908		0.0%	1,445,538	1.6%	Medical
LB PHARMACEUTICALS INC	$45,279,611	$2,325,508 â–²	5.4%	1,839,489	1.3%	COMM
SURROZEN INC	$42,911,432	$42,911,432 â–²	New Holding	1,473,101	1.2%	COMM
ADCT ADC Therapeutics	$42,713,156		0.0%	11,390,175	1.2%	Medical
RLAY Relay Therapeutics	$42,519,892	$10,479,041 â–²	32.7%	4,273,356	1.2%	Medical
FULC Fulcrum Therapeutics	$40,267,500		0.0%	5,250,000	1.2%	Medical
BHVN Biohaven	$39,180,942		0.0%	4,631,317	1.1%	Medical
IPSC Century Therapeutics	$39,021,574	$39,021,574 â–²	New Holding	17,754,430	1.1%	Medical
TECTONIC THERAPEUTIC INC	$37,243,181	$37,243,181 â–²	New Holding	1,204,891	1.1%	COMM
PERSPECTIVE THERAPEUTICS INC	$33,007,914	$33,007,914 â–²	New Holding	7,915,567	0.9%	COMM
XNCR Xencor	$29,572,784		0.0%	2,452,138	0.8%	Medical
TRDA Entrada Therapeutics	$28,868,250	$2,512,743 â–²	9.5%	2,287,500	0.8%	Medical
ALXO ALX Oncology	$26,088,757	$26,088,757 â–²	New Holding	13,011,849	0.7%	Medical
ARVN Arvinas	$25,307,087	$2,954,803 â–¼	-10.5%	2,387,461	0.7%	Medical
JANX Janux Therapeutics	$24,875,676		0.0%	1,789,617	0.7%	Medical
AGOMAB THERAPEUTICS NV	$21,538,414	$21,538,414 â–²	New Holding	2,053,233	0.6%	ADRS
ALEC Alector	$21,500,000		0.0%	10,000,000	0.6%	Medical
MBX BIOSCIENCES INC	$19,402,500		0.0%	650,000	0.6%	COMM
SLN Silence Therapeutics	$15,986,861		0.0%	3,033,560	0.5%	Medical
LQDA Liquidia	$15,211,032	$49,327,540 â–¼	-76.4%	403,048	0.4%	Medical
OCUL Ocular Therapeutix	$13,956,459	$34,663,296 â–¼	-71.3%	1,647,752	0.4%	Medical
AVALO THERAPEUTICS INC	$11,024,058	$3,812,868 â–²	52.9%	738,383	0.3%	COMM
URGN Urogen Pharma	$7,288,463	$5,609,437 â–¼	-43.5%	405,365	0.2%	Medical
MONOPAR THERAPEUTICS INC	$7,237,923	$537,599 â–¼	-6.9%	132,103	0.2%	COMM
CNTX Context Therapeutics	$7,028,664	$7,028,664 â–²	New Holding	2,682,696	0.2%	Medical
GPCR Structure Therapeutics	$6,767,810	$37,617,496 â–¼	-84.8%	140,411	0.2%	Medical
CGEM Cullinan Therapeutics	$5,780,429	$5,780,429 â–²	New Holding	406,786	0.2%	Medical
KORRO BIO INC	$4,712,527		0.0%	416,301	0.1%	COMM
LEONABIO INC	$4,666,596		0.0%	464,398	0.1%	COMM
UPSTREAM BIO INC	$1,629,567	$5,065,407 â–¼	-75.7%	181,063	0.0%	COMM
VTGN VistaGen Therapeutics	$1,529,665		0.0%	2,676,580	0.0%	Medical
RAPT THERAPEUTICS INC	$0	$87,466,159 â–¼	-100.0%	0	0.0%	COMM
EYPT Eyepoint Pharmaceuticals	$0	$65,266,560 â–¼	-100.0%	0	0.0%	Medical
AGIO Agios Pharmaceuticals	$0	$32,169,712 â–¼	-100.0%	0	0.0%	Medical
MAZE THERAPEUTICS INC	$0	$7,201,197 â–¼	-100.0%	0	0.0%	COMM
VTYX Ventyx Biosciences	$0	$2,855,241 â–¼	-100.0%	0	0.0%	Medical

Showing largest 100 holdings. View all holdings.

More Institutional Buying and Selling Information

SEC Filings and Trading Data

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Tcg Crossover Management, LLC Top Holdings and 13F Report (2026)

About Tcg Crossover Management, LLC

Investment Activity

Largest Holdings

Largest New Holdings this Quarter

Largest Purchases this Quarter

Largest Sales this Quarter

Sector Allocation Over Time

Latest 13F Holdings and Changes Since Previous Quarterly Filing

More Institutional Buying and Selling Information

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Tcg Crossover Management, LLC Top Holdings and 13F Report (2026)

About Tcg Crossover Management, LLC

Investment Activity

Largest Holdings

Largest New Holdings this Quarter

Largest Purchases this Quarter

Largest Sales this Quarter

Sector Allocation Over Time

Map of 500 Largest Holdings ofTcg Crossover Management, LLC

Latest 13F Holdings and Changes Since Previous Quarterly Filing

More Institutional Buying and Selling Information

MarketBeat All Access Features

Best-in-Class Portfolio Monitoring

Stock Ideas and Recommendations

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