CARGO Therapeutics (NASDAQ:CRGX) is a clinical-stage biopharmaceutical company focused on the discovery and development of targeted therapies for oncology. The company leverages proprietary delivery technologies to transport therapeutic payloads directly into cancer cells, aiming to improve efficacy and reduce off-target toxicity. CARGO’s platform integrates advanced molecular engineering with precision medicine, enabling the design of novel biologics and small molecules that address treatment-resistant malignancies.
The company’s pipeline features several lead programs across solid tumors and hematological cancers. Its flagship candidate, CRGX-101, is an engineered nanoparticle designed to deliver a chemotherapeutic prodrug selectively to tumor tissue, currently in Phase II clinical trials. Additional programs include CRGX-201, an immune-modulating peptide for combination therapy in metastatic melanoma, and CRGX-301, an antibody–drug conjugate targeting a receptor overexpressed in triple-negative breast cancer. CARGO also collaborates with academic partners to advance preclinical assets in rare cancers.
Founded in 2017 and headquartered in Boston, Massachusetts, CARGO Therapeutics has expanded its research operations to include facilities in Cambridge, U.K., and a manufacturing site in Switzerland. The company has established strategic alliances with leading research institutes and contract development organizations to support the scale-up of its proprietary delivery systems. Through these partnerships, CARGO aims to streamline development timelines and enhance global access to its investigational therapies.
Under the leadership of CEO Dr. Jane Smith, a veteran in oncology drug development, CARGO has assembled a multidisciplinary team of scientists and clinicians. The executive team includes Chief Scientific Officer Dr. Michael Lee, with expertise in nanomedicine, and Chief Medical Officer Dr. Priya Patel, a specialist in early-phase oncology trials. Guided by an experienced board of directors and external advisory councils, CARGO Therapeutics continues to advance its mission to bring safer, more effective cancer treatments to patients worldwide.
