Vertex Pharmaceuticals Q4 2022 Earnings Call Transcript

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Provided by Quartr
February 7, 2023

There are 13 speakers on the call.

Operator

Good day, and welcome to the Vertex Pharmaceuticals 4th Quarter and Full Year 2022 Conference Call. All participants will be in a listen only mode. After today's presentation, there will be an opportunity to ask questions. Please note this event is being recorded. I would now like to turn the conference over to Ms.

Operator

Susie Lisa. Please go ahead.

Speaker 1

Good evening, everyone. My name is Susie Lisa, and as the Senior Vice President of Relations for Vertex, it is my pleasure to welcome you to our Q4 and full year 2022 financial results conference call. On tonight's call making prepared remarks, we have Doctor. Reshma Kewalramani, Vertex's CEO and President Stuart Arbuckle, Chief Operating Officer and Charlie Wagner, Chief Financial Officer. We recommend that you access the webcast slides as you listen to this call.

Speaker 1

The call is being recorded and a replay will be available on our website. We will make forward looking statements on this call that are subject to the risks and uncertainties discussed in detail in today's press release and in our filings with the Securities and Exchange Commission. These statements, including without limitation, those regarding Vertex's marketed cystic fibrosis medicines, our pipeline and Vertex's future financial performance are based on management's current assumptions. Actual outcomes and events could differ materially. I would also note that select financial results and guidance that we will review on the call this evening are presented on a non GAAP basis.

Speaker 1

In addition, the impact of the foreign exchange is presented inclusive of our foreign exchange risk management program. I'll now turn the call over to Reshma.

Speaker 2

Thanks, Susie. Good evening, all, and thank you for joining us on the call today. We are pleased to have closed out a strong 2022 with full year global CF product revenue up 18% versus 2021. Our full year 2023 product revenue guidance is $9,550,000,000 to $9,700,000,000 representing 7% to 9% growth year on year, inclusive of FX headwind of approximately 1.5%. We have more than 20,000 patients still to reach with CFTR modulators, and we continue to work with focus and urgency to reach all patients with CF around the globe who may benefit from our therapies.

Speaker 2

It is an exciting time for Vertex. Our medicines have transformed CF and the growth of our CF business has transformed Vertex. Our differentiated R and D approach led to our multiple life changing therapies in cystic fibrosis and is designed to deliver transformative medicines for serious diseases at high rates of success, agnostic to modality. It is delivering just that. In aggregate, our mid- and late stage clinical pipeline Holds a promise to deliver potentially transformative benefit for patients across 8 disease areas as detailed on Slide 5.

Speaker 2

Each program holds the potential to be best in class and transform the disease, and each represents a multibillion dollar market opportunity. Furthermore, we see the opportunity to launch new products into 5 of these disease areas within the next 5 years or our 5 and 5 goal. And we're not done. The next wave of innovation is also making progress and advancing through preclinical development, including programs in Duchenne's muscular dystrophy and Myotonic Dystrophy Type 1. This breadth of pipeline success, accelerated pace of clinical trial progress and build out of commercial capabilities for upcoming product launches warrant continued investments in 2023.

Speaker 2

As such, we are strategically investing and focusing on execution to drive forward this significant opportunity. With a uniquely strong and durable CF franchise, a deep, broad and advancing R and D pipeline with multiple potentially near term commercial opportunities, a strong balance sheet and a deeply talented and committed team, Vertex is well positioned to deliver for patients and shareholders for years to come. With that overview, I'll turn to the details of recent R and D progress, Starting with CF, we'll continue our journey in cystic fibrosis as we serially innovate to bring highly efficacious therapies to all CF patients. Our next in class Vansacaftor triple combination completed enrollment in its 2 Phase 3 clinical trials, Skyline 102 and Skyline 103 in patients ages 12 years and older in Q4 of 2022. While Trikafta sets a very high bar, our enthusiasm for this Vansacaftor program is also high.

Speaker 2

This program could deliver even greater benefits to patients given: 1, our highly predictive in vitro Human bronchialepithelial or HBE cell assays showed the VANZA triple was superior to Trikafta in improving chloride transport, a direct measure of CFTR function. 2, our Phase 2 clinical data also suggests The potential for greater efficacy for Vansacaftor versus Trikafta. And 3, The Vansacaftor triple also has the benefit of once daily oral dosing and a substantially reduced royalty burden relative to Trikafta. The Phase III trials are currently in the 52 week dosing period, and we anticipate their completion towards the end of this year. Another important program is the VX-five twenty two program, our CFTR mRNA approach that we are developing in partnership with Moderna for CF patients who cannot benefit from our CFTR modulators.

Speaker 2

In December of 2022, the FDA cleared the IND for VX-five 522 and the single ascending dose study in CF patients was initiated last year, a major milestone for Vertex and the field. We have high expectations given over 5 years of research that led to the discovery of VX-five twenty two with the following properties: 1, delivery of mRNA at high efficiency into HBE cells 2, expression of CFTR protein leading to high levels of chloride transport and 3, in both rodents and non human primates, expression of CFTR protein in the desired cells and lastly, a preclinical safety profile that supported advancement into human clinical trials. We are excited with the progress of VX-five twenty two, which brings hope to the more than 5,000 CF patients who are still waiting for a treatment that targets the underlying cause of their disease. Turning now to Our gene editing program for severe sickle cell disease and transfusion dependent beta thalassemia. This is our most advanced program outside of CF, and we expect Exacel to be our next commercial launch.

Speaker 2

In late Q4, we completed our regulatory submissions for ExaCell for both sickle cell disease and beta thalassemia in the EU and UK. Both the EMA and the MHRA have recently validated the MAA submissions, and in the U. S, we remain on track to complete our rolling VLA submission by the end of this quarter. The remarkable clinical benefits are evident in the data we've shared to date. ExaCell holds the promise to be the 1st CRISPR based gene editing treatment to be approved and represents a near term and significant market opportunity, which Stuart will detail.

Speaker 2

Turning next to VX-five forty eight and our pain program. VX-five forty eight is our novel, selective, NaV1.8 inhibitor that holds the promise of highly effective pain relief without the side effects or addictive potential of opioids. If approved, VX-five forty eight would represent the 1st new class of pain medicine in decades with the potential to address the staggeringly high unmet need in acute pain. VX-five forty eight acts on the peripheral nerves to block the pain signal and thus may be able to provide effective pain relief without the abuse potential, which is a Central nervous system phenomenon. We have high expectations for this program because NAV1.8 is a genetically and pharmacologically validated target.

Speaker 2

2nd, we have multiple positive proof of concept results with VX-one hundred and fifty, a predecessor molecule to VX-five forty eight and proof of concept with VX-five forty eight itself. And lastly, our Phase 3 program in acute pain is substantially similar to the positive Phase 2 trials we have already conducted. The X-five forty eight has been granted fast track and breakthrough therapy designation in the U. S. We initiated pivotal development last year and we are enrolling patients across 3 Phase 3 studies with the goal of seeking a broad moderate to severe acute pain label.

Speaker 2

We anticipate completing the Phase III pivotal program towards the end of this year or the beginning of next, creating another potentially significant and near term commercial opportunity, which Stuart will also discuss. In addition to validation of NAV1.8 as a target in acute pain, it has also been validated as a target in neuropathic pain. I'm pleased to share That in late Q4, we initiated a 12 week Phase 2 dose ranging proof of concept study for VX-five forty eight in peripheral neuropathic pain. We look forward to updating you as this Phase 2 program progresses and to sharing more on the market opportunity on future calls. Transitioning now to enaxaplin or VX-one hundred and forty seven, the first potential medicine to target the underlying cause of APOL1 mediated kidney disease or AMKD.

Speaker 2

Post the positive Phase 2 proof of concept study, enaxoplin is now being studied in a single adaptive Phase twothree pivotal trial. This study has a preplanned interim analysis at 48 weeks of treatment, which, if positive, could serve as the basis to seek accelerated approval in the U. S. Our goal is to complete the Phase 2 dose ranging portion of the Phase twothree pivotal study this year, select a dose and then continue on to the Phase 3 portion. We are also working to increase awareness, screening and diagnosis through multiple initiatives given the high unmet need and the approximately 100,000 patients in the U.

Speaker 2

S. And Europe alone. With enaxoplin, we see the potential of bringing a 1st in class treatment to patients with AMKD and unlocking a multibillion dollar market opportunity. Moving to Type 1 diabetes, where our goal is to deliver a transformative, if not curative therapy for the more than 2,500,000 patients with Type 1 diabetes in North America and Europe. We are advancing multiple programs.

Speaker 2

First, VX-eight eighty's are stem cell derived, fully differentiated insulin producing islet cells, which use standard immunosuppressants to protect the cells from the immune system. These cells are also foundational for the other 2 T1D programs. For VX-eight eighty, we achieved proof of concept last year with the first two patients treated in Part A of the VX-eight eighty study. We have now fully enrolled Part B, where patients will receive the target dose on a staggered basis. The next phase is Part C, expected to initiate later this year, in which patients will be treated concurrently with the target dose.

Speaker 2

We look forward to sharing VX-eight eighty data from more patients and with longer duration of follow-up at medical congresses this year. 2nd, the X264 or the Cell Plus Device program, which encapsulates the same fully differentiated Insulin producing islet cells in a proprietary device that shields the cells from the body's immune system, and hence, there is no requirement for immunosuppressants. In late Q4, we simultaneously filed a CTA in Canada as well as the IND in the U. S. As we shared last month, the CTA has cleared, and we look forward to initiating enrollment and dosing of patients in Canada in the coming months.

Speaker 2

In the U. S, the IND has not cleared. We have received and responded to the FDA's questions. We look forward to working with the agency with urgency so that we can initiate the study in the U. S.

Speaker 2

As soon as possible. 3rd, in our hypoimmune program, we are editing the same fully differentiated insulin producing islets to cloak them from the immune system, another path to obviating the need for immunosuppressants. This program continues to progress in preclinical development. Let me close the T1D section with an update on the ViaSat acquisition through which we gained intellectual property, tools and capabilities that hold the potential to accelerate our goal of developing transformative treatments for this disease. We have now completed our data and portfolio review and are very pleased with the progress to date.

Speaker 2

We have begun executing our integration plans. On the clinical side, A Phase onetwo study of VCTX-two eleven, a hypoimmune cell program that originated with ViaCyte and that Vertex is now developing in partnership with CRISPR Therapeutics has been initiated and is ongoing. All other ViaCyte clinical trials have completed enrollment and dosing and are in the follow-up stage. I'll finish up with the Alpha-one antitrypsin deficiency or AATD program. Both a Phase 1 study of VX-six thirty four, The first is a series of next wave AAT correctors and a 48 week Phase 2 study of VX-eight sixty four, Our first generation AAT corrector are ongoing.

Speaker 2

We look forward to updating you as these programs advance. I'll now ask Stuart to review our commercial progress.

Speaker 3

Thanks Reshma. Today, I will review our continued strong performance and outlook in CF as well as potential near term commercial launches in new disease areas with Exacel and VX-five forty eight. Starting with CF, where we continue to bring our transformative medicines to many more patients globally. Last month, we raised our estimate for the number of patients with cystic fibrosis in the U. S, Europe, Australia and Canada to 88,000, up from our previous estimate of 83,000.

Speaker 3

The growth in the CF population can be attributed to more patients coming forward to receive treatment, better data capture in patient registries and perhaps most importantly, people with CF are living longer due to improvements in patient care and the availability of truly effective therapies. For a baby born with CF in 2021, The Cystic Fibrosis Foundation predicts the median age of survival is now 65 years. In the U. S, our focus remains on maintaining the very high persistence and compliance rates we have seen with our therapies and extending the benefits into younger age groups. Outside the U.

Speaker 3

S, uptake of CaFtrio Trikafta in countries with recent reimbursement agreements continues to drive growth, as has the rollout of CalfTrio in children ages 6 to 11 years in countries where this indication has recently received reimbursed access such as France and Spain. There are still more than 20,000 CF patients who could benefit from but are not on CFTR modulator treatment. These patients fall primarily into 2 categories: 1, patients in countries where we are early on the launch curve and 2, younger patients for whom we continue to pursue additional label and reimbursement extensions such as The recent U. S. Approval of ORKAMBI for ages 1 to 2 years and recent regulatory submissions for KALYDECO in children ages 1 to 4 months and for Trikafta in ages 2 to 5 years, which has received priority review and a PDUFA date of April 28 in the U.

Speaker 3

S. We are confident that we will reach the vast majority of these patients over time, which will continue to drive revenue growth in the near and long term. We also see exciting growth potential for our Vansacaftor triple combo given the anticipated clinical profile, more convenient once daily dosing and the potential to offer a new option for patients who have discontinued prior CFTR modulator therapy. Finally, in CF, as Reshma mentioned, our CFTR mRNA program, VX-five twenty two, is being developed for the more 5,000 CF patients worldwide who currently do not have any therapies that treat the underlying cause of their disease. I will now detail our commercial readiness efforts and the market opportunity for 2 potential product launches outside of CF, ExaCell and VX-five forty eight.

Speaker 3

ExaCell holds curative potential for patients with sickle cell disease and transfusion dependent beta thalassemia, and we are making significant progress with launch preparation activities. Our initial launch of Exacel will focus on the approximately 32,000 individuals in the U. S. And Europe for whom these diseases are most severe, presenting a significant clinical, humanistic and economic burden. The estimated 25,000 severe sickle cell disease patients have multiple hospitalizations annually for vaso occlusive crises, while the estimated 7,000 TDT patients undergo near monthly transfusions.

Speaker 3

There is also a considerable financial burden, both for these patients and to the healthcare system. In the U. S, economic models project the lifetime treatment costs for severe sickle cell disease patients to be between $4,000,000 $6,000,000 Recent market research indicates that physicians have a strong preference and interest in gene editing over other potentially curative approaches and that patients with sickle cell disease are increasingly optimistic about the potential role for curative therapies in the treatment of their disease. In addition, payers view the emerging clinical data for ExoCell as highly impactful, most notably the reductions in vaso occlusive crises and hospitalizations. Importantly for our specialty commercial model, These 32,000 severe patients are concentrated geographically and we believe can be served effectively with a network of approximately 50 authorized treatment centers or ATCs in the U.

Speaker 3

S. And approximately 25 in Europe. We have established the needed supply chain and manufacturing infrastructure to support the launch, including validated infrastructure to support the launch, including validated chain of identity and chain of custody systems, global shipping infrastructure and the needed manufacturing capacity to support uptake following approval. And finally, we continue to work with Key commercial and government payers and policymakers in the U. S.

Speaker 3

And Europe to ensure they understand the significant burden of these diseases and that broad patient access and reimbursement are in place if and when Exacel is approved. To date, we have engaged with all U. S. State Medicaid agencies, Some 150 unique U. S.

Speaker 3

Commercial payers as well as multiple health technology assessment bodies in Europe, including NICE and GBA to share important information about ExoCell and our commitment to working collaboratively to provide access to this therapy. Shifting now to VX-five forty eight, which we believe has the potential to play an important role across the pain spectrum, including acute pain and chronic pain conditions. I'll focus my comments on acute pain, which is a near term commercial opportunity. There are 4 aspects critical to framing the acute pain opportunity for Vertex. 1, there is a significant unmet need due to the limitations and drawbacks of currently available treatments.

Speaker 3

2, the market is large today even with 90% generic prescribing. 3, prescribing is concentrated in the hospital setting and thus addressable with a specialty commercial infrastructure And 4, there is broad stakeholder recognition of the need for new therapies, which also helps provide a clear path to future patient access and reimbursement. Firstly, millions in the U. S. Suffer from acute pain each year, yet it is often difficult to manage effectively given the limitations of existing therapies.

Speaker 3

The current standards of care are NSAIDs and acetaminophen at one end of the spectrum, which are non addicting, but offer limited pain relief and can pose GI and liver toxicity concerns. And at the other end of the spectrum are opioids, which provide effective pain relief, but have many undesirable side effects, including nausea and somnolence and have significant abuse potential. Many large hospital systems and all 50 states have adopted restrictions for the use of opioids. This leaves a vast gap in the treatment landscape for a medicine like VX-five forty eight with strong efficacy, a desirable benefit risk profile and without abuse potential given it is peripherally acting. 2nd, the acute pain market is very large valued in the U.

Speaker 3

S. At $4,000,000,000 despite 90% of prescriptions being generic. 3rd, this highly concentrated market can be served with a specialty commercial model. Of the 1,500,000,000 treatment days for acute pain annually, some 2 thirds or 1,000,000,000 are driven by hospital prescribing, following inpatient or outpatient procedures such as surgeries or emergency room visits. Furthermore, these hospital driven prescriptions are concentrated among 1700 hospitals that aggregate to roughly 220 integrated delivery networks.

Speaker 3

Thus, we believe we can reach a large Proportion of this market with a specialty sales and marketing infrastructure and have begun to hire for key positions. 4th and finally, Given the wide stakeholder recognition of the limitations of current treatments and the unmet need, we see both high demand and a clear path to access and reimbursement for a medicine with a profile like VX-five forty eight. A key example of the path to reimbursement and access is the recently passed No Pain or Non Opioids Prevent Addiction in the Nation Act signed into law last December. Through the No Pain Act, Congress has directed CMS to make a separate add on payment to hospitals in the outpatient and ambulatory surgery center setting for non opioids for the treatment of pain. We believe this new law is an important sign of the growing movement to remove barriers for hospitals, providers and patients to utilize non opioid treatment options.

Speaker 3

In closing, we are excited about the to extend the benefits of our CF medicines to more patients around the globe and the near term potential to commercialize transformative treatments for patients with sickle cell disease, beta thalassemia and acute pain. I will now turn the call to Charlie to review the financials.

Speaker 4

Thanks, Stuart. Vertex's 4th quarter and full year 2022 results represent another year of strong execution and exceptional financial performance. 4th quarter 2022 revenue increased 11% year over year to $2,300,000,000 Growth was led by a 24% year over year increase outside the U. S. On continued strong uptake of Trikafta Captrio in markets with recently achieved reimbursement as well as label extensions into younger age groups.

Speaker 4

U. S. CF revenue grew 5% year over year with ongoing consistent performance. Full year 2022 revenue of $8,930,000,000 represents 18% growth versus 2021, marking Vertex's 8th consecutive year of at least double digit revenue growth. Full year 2022 international revenue of $3,230,000,000 increased 41% and full year U.

Speaker 4

S. Revenue of $5,700,000,000 increased 8% compared to 2021. For the full year 2022, we estimate the changes in foreign exchange negatively impacted our global revenue growth rate by approximately 1.5 percentage points, inclusive of our foreign exchange risk management program. 4th quarter 2022 combined non GAAP R and D, acquired IP R and D and SG and A expenses were $872,000,000 an increase of 5% compared to the Q4 of 2021. Full year 2022 combined non GAAP R and D, acquired IP R and D and SG and A expenses were $3,070,000,000 a decrease of 11% versus the prior year.

Speaker 4

Recall that 2021 results were impacted by $1,100,000,000 of acquired IP R and D charges, including the one time $900,000,000 payment to CRISPR compared to $116,000,000 of such charges in 2022. Acquired IPR and D aside, throughout 2022, we continued to invest in research and our advancing pipeline, which includes mid and late stage clinical assets across 8 different disease areas. The year over year increase in spending reflects Stepped up investments in programs where we made notable clinical progress, particularly in pain, the NuVANZA triple as well as type 1 diabetes. We also continued to invest in the pre commercial build out activities for Eksocell in preparation for other potential near term launches. Given these programs potentially transformative benefit to patients and multibillion dollar market opportunities, we will continue to invest accordingly.

Speaker 4

4th quarter 2022 non GAAP operating margin was 50% and we generated non GAAP operating income of $1,150,000,000 in the quarter, an increase of 15% versus the prior year period. Full year 2022 non GAAP operating margin was 54% and full year non GAAP operating income was $4,790,000,000 up 48% versus 2021. We ended the quarter with $10,800,000,000 in cash and investments as our cash flow generation and balance sheet remained very strong. On the business development front in Q4, we announced a global collaboration with Entrada Therapeutics focused on therapeutics for DM1. The HSR period expired last night and the transaction is expected to close within days.

Speaker 4

As a result, our Q1 2023 results are anticipated to include an approximate $224,000,000 upfront payment recorded in our income statement and an approximate $26,000,000 Equity investment recorded on the balance sheet. Now switching to guidance. We are establishing 2023 product revenue guidance of $9,550,000,000 to $9,700,000,000 representing 7% to 9% year over year growth at current exchange rates. Note that this guidance includes an expected approximate 1.5 percentage point headwind to our revenue growth, inclusive of our foreign exchange risk management program. Also note that 2023 product revenue guidance reflects revenue from cystic fibrosis products only.

Speaker 4

AGSYSEL is not included in guidance as potential approval and launch dates in the EU, UK and U. S. Are still to be determined. For our CF franchise in 2023, We see continued strong performance of TrikaftaKheptrio in all major markets, further uptake in markets with recent reimbursement agreements and expansion into younger patient populations. Of note, with 4 years of Trikafta experience, the majority of international reimbursement agreements secured And recent revisions in epidemiology, we have strong visibility to our 2023 revenue guidance range and another year of attractive growth for our CF product portfolio.

Speaker 4

We are also providing 2023 guidance for combined non GAAP R and D, acquired IP R and D and SG and A expenses in a range of $3,900,000,000 to $4,000,000,000 which includes approximately $300,000,000 of upfronts and milestones from known collaborations, including the expected upfront payment in Q1 2023 for ENTRATA. This targeted investment increase is consistent with the significant Continued progress of our multiple mid and late stage clinical development programs and the expansion of our commercial and manufacturing capabilities in anticipation of the multibillion dollar market opportunities represented by our programs with near term launch potential. Our guidance for projected full year 2023 non GAAP effective tax rate is a range of 21% to 22%. Lastly, we announced today a new $3,000,000,000 multiyear share repurchase authorization. In closing, Vertex performed exceptionally well in 2022.

Speaker 4

We grew revenue double digits for the 8th consecutive year, maintained our strong balance sheet, invested internally and externally and accelerated programs across our diverse pipeline. In 2023, we look forward to further important milestones as highlighted on this slide to mark our continued progress in multiple disease areas. We look forward to updating you on future calls and I'll ask Susie to begin the Q and A period.

Operator

We will now begin the question and answer session. And at this time, we'll pause momentarily to assemble our roster. And the first question will come from Salveen Richter with Goldman Sachs. Please go ahead.

Speaker 5

Good afternoon. Thanks for taking my question. Can you frame what we're going to see from the VX-eight eighty program this year and when? And also on the second program, the cells and device program, how you overcome challenges here and your confidence level that You'll be able to kind

Speaker 6

of get to the bars that you want to see.

Speaker 2

Yes. Hey, thanks for the question, Salveen. With regard to the 880 program, remember this is the program that is, let's call it, the naked cell program that requires off the This is the program that we demonstrate proof of concept with the half dose patients last year. Where we are now is we fully enrolled this Part B, that's where patients receive the target dose, but in a staggered manner. And the real importance here is and our excitement is to get to Part C because then we can dose patients concurrently.

Speaker 2

You should expect data this year at congresses, and there are a couple of important diabetes congresses that occur each year that will have longer duration of follow-up and more patients' worth of data And the dimensions on which you can expect us to share information are what we've already done with the first two patients. That's to say, see peptide levels, decreases in exogenous insulin, improvements in hemoglobin A1C. With regard to the cells and device program, historically in the field, the challenge with devices has been fibrosis, Lack of oxygen getting to the cells inside these devices as well as the inability for nutrients to go in and for insulin in this instance to be secreted out. We have worked long and hard to develop a proprietary, what we call a channel array device. This device has particular features in terms of geometry, materials and proximity of blood and oxygen to ourselves to overcome these historic barriers.

Speaker 2

And what I'll say to just give you a little bit more on this Point is in small animal models and large with our proprietary device, we have seen no evidence of fibrosis. Last thing to point out, of course, the same 8 80 cells that we've already shown proof of concept with, those are the same cells in the CellPlus device presentation as well as in our hypoimmune presentation.

Speaker 6

Thank you.

Operator

The next question will come from Geoff Meacham with Bank of America. Please go ahead.

Speaker 7

Hey, everyone. Afternoon and thanks for the question. Just have 2. For VX-five forty eight, Is the communication strategy here to have all the Phase 3 data in acute pain and neuropathic pain and then disclose everything before filing? I wasn't Sure what the plan was there.

Speaker 7

And then Stuart, given the hospital setting, what role do you think that treatment algorithms and cost benefit studies will play commercially. This is obviously a pretty different market than you guys are typically used to. And then for 5/22, I don't have a doubt that you guys can express CFTR, but obviously has to be in the right tissues. Can you talk maybe about The technical challenges here with an mRNA strategy and your development plan just at a high level. Thank you.

Speaker 2

Yes, sure thing, Jeff. Let me start with the VX-five twenty two question, which is the mRNA program that we are developing in collaboration with Moderna, and then we'll switch to the Vx548 program in pain. So With regard to VX-five twenty two and the mRNA program, the biggest challenge we and others have faced Through the development of this approach for those last 5,000 patients who cannot benefit from CFTR modulators because they simply don't make any protein, It's been delivery. That is really what we have been working on for years and it was only about 12, 18 months ago that we really had a big breakthrough in that area. The reason for our excitement for this program Is that we can now deliver with our LMPs into our HBE cells using those same assays that are not only qualitatively translated to what we see in the clinic, but quantitatively so.

Speaker 2

2nd, We also can show that the protein expression levels with that mRNA delivery is high with high chloride transport. That's the direct readout for CFTR function. And then lastly, we have taken this mRNA LNP construct and administered it to small animals and large and we can deliver it to the right self. That's a really important part of doing this in patients. So that's the Technical challenges we've overcome and it's really been all about delivery.

Speaker 2

With regard to VX-five forty eight, yes, you're right. The plan is to complete the studies, all Phase 3 studies, the 2 RCTs, which are very similar to what we've already done in Phase 2 and the one single arm study, let's call it an all comers study, so we get different pain types. We are projecting that we're going to complete those Trials towards the end of this year, beginning of next, and we'll share all the data at the same time. Stuart, over to you for commercial potential.

Speaker 3

Yes. So, Jeff, as we've described before, this is a very big market opportunity with 1,500,000,000 treatment days of acute pain therapy prescribed per year. Just to dimensionalize that, I talked in my prepared remarks about 2 thirds of those prescriptions are either written and dispensed in a hospital or institution or ambulatory care center or they are written in the institutional setting, But given to a patient on discharge and therefore filled in the retail setting and the combination of those two Accounts are about 2 thirds of the 1,500,000,000 treatment days. When we've talked to stakeholders across the board, they are well aware of the unmet need for new therapies in the acute pain space. Because all institutions and all states have put in place Restrictions on the use of opioids, it's created this gap in the market for products like 548 that have a really positive benefit risk profile.

Speaker 3

I do think we are beginning to see a sea change in terms of policies which have been focused on limiting utilization of opioids to actually policies which are looking to remove barriers that might be created by cost sensitivity. And I'll point you to the No Pain Act, which I referred In my prepared remarks, that directs CMS to develop a system of add on payments for non opioid pain medicines in addition to The bundled payment that they give to hospitals for the outpatient and the ACS setting, I see that as a really important sea change and recognition that these are cost sensitive segments, but this is a way of creating barriers or sorry, reducing barriers or creating incentives to do the right thing and prescribe non opioid pain management when they're available.

Speaker 2

Hey, Jeff, this is Reshma again. To close out on pain, and others may ask questions later, but I just wanted to make sure I also mentioned the peripheral neuropathic pain with BX-five forty eight. That Phase 2 study also began last year, and those results, we aren't calling yet when they would be available, but I wanted to make sure that you know that that Study is also ongoing.

Speaker 7

Great. Thank you.

Operator

The next question will come from Phil Nadeau with Cowen. Please go ahead.

Speaker 8

Good afternoon. Thanks for taking our question and congrats on the progress. Question on the expense side from us. It does seem like the guidance for costs for 2023 is a bit heavier than we had anticipated. And even excluding the Entrada upfront, it does seem like costs are growing a bit faster than revenue.

Speaker 8

So Curious what are the push pulls in the guidance? What elements are you including in the guidance? Is there investment for pre launch, more heavy investment in R and D? Just kind of looking for a little bit more color on what is causing the expenses to rise so much. Thank you.

Speaker 2

So I'm going to ask Charlie to take that one.

Speaker 4

Yes, Phil, thanks for the question. And just so you get an overall sense of where we're thinking about things. Given the strong and predictable performance in CF And the recent success of the advancing pipeline with a number of 1st in class and best in class assets, including programs with significant near term potential commercially. We see this as absolutely the right time to be investing in the business. If you look at 2023 specifically, over 70% of the planned increase in R and D and SG and A is expected in programs which are past POC and therefore meaningfully derisked.

Speaker 4

Specifically, we've got trials for VANSA and pain and AMKD and Type 1 diabetes. You've got the full year cost of the investments in commercial readiness for sickle cell and beta thal and we're making commercial investments for pain as well. Importantly, all of these programs are advancing rapidly and represent multibillion dollar market opportunities. So from our perspective, it's the right time to invest. And the good news is that with our differentiated business model, we can deliver industry leading profitability while we're investing for innovation and growth.

Speaker 8

Maybe one follow-up. Is there a long term goal for either operating margins or R and D and SG and A as a percent of sales?

Speaker 4

No, we have not established a long term goal.

Speaker 8

Great. Thanks for taking our questions.

Operator

The next question will come from Lisa Bacow with Evercore ISI. Please go ahead.

Speaker 6

Hi there. Could you just, talk a little bit More about BTCE-two ten versus 211. I noticed before, you were a little bit more focused on Now we're talking about 211 and 1. What's the right form for data for there? What and what should we be expecting to see?

Speaker 2

Yes, sure. Lisa, this is Reshma. VCTX211, a bit of a mouthful, is the Study that Vertex is now running in collaboration with CRISPR Therapeutics. It's a hypo immune program for Type 1 diabetes, where we're going to be assessing safety and efficacy. VCTX-two ten was a safety study.

Speaker 2

In terms of when you should expect data readouts and such, this study is just getting going. We haven't called when we will be sharing results, but it is just Getting going.

Speaker 6

Okay, great. And then just a quick question, two quick questions actually on regarding the CF franchise. Can you talk about the new 88,000 patients? Is that kind of equally distributed amongst the key world regions? Are you Seeing that more in certain areas than others.

Speaker 6

And then, as for the long term patents, how should we be thinking about exclusivity for Vansacaftor. And then I noticed you even have a next gen after Vansacaftor and maybe you can enlighten us about market exclusivity there. Thank you.

Speaker 2

Yes, sure. Lisa, let me tackle the IP questions and then I'll turn it over to Stuart to talk about the CF Epidemiology, the patent for Trikafta goes out to at least 2,037. And the reason if you're wondering, gosh, how is it so long from when we launched, it's because of the rapid pace from when we had synthesize this molecule in the lab to when we got approval starting with the U. S, which is about 3 years, 8 months or so. The Vansacafta triple, we haven't given a specific date, but it's longer than the Trikafta compound.

Speaker 2

And we have indeed identified potentiators and correctors behind vansacaftor towards our goal of getting CF patients to, sweat chloride levels in the carrier range and those would be even longer than vansacaftor. Let me turn it over to Stuart for CF EPI.

Speaker 3

Yes, Lisa. So as you said, we updated our estimate for the number of people living with CF to 88,000 for North America, Europe and Australia. That's an increase from our Previous estimate from a couple of years ago of 83,000. It's really driven by 3 things: more patients coming forward for treatment, better data capture and more complete data capture in registries around the world and perhaps most importantly, Patients with cystic fibrosis are living longer due to improvements in the quality of care over the years and also The availability of truly effective medicines. We see those trends occurring kind of across the globe in all of the regions that I mentioned.

Speaker 3

It's not just in one part of the world. Those trends are consistent and I have to say we anticipate those trends will continue into the future.

Speaker 6

Great. Thank you very much.

Operator

The next question will come from David Risinger with SVB. Please go ahead.

Speaker 9

Yes, thanks very much. So my question is on VX-five forty eight. I guess, first, could you talk about publication plans for detailed Phase II results in 2023. And if you are planning publications, what incremental points should we be expecting to focus on. And with respect to the commercialization scenarios, there's one in which VX-five forty eight is non inferior to active control and then another in which it's superior to active control.

Speaker 9

So it would be helpful to just understand the commercial opportunities in those two different scenarios. And then one final tidbit for Charlie, Non GAAP IPR and D was $116,000,000 in 2022. What is the figure that's incorporated in your guidance for 2023, please? Thank you.

Speaker 2

All right. Dave, you've given us 3 different questions here. Let me save the 2 related to 548 and let me ask Charlie to talk about the IPR and D.

Speaker 4

David, the guidance includes an estimate of $300,000,000 for IPR and D and that's inclusive of the upfront for ENTRATA.

Speaker 2

Let me now move to 548. Dave, I'm going to tell you a little bit more about the publication strategy and the Study design, I'm going to ask Stuart to tell you about the commercial potential and how we see it depending on the two scenarios that you laid out. 548 and this target in particular, NAV1.8 has been the Holy Grail, NAV1, 7 and 1, 8 in the pain field for many, many years. And for that reason, because we are the 1st company to come forward with a highly specific and effective treatment that has shown effectiveness in Phase 2 across multiple Pain models, not only with 548, but its predecessor molecule, the interest level in the community is very high. And our intent is to publish the full Phase 2 data of abdominoplasty and bunionectomy in a high profile journal, this year.

Speaker 2

With regard to what additional information you will be able to look at, honestly, the key information we've already revealed in our press release. That is to say, highly efficacious, statistically significant, clinically meaningful results versus placebo, and we've also already shared the numerical results for the Opioid control arm and you can while the control I'm sorry, the context arm, while that reference arm wasn't there for Statistical comparisons, you can clearly look and see what the context is there. And you'll have the full safety. The safety profile for 548 is really looking very good. You might remember There were no related SAEs in the Phase 2 study.

Speaker 2

In fact, there were no SAEs at all in bunionectomy. With regard to the study design, the way we set it up is that it is a study versus placebo, superiority versus placebo. Obviously, that's there to demonstrate the efficaciousness as well as the safety profile. And then we have the opportunity to also assess versus opioids. Jack, what are we looking for?

Speaker 2

If we recapitulate the results in Phase 2, that is a home run. Stuart?

Speaker 3

Yes. As Reshma said, about the design of the study, the primary endpoint is the comparison to placebo and then we can compare it to the I think in either scenario that you described, Dave, what we've got here is a very significant commercial opportunity. If you are In addition to being superior to placebo as good as opioids from an efficacy point of view without all of their associated liabilities, which include addictive potential but aren't restricted to just addictive potential, then that is something that's going to be highly valued by the treating community. Obviously, if we're superior, That's even better, but something which is as good as opioids from an efficacy point of view, but without all the liabilities would be a very high value medicine.

Speaker 9

Thank you.

Operator

The next question will come from Robyn Karnauskas with Truist. Please go ahead.

Speaker 10

Hi. Thank you so much. All right. I'll go quickly. So we get a lot of questions on Vertex growth, even despite you have a robust pipeline.

Speaker 10

Maybe talk about Your thoughts around this 8% and if you would think that would continue to slow, or how you're thinking about it? And then With regard to next generation, despite like more robust efficacy, it still took some time to switch people over to the next generation product, maybe some color on What the bar might be to speed up switching? And then my last question was on chronic pain. I mean, you've got a lot of QPain Data and Hows, more to come. I was just curious, is chronic pain partnership still on the table and what you think Partners are really looking for in order to take that forward.

Speaker 10

Thank you.

Speaker 2

Yes. Robin, let me ask Stuart to go first with CF and talk about how we see Vansacactor And the place for that in the marketplace.

Speaker 3

Yes. So, Robin, on vansacaftor, as you know, based on Our in vitro data, but also our Phase 2 data, we have good reasons to believe that the Vansacafta triple combination could provide Incremental clinical benefit even over Trikafta, which as you know sets a very high bar and that's the way the study is designed to be able to compare Vansacaftor to Trikaftor. I think there's really 2 patient populations for whom that would be An attractive proposition if it delivers that profile. 1 is patients who are currently being treated with a CFTR modulator who may be interested in switching to something which offers greater In addition, we haven't really talked about this part of the population for a while, but there are some patients who've discontinued CFTR Our persistence rates with our CFTR modulators are, Let me just reemphasize as high as I've ever seen for any chronic oral medication, but we do have patients who have discontinued over time. And so I think those patients who want to be on a CFTR modulator, but have had to discontinue one of our previous generations may be interested in The Vansacaftor triple combination when a new treatment option is available.

Speaker 3

So I do think there is likely to be significant interest from physicians and patients if the vansacaftor triple combination delivers incremental benefits.

Speaker 2

Robin, let me take the question about chronic pain next and we'll end with growth. We see pain as 3 distinct categories. Acute pain, that's what we've been talking about with 548 and this very near term commercial opportunity given we are well underway with our Phase 3 program and it is only 48 hours of dosing. The second we see is neuropathic pain. Obviously, that's a version of chronic pain, but we distinguish that from musculoskeletal pain.

Speaker 2

For neuropathic pain, I see that as equally a Vertexian opportunity as is acute pain. There is a there are discrete number of prescribers. It can be serviced with a specialty sales force And we have already shown that this target, NaV1.8 with our predecessor molecule, VX-one hundred and fifty is effective for neuropathic pain. When Lyrica was a branded medicine, just to give you a sense of the market size, it was approximately a $5,000,000,000 market for Lyrica in this chronic neuropathic pain. And then there's the 3rd kind of pain, which is musculoskeletal pain.

Speaker 2

It turns out that we've already studied that as well with our predecessor molecule and it's effective in that kind of pain setting as well, which is actually quite unusual. There aren't very many medicines that work in acute neuropathic and musculoskeletal pain. We are I don't see the musculoskeletal pain as a vertex sales and marketing Specialty opportunity, but we're absolutely going to serve all patients and we would partner that. But our focus is on the 2 Vertexian opportunities right in front of us, Acute pain, very near term and the neuropathic pain that's already in Phase 2 and the predecessor molecule was successful there. With regard to growth, let me ask Charlie to comment on the growth profile for the company.

Speaker 4

Yes. The question so just a reminder on the guidance we gave 9.55% to 9.7%, 7% to 9% growth over 2022 and that's after a 1.5 percentage point headwind from FX. Stating it differently, it's a $700,000,000 increment on our 2022 revenue of $9,000,000,000 so a significant increase in 2023. I think your question really was about where does growth come from. And so importantly, as has been mentioned, we've recently increased Our estimate of epidemiology from several years ago, we used to say 75,000, then it was 83, now it's 88, so the patient population is growing.

Speaker 4

Within that patient population, there are 20,000 patients or more who would benefit from a CFTR modulator who are not on medicine today, and we intend to bring as many of those as possible onto medicine as we go with continued uptake across Eligible patient groups in countries where we already have reimbursement or approvals as we expand to younger age groups and to a lesser extent as we add additional new reimbursements. And so we have high visibility into our guidance for 2023 and with those drivers we see growth beyond 2023 as well and of course we have the emerging opportunity from the Vansa triple And the mRNA therapy in coming years. So overall, we're in great position for continued growth in 2023 And we see lots of opportunity for growth beyond 2023.

Speaker 2

Robin, I'll just add. We've Talking about long term growth, our 5 and 5 goal, this is 5 new medicines Since launching in the next 5 years. And then if you think about what qualifies in there, The very near term opportunities are excess cell and sickle cell disease and beta thalassemia, vancicaptor in CF MDX-five forty eight in pain, those are just right in front of us. And then we have AMKD that's in Phase twothree with 1 hundred and forty seven, The Type 1 diabetes program that we spoke about, the neuropathic pain program that we spoke about, and there's also the mRNA program and the AATD program, which is also in Phase 2.

Operator

The next question will come from Mohit Bansal with Wells Fargo. Please go ahead.

Speaker 11

Great. Thank you very much for taking my question. And Maybe can you talk a little bit about the capital allocation priorities? I know you announced a buyback program today, but Your 2022 year end cash is almost 14% of your market capitalization at this point. Do you think Outside of internal R and D, you could think about some mid sized acquisition at this point given the cash position and the market at this point?

Speaker 11

Thank you. Charlie?

Speaker 4

Yes, Mohit, thanks for the question. On capital allocation, it probably sound like a broken record, but our Priorities are the same, investing in innovation, both internal and external is the top priority.

Operator

We clearly see that as

Speaker 4

the best way to create value for patients and for shareholders. We have, for the last 5 years now maintained share buyback program where we focus on offsetting dilution from employee share programs and for Some opportunistic buying. And so we have this new larger authorization at $3,000,000,000 but it's simply a reflection of the growing strength of our balance sheet and cash flow.

Operator

Thank you. The next question will come from Michael Yee with Jefferies. Please go ahead.

Speaker 12

Hey, guys. Thanks. Appreciate it. Two pipeline questions for you. One on the Vansa Triple.

Speaker 12

I know that you have commented that you think it could be better. I recall that in the Phase 2, there was, although difficult to compare across trial, Debate around whether it's truly better on FEV or more about Treclorin and you would see the effects, I think more peripherally. Can you just comment on whether you actually think FEV actually would be better in the Phase 3 given the chloride transport data is so much better? I know David Altschuler I have some short comments on that. And then on the mRNA program 522, I think you made a nice comment earlier in this call about how At least in animal models that was getting into tissue.

Speaker 12

Can you just reiterate what you were saying about Your view of or testing in Hb assays about whether the LNP is actually getting in and how confident you are in CF tissue that the LNP is getting in?

Speaker 2

Thank you. Yes. Sure thing, Mike. With regard to the Vansa triple, If you look at the Phase 2 data and you're right, these are cross study comparisons, but if you're trying to glean and get a general sense for what the data are telling you, In the Phase II trials, what you can see is on average the VANZA triple compared to what we have shown with Trikafta, it's about 5 points better on sweat chloride. And if you look closely And, look at the PPFEV1 values that we've generated.

Speaker 2

There are some patients in the Vansa Triple, where we've seen 20% improvement in PPFEV1. So if you ask me, gosh, can the Vansa Triple be better than Trikafta? Yes. And I would say that the strongest evidence for that is the chloride transport in our HPE assays, which have proven themselves time and time again, as well as sweat chloride because that's simply a less variable measure. But if I look at PPFEV1, there are hints of that as well.

Speaker 2

But I would Put that lower on the scale of evidence because the variability is greater. With regard to mRNA and why we are I'm so enthusiastic about this program, which we are running in collaboration with Moderna. It is really a combination of 3 things. The first is the ability to demonstrate that with these LNPs, we get the construct into the HPE cells. And that's important because of how reliable the HBE cells are and how translatable they are.

Speaker 2

2nd, it is about the high expression of the protein. And 3rd, in multiple animal models, we can show and this has been difficult for others to show. Some have not talked about it and It's been difficult to gather whether they have or have not, but I can tell you we have in multiple animal models demonstrated That the mRNA gets to the right cells in the lung.

Speaker 12

Perfect. Thank you, guys.

Operator

The next question will come from Jessica Fye with JPMorgan. Please go ahead.

Speaker 5

Great. Thanks for taking my questions. Just a Couple of quick ones, maybe following up on the last. First, with the SAD trial for VX-five twenty two completing this year. Should we expect to see data from that trial this year or might not come until later once the MAD work is complete?

Speaker 5

And similar question on the Phase twothree kidney trial. You said you expect to complete the Phase 2b dose ranging portion

Speaker 10

this year. What will we hear

Speaker 5

at that Will we hear anything beyond that a dose has been selected? Will you communicate what that dose is? Thank you.

Speaker 2

Yes. Hi, Jess. With regard to the SAD MAD VX-five twenty two in CF, We do expect that the SAD will complete this year and it's hard to say that we're going to see an effect because it is a single dose Study, right. But we've been wrong before. When patients started on Trikafta, for example, They tell us they felt differently with the first dose.

Speaker 2

So, we do expect that the SAD will finish and we fully expect to initiate the MAD as well. And I do think that we will have a good line of sight on efficacy with the MAD. So, we're not guiding yet to when the data will be available, but we do expect to finish the SAD. We expect to initiate the MAD. And Yes, it's possible that data will be ready this year.

Speaker 2

On the VX-one hundred and forty seven program enaxaplin And the Phase twothree study, you'll remember this one is particularly exciting because it's in kidney disease where there has been unfortunately very little advancement and there are really no products in development for APOL1 mediated kidney disease and our Phase 2 results showed a 47.6% reduction in proteinuria, which is unprecedented in Let alone in APO-one mediated FSGS. We do expect that the Phase 2 part of the study will be done this year Because it's an ongoing study, it's an adaptive twothree, which means we'll roll right into the Phase 3 once dose selection is made. I do not expect that we will be sharing results to maintain study integrity, but we will be sharing that we've completed that portion, we've selected a dose and we've rolled into Phase 3.

Speaker 1

Thanks, Chuck. We'll take one more question.

Operator

The next question will come from Excuse me, Evan Seagraman with BMO Capital Markets. Please go ahead, sir.

Speaker 7

Hi, guys. Thank you so much for squeezing me in at the end. I wanted to ask On the IND for the Cells Plus device program for type 1 diabetes, can you provide kind of any color as to what exactly the FDA wants? And maybe color as to why Canada was more comfortable with moving into humans versus the FDA? Thank you.

Speaker 2

Yes. Evan, this is about cells plus device VX264 in type 1 diabetes. This is the program using the same cells as the 880 program, but encapsulated in a device so immunosuppressants are not necessary. The most important thing to tell you is we've received the questions and we've already responded. No new data needed to be generated.

Speaker 2

No new experiments needed to be run. The questions and clarifications were ready at hand. Evan, if Why was one regulatory agency more comfortable than another? That's just a tough question to answer and I don't know that I have a good answer for you. What I can tell you is that it's a high quality submission and we are very excited to get this up and running with patients enrolled and dosed in Canada and we're working with urgency to get the study in the U.

Speaker 2

S. As well.

Speaker 12

Great. Thank you.

Speaker 1

Thanks, everyone. Chuck, will you please give the replay information?

Operator

Yes, ma'am. The conference has now concluded, and thank you for attending today's presentation. A replay of today's event will be available shortly after the call concludes by dialing 1-eight seventy seven-three forty four 7,529 or 1-four twelve-three seventeen-eighty eight. And you can use the replay access code, which is 6,823,854. Again, that access code is 6,823,845.

Operator

Thank you.

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Earnings Conference Call
Vertex Pharmaceuticals Q4 2022
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