Absci Q1 2024 Earnings Report

Absci EPS Results

• Actual EPS: -$0.22
• Consensus EPS: -$0.19
• Beat/Miss: Missed by -$0.03
• One Year Ago EPS: -$0.26

Absci Revenue Results

• Actual Revenue: $0.90 million
• Expected Revenue: $2.50 million
• Beat/Miss: Missed by -$1.60 million
• YoY Revenue Growth: N/A

Absci Announcement Details

• Quarter: Q1 2024
• Date: 5/13/2024
• Time: Before Market Opens
• Conference Call Date: Tuesday, May 14, 2024
• Conference Call Time: 8:00AM ET

Absci (NASDAQ:ABSI) (NASDAQ: ABSI) is a biotechnology company that applies machine learning, synthetic biology and automation to accelerate the discovery and development of protein-based therapeutics. The company’s Integrated Drug Creation® (IDC®) platform is designed to identify and produce novel antibody and enzyme candidates at speeds and scales that traditional biopharma discovery methods cannot match. Absci works with pharmaceutical and biotechnology partners to generate, screen and optimize protein molecules for a wide range of therapeutic applications.

The core of Absci’s offering is its end-to-end discovery engine, which combines proprietary algorithms, high-throughput laboratory automation and a deep learning framework. By integrating AI-driven protein design with advanced screening processes, the company seeks to rapidly advance promising biologic candidates from concept through lead optimization. Absci’s platform supports research in areas such as oncology, immunology and metabolic disease, providing partners with drug-like protein candidates and data insights that can de-risk preclinical development.

Founded in 2018 and headquartered in Seattle, Washington, Absci maintains collaborative relationships with multiple global pharmaceutical organizations and operates additional research facilities in the United States. The company’s leadership team brings together experts in protein engineering, data science and drug development, aiming to transform biologics discovery through technological innovation. As Absci continues to expand its pipeline partnerships and platform capabilities, it remains focused on delivering scalable solutions for the next generation of protein therapeutics.

Absci Q1 2024 Earnings Call Transcript

Key Takeaways

• Absci has adopted a hybrid business model that combines partner programs with an internal pipeline and will host quarterly business update calls to share progress and engage with investors.
• The company’s integrated platform of scalable biological data, AI-driven de novo antibody design and WetLab validation delivers candidates in 14 months for under $5 million, compared to industry norms of 3+ years and $30–50 million.
• Lead internal program ABS-101, an anti-TL1A antibody engineered for epitope-specific monomer/trimer binding, has shown high affinity, extended half-life and favorable developability, and is now in IND-enabling studies with Phase I expected in early 2025.
• In Q1 2024, Absci raised about $86.4 million in a public offering, ended the quarter with $161.5 million in cash, and projects a gross cash burn of ~$80 million for 2024—providing a financial runway into mid-2027—while targeting at least four new partnerships this year.
• Additional internal assets include ABS-201 (dermatology) and ABS-301 (first-in-class immuno-oncology), with lead candidate selection and mode-of-action validation expected in H2 2024, plus plans to advance at least one more program to lead stage.

Presentation

[Operator]

Ladies and gentlemen, thank you for standing by. Welcome to Absci First Quarter 2024 Business Update Call. At this time, all participants are in a listen-only mode. After the speaker's presentation, there will be a question-and-answer session. To ask a question during this session, you will need to press star one one on your telephone. You will then hear an automated message advising your hand is raised. To withdraw your question, please press star one one again. Please be advised that today's conference is being recorded. I would like now to turn the conference over to Alex Khan, Vice President, Finance and Investor Relations. Please go ahead.

[Alex Khan, VP of Finance and Investor Relations at Absci]

Thank you. Earlier today, Absci released financial and operating results for the quarter ended March 31, 2024. If you haven't received this news release or if you would like to be added to the company's distribution list, please send an email to investors@absci.com. An archived webcast of this call will be available for replay on Absci's Investor Relations website at investors.absci.com for at least 90 days after this call. Joining me today are Sean McClain, Absci's Founder and CEO, and Zach Jonasson, Chief Financial Officer and Chief Business Officer. Christian Stegmann, Absci's SVP of Drug Creation, will also join for Q&A following prepared remarks. Before we begin, I'd like to remind you that management will make statements during this call that are forward-looking within the meaning of the federal securities laws.

[Alex Khan, VP of Finance and Investor Relations at Absci]

These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated, and you should not place any undue reliance on forward-looking statements. Additional information regarding these risks, uncertainties, and factors that could cause results to differ appears in the section entitled Forward-Looking Statements in the press release Absci issued today, and the documents and reports filed by Absci from time to time with the Securities and Exchange Commission. Except as required by law, Absci disclaims any intention or obligation to update or revise any financial or product pipeline projections or other forward-looking statements, either because of new information, future events, or otherwise. This conference call contains time-sensitive information and is accurate only as of the live broadcast, May 14, 2024. With that, I'll turn the call over to Sean.

[Sean McClain, Founder and CEO at Absci]

Thanks, Alex. Good morning, and thank you to everyone for joining us today for our first business update conference call since 2021. A lot has changed since then. While we have been active at investor conferences and other venues sharing our progress, we are excited to welcome you to our quarterly update call, which we'll host on a regular basis moving forward. There are a few reasons for this change. Among them, we are pleased with the expansion of our shareholder base and research analyst coverage. We want to provide an open setting to share our latest progress in details and allow for interactive dialogue. Additionally, our business model previously revolved almost exclusively around partner programs, where our communication was influenced by our partner. Our new hybrid business model, including our internal pipeline, gives us more opportunity to discuss the exciting progress we are making on each program.

[Sean McClain, Founder and CEO at Absci]

With that in mind, I'd like to begin with a brief recap of the achievements we made in 2023 before discussing our progress in 2024. Later in the call, Zach will provide more detail on the status and outlook for each of our internal programs and our business as a whole. We are often asked about our differentiating features, what sets us apart, and positions us as leaders in AI drug discovery for biologics and a partner of choice across the industry. Any discussion of our Integrated Drug Creation Platform starts and stops with the data. The ability to generate and screen massive amounts of scalable biological data is an industry breakthrough that enables our platform to operate as it does.

[Sean McClain, Founder and CEO at Absci]

Based on these pillars of data to train, AI to create, and wet lab to validate, our platform is designed to continuously learn and improve as a result of our data generation capabilities and integration with our wet lab operations. Looking back on our accomplishments from the first quarter of 2024, it is clear they were only made possible due to the groundwork laid by our dedicated team in the previous year. The ability of our platform to rapidly design and create differentiated antibody candidates in a capital-efficient manner while achieving epitope specificity, is a direct result of our team's efforts through 2023. We started 2023 with the release of a foundational manuscript demonstrating a first in creating and validating de novo antibodies with zero-shot generative AI.

[Sean McClain, Founder and CEO at Absci]

Over the year, we expanded our models, harnessing the proprietary wet lab technologies to generate scalable biological data for model training and validation. We continue to build our talented team, optimize our organization, and integrate all of our platform capabilities deeply. In line with our hybrid business model, these steps aimed to leverage our platform to create a pipeline of assets and establish validating partnerships with companies like AstraZeneca and Almirall. In October of last year, at our inaugural R&D Day, we reached a pivotal moment by unveiling our internal pipeline of asset programs, including potential best-in-class and first-in-class antibody programs. We are excited to continue advancing each of these programs, which Zach will be discussing in greater detail later. But stepping back, it is humbling and gratifying to see the translation of an idea, using generative AI with our platform to create differentiated antibody candidates into reality.

[Sean McClain, Founder and CEO at Absci]

We demonstrated our platform's ability to create a differentiated antibody like ABS-101, our anti-TL1A antibody program, with potential best-in-class properties, in a very time and capital-efficient manner compared to industry standards. At the beginning of 2024, we unveiled positive preclinical data for this program, and by the end of February, we initiated our IND enabling studies. As we advance this program, I want to highlight our platform's efficiency in generating this program and the potential vast implications. In just 14 months, we generated and selected our drug candidate at a cost of less than $5 million. ABS-101 is an early example of the power of our platform, and we see additional opportunities to demonstrate similar results through our other current and future pipeline programs. At a high level, our platform unlocks the potential for a powerful, novel biotech business model.

[Sean McClain, Founder and CEO at Absci]

We could generate a differentiated antibody candidate and complete IND-enabling studies at a cost of approximately $15 million. This could enable a new paradigm in biotech, where capital typically allocated for one asset could be spread across multiple candidates, improving the overall probability of success. In addition to applying our platform to our internal pipeline, we are encouraged by the industry reception, including recent partnerships with industry leaders. It is humbling to count companies like Merck and AstraZeneca among our partners, who bring invaluable talent, skill, and expertise to our collaborations. This year and beyond, we look forward to entering into additional partnerships with pharma and biotech companies. These partnerships will leverage our platform to enable and advance their drug discovery programs by potentially shortening time frames, lowering costs, improving success probabilities, and unlocking new biologies previously thought unachievable.

[Sean McClain, Founder and CEO at Absci]

I'm incredibly proud of our team at Absci for these achievements and excited to see the promise of our platform applied to further internal programs, demonstrating the potential for disruptive improvements in biotech economics. At Absci, we come to work every day with a mindset focused on innovation and continuous improvement. We are driven by our mission to create better biologics for patients faster. A few months ago, we decided to further strengthen our balance sheet and capital position through an underwritten public offering of common stock. We were encouraged by the positive reception and support from a large and diverse group of investors, both new and existing. This support will help us continue to pursue our vision. As we look ahead to the rest of the year, I'm very excited about what lies ahead.

[Sean McClain, Founder and CEO at Absci]

We remain laser-focused on execution across all aspects of our business, including partnered and internal programs, with innovation and the pursuit of the impossible at the core of everything we do. With that, I'll turn the call over to Zach to walk through each of our programs, provide our outlook, and give an update on our financials. Zach?

[Zach Jonasson, CFO and Chief Business Officer at Absci]

Thanks, Sean. As Sean discussed, this past quarter, we closed an underwritten public offering of common stock, raising gross proceeds of approximately $86.4 million. This additional capital will further support our ability to advance our internal pipeline of asset programs. This strategy reflects the hybrid business model that we introduced last year, wherein we intend to develop our internal programs to a certain value through certain value inflection points, for example, through a phase I or potentially phase II clinical trial, before selling, partnering, or out-licensing said asset. A primary rationale for our strategy stems from our platform's ability to create differentiated antibody drug candidates in a highly efficient manner. We believe our strategy will allow us to create and capture more of the overall value of these internally generated programs.

[Zach Jonasson, CFO and Chief Business Officer at Absci]

As we have said in the past, every program is unique, and there is no one-size-fits-all strategy for these assets. As a best practice and guiding strategy, we will look for the right partner at the right time. As Sean mentioned earlier, we generated the ABS-101 candidate in just 14 months at a cost of less than $5 million. By comparison, pharma industry estimates we have seen peg such figures at 3+ years to reach a drug candidate and at a cost of $30 million-$50 million. As our platform continues to improve via our data generation and screening cycles, we believe over time that we will even further reduce the time it takes us to generate additional drug candidates. Turning back to our current internal program pipeline, our lead program, ABS-101, is a potential best-in-class anti-TL1A antibody.

[Zach Jonasson, CFO and Chief Business Officer at Absci]

In January, we presented early preclinical data from three advanced leads from this program. This data showed properties consistent with a potentially superior product profile, including demonstrated high affinity, high potency, favorable developability, and extended half-life. We used our de novo AI model to design ABS-101 leads … towards a specific epitope of TL1A, with the objective of creating a drug candidate with superior potency and lower immunogenicity. This target product profile, combined with anticipated high bioavailability, could ultimately improve patient experience with easier, less frequent dosing. Following further confirmatory PK studies, in February, we selected a primary and a backup development candidate to advance into IND-enabling studies. We also recently completed studies demonstrating ABS-101 candidate's ability to bind both the TL1A monomer and trimer, which could potentially lead to differentiated clinical efficacy. We plan to share additional preclinical data, including data from non-human primate studies, in the next few months.

[Zach Jonasson, CFO and Chief Business Officer at Absci]

We then expect to initiate phase I clinical studies in early 2025, with an interim data readout expected in the second half of 2025. Next, ABS-201, a potentially best-in-class antibody for an undisclosed dermatology target, is designed for an undisclosed dermatological indication with significant unmet need, where the efficacy for the pharmacological standard of care is not satisfactory. We anticipate selecting a development candidate for this program in the second half of 2024. Finally, ABS-301, a potentially first-in-class antibody for an undisclosed immuno-oncology target, is a fully human antibody designed to bind to a novel target discovered through our Reverse Immunology platform. This antibody inhibits an immunosuppressive cytokine and is believed to stimulate an innate immune response. ABS-301 is being evaluated for broad applicability to a variety of oncology indications, and comprehensive profiling of this program is in progress.

[Zach Jonasson, CFO and Chief Business Officer at Absci]

We anticipate completion of the mode-of-action validation studies for this program in the second half of 2024. As a reminder, our Reverse Immunology platform is designed to discover novel antibody targets based on the analysis of tertiary lymphoid structures, or TLSs, from patient samples. Within this platform, we mine the antibody repertoires from the TLS samples derived from patients who have exhibited an extraordinary immune response. We discovered the ABS-301 novel human antibody and its corresponding target using this platform. We look forward to sharing additional details later this year. In addition to further development of ABS-101, ABS-201, and ABS-301, we continue to expect to advance at least one additional internal asset program to a lead stage in 2024. Further, in line with our hybrid business model, we continue to execute and make solid progress on our existing drug creation partnerships.

[Zach Jonasson, CFO and Chief Business Officer at Absci]

I am pleased to see the close collaboration between our partners and our own R&D teams. While we cannot disclose much detail about our partnered programs, the work we are doing with these partners is progressing well and according to our expected timelines. We look forward to sharing more details about these programs at a later date. Additionally, we continue to anticipate planning additional drug creation partnerships with at least four partners in 2024, including one or more multi-program partnerships. I'm also pleased to share that we have a robust and diverse pipeline of potential partners, and we look forward to updating you on these over the course of the year. Turning now to our financials. Revenue in the first quarter of 2024 was $900,000, as we continue to progress our partnered and internal programs concurrently.

[Zach Jonasson, CFO and Chief Business Officer at Absci]

Research and development expenses in the first quarter of 2024 were $12.2 million, as compared to $12.7 million in the prior year period. This decrease was primarily driven by lower personnel costs, offset by an increase in stock compensation expense. Selling, general, and administrative expenses were $8.7 million in the first quarter of 2024, as compared to $9.6 million in the prior year period. This decrease was due to a lower personnel cost and continued reduction in administrative costs, offset by an increase in stock compensation expense. Turning to our balance sheet, we ended the quarter with $161.5 million in cash, cash equivalents, and short-term investments, as compared to $97.7 million as of December 31st, 2023.

[Zach Jonasson, CFO and Chief Business Officer at Absci]

For 2024, we continue to expect a gross use of cash, cash equivalents, and short-term investments of approximately $80 million, inclusive of the expected costs associated with completing the IND-enabling studies for ABS-101 with a third-party CRO. Based on our current plans, we believe our existing cash, cash equivalents, and short-term investments will be sufficient to fund our operations into the first half of 2027. Altogether, we are very encouraged by the progress we have made on our internal programs and confident in our ability to execute on these and our partner programs over the course of 2024 and beyond. With that, I'll turn it back to Sean.

[Sean McClain, Founder and CEO at Absci]

Thanks, Zach. 2023 was a pivotal and successful year for Absci and our company's evolution. In 2024, we will continue to focus on execution and further demonstrate the power of our platform to create differentiated antibody assets. We are thrilled to advance each of our programs with the goal of creating better medicines for patients faster and fundamentally improving the economics of biotech. We look forward to updating you along the way. With that, I'll turn it back to the operator to begin Q&A. Operator?

[Operator]

... Thank you. As a reminder, to ask a question, please press star one one on your telephone and wait for your name to be announced. To withdraw your question, please press star one one again. One moment for the first question. The first question comes from Kripa Devarakonda with Truist Securities. Your line is open.

[Kripa Devarakonda, Biotech Equity Analyst at Truist Securities]

Hey, guys. Thank you so much for taking my question. I have a question about ABS-101. You know, we recently saw exciting preclinical data from the program. I was just wondering if you can talk about your level of confidence that this drug is differentiated versus the other drugs in the same class. You know, do we truly understand the biology about the importance of targeting monomer versus trimer? And what sort of an edge do you have in understanding that part of it? And then I have a follow-up question.

[Sean McClain, Founder and CEO at Absci]

Yeah, absolutely. Thank you, Kripa. I'll hand that over to Christian to talk about the differentiated properties that we see with the TL1A, and in particular, with the monomer versus trimer.

[Christian Stegmann, SVP of Drug Creation at Absci]

Yeah. Thank you, Sean. Absolutely. First off, we do think that our extended half-life is an absolutely critical and very differentiated parameter that will address patient convenience topics. But and more importantly, also on the monomer trimer question, I think it's important to highlight that our AI-guided antibody design strategy is really based on epitope-specific targeting using 3D structures, and specifically for 3D structures of TL1A. So we selectively chose an epitope on the monomer that shows no discrimination for monomer versus trimer binding, and we designed antibodies using AI. So we completely avoid epitopes that span multiple subunits. And this allowed us to produce a development candidate that equally targets both TL1A states, and it also addresses, to our knowledge, all known monomer isoforms.

[Christian Stegmann, SVP of Drug Creation at Absci]

This may have relevance in clinical trials because it's known that certain monomers are expressed differentially in certain patient populations.

[Kripa Devarakonda, Biotech Equity Analyst at Truist Securities]

Great. Thank you so much. Sean, I have a question for you, a big, bigger picture question. You were talking about, you know, using generative AI models. I was just wondering, with the improved generative AI models and new data, do you think you can continue to improve efficiency and reduce the drug development timelines? I know, you know, 14 months is already, is already great, and $5 million to develop a drug is already great, but just wondering about that. Thank you.

[Sean McClain, Founder and CEO at Absci]

Yeah, absolutely. As the models get more and more accurate with the more data we're training and the... You know, as we continue to improve the AI architectures and our models, we do see these timelines continuing to decrease over time and the overall cost decreasing. And this is a very important metric for us internally, these cycle times, and you are gonna continue to see over time these overall costs decrease, both on how long it takes us to get to a drug candidate, as well as the overall costs associated with generating a drug candidate. So do expect that in the future.

[Kripa Devarakonda, Biotech Equity Analyst at Truist Securities]

Great. Thank you so much.

[Operator]

One moment for the next question. Next question comes from George Farmer with Scotiabank. Your line is open.

[George Farmer, Biotechnology Analyst at Scotiabank]

Hi, good morning, everyone. Thanks for taking my question. I was wondering if you could give us a heads-up on what we can expect to see from the non-human, human primate studies ongoing with ABS-101 later this year?

[Sean McClain, Founder and CEO at Absci]

Yeah, absolutely. Christian, do you want to take that?

[Christian Stegmann, SVP of Drug Creation at Absci]

Yeah, absolutely. So, our non-human primate pharmacokinetic studies are expected to demonstrate that we indeed are able to show an extended half-life of our antibody, thus de-risking the pharmacokinetic profile in humans. So we, in the next few months, we'll be able to demonstrate that our antibody engineering approach to extend the half-life of the antibody has worked.

[George Farmer, Biotechnology Analyst at Scotiabank]

Okay. Anything else from those studies we should be looking out for? PD markers, anything like that, that can kind of shed light on the differentiation of the, of the antibody from competitors?

[Christian Stegmann, SVP of Drug Creation at Absci]

Yes, we will absolutely measure the known pharmacodynamic marker as well, obviously, and exactly as you, as you mentioned, demonstrating an extended effect on the pharmacodynamic biomarker will then obviously also de-risk efficacy. Very, very good point.

[George Farmer, Biotechnology Analyst at Scotiabank]

Okay, great. And then, maybe a bit on cash. Your guidance implies, I think, some funding coming in, probably from partnerships is probably the best guess. Can you kind of elaborate a little bit more on that, relative to how we should think about cash usages through 2027?

[Sean McClain, Founder and CEO at Absci]

Yeah, we-

[Zach Jonasson, CFO and Chief Business Officer at Absci]

Yeah, I can take that one.

[Sean McClain, Founder and CEO at Absci]

We do see... Yeah, go for it, Zach.

[Zach Jonasson, CFO and Chief Business Officer at Absci]

Yeah, I was going to say, George, we continue to reiterate our guidance of $80 million of gross cash usage for 2024. That's obviously a gross figure, and that includes the costs associated with completing the IND enabling studies for ABS-101. Our forecast that takes us into 2027 includes some modest assumptions around partnering on a regular cadence, but it doesn't include any assumptions around a significant partnership deal.

[Zach Jonasson, CFO and Chief Business Officer at Absci]

So it's kind of our typical run rate assumptions built into that. And then I would point out, too, if you look at our net cash usages, that typically comes in well under gross. So for example, if you look at H2 of 2023, the net cash usage for that second half of last year was roughly $27 million in total, and the net cash usage for Q1 of this year was roughly $16.9 million, which is a little higher given that we paid bonuses in March. So as you can see, our net cash usage is coming well in, coming well under the gross cash usage.

[George Farmer, Biotechnology Analyst at Scotiabank]

Yep. Okay. Thanks very much, Zach.

[Operator]

One moment for the next question. The next question comes from Jacqueline Kisa with TD Cowen. Your line is open.

[Jacqueline Kisa, Equity Research Associate at TD Cowen]

Hi, this is Jacqueline Kisa on for Steven Mah. Thanks so much for taking the questions. With ongoing bipartisan discussions regarding biosecurity, can you give us any color on the third-party CRO you're using for your IND studies? Is it WuXi Biologics or a China-based CRO?

[Sean McClain, Founder and CEO at Absci]

Yeah, that's a great question. We are using WuXi at the current moment. Given the, you know, recent discussions that have been ongoing with that, we do believe that the relationship with WuXi will not put us at risk with the current program. But we are engaging with other CROs and do have backup strategies to, you know, mitigate any other potential tailwinds that may occur with the new legislation that may come out.

[Jacqueline Kisa, Equity Research Associate at TD Cowen]

Great. Thank you. I appreciate the color. Regarding your fourth internal asset, can you give us any insight onto the disease area you're looking to focus on? Is it one you've targeted before or a new therapeutic area? Is the company right-sized to serve both your internal and partnered programs?

[Sean McClain, Founder and CEO at Absci]

Yeah, it's a great question. So we are focused in on I&I as well as oncology, so we'll fall in one of those therapeutic areas. And then additionally, we are currently right-sized to be able to continue to take on more programs. As we continue—as our model continues to get more and more accurate, we're able to do more with less resources. But one area that we are going to continue to grow in that does not correlate to the model itself is on the disease biology and the translational side. So we're going to continue to build out our drug creation team again, both on the disease biology, the translational side and clinical side.

[Sean McClain, Founder and CEO at Absci]

But we see that as modest growth as these programs are being undertaken.

[Jacqueline Kisa, Equity Research Associate at TD Cowen]

Great, thank you. And then if I could just squeeze one more in. Technologies in the AI drug discovery are pretty fragmented. Are there any white spaces in the tech stack that you could fill inorganically, or do you expect to build on your tech in-house?

[Sean McClain, Founder and CEO at Absci]

Yeah. One of the areas that we see as big differentiation is the epitope specificity. So being able to landscape an epitope and target an epitope of interest or be able to test epitopes that may, you know, give you a new novel biology. You know, with standard, you know, approaches like phage display, immunization, you have no control over this epitope specificity. And to the best of our knowledge, this is the only technology that exists out there that allows you to hone in on these epitopes of interest and allow you to elucidate potential new novel biology from those epitopes. And so we see this as a major differentiation.

[Sean McClain, Founder and CEO at Absci]

This is really what's driven partnerships with AstraZeneca, Almirall, Merck, and, you know, will continue to drive our partnership pipeline, but also drive our own internal development as well. And we have applied this to the internal programs as well.

[Jacqueline Kisa, Equity Research Associate at TD Cowen]

Great. Thank you so much. I appreciate it.

[Operator]

One moment for the next question. The next question comes from Steve Dechert with KeyBanc. Your line is open.

[Steve Dechert, Associate Analyst at KeyBanc]

Hey, guys, thanks for the question. Could you give some more color on how discussions are going with potential partners as they're late to getting to your goal of four new partners this year?

[Zach Jonasson, CFO and Chief Business Officer at Absci]

Yeah, I can comment on that, Sean.

[Zach Jonasson, CFO and Chief Business Officer at Absci]

I'd say, well, you know, while signing partnerships is always a little bit lumpy, and if you look at our cadence last year, it's hard to have them come out on an even cadence throughout the year. But I would say that our pipeline of discussions is robust and covers both large pharma, mid and small biotech, as well as leading academic institutions. And as we have these discussions and prosecute the BD strategy, we're really looking for partners that bring a strong synergy to the table. And typically, that means really robust and deep knowledge of the target biology. That's where we see a really fertile ground for partnering. So I would say we feel like we're well on track to hitting the metrics that you mentioned.

[Steve Dechert, Associate Analyst at KeyBanc]

... Okay, thanks. And then are there any new capabilities that you're investing in as it relates to your platform? Thanks.

[Sean McClain, Founder and CEO at Absci]

Yeah. One of the areas that we're continuing to invest in, not only on the de novo AI side, but actually on the reverse immunology side. And one of the areas that we see as a bottleneck that AI could really unlock for us is the de-orphaning process. So once we take antibodies from a patient, we do a proteome panel screen to find out what these antibodies are binding to, and this is a very laborious and time-consuming step. And what we want to do is actually go in the reverse direction of the de novo model. Instead of going target to antibody, we go antibody to target. This would allow us to rapidly de-orphan and discover new novel targets much faster than previous.

[Sean McClain, Founder and CEO at Absci]

We could scale patient data and hospital partnerships as well. This is a kind of another key area of focus for us on the AI development front.

[Operator]

As a reminder, to ask a question, please press star one one on your telephone and wait for your name to be announced. Please stand by for the next question. The next question comes from Li Chen with H.C. Wainwright. Your line is open.

[Li Chen, Equity Research Associate at H.C. Wainwright]

Hello, good morning. This is Li Chen. Can you hear me well?

[Sean McClain, Founder and CEO at Absci]

Yes.

[Li Chen, Equity Research Associate at H.C. Wainwright]

Hi, I have two questions. One is to expand on previous discussion on Absci's differentiation. So, since the release of the 101 data, have you seen any shifts in the nature of the inbound partnerships or partner interest? What I mean is that you said the previous partnerships were primarily driven by the epitope-specific antibody design. So any other capability that your partner is interested with primary focus on antibody design? And I have another question around 201.

[Sean McClain, Founder and CEO at Absci]

Yeah. Zach can speak to the interest on ABS-101 and the discussions that we've been having on that, but I can say that they are very robust discussions. But Zach, I'll hand that over to you.

[Zach Jonasson, CFO and Chief Business Officer at Absci]

Yeah. We have had a lot of nice inbound interest around that asset and continue to have discussions. Our strategy, as Sean stated earlier, is to move that asset forward into phase I clinical studies. But we're certainly entertaining discussions now and happy to see the interest from potential partners in that area. And the second part of your question, I'll just mention, I think this epitope specificity has been really intriguing to potential partners. So highlighting the capabilities of our platform in designing that asset, I think have been quite intriguing to a number of potential partners and existing partners, as well as our ability to design in unique features.

[Zach Jonasson, CFO and Chief Business Officer at Absci]

So in some of our other assets and case studies, we've shown an ability to design in pH-dependent binding, multivalency, unique properties that can be differentiating in a clinical setting. So I think that's an exciting new area for us.

[Li Chen, Equity Research Associate at H.C. Wainwright]

Great. Thank you very much. My second question is on 201. Can you give us some color on the current competitive landscape of 201 in that undisclosed disease area? And what's your confidence of the differentiation factors from the current SOC and pipeline drugs? Thank you.

[Sean McClain, Founder and CEO at Absci]

Yeah, absolutely. Christian, do you wanna take that one?

[Christian Stegmann, SVP of Drug Creation at Absci]

Yes, thank you. My audio is cutting out from him. So your question is around ABS-201?

[Li Chen, Equity Research Associate at H.C. Wainwright]

Yes, 201-

[Sean McClain, Founder and CEO at Absci]

Yes, please.

[Li Chen, Equity Research Associate at H.C. Wainwright]

-around the competitive landscape and differentiation factors.

[Christian Stegmann, SVP of Drug Creation at Absci]

Yes. So we have not disclosed the precise indication for ABS-201 yet. But I will share that this is an indication of high unmet medical needs where the current standard of care is unsatisfactory. And we also plan to employ extended half-life antibody technology to basically improve patient convenience as well, just like we did for ABS-101. So in essence, we will deliver a best-in-class profile, not only from an efficacy standpoint, but also from a patient convenience standpoint.

[Sean McClain, Founder and CEO at Absci]

Yeah, and I will, I will also mention as well, this target is a very underappreciated derm target. And in this case, we would be second to the clinic. So it's not a very crowded space, a very underappreciated target, I'd say, almost very similar to TL1A.

[Li Chen, Equity Research Associate at H.C. Wainwright]

Great. Thank you very much.

[Operator]

I show no further questions at this time. This will conclude today's conference call. Thank you for participating. You may now disconnect.

Participants

Executives

• Alex Khan, VP of Finance and Investor Relations
• Christian Stegmann, SVP of Drug Creation
• Sean McClain, Founder and CEO
• Zach Jonasson, CFO and Chief Business Officer

Analysts

• George Farmer, Biotechnology Analyst at Scotiabank
• Jacqueline Kisa, Equity Research Associate at TD Cowen
• Kripa Devarakonda, Biotech Equity Analyst at Truist Securities
• Li Chen, Equity Research Associate at H.C. Wainwright
• Steve Dechert, Associate Analyst at KeyBanc