Dyadic International Q1 2025 Earnings Report

Dyadic International EPS Results

• Actual EPS: -$0.07
• Consensus EPS: N/A
• Beat/Miss: N/A
• One Year Ago EPS: N/A

Dyadic International Revenue Results

• Actual Revenue: $0.39 million
• Expected Revenue: N/A
• Beat/Miss: N/A
• YoY Revenue Growth: N/A

Dyadic International Announcement Details

• Quarter: Q1 2025
• Date: 5/14/2025
• Time: After Market Closes
• Conference Call Date: Wednesday, May 14, 2025
• Conference Call Time: 5:00PM ET

Dyadic International (NASDAQ:DYAI), Inc., a biotechnology platform company, develops, produces, and sells enzymes and other proteins in the United States and internationally. It utilizes C1-cell protein production platform based on an industrially proven microorganism (C1) for the development and production of biologic products including enzymes and other proteins for human and animal health. The company offers DYAI-100, SARS-CoV-2-RBD antigen vaccine candidate towards a first-in-human Phase 1 clinical trial to demonstrate the safety in humans of a protein produced using the C1 platform. It has also developed the Dapibus thermophilic, a filamentous fungal-based microbial protein production platform to enable the development and large-scale manufacture of cost-effective proteins, metabolites, and other biologic products for use in non-pharmaceutical applications, including food, nutrition, and wellness. The company has a research and development agreement with VTT Technical Research Centre of Finland, Ltd.; license agreement with South Africa's Rubic One Health; Joint Development Agreement with a Global Food Ingredient Company; and sub-license agreement with Abic Biological Laboratories Ltd., Alphazyme, LLC, and Abic Biological Laboratories Ltd. Dyadic International, Inc. was founded in 1979 and is headquartered in Jupiter, Florida.

Dyadic International Q1 2025 Earnings Call Transcript

Key Takeaways

• Dyadic announced a strategic pivot toward commercializing high-value non-pharmaceutical recombinant enzymes and proteins using its proprietary C1 and dAPIVIS platforms to target life science, nutrition, and industrial markets.
• The company expects to launch recombinant human serum albumin in Q3 2025 through its ProLiant collaboration and to receive a third milestone payment in Q2, addressing a $6.1 billion cell culture media market growing at a 13% CAGR.
• In its animal-free dairy segment, Dyadic is advancing alpha-lactalbumin sampling with promising functional data, optimizing human lactoferrin production, and scaling up its first recombinant dairy enzyme for a year-end commercial launch.
• Industrial applications continue to gain traction, highlighted by a large Q1 follow-on purchase order for N3Xime from Fermbox with production underway and progress on enzyme cocktails for pulp and paper as well as biogas markets.
• Financially, Q1 revenue rose to $394,000 from $335,000 year-over-year but Dyadic reported a net loss of $2.03 million and cash and investments decreased to $7.4 million, underscoring ongoing funding requirements.

Presentation

[Operator]

Evening, and welcome to the Dyadic International First Quarter twenty twenty five Financial Results Conference Call. Currently, all participants are in a listen only mode. Following management's prepared remarks, there will be a brief question and answer session. As a reminder, this call is being recorded today, 05/14/2025. I would now like to turn the call over to miss Ping Rawson, Dyadic's chief financial officer. Please go ahead.

[Ping Rawson, Chief Financial Officer at Dyadic International]

Thank you. Good evening, and welcome, everyone, to Dyadic International's q one twenty twenty five conference call. I hope you have had the opportunity to review Dyadic's press release announcing financial results for the fiscal year ended 03/31/2025. You may access our release and Form 10 Q under the Investors section of the company's website, ibiotics.com. On today's call, our President and CEO, Mark Inoufarb and our Chief Operating Officer, Joe Hazleton, will give a review of our Q1 twenty twenty five business and corporate highlights and provide a commentary on the strategic direction of the business.

[Ping Rawson, Chief Financial Officer at Dyadic International]

I will follow with a review of our financial results in more detail. We'll then hold a brief Q and A session. At this time, I would like to inform you that certain commentary made in this conference call may be considered forward looking statements, which involve risks and uncertainties and other factors that could cause Dyadic's actual results, performance, scientific or otherwise, or achievements to be materially different from those expressed or implied by these forward looking statements. Zydeco expressly disclaims any duty to provide updates to its forward looking statements, whether because of new information, future events, or otherwise. Participants are directed to the risk factors set forth in Dyadic's reports filed with the SEC.

[Ping Rawson, Chief Financial Officer at Dyadic International]

It is now my pleasure to pass the call to our CEO, Mark Imofar. Mark?

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

Thank you, Ping. Welcome, everyone, and thank you for joining Dyadic's Q1 twenty twenty five conference call. In Q1 twenty twenty five, Dyadic continued its transformation by focusing on commercializing high value, high demand recombinant enzymes and proteins using our proprietary C1 and DAPIVIS microbial expression platforms for the development of functional recombinant solutions and proprietary production strains to manufacture large quantities of precision engineered proteins and enzymes for use in life science, nutrition and industrial applications. We are leaning into our core strengths aimed at driving sustainable growth in non pharmaceutical sectors with strong demand and clear market opportunities to target pressing market needs. While we maintain strategic partnerships in vaccine therapeutic developments, such as with the Coalition for Epidemic Preparedness, CEPI, the Gates Foundation, and Foundatione Biotech Napolo di Siena, FBS.

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

The core of our growth strategy is now centered on products in the high value life sciences, bioactives, ingredients and industrial markets such as cell culture, media, nucleic and other enzyme markets that can drive recurring revenue. As we move forward, Dyadic remains deeply committed to delivering sustainable value to our shareholders and partners. With a growing pipeline, a strong network of collaborators and platforms built for efficiency and scalability, we are well positioned to lead in the global production of enzymes, alternative proteins and biopharmaceuticals meeting the demands of today and shaping the solutions of tomorrow. I will now turn the call over to Joe Hazleton, our Chief Operating Officer, who will provide you with an update on our Q1 progress towards exploiting commercialization opportunities. Joe?

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Thank you, Mark. We are increasingly focused on building a strong portfolio of commercial ready, nonpharmaceutical products across the life sciences, bioactives and ingredients, and industrial sectors, areas where our Xpression platforms offer significant advantages in speed, scalability and cost efficiency. In these segments, we're developing and advancing a diverse range of high value recombinant proteins, enzymes and bio bioactive ingredients that are well aligned with growing global demand for sustainable animal free solutions. Our top commercialization priority lies in the cell culture media space, a market valued at over $6,100,000,000 globally and growing at a robust 13% compound annual growth rate. Within this segment, through our collaboration with ProLiant Health and Biologics, we expect the launch of recombinant human serum albumin in Q3 twenty twenty five.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

This product is designed to replace animal derived components in key markets such as diagnostics, medical device coatings, gene therapy products, and chemically defined cell culture media. We also anticipate achieving a third milestone payment related to productivity improvements in Q2. In parallel, we're advancing our recombinant transferrin, which has demonstrated comparable cell growth performance through reference standards in preliminary studies. Sampling programs are active and we are engaged in early stage partnership discussions. Additionally, we are developing fibroblast growth factors or FGFs, a critical class of proteins for regenerative medicine and cell based manufacturing.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Our recombinant FGF products have shown promising bioactivity and cell proliferation assays and we plan to begin sampling in Q2 twenty twenty five to accelerate partner engagement. In the area of DNA and RNA manipulation tools, we are making notable strides to address growing market demand. Our recombinant DNase-one, RNase free enzyme is a key reagent in gene therapy, biopharma production, and molecular diagnostics. To bring this product to market, we're working closely with the European Contract Development and Manufacturing Organization, CDMO, to validate our production process and initiate the manufacture of research grade material. Beyond DNA swab, we've developed and validated several additional enzyme prototypes, including RNase inhibitors and T7 RNA polymerase.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

These are part of our broader strategy to expand into the nucleic acid tools market, which is projected to exceed $4,000,000,000 globally by 2028. These products are undergoing continued development and optimization with performance results expected by year end. Turning to nutrition, in the animal free dairy product products market valued at approximately 25 or $26,500,000,000 in 2023, our work in non animal dairy proteins continues to gain momentum, offering both functional and nutritional advantages across multiple sectors. Alpha lactalbumin, a key whey protein, is currently undergoing detailed characterization and is being sampled for applications in research, biochemical analysis, and ultimately food grade nutritional products. We're seeing increased partner interest in this animal free alternative as demand rises across the specialized nutrition markets like infant formula, medical nutrition, and wellness products. In parallel, we're advancing human lactoferrin, a multifunctional protein with potential applications in nutrition, research, and pharmaceutical markets, particularly as a functional bioactive antimicrobial, anti inflammatory, or immune supportive agent. We're currently advancing optimization to ensure high yield scalable production and accelerating characterization efforts to further refine the product. Looking ahead, we anticipate initiating sampling efforts with prospective partners and customers in late twenty twenty five. Also within the animal free dairy space, scale up is ongoing for the first recombinant dairy enzyme in partnership with our collaborator with a commercial launch expected by year end. Additional dairy enzyme candidates are progressing under the 2023 license agreement we signed to develop and commercialize non animal derived enzyme solutions for dairy processing.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

In industrial applications, we've made significant progress with enzyme systems that enhance process efficiency. N3xime, a product developed by using our daphobis expression platform under license to firm MoxBio and launched in 2024 as a sustainable solution to convert pretreated agricultural residues into fermentable sugars for more efficiently and cost effectively. Building on that momentum, FirmBox received a large follow on purchase order in Q1 twenty twenty five and production is now underway with deliveries expected in the coming months. This marks an important step forward in driving commercial traction in the bioindustrial market. In parallel, we've developed and are currently testing an enzyme cocktail targeting the approximately $400,000,000 global enzyme market for pulp and paper applications, as well as a candidate cocktail for the biogas industry where demand continues to grow for cost effective, sustainable processing technologies.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

While our primary focus is on non pharmaceutical product commercialization, we continue to strengthen and validate our C1 expression platform through a series of high impact fully funded collaborative programs. We believe these initiatives can serve as important proof points for the scalability, speed, and cost efficiency of our microbial production technologies. One such initiative is the $4,500,000 grant from the Coalition for Epidemic Preparedness Innovations, or SEPI, awarded to Foundation Biotechnipolo de Siena, where Dyadic is a subcontractor eligible to receive up to $2,400,000 The grant supports the development of recombinant vaccines against emerging infectious diseases using the C1 platform, potentially enabling more rapid, cost effective pandemic response. Also, we are executing a $3,000,000 program funded by the Gates Foundation to produce low cost monoclonal antibodies for malaria and respiratory syncytial virus or RSV. This disease continues to place a heavy burden on global health, particularly in low and middle income countries where effective antibody based treatments have been cost prohibitive.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

In addition, DIAMIC has been selected to participate in the European Vaccines Hub for Pandemic Readiness, or EVH, a new €100,000,000 initiative funded by the European Union. This collaborative initiative is designed to build centralized vaccine R and D and manufacturing capacity, and Dyadic's C1 technology will be evaluated among other cutting edge solutions. This not only highlights the growing recognition of our microbial expression systems, but also underscores the growing demand for scalable non mammalian production platforms in pandemic preparedness efforts. Our technology is also further explored through the CEPI UVAX collaboration, which includes a $2,600,000 grant to support the development of a MERS vaccine candidate. At the same time, this program is evaluating the C1 expression system's potential to reduce manufacturing costs and accelerate vaccine production timelines.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Beyond human health, we're also demonstrating the flexibility of the C1 platform in growing the animal health sector. Our collaborations with FIBRA Animal Health, Verivax LLC, and others focus on further development of ferritin nanoparticle based vaccines and other vaccines targeting infectious diseases such as avian influenza or bird flu and other livestock pathogens. The H5 ferritin nanoparticle vaccine candidate produced using our C1 platform in partnership with Verivax LLC is being evaluated in poultry. Early trials show the generation of neutralizing antibody responses supporting the potential for vaccine and diagnostic use. These programs expand how C1 can be used and highlight its strong potential to reduce bioproduction costs in a variety of veterinary applications.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

These advancements in our life science, bioactive ingredients and industrial segments reinforce the versatility and scalability of our C1 Adaptive List platforms across diverse market segments. As we continue to translate scientific innovation into commercial opportunities, it's equally important to maintain a strong financial foundation to support our growth. With that, I'll now turn the call over to our Chief Financial Officer, Ping Rawson, who will walk through our first quarter twenty twenty five financial results. Ping?

[Ping Rawson, Chief Financial Officer at Dyadic International]

Thank you, Joe. I will now go over our key financial results for the quarter ended 03/31/2025, in more detail. You can find additional information in earnings press release and Form 10 Q, which we filed earlier today. Total revenue for the quarter ended 03/31/2025 increased to approximately $394,000 compared to $335,000 for the same period one year ago. The increase is driven by the increase in grants revenue of approximately $210,000 for the Gates from the Gates Foundation and SAPI in 2025.

[Ping Rawson, Chief Financial Officer at Dyadic International]

There was no grant revenue for the three months ended 03/31/2024. Cost of research and development revenue for the quarter ended 03/31/2025, decreased to approximately $126,000 comparing to $144,000 for the same period a year ago. The decrease in cost of research and development revenue was due to the decreasing number collaborations in 2025. Cost of grant revenue for the quarter ended 03/31/2025 was approximately $171,000 compared to zero for the same period a year ago. Research and development expenses for the quarter ended 03/31/2025 decreased to $495,000 compared to $523,000 for the same period a year ago.

[Ping Rawson, Chief Financial Officer at Dyadic International]

The decrease reflected a decrease in the amount of ongoing internal research projects. G and A expenses for the quarter ended 03/31/2025, decreased by 10.8% to $1,596,000 compared to $1,789,000 for the same period a year ago. The decrease reflected decreases in business development and investor relations expenses of $97,000 management incentive of $78,000 accounting and legal expenses of $41,000 partially offset by other increases of $34,000 Loss from operations for the quarter ended 03/31/2025 decreased to $2,002,000 compared to $2,126,000 for the same period a year ago. Net loss for the quarter ended 03/31/2025 was $2,028,000 or $07 per share compared to $2,010,000 or $07 per share for the same period a year ago. As of 03/31/2025, we have cash and investment grade securities of $7,400,000 compared to $9,400,000 as of 12/31/2024.

[Ping Rawson, Chief Financial Officer at Dyadic International]

We continue to strengthen our balance sheet to support our near term revenue growth and accelerate our strategic objectives of commercialization opportunities for pharmaceutical and nonpharmaceutical applications. With that, I will now ask the operator to begin our Q and A session. Each caller will be allowed one question and one follow-up question to provide all callers with an opportunity to participate. If time permits, the operator will allow additional questions from those who have already spoken. I will now ask the operator to begin our Q and A session.

[Ping Rawson, Chief Financial Officer at Dyadic International]

After which, Mark Inesarb, our CEO, will provide closing remarks. Operator?

[Operator]

Thank you. We'll now be conducting a question and answer session. For participants using speaker equipment, it may be necessary to pick up the handset before pressing the star keys. One moment please while we poll for questions. Our first question is from John Vandermosten with Zacks.

[John Vandermosten, Senior Analyst at Zacks Small Cap Research]

Great. Thank you and good afternoon, Mark, Joe and Ting. So congratulations on the firm box deal there. That's nice to see that. Can you tell me how the royalty arrangement works with them and and how you might recognize some some benefit from that from that contract that they got?

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

Joe, do you want to go ahead and answer that?

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Go ahead, Mark, and then I can fill in.

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

Yes. So basically, we have a joint venture collaboration with Fermbox, a multitude of different product opportunities, including this one that we're talking about here today. And the profit split is going to be split between the two companies. And we're not getting into the exact details here, but it's a fairly large profit split for both of us. So as he ramps up and lowers his cost of goods and starts delivering these enzymes for this application, we expect that to be quite a large application.

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

And we'll fill you in on future quarters on that. I don't know, Joe, is there anything

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

I think the only thing I would add to that is that the revenue sharing is immediate. It's not going to be, I guess, delayed. So as the sales start to roll in, we'll start to see some revenue coming in from those.

[John Vandermosten, Senior Analyst at Zacks Small Cap Research]

Okay. And I also want to follow-up on the albumin arrangement and see if you could comment on the progress here. Then also if there had been any advanced orders placed by customers for that product through ProLiant?

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

No advanced orders at the current time. They're not actually taking them until the samples have gone out. That's expected within the second quarter here that sampling will begin so that the orders can start being fulfilled and taken in the third quarter. So hopefully in the second quarter, we'll start to see some of those, but we're still getting the final phases of scaling up and fill and finish. But everything right now is looking positive and we're keeping our fingers crossed and keeping the foot on the gas to make sure that this gets to market as quickly as possible.

[John Vandermosten, Senior Analyst at Zacks Small Cap Research]

Okay. Thanks, Joe. Our

[Operator]

next question is from Dick Williams with Williams Resource Group.

[Dick Williams, Analyst at Williams Resource Group]

Hi, guys. John asked the same question about what I was asking on Fernbox. But maybe there's one part you didn't cover, Joe. This is for Joe. They have won a what I understand, they want a bid that they put in I don't know with whom.

[Dick Williams, Analyst at Williams Resource Group]

I think it was the government, but I'm not sure. And that's what we're talking about. That is some revenue generation for us once they start delivering these things. But is there any opportunity for them to bid other contracts with the government or others where we also are a 50% participant?

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Dick, thanks for the question. I can't get into exactly the specifics on the order itself, but you're absolutely correct. It's not a one and done from a bid standpoint. We're evaluating not only options from a government standpoint but also in the private sector as well. So we're hoping that this continues to grow as we start to see this getting out to the market, but definitely not going to be limited to just government.

[Dick Williams, Analyst at Williams Resource Group]

Okay. Thanks. That's all for me. Thanks.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Thanks, Nick.

[Operator]

Our next question is from Paul Rosenbaum with SWR.

[Paul Rosenbaum, CEO at SWR Sound Corporation]

Hi, Joe. I guess this is a question for I've been around a long time. I own a hell of a lot of shares in this company. And what I heard on this call today was that you have a large commercial order and that you're going to concentrate on the non pharmaceutical commercial area. When does the either one, Mark or Joe, when do you start spending less money on the $4,600,000 in research and the $3,000,000 in the Gates Foundation, which I've been around a long time.

[Paul Rosenbaum, CEO at SWR Sound Corporation]

There's no revenue coming in there. It's exciting that there's going to be revenue in the protein area. When does the board decide that you're going to spend less money in one area and a lot more money in the area where revenue is coming in? This is not a criticism. It's just an observation on my part.

[Paul Rosenbaum, CEO at SWR Sound Corporation]

I think I'm allowed to say that considering how long I've been a friend of this company.

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

Paul, yes, go ahead, Joe.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Yes. First of all, again, appreciate the question. It's absolutely the right to voice your opinion, and we're glad to hear it. I think the key is it's now. Now we are starting to reprioritize all of our resources and all of our focus in the non pharmaceutical sector for revenue generation through commercialization ready products like albumin or in the dairy space with the non animal dairy enzymes.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

It isn't, you know, that we are putting a lot of effort and resources into the human health. It's kind of, I don't want say on autopilot, but we've taken it as far, I think, as we can take it as a company, and now we need to rely on our partners and our collaborations to take it further. So in the coming weeks, months, years, it's going to be the focus on product development rather than, development. Any platform development that we need to do, we focus on the products that are going through. And I think the toolbox that Mark and the team have created over the last ten years has enabled us to do that.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Now we just need to resource it and focus appropriately in those segments. But it's it's a valid question, and we absolutely are are moving in that direction.

[Paul Rosenbaum, CEO at SWR Sound Corporation]

Encouraging to hear, and I I appreciate that. Thank you.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Mhmm. Thank you.

[Operator]

Our next question is from John Vandermosten with Dax.

[John Vandermosten, Senior Analyst at Zacks Small Cap Research]

Great. Thank you for the chance to ask a follow-up. Looking at your nondairy applications portfolio, what product of those three appears to have the best margins? And then how does this compare with the reagent proteins in terms of attractive margins?

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

It's a that's a great of all the the current pipeline, lactoferrin probably has the highest margin potential simply because it's a much smaller portion of, the protein concentration in milk products. That being said, alpha lactalbumin, I think, overall has the largest market potential in terms of volume and margins for us because it's a lot larger. It's still a high value segment, and it's not quite as easy to produce in some systems, so we just happen we're very fortunate that our development is moving well. We have a very productive strain. And so far, the initial testing has demonstrated not only we, equivalent to current research grade alfalfa matte gum products that are on the market, we also have some application testing in the food products that's ongoing right now, and the initial results look positive.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

So, I'm cautiously optimistic that we don't have to do too much more work on that, that we can, continue to progress towards commercialization more rapidly and just start to drive the production. So I definitely understand, you know, where you're coming from. Some of these segments are very thin, like the dairy enzyme segment. So the margins are a lot tighter. But when you get into these specialized medical nutrition infant formula products, they're definitely higher value segments, that we're going be chasing.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

But I do think AlphaLac represents probably the largest and quickest potential. Lactoferrin, there's been a couple of companies over the years that have tried it and haven't done quite so well. And, you know, we're not trying to launch the products ourselves. We're just trying to launch the the product. Sorry about that.

[John Vandermosten, Senior Analyst at Zacks Small Cap Research]

Okay. No. Great great detail on that. That's great information.

[Operator]

Our next question is from Tony Bowers with IntroAct.

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

Hi, Tony. Are you there? Tony, is your line on mute?

[Tony Bowers, Director of Corporate sales at Intro-act]

Hi, Mark. Joe, is that better? I'm off speaker.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Yes, thanks. That's better.

[Tony Bowers, Director of Corporate sales at Intro-act]

A couple of different questions. You give a statistic on the number of paid collaborators dropping nine to four. Is that partly because of the pivot? Is there any color on why folks have dropped out, what results there were when they're satisfied with the collaboration but just aren't going ahead? It's obviously a very weird environment right now in life sciences.

[Tony Bowers, Director of Corporate sales at Intro-act]

That's the first question. The second is tariffs are pretty topical right now. Is there any quantifiable tariff problems for you guys with the initiatives you've got going?

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

You want to answer that first or do want me to do that?

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Yes, sure. You probably start quick to handle the tariffs. Address that first. Right now we don't see a significant problem, but we actually see potential opportunity. When you look at onshoring, especially with biologics and manufacturing, that could potentially be an area of potential for us.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Obviously, we're looking at expanding our capability for manufacturing here in The U. S. We do have a pretty good footprint abroad. As you look at some of the other markets or some of other collaborators that have dropped off, it is due to the pivot. We are focusing on licensing deals and product partnerships rather than collaborations that require use of our resources and potential investment.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

We're actually trying make sure that everything we're doing is focused on bringing products to market, whether that's by ourselves or in conjunction, with other partners. So we have a lot of ongoing, discussions happening right now, a lot of term sheets that are being exchanged. So, we're this is going to pick up rather quickly. Can't get into a lot of that, but it definitely is a much different focus for us rather than chasing collaborations that will take development and twelve years to produce a product. We wanna be producing products like we do with Proliant and partnering them within twelve to eighteen months, somewhere in that neighborhood.

[Tony Bowers, Director of Corporate sales at Intro-act]

And the the firm box initiative, this is back to your old roots. Will is that if I think of it as ethanol, for example, is it something like that as an end product?

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

Yes, you're absolutely right. That is exactly how you would think of it.

[Tony Bowers, Director of Corporate sales at Intro-act]

Okay. So it fits into the Like

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

a renewable biofuel. Yep. And the thing with Thornbox, it's not just a one off, as Joe pointed out earlier. We're in discussions with Zelman on their own for additional partners and collaborators that would like to build multiple plants based on the success of this first customer. So we've been testing different substrates with those enzymes to see how well they get digested and turned into glucose sugars for renewable chemicals and fuels.

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

So it's not a one off, but we think it's a reproducible, consistent growth area for us and for Fermbox as well as other products, as Joe pointed out earlier, sort of pulp and paper and biogas and other things that we're looking at developing. Question about tariffs and how it would affect us, think we want to make it clear, the albumin is being produced here in America. So it's not going to affect at all for Reliant. So that's a domestic production. And we have other things.

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

The enzymes actually with our enzyme company. It's going to be launching a dairy enzyme. It's produced here in America as well. So both of those are being scaled up here in The US. So that's a good thing.

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

And then as Jill pointed out, on biomanufacturing, as you saw, I think the other day, there's an executive order to reduce the cost of drugs, which include biologics, which are the most expensive, there's pressure on the pharmaceutical industry. That hopefully will be looking for more efficient ways to produce their products so they can maintain their margins as they're getting squeezed on the other side.

[Tony Bowers, Director of Corporate sales at Intro-act]

That's great. If I missed it, sorry, did Ping forecast the burn rate going ahead?

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

No, she did not. Okay.

[Tony Bowers, Director of Corporate sales at Intro-act]

Any aspirations on I

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

think we hope to, like we showed in the third quarter, when we get money in from ProLiant and we get money in from our dairy milestone, that we will have license agreements of we hope significantly more money upfront milestones. And then of course launching these products, getting revenue in from both Reliant on the Albion sales and also from FirmBox and launching to transfer in a DNase one either on our own or in collaboration with different parties that we're in discussions with now. Don't know, Joe, you want to add any color to that?

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

No, I think probably the decrease in the number of collaborators too is due to the fact that we need to take these products further in order to maximize the potential. You look at albumin, just taking albumin as an example, the company sold for $500,000,000 but they worked on it for twenty years. Obviously, we don't want to have those types of those types of products. It takes a little too long. But in the the segment, we really do need to take these a little further.

[Joseph Hazelton, Chief Operating Officer at Dyadic International]

And if we're going to have more upfront monies and longer or shorter term revenue projections, we'll need to have these products validated, have production methods at least somewhat up and running and have the protein characterized and the correct assays done because that's that's what drives the value. If we partner these too early, we're kinda shooting ourselves in the foot. We're taking a little bit more time to make sure that we have all the necessary information to extract as much value in our partnerships or in our sales as possible.

[Operator]

Thank you. There are no further questions at this time. I'd like to hand the floor back over to Mark Amelform for any closing remarks.

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

I'd like to thank all of you for joining us today and for your support over the years. In closing, Q1 twenty twenty five marked a pivotal step forward in Dyadic's evolution from a development stage biotech company to a product driven revenue generating enterprise.

[Mark Emalfarb, President and Chief Executive Officer at Dyadic International]

By focusing our efforts on the development of functional recombinant solutions and proprietary production strains to manufacture large quantities of precision engineered proteins and enzymes for use in life science, nutrition and industrial applications. We are positioning ourselves and our partners to meet the growing global demand for scalable and affordable animal free precision engineered proteins and enzymes. With commercial launches on a near horizon, a robust pipeline backed by non dilutive funding and a powerful technology platform both for C1 and APOBIS validated across multiple sectors, we believe Dyadic is well on its way to unlocking meaningful long term value for our shareholders. We appreciate your continued support and look forward to updating you on our progress in the months ahead.

[Operator]

This concludes today's conference.

[Operator]

You may disconnect your lines at this time. Thank you for your participation.

Participants

Executives

• Ping Rawson, Chief Financial Officer
• Mark Emalfarb, President and Chief Executive Officer
• Joseph Hazelton, Chief Operating Officer

Analysts

• John Vandermosten, Senior Analyst at Zacks Small Cap Research
• Dick Williams, Analyst at Williams Resource Group
• Paul Rosenbaum, CEO at SWR Sound Corporation
• Tony Bowers, Director of Corporate sales at Intro-act