NASDAQ:ONCY Oncolytics Biotech Q1 2025 Earnings Report $0.89 -0.01 (-1.12%) Closing price 05/8/2026 04:00 PM EasternExtended Trading$0.88 0.00 (-0.55%) As of 05/8/2026 07:48 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. ProfileEarnings HistoryForecast Oncolytics Biotech EPS ResultsActual EPS-$0.06Consensus EPS -$0.09Beat/MissBeat by +$0.03One Year Ago EPSN/AOncolytics Biotech Revenue ResultsActual RevenueN/AExpected RevenueN/ABeat/MissN/AYoY Revenue GrowthN/AOncolytics Biotech Announcement DetailsQuarterQ1 2025Date5/14/2025TimeAfter Market ClosesConference Call DateWednesday, May 14, 2025Conference Call Time4:30PM ETUpcoming EarningsOncolytics Biotech's Q1 2026 earnings is estimated for Wednesday, May 13, 2026, based on past reporting schedulesConference Call ResourcesConference Call AudioConference Call TranscriptPress Release (6-K)Earnings HistoryCompany ProfilePowered by Oncolytics Biotech Q1 2025 Earnings Call TranscriptProvided by QuartrMay 14, 2025 ShareLink copied to clipboard.Key Takeaways OnClinix has an active CEO search under way to identify a leader to advance its pelareorep (Pella) oncology program and initiate registrational trials. Interim results from Goblet Cohort 4 in relapsed anal carcinoma reported a 33% objective response rate, including one complete response lasting over 15 months, leading to cohort expansion. Goblet Cohort 5, evaluating Pella with modified FOLFIRINOX with or without atezolizumab in metastatic pancreatic cancer, has completed its safety run-in and is over halfway enrolled, with efficacy data expected later this year. Two randomized Phase II breast cancer studies showed nearly double median overall survival and significant progression-free survival gains for Pella plus paclitaxel versus paclitaxel alone, supporting a potential accelerated approval pathway. As of March 31, 2025, the company held CA$15.3 million in cash (runway into Q3 2025) and secured a US$20 million share purchase agreement to provide additional capital at management’s discretion. AI Generated. May Contain Errors.Conference Call Audio Live Call not available Earnings Conference CallOncolytics Biotech Q1 202500:00 / 00:00Speed:1x1.25x1.5x2xTranscript SectionsPresentationParticipantsPresentationSkip to Participants Operator00:00:00Good afternoon, and welcome to Oncolytics Biotech's first quarter conference call. All participants are now in listen-only mode. There will be a question-and-answer session at the end of this call. Please be advised that this call is being recorded at the company's request. I would now like to turn the call over to Jon Patton, Director of Investor Relations and Communication. Please go ahead. Jon PattonDirector of Investor Relations and Communication at Oncolytics Biotech00:00:23Thank you, Operator. Today, we'll provide an update on the quarter and a review of our financials. As a reminder, various remarks made during this call contain certain forward-looking statements relating to the company's business prospects and the development and commercialization of pelareorep, including statements regarding the company's ongoing CEO search, our mission, strategies, and milestones, the company's belief as to the potential and mechanism of action of pelareorep as a cancer therapeutic, our potential registrational opportunities for pelareorep, and our plans and strategies related thereto, our plans to continue enrollment in GOBLET Cohort 5, our ongoing business development initiatives, and other statements related to anticipated developments in the company's business. Jon PattonDirector of Investor Relations and Communication at Oncolytics Biotech00:01:04These statements are based on management's current expectations and beliefs and are subject to a number of factors which involve non- and unaddressed delays, uncertainties, and other factors not under the company's control that may cause actual results, performance, or achievements of the company to be materially different from the results, performance, or expectations implied by these forward-looking statements. In any forward-looking statement in which Oncolytics expresses an expectation or belief as to future results, such expectations or beliefs are expressed in good faith and are believed to have a reasonable basis, but there can be no assurance that these statements or expectations or beliefs will be achieved. These factors include results of current or pending clinical trials, risks associated with intellectual property protection, financial projections, actions by regulatory agencies, and those other factors detailed in the company's filings with CDAR and the SEC. Jon PattonDirector of Investor Relations and Communication at Oncolytics Biotech00:01:50Oncolytics does not undertake any obligation to update these forward-looking statements except as required by applicable laws. On today's call, I'm joined by Chair of Oncolytics Board of Directors, Interim CEO Wayne Pisano, Chief Medical Officer Dr. Tom Heinemann, VP Business Development Christophe Degois, and Chief Financial Officer Kirk Look. The team will be available for Q&A at the end of this call. With that, I'll hand it over to Wayne. Wayne PisanoInterim CEO at Oncolytics Biotech00:02:18Good afternoon, everyone, and thank you, Jon. I know it's only been a short time since we last provided a corporate update, so today's call will be relatively brief. I'll run through the important developments from the quarter and then ask Tom to discuss our clinical progress and Christophe to share a business development update. Kirk will say a few words about our financials. To start, I want to let you know that our CEO search is active and we've met several excellent candidates. With an asset like pelareorep, which has potential in numerous consequential indications, we are aiming to find a leader who can steward pela with a laser focus on clinical trial execution. Wayne PisanoInterim CEO at Oncolytics Biotech00:02:59Our clinical data continues to exceed expectations, and we believe the further development of pelareorep will allow it to fulfill its potential as a valuable treatment option for patients with several difficult-to-treat malignancies, including pancreatic cancer, breast cancer, and anal carcinoma, all of which have a high unmet medical need. Additionally, the new CEO will provide invaluable leadership and strategic decision-making surrounding our planned registration-enabling study evaluating pela and paclitaxel in advanced or metastatic HR-positive, HER2-negative breast cancer. I hope we will announce our new CEO in the near future. Pelareorep, or pela as we often call it, is a unique and versatile immunotherapeutic agent that we believe has tremendous potential to help a wide range of cancer patients. Wayne PisanoInterim CEO at Oncolytics Biotech00:03:51As discussed during a key opinion leader event in March, Professor Alexander Eggermont described pela's benefits, including intravenous administration, the ability to be taken to tumor sites via monocytes and lymphocytes, and that it does not create anti-agent antibodies, allowing T cells to reach the tumor for long-lasting responses, all without infecting normal healthy cells. During the same call, Professor Martine Piccart, a leading expert in breast cancer, shared her experience in the clinic and confirmed intravenous administration is much preferred to any intratumoral interventions. She also discussed pela's opportunity in breast cancer and the multitude of registrational opportunities for an asset like pela. She confirmed support for the continued advancement of pela based on two randomized studies confirming its ability to provide an overall survival benefit in breast cancer. Wayne PisanoInterim CEO at Oncolytics Biotech00:04:43She also discussed her belief that there could be an opportunity for pela to benefit patients at an earlier stage of treatment, possibly in a curative setting. Additionally, in the first quarter, we were able to showcase the versatility of pela in gastrointestinal cancers when we presented data at ASCO GI in both pancreatic and anal cancers. Tom will lead the discussion of that clinical data shortly. Looking forward, we'll be sharing pancreatic cancer data at this year's ASCO meeting, highlighting pela's unique mechanism of action, which stimulates both innate and adaptive immune responses. I'd now like to turn the call over to Tom for an update on our clinical progress and plans. Tom? Tom HeinemanChief Medical Officer at Oncolytics Biotech00:05:25Thanks, Wayne. Thanks for teeing up the data that we have shared and will be sharing this year at medical conferences such as ASCO and ASCO GI. The impactful data that Wayne mentioned was presented in January of this year at the ASCO GI Conference. Interim results from GOBLET Cohort 4, which investigates pelareorep and atezolizumab in relapsed anal carcinoma, showed a 33% objective response rate, including one patient with a complete response that lasted more than 15 months. We have expanded this cohort to stage two, in which an additional 18 patients will be enrolled. If the efficacy signal in this cohort persists, we will engage in discussions with our scientific advisory board and key opinion leaders to optimize the development of pelareorep in this indication. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:06:15While anal carcinoma is not as large a commercial opportunity as breast or pancreatic cancer, achieving regulatory approval in this indication would serve as an important validation of pelareorep's potential in gastrointestinal cancers and could greatly benefit patients with a very high unmet medical need. In addition, GOBLET cohort 5, which is funded by a $5 million grant from Pancreatic Cancer Action Network (PanCAN), is currently enrolling newly diagnosed metastatic pancreatic cancer patients. This cohort is evaluating pela combined with modified FOLFIRINOX with or without atezolizumab. Enrollment into the safety run-in phase of this cohort was recently completed. After review of the safety data by an independent data safety monitoring board and the German regulatory authorities, we received all necessary permissions to proceed with full enrollment, which is ongoing. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:07:12This cohort has enrolled more than half of the patients required to complete stage one of the study, which requires a total of 30 evaluable patients, 15 each in the arm with atezolizumab and the arm without atezolizumab. Upon completion of stage one enrollment, a decision will be made whether to advance either one or both arms to stage two enrollment. If the efficacy data are encouraging, this study could lead to yet another registrational opportunity. We expect to review initial efficacy data from this cohort later this year and share it publicly next year. In addition to the exciting progress in our gastrointestinal cancer studies, I'd also like to remind you of the compelling breast cancer results from two randomized phase two studies in which pela-based combination therapy substantially outperformed standard-of-care treatment. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:08:03The first of these was the IND-213 study in metastatic breast cancer, in which median overall survival in the pela group was nearly double that in the control arm. We followed IND-213 with the BRACELET-1 study to confirm the efficacy signal. In BRACELET-1, we evaluated patients with advanced or metastatic HR+, HER2-negative breast cancer who had progressed on hormonal therapy, including a CDK4/6 inhibitor. The BRACELET-1 data became available last fall and showed a substantial clinical benefit for pela combined with paclitaxel compared to paclitaxel monotherapy. This was based on a near doubling of both the median progression-free survival and the two-year survival rate, a near tripling of the confirmed objective response rate, and a median overall survival more than a year longer than that in the control arm. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:08:59With two randomized phase 2 studies pointing to a meaningful clinical benefit, as well as supportive mechanism of action data from several studies, including the AWARE1 breast cancer trial, we believe we have largely de-risked this program, setting the stage for continued development of pelareorep in breast cancer. In the evolving breast cancer treatment landscape, we have a number of attractive options for the continued development of pelareorep. These include a potential registration-enabling study designed to take advantage of the accelerated approval pathway, which was successfully utilized by breast cancer drugs such as Pfizer's Ibrance and Daiichi Sankyo's Enhertu. We also have the option to conduct studies in patients at different stages in the breast cancer treatment path, including patients with an operable disease who have failed antibody-drug conjugate therapy and early-stage patients utilizing a neoadjuvant approach. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:09:56This latter is one of the pathways suggested by key opinion leaders, including Professor Martine Piccart, who spoke at the KOL event Wayne mentioned at the start of this call. Next, I would like to introduce Christophe, who will comment on our ongoing business development activities. Christophe? Christophe DegoisVP of Business Development at Oncolytics Biotech00:10:16Thanks, Tom. I'm happy to share an update on our BD activities in addition to development involving our current collaboration. As we discussed, the data presented at ASCO GI continue to show the versatility of pela in multiple indications, specifically pancreatic and anal cancer. One underappreciated aspect is a remarkable safety profile of pela. pela has been administered to over 1,100 patients over the course of its development. While we're encouraged to see there remain no safety concern in anal cancer, where pela is being evaluated with a checkpoint inhibitor, atezolizumab, it is now being tested in combination with modified FOLFIRINOX in pancreatic cancer. This chemotherapy regimen has a different safety profile than gemcitabine plus nab-paclitaxel, the chemotherapy regimen from cohort one of the GOBLET study. Christophe DegoisVP of Business Development at Oncolytics Biotech00:11:09The fact that we are able to combine pela with multiple chemotherapies and checkpoint inhibitors while maintaining a favorable safety profile in pancreatic cancer makes it easier to engage in productive BD conversation. We had encouraging business development interaction in January at the JPMorgan Conference and will continue to meet with potential biopharma partners at ASCO in Chicago and Bio in Boston. We're also supported by key opinion leaders like Professor Martine Piccart and Professor Alex Eggermont, who continue to be enthusiastic supporters of pela's potential. During the previously discussed KOL event organized by H.C. Wainwright, both Professor Piccart and Professor Eggermont highlighted the need for new treatment innovations, such as pela that work to activate the immune system to recognize and kill cancer. Furthermore, we already have support from advocacy groups like PanCAN, who are funding cohort five of the GOBLET study. Christophe DegoisVP of Business Development at Oncolytics Biotech00:12:06As I mentioned on our previous call, the compelling data pela has generated across multiple indications serves us well. We have two randomized phase 2 studies showing pela's benefits in HR-positive, HER2-negative metastatic breast cancer, multiple pancreatic studies pointing to pela's meaningful impact, and an emerging efficacy signal that has continued to persist in anal cancer. In summary, this continues to be an exciting time for pela as we evaluate the most efficient way to pursue regulatory approval and further demonstrate the potential of our unique immunotherapeutic asset in helping improve the lives of cancer patients. I look forward to our next chance to update you on our BD opportunities and activities. I now turn the presentation over to Kirk, who will discuss our financials for the quarter. Kirk? Kirk LookCFO at Oncolytics Biotech00:13:00Thanks, Christophe. Good afternoon, everyone. I'd like to discuss our financial results for the first quarter of 2025, which will be provided in CAD unless otherwise noted. A full summary of our financial results can be found on the Investor section of our website under Filings and Reports or in the press release issued earlier this afternoon. Turning to our financial results for the first quarter, as of March 31, 2025, we reported cash and cash equivalents of CAD 15.3 million, providing runway through key value-driving milestones and through the third quarter of 2025. Net cash used in operating activities for the quarter was CAD 6.5 million compared to CAD 7.5 million in the same period last year. The decrease reflects lower net operating expenditures partially offset by changes in non-cash working capital. General and administrative expenses were CAD 3 million for the first quarter, consistent with the prior year. Kirk LookCFO at Oncolytics Biotech00:13:58Research and development expenses totaled $4.1 million, down from $5.7 million in Q1 of 2024. This decrease was primarily driven by reduced manufacturing and clinical trial costs, partially offset by increased personnel-related and share-based compensation expenses associated with leadership transition activities. The net loss for the quarter was $6.7 million, or $0.08 per basic and diluted share, compared to a net loss of $6.9 million, or $0.09 per share in Q1 of 2024. Finally, following the end of our quarter, we were pleased to announce a $20 million share purchase agreement with Alumni Capital. This agreement provides the company with access to capital solely at our discretion, helping us extend our financial runway. Now, this concludes our financial review. We look forward to providing further updates throughout the year and encourage you to watch for our upcoming poster presentation on pelareorep's mechanism of action at ASCO. Kirk LookCFO at Oncolytics Biotech00:14:57On behalf of the entire Oncolytics team, I'd like to thank our patients, caregivers, healthcare providers, employees, and shareholders for their ongoing support. Now, I would like to open the call for a Q&A. Operator? Operator00:15:12Thank you. Ladies and gentlemen, we will now begin the question-and-answer session. Should you have a question, please press star followed by the one on your telephone keypad. You will hear a prompt that your hand has been raised. Should you wish to cancel a request, please press star followed by the two. If you are using a speakerphone, please lift the handset before pressing any keys. One moment, please, for your first question. Your first question comes from the line of Patrick Trucchio from H.C. Wainwright. Please go ahead. Patrick TrucchioAnalyst at H.C. Wainwright00:15:44Thanks. Good afternoon, and congrats on all the progress. Just first, regarding the anticipated start of the registrational trial in HR-positive, HER2-negative metastatic breast cancer, what can you share about the potential trial design for the study? Will PFS be a primary endpoint? How are you incorporating feedback from regulatory agencies? Separately, have there been any recent interactions with the FDA or other regulatory bodies regarding the pancreatic cancer program? What feedback, if any, have you received concerning potential registrational pathways? Tom HeinemanChief Medical Officer at Oncolytics Biotech00:16:20Yeah. Hi, Patrick. Tom Heineman here. Maybe I can answer those, and others can step in if there's more to say. Regarding the breast cancer side, we, as you know, have discussed the study with the FDA at a type C meeting in the second or third quarter of last year, right? We continue to—pardon—we continue to work towards the initiation of our next study in breast cancer. At the time that we discussed this with the FDA, we obviously discussed many elements of the study design, including the primary endpoint, which we do anticipate will be progression-free survival in our next breast cancer study. That's on the breast cancer side. On the pancreatic cancer side, we have not had—I mean, we have—the FDA is aware of our pancreatic cancer program, including having granted us fast-track approval in pancreatic cancer. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:17:25We have been working with GCAR, as you may be aware, to develop a protocol in pancreatic cancer. That activity is ongoing. Of course, we're talking to key opinion leaders and exploring all the best options for moving our pancreatic cancer program forward. We have not had any additional discussions with the FDA recently. If we were to move forward with a registrational study through any means, that would require an FDA meeting before we initiated that study, however. I hope that answered your question. If I forgot anything, let me know. Patrick TrucchioAnalyst at H.C. Wainwright00:18:10Yeah. That's helpful. Just to follow up, if I may, on the business development activities, I'm wondering if there are specific areas like regional rights or co-development opportunities, or other areas that are being prioritized. Just given pelareorep or AWARE-1's mechanism of action, are there plans to explore additional combination approaches, maybe with immune checkpoint inhibitors or in other tumor types? Christophe DegoisVP of Business Development at Oncolytics Biotech00:18:37Hi, Patrick. This is Christophe. Yeah. I'm happy to answer the first question. I think Tom can comment on the second part of the question because we're already doing that. Yeah. What we're doing right now, as we mentioned, we've been busy at JPMorgan. We'll be at ASCO. We'll be at Bio. We're looking at different potential different partnerships. For us, what's very important is, as we discussed during this call, Pelareorep has a potential multiple indication. So we'd like to have, obviously, breast and pancreatic being our top priorities. We'd like a partner that could help us maximize the value of the asset in this multiple indication. That could be done either through a global partnership or a more regional, like Europe, European partnership. We are looking at both avenues right now. Does that answer your question? Patrick TrucchioAnalyst at H.C. Wainwright00:19:31Yeah. That's helpful. Christophe DegoisVP of Business Development at Oncolytics Biotech00:19:34Tom, do you want to comment? Yeah. Do you want to comment on the combination? Tom HeinemanChief Medical Officer at Oncolytics Biotech00:19:39Yeah. Yeah. Sure. If you don't mind, Patrick, I'll just mention the combination with checkpoint inhibitors specifically. So we've done a lot of work, translational work based on samples from clinical trials in a number of different indications, including breast and pancreatic cancer, and have shown, particularly in pancreatic cancer, but also in breast cancer, that pela clearly potentiates the activity of checkpoint inhibitors, right? Now, in breast cancer, we have seen very strong efficacy data with pela without a checkpoint inhibitor. So it's not necessarily essential in every context. In pancreatic cancer specifically, we have really solid clinical and translational data indicating a synergy with checkpoint inhibitors. This is something that we will continue to explore and leverage on an indication-by-indication basis. Patrick TrucchioAnalyst at H.C. Wainwright00:20:34Great. Thanks so much. Operator00:20:38Thank you. Once again, should you have a question, please press star followed by the one on your telephone keypad. Your next question comes from the line of Michael Freeman from Raymond James. Please go ahead. Michael FreemanEquity Research Analyst at Raymond James00:20:50Hey. Good afternoon, Wayne, Kirk, Tom, Christophe, Jon. Just a few questions here. You mentioned on the metastatic breast program, you've previously discussed a registration path that might enable accelerated approval. I think I'm hearing for the first time discussion of treatment of patients at different stages of the treatment journey and leaning toward earlier stage patients, if I'm hearing it, if I heard it right. I wonder if you could discuss—just dive into that a little more. Would this be an alternative to a registration-enabling trial, or would this be a separate cohort along the treatment journey? If you could just discuss the rationale and different potential registration paths. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:21:42Yeah. Tom here. Just to be clear, we're not trying to imply that we would be shifting towards earlier stage necessarily. I'm just trying to indicate that there are a lot of different populations in the breast cancer treatment path that could provide valuable information and advance the overall program. One of those may be an earlier-stage study in neoadjuvant patients. The other thing to consider is that the antibody-drug conjugates, as you're certainly aware, are changing the landscape in breast cancer. This provides us with a real opportunity because, following antibody-drug conjugate therapy, the treatment for these patients is much less clear and is wide open for agents like pela-based combination therapy to step in. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:22:42Discussing with key opinion leaders, there is a sense that one potential way to advance the program and de-risk it, and move it forward efficiently would be to specifically generate data in patients who have—these are not earlier stage patients, but these are patients who have failed hormonal therapy and then also failed an antibody-drug conjugate. We have every reason to believe that pela would be a successful agent in that patient population. Generating direct data in that population could be a very nice way to further de-risk the program and also stimulate additional interest by potential partners, investors, and so forth who are looking to understand as well as possible where pela could fit into the overall treatment path. I hope that answers your question. I don't know if anyone else on the call may want to contribute to that answer, but. Michael FreemanEquity Research Analyst at Raymond James00:23:48Yeah. That's helpful. Just a little more on that. I'm curious, was that not similar to what you had contemplated for the original registration-enabling trial, that it would line up after ADCs? Or are you now sort of considering a smaller cohort study that would exclusively look at post-ADC, like patients that had failed hormonal therapy and ADCs? Tom HeinemanChief Medical Officer at Oncolytics Biotech00:24:18Yeah. We had anticipated that before. The reality of the matter is that at that time, it was more hypothetical because the ADCs had not yet been approved as the first-line therapy immediately following failure on hormonal therapy, right? Now, with that approval—I do not remember when that was—but first quarter of this year, with that approval now on the books, that opens up a slightly different population and leads us to expect that the ADCs are going to be used even earlier in the treatment path than had been obvious before, right? That provides us with some additional opportunity and motivation to further solidify pela's efficacy in that population. You see what I am saying? Michael FreemanEquity Research Analyst at Raymond James00:25:17Yes. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:25:17If we were to go down that path, we certainly would do it in a smaller study. We would not do it in a tiny study. We would definitely want to make sure that the data that were generated there are robust enough to really move the program forward as rapidly and with as little risk as possible. Michael FreemanEquity Research Analyst at Raymond James00:25:38Okay. All right. Great. I appreciate you guys being dynamic to the landscape. Now, I have a question for Kirk. On the share purchase agreement, congratulations on finding that access to capital. I wonder if you could describe just the basic structure of this agreement, any terms, conditions, benefits to Alumni Capital, and just the flexibility that it offers you. Kirk LookCFO at Oncolytics Biotech00:26:07Yeah. For sure, Michael. I think essentially this share purchase agreement does provide us with access to capital at our discretion. Importantly, the minimum purchase notice is set at $750,000. Often, what we see are smaller purchase notices moving forward. We felt that that was important. The structure in terms of commitment fees, there was an upfront commitment fee that was granted. There is an additional fee that is attached on a pro-rata basis as well in an effort to reduce the cost of capital, which we were pleased with. Kirk LookCFO at Oncolytics Biotech00:26:59It really allows us to, based on kind of the market dynamics of the time, allows us a source of capital that we can, at our discretion, take advantage of and allows us to move the programs forward, get us through our milestones, especially around the GOBLET study that's coming up here, and get through this CEO transition, and importantly, move the runway forward. Michael FreemanEquity Research Analyst at Raymond James00:27:37Okay. All right. That's helpful. Yeah. Have you tapped that since announcing it? Kirk LookCFO at Oncolytics Biotech00:27:48Yes. We've tapped it a little bit. Again, we're just making sure that it works as described, and we're doing it in a strategic manner. Michael FreemanEquity Research Analyst at Raymond James00:28:04Okay. Thank you. That's all for me. Congratulations. Operator00:28:10Thank you. There are no further questions at this time. I would now hand the call back to Mr. Kirk Look for any closing remarks. Kirk LookCFO at Oncolytics Biotech00:28:19Thanks, operator. Once again, I would like to thank everyone for taking the time to hear about our recent progress and plans for the future. We continue to be excited about 2025 and how pela is positioned to positively impact the lives of cancer patients. Wishing everyone a great day. Thanks very much. Operator00:28:36This concludes today's call. Thank you for participating. You may all disconnect.Read moreParticipantsExecutivesWayne PisanoInterim CEOKirk LookCFOJon PattonDirector of Investor Relations and CommunicationChristophe DegoisVP of Business DevelopmentTom HeinemanChief Medical OfficerAnalystsPatrick TrucchioAnalyst at H.C. WainwrightMichael FreemanEquity Research Analyst at Raymond JamesPowered by Earnings DocumentsPress Release(6-K) Oncolytics Biotech Earnings HeadlinesOncolytics Biotech® Reports Durable Responses in Second-Line RAS-Mutant MSS Colorectal CancerMay 4, 2026 | globenewswire.comOncolytics Biotech Inc. (NASDAQ:ONCY) Receives Average Recommendation of "Moderate Buy" from AnalystsMay 1, 2026 | americanbankingnews.comBefore you buy SpaceX shares, consider this alternative approachSpaceX has confidentially filed for an IPO with the SEC, targeting a June 2026 listing at a valuation exceeding $1.75 trillion - potentially the largest IPO in history. But one expert says buying shares directly may not be the smartest move. There is a lesser-known way to tap into this windfall that most investors haven't considered.May 10 at 1:00 AM | Weiss Ratings (Ad)Oncolytics Biotech, Inc.: Oncolytics Aligns with FDA on Planned Pivotal Anal Cancer StudyApril 27, 2026 | finanznachrichten.deOncolytics Aligns with FDA on Planned Pivotal Anal Cancer StudyApril 27, 2026 | globenewswire.comOncolytics Could Re-Rate As Pelareorep Focuses On Registrational PathsApril 25, 2026 | seekingalpha.comSee More Oncolytics Biotech Headlines Get Earnings Announcements in your inboxWant to stay updated on the latest earnings announcements and upcoming reports for companies like Oncolytics Biotech? Sign up for Earnings360's daily newsletter to receive timely earnings updates on Oncolytics Biotech and other key companies, straight to your email. Email Address About Oncolytics BiotechOncolytics Biotech (NASDAQ:ONCY) (NASDAQ: ONCY) is a clinical-stage biotechnology company focused on the development of novel oncolytic viral therapies for the treatment of cancer. The company’s lead investigational agent, pelareorep (Reolysin), is a proprietary formulation of reovirus engineered to selectively infect and destroy tumor cells while stimulating a systemic antitumor immune response. Oncolytics leverages the natural biology of the virus to enhance the activity of standard‐of‐care treatments and immune checkpoint inhibitors. Pelareorep has progressed into multiple advanced clinical trials, with combination studies conducted in metastatic breast cancer, non‐small cell lung cancer and head and neck cancers. Collaborations with academic centers and pharmaceutical partners support ongoing research into optimal dosing regimens, novel combination strategies and biomarker identification. The company also maintains an early-stage pipeline of additional viral candidates aimed at broadening its platform of immune‐activating cancer therapies. Headquartered in Calgary, Alberta, with a research and development facility in Houston, Texas, Oncolytics sustains a presence in major North American life science hubs. The company’s infrastructure supports integrated translational research, process development and global clinical trial management, with a focus on advancing regulatory filings and securing strategic partnerships to accelerate commercialization. Under the leadership of President and Chief Executive Officer Brad Thompson, Oncolytics’ management team brings extensive experience in oncology drug development, virology and biopharmaceutical operations. The company remains committed to advancing its viral immunotherapy platform through rigorous clinical investigation and collaborative programs designed to address unmet needs in oncology.View Oncolytics Biotech ProfileRead more More Earnings Resources from MarketBeat Earnings Tools Today's Earnings Tomorrow's Earnings Next Week's Earnings Upcoming Earnings Calls Earnings Newsletter Earnings Call Transcripts Earnings Beats & Misses Corporate Guidance Earnings Screener Latest Articles MarketBeat Week in Review – 05/04 - 05/08Quantum Earnings Season Is Ramping Up—What to Watch From 2 Major PlayersRocket Lab Posts Record Q1 Revenue, Raises Q2 Guidance3 Under-The-Radar Small Caps Making New All-Time HighsFlutter Sees Post-Earnings Boost as FanDuel Shows Signs of RecoveryHims & Hers Earnings Preview: The Novo Nordisk Shift Puts GLP-1 Strategy in FocusWater Infrastructure: Why This Boring Sector Could Get Exciting Upcoming Earnings Constellation Energy (5/11/2026)Barrick Mining (5/11/2026)Petroleo Brasileiro S.A.- Petrobras (5/11/2026)Simon Property Group (5/11/2026)SEA (5/12/2026)Cisco Systems (5/13/2026)Alibaba Group (5/13/2026)Manulife Financial (5/13/2026)Sumitomo Mitsui Financial Group (5/13/2026)Takeda Pharmaceutical (5/13/2026) Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. Real-time analyst ratings, insider transactions, earnings data, and more. Our daily ratings and market update email newsletter. Sign in to your free account to enjoy all that MarketBeat has to offer. Sign In Create Account Your Email Address: Email Address Required Your Password: Password Required Log In Email Me a Login Link or Sign in with Facebook Sign in with Google Forgot your password? Your Email Address: Please enter your email address. Please enter a valid email address Choose a Password: Please enter your password. Your password must be at least 8 characters long and contain at least 1 number, 1 letter, and 1 special character. Create My Account (Free) or Sign in with Facebook Sign in with Google By creating a free account, you agree to our terms of service. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
PresentationSkip to Participants Operator00:00:00Good afternoon, and welcome to Oncolytics Biotech's first quarter conference call. All participants are now in listen-only mode. There will be a question-and-answer session at the end of this call. Please be advised that this call is being recorded at the company's request. I would now like to turn the call over to Jon Patton, Director of Investor Relations and Communication. Please go ahead. Jon PattonDirector of Investor Relations and Communication at Oncolytics Biotech00:00:23Thank you, Operator. Today, we'll provide an update on the quarter and a review of our financials. As a reminder, various remarks made during this call contain certain forward-looking statements relating to the company's business prospects and the development and commercialization of pelareorep, including statements regarding the company's ongoing CEO search, our mission, strategies, and milestones, the company's belief as to the potential and mechanism of action of pelareorep as a cancer therapeutic, our potential registrational opportunities for pelareorep, and our plans and strategies related thereto, our plans to continue enrollment in GOBLET Cohort 5, our ongoing business development initiatives, and other statements related to anticipated developments in the company's business. Jon PattonDirector of Investor Relations and Communication at Oncolytics Biotech00:01:04These statements are based on management's current expectations and beliefs and are subject to a number of factors which involve non- and unaddressed delays, uncertainties, and other factors not under the company's control that may cause actual results, performance, or achievements of the company to be materially different from the results, performance, or expectations implied by these forward-looking statements. In any forward-looking statement in which Oncolytics expresses an expectation or belief as to future results, such expectations or beliefs are expressed in good faith and are believed to have a reasonable basis, but there can be no assurance that these statements or expectations or beliefs will be achieved. These factors include results of current or pending clinical trials, risks associated with intellectual property protection, financial projections, actions by regulatory agencies, and those other factors detailed in the company's filings with CDAR and the SEC. Jon PattonDirector of Investor Relations and Communication at Oncolytics Biotech00:01:50Oncolytics does not undertake any obligation to update these forward-looking statements except as required by applicable laws. On today's call, I'm joined by Chair of Oncolytics Board of Directors, Interim CEO Wayne Pisano, Chief Medical Officer Dr. Tom Heinemann, VP Business Development Christophe Degois, and Chief Financial Officer Kirk Look. The team will be available for Q&A at the end of this call. With that, I'll hand it over to Wayne. Wayne PisanoInterim CEO at Oncolytics Biotech00:02:18Good afternoon, everyone, and thank you, Jon. I know it's only been a short time since we last provided a corporate update, so today's call will be relatively brief. I'll run through the important developments from the quarter and then ask Tom to discuss our clinical progress and Christophe to share a business development update. Kirk will say a few words about our financials. To start, I want to let you know that our CEO search is active and we've met several excellent candidates. With an asset like pelareorep, which has potential in numerous consequential indications, we are aiming to find a leader who can steward pela with a laser focus on clinical trial execution. Wayne PisanoInterim CEO at Oncolytics Biotech00:02:59Our clinical data continues to exceed expectations, and we believe the further development of pelareorep will allow it to fulfill its potential as a valuable treatment option for patients with several difficult-to-treat malignancies, including pancreatic cancer, breast cancer, and anal carcinoma, all of which have a high unmet medical need. Additionally, the new CEO will provide invaluable leadership and strategic decision-making surrounding our planned registration-enabling study evaluating pela and paclitaxel in advanced or metastatic HR-positive, HER2-negative breast cancer. I hope we will announce our new CEO in the near future. Pelareorep, or pela as we often call it, is a unique and versatile immunotherapeutic agent that we believe has tremendous potential to help a wide range of cancer patients. Wayne PisanoInterim CEO at Oncolytics Biotech00:03:51As discussed during a key opinion leader event in March, Professor Alexander Eggermont described pela's benefits, including intravenous administration, the ability to be taken to tumor sites via monocytes and lymphocytes, and that it does not create anti-agent antibodies, allowing T cells to reach the tumor for long-lasting responses, all without infecting normal healthy cells. During the same call, Professor Martine Piccart, a leading expert in breast cancer, shared her experience in the clinic and confirmed intravenous administration is much preferred to any intratumoral interventions. She also discussed pela's opportunity in breast cancer and the multitude of registrational opportunities for an asset like pela. She confirmed support for the continued advancement of pela based on two randomized studies confirming its ability to provide an overall survival benefit in breast cancer. Wayne PisanoInterim CEO at Oncolytics Biotech00:04:43She also discussed her belief that there could be an opportunity for pela to benefit patients at an earlier stage of treatment, possibly in a curative setting. Additionally, in the first quarter, we were able to showcase the versatility of pela in gastrointestinal cancers when we presented data at ASCO GI in both pancreatic and anal cancers. Tom will lead the discussion of that clinical data shortly. Looking forward, we'll be sharing pancreatic cancer data at this year's ASCO meeting, highlighting pela's unique mechanism of action, which stimulates both innate and adaptive immune responses. I'd now like to turn the call over to Tom for an update on our clinical progress and plans. Tom? Tom HeinemanChief Medical Officer at Oncolytics Biotech00:05:25Thanks, Wayne. Thanks for teeing up the data that we have shared and will be sharing this year at medical conferences such as ASCO and ASCO GI. The impactful data that Wayne mentioned was presented in January of this year at the ASCO GI Conference. Interim results from GOBLET Cohort 4, which investigates pelareorep and atezolizumab in relapsed anal carcinoma, showed a 33% objective response rate, including one patient with a complete response that lasted more than 15 months. We have expanded this cohort to stage two, in which an additional 18 patients will be enrolled. If the efficacy signal in this cohort persists, we will engage in discussions with our scientific advisory board and key opinion leaders to optimize the development of pelareorep in this indication. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:06:15While anal carcinoma is not as large a commercial opportunity as breast or pancreatic cancer, achieving regulatory approval in this indication would serve as an important validation of pelareorep's potential in gastrointestinal cancers and could greatly benefit patients with a very high unmet medical need. In addition, GOBLET cohort 5, which is funded by a $5 million grant from Pancreatic Cancer Action Network (PanCAN), is currently enrolling newly diagnosed metastatic pancreatic cancer patients. This cohort is evaluating pela combined with modified FOLFIRINOX with or without atezolizumab. Enrollment into the safety run-in phase of this cohort was recently completed. After review of the safety data by an independent data safety monitoring board and the German regulatory authorities, we received all necessary permissions to proceed with full enrollment, which is ongoing. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:07:12This cohort has enrolled more than half of the patients required to complete stage one of the study, which requires a total of 30 evaluable patients, 15 each in the arm with atezolizumab and the arm without atezolizumab. Upon completion of stage one enrollment, a decision will be made whether to advance either one or both arms to stage two enrollment. If the efficacy data are encouraging, this study could lead to yet another registrational opportunity. We expect to review initial efficacy data from this cohort later this year and share it publicly next year. In addition to the exciting progress in our gastrointestinal cancer studies, I'd also like to remind you of the compelling breast cancer results from two randomized phase two studies in which pela-based combination therapy substantially outperformed standard-of-care treatment. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:08:03The first of these was the IND-213 study in metastatic breast cancer, in which median overall survival in the pela group was nearly double that in the control arm. We followed IND-213 with the BRACELET-1 study to confirm the efficacy signal. In BRACELET-1, we evaluated patients with advanced or metastatic HR+, HER2-negative breast cancer who had progressed on hormonal therapy, including a CDK4/6 inhibitor. The BRACELET-1 data became available last fall and showed a substantial clinical benefit for pela combined with paclitaxel compared to paclitaxel monotherapy. This was based on a near doubling of both the median progression-free survival and the two-year survival rate, a near tripling of the confirmed objective response rate, and a median overall survival more than a year longer than that in the control arm. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:08:59With two randomized phase 2 studies pointing to a meaningful clinical benefit, as well as supportive mechanism of action data from several studies, including the AWARE1 breast cancer trial, we believe we have largely de-risked this program, setting the stage for continued development of pelareorep in breast cancer. In the evolving breast cancer treatment landscape, we have a number of attractive options for the continued development of pelareorep. These include a potential registration-enabling study designed to take advantage of the accelerated approval pathway, which was successfully utilized by breast cancer drugs such as Pfizer's Ibrance and Daiichi Sankyo's Enhertu. We also have the option to conduct studies in patients at different stages in the breast cancer treatment path, including patients with an operable disease who have failed antibody-drug conjugate therapy and early-stage patients utilizing a neoadjuvant approach. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:09:56This latter is one of the pathways suggested by key opinion leaders, including Professor Martine Piccart, who spoke at the KOL event Wayne mentioned at the start of this call. Next, I would like to introduce Christophe, who will comment on our ongoing business development activities. Christophe? Christophe DegoisVP of Business Development at Oncolytics Biotech00:10:16Thanks, Tom. I'm happy to share an update on our BD activities in addition to development involving our current collaboration. As we discussed, the data presented at ASCO GI continue to show the versatility of pela in multiple indications, specifically pancreatic and anal cancer. One underappreciated aspect is a remarkable safety profile of pela. pela has been administered to over 1,100 patients over the course of its development. While we're encouraged to see there remain no safety concern in anal cancer, where pela is being evaluated with a checkpoint inhibitor, atezolizumab, it is now being tested in combination with modified FOLFIRINOX in pancreatic cancer. This chemotherapy regimen has a different safety profile than gemcitabine plus nab-paclitaxel, the chemotherapy regimen from cohort one of the GOBLET study. Christophe DegoisVP of Business Development at Oncolytics Biotech00:11:09The fact that we are able to combine pela with multiple chemotherapies and checkpoint inhibitors while maintaining a favorable safety profile in pancreatic cancer makes it easier to engage in productive BD conversation. We had encouraging business development interaction in January at the JPMorgan Conference and will continue to meet with potential biopharma partners at ASCO in Chicago and Bio in Boston. We're also supported by key opinion leaders like Professor Martine Piccart and Professor Alex Eggermont, who continue to be enthusiastic supporters of pela's potential. During the previously discussed KOL event organized by H.C. Wainwright, both Professor Piccart and Professor Eggermont highlighted the need for new treatment innovations, such as pela that work to activate the immune system to recognize and kill cancer. Furthermore, we already have support from advocacy groups like PanCAN, who are funding cohort five of the GOBLET study. Christophe DegoisVP of Business Development at Oncolytics Biotech00:12:06As I mentioned on our previous call, the compelling data pela has generated across multiple indications serves us well. We have two randomized phase 2 studies showing pela's benefits in HR-positive, HER2-negative metastatic breast cancer, multiple pancreatic studies pointing to pela's meaningful impact, and an emerging efficacy signal that has continued to persist in anal cancer. In summary, this continues to be an exciting time for pela as we evaluate the most efficient way to pursue regulatory approval and further demonstrate the potential of our unique immunotherapeutic asset in helping improve the lives of cancer patients. I look forward to our next chance to update you on our BD opportunities and activities. I now turn the presentation over to Kirk, who will discuss our financials for the quarter. Kirk? Kirk LookCFO at Oncolytics Biotech00:13:00Thanks, Christophe. Good afternoon, everyone. I'd like to discuss our financial results for the first quarter of 2025, which will be provided in CAD unless otherwise noted. A full summary of our financial results can be found on the Investor section of our website under Filings and Reports or in the press release issued earlier this afternoon. Turning to our financial results for the first quarter, as of March 31, 2025, we reported cash and cash equivalents of CAD 15.3 million, providing runway through key value-driving milestones and through the third quarter of 2025. Net cash used in operating activities for the quarter was CAD 6.5 million compared to CAD 7.5 million in the same period last year. The decrease reflects lower net operating expenditures partially offset by changes in non-cash working capital. General and administrative expenses were CAD 3 million for the first quarter, consistent with the prior year. Kirk LookCFO at Oncolytics Biotech00:13:58Research and development expenses totaled $4.1 million, down from $5.7 million in Q1 of 2024. This decrease was primarily driven by reduced manufacturing and clinical trial costs, partially offset by increased personnel-related and share-based compensation expenses associated with leadership transition activities. The net loss for the quarter was $6.7 million, or $0.08 per basic and diluted share, compared to a net loss of $6.9 million, or $0.09 per share in Q1 of 2024. Finally, following the end of our quarter, we were pleased to announce a $20 million share purchase agreement with Alumni Capital. This agreement provides the company with access to capital solely at our discretion, helping us extend our financial runway. Now, this concludes our financial review. We look forward to providing further updates throughout the year and encourage you to watch for our upcoming poster presentation on pelareorep's mechanism of action at ASCO. Kirk LookCFO at Oncolytics Biotech00:14:57On behalf of the entire Oncolytics team, I'd like to thank our patients, caregivers, healthcare providers, employees, and shareholders for their ongoing support. Now, I would like to open the call for a Q&A. Operator? Operator00:15:12Thank you. Ladies and gentlemen, we will now begin the question-and-answer session. Should you have a question, please press star followed by the one on your telephone keypad. You will hear a prompt that your hand has been raised. Should you wish to cancel a request, please press star followed by the two. If you are using a speakerphone, please lift the handset before pressing any keys. One moment, please, for your first question. Your first question comes from the line of Patrick Trucchio from H.C. Wainwright. Please go ahead. Patrick TrucchioAnalyst at H.C. Wainwright00:15:44Thanks. Good afternoon, and congrats on all the progress. Just first, regarding the anticipated start of the registrational trial in HR-positive, HER2-negative metastatic breast cancer, what can you share about the potential trial design for the study? Will PFS be a primary endpoint? How are you incorporating feedback from regulatory agencies? Separately, have there been any recent interactions with the FDA or other regulatory bodies regarding the pancreatic cancer program? What feedback, if any, have you received concerning potential registrational pathways? Tom HeinemanChief Medical Officer at Oncolytics Biotech00:16:20Yeah. Hi, Patrick. Tom Heineman here. Maybe I can answer those, and others can step in if there's more to say. Regarding the breast cancer side, we, as you know, have discussed the study with the FDA at a type C meeting in the second or third quarter of last year, right? We continue to—pardon—we continue to work towards the initiation of our next study in breast cancer. At the time that we discussed this with the FDA, we obviously discussed many elements of the study design, including the primary endpoint, which we do anticipate will be progression-free survival in our next breast cancer study. That's on the breast cancer side. On the pancreatic cancer side, we have not had—I mean, we have—the FDA is aware of our pancreatic cancer program, including having granted us fast-track approval in pancreatic cancer. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:17:25We have been working with GCAR, as you may be aware, to develop a protocol in pancreatic cancer. That activity is ongoing. Of course, we're talking to key opinion leaders and exploring all the best options for moving our pancreatic cancer program forward. We have not had any additional discussions with the FDA recently. If we were to move forward with a registrational study through any means, that would require an FDA meeting before we initiated that study, however. I hope that answered your question. If I forgot anything, let me know. Patrick TrucchioAnalyst at H.C. Wainwright00:18:10Yeah. That's helpful. Just to follow up, if I may, on the business development activities, I'm wondering if there are specific areas like regional rights or co-development opportunities, or other areas that are being prioritized. Just given pelareorep or AWARE-1's mechanism of action, are there plans to explore additional combination approaches, maybe with immune checkpoint inhibitors or in other tumor types? Christophe DegoisVP of Business Development at Oncolytics Biotech00:18:37Hi, Patrick. This is Christophe. Yeah. I'm happy to answer the first question. I think Tom can comment on the second part of the question because we're already doing that. Yeah. What we're doing right now, as we mentioned, we've been busy at JPMorgan. We'll be at ASCO. We'll be at Bio. We're looking at different potential different partnerships. For us, what's very important is, as we discussed during this call, Pelareorep has a potential multiple indication. So we'd like to have, obviously, breast and pancreatic being our top priorities. We'd like a partner that could help us maximize the value of the asset in this multiple indication. That could be done either through a global partnership or a more regional, like Europe, European partnership. We are looking at both avenues right now. Does that answer your question? Patrick TrucchioAnalyst at H.C. Wainwright00:19:31Yeah. That's helpful. Christophe DegoisVP of Business Development at Oncolytics Biotech00:19:34Tom, do you want to comment? Yeah. Do you want to comment on the combination? Tom HeinemanChief Medical Officer at Oncolytics Biotech00:19:39Yeah. Yeah. Sure. If you don't mind, Patrick, I'll just mention the combination with checkpoint inhibitors specifically. So we've done a lot of work, translational work based on samples from clinical trials in a number of different indications, including breast and pancreatic cancer, and have shown, particularly in pancreatic cancer, but also in breast cancer, that pela clearly potentiates the activity of checkpoint inhibitors, right? Now, in breast cancer, we have seen very strong efficacy data with pela without a checkpoint inhibitor. So it's not necessarily essential in every context. In pancreatic cancer specifically, we have really solid clinical and translational data indicating a synergy with checkpoint inhibitors. This is something that we will continue to explore and leverage on an indication-by-indication basis. Patrick TrucchioAnalyst at H.C. Wainwright00:20:34Great. Thanks so much. Operator00:20:38Thank you. Once again, should you have a question, please press star followed by the one on your telephone keypad. Your next question comes from the line of Michael Freeman from Raymond James. Please go ahead. Michael FreemanEquity Research Analyst at Raymond James00:20:50Hey. Good afternoon, Wayne, Kirk, Tom, Christophe, Jon. Just a few questions here. You mentioned on the metastatic breast program, you've previously discussed a registration path that might enable accelerated approval. I think I'm hearing for the first time discussion of treatment of patients at different stages of the treatment journey and leaning toward earlier stage patients, if I'm hearing it, if I heard it right. I wonder if you could discuss—just dive into that a little more. Would this be an alternative to a registration-enabling trial, or would this be a separate cohort along the treatment journey? If you could just discuss the rationale and different potential registration paths. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:21:42Yeah. Tom here. Just to be clear, we're not trying to imply that we would be shifting towards earlier stage necessarily. I'm just trying to indicate that there are a lot of different populations in the breast cancer treatment path that could provide valuable information and advance the overall program. One of those may be an earlier-stage study in neoadjuvant patients. The other thing to consider is that the antibody-drug conjugates, as you're certainly aware, are changing the landscape in breast cancer. This provides us with a real opportunity because, following antibody-drug conjugate therapy, the treatment for these patients is much less clear and is wide open for agents like pela-based combination therapy to step in. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:22:42Discussing with key opinion leaders, there is a sense that one potential way to advance the program and de-risk it, and move it forward efficiently would be to specifically generate data in patients who have—these are not earlier stage patients, but these are patients who have failed hormonal therapy and then also failed an antibody-drug conjugate. We have every reason to believe that pela would be a successful agent in that patient population. Generating direct data in that population could be a very nice way to further de-risk the program and also stimulate additional interest by potential partners, investors, and so forth who are looking to understand as well as possible where pela could fit into the overall treatment path. I hope that answers your question. I don't know if anyone else on the call may want to contribute to that answer, but. Michael FreemanEquity Research Analyst at Raymond James00:23:48Yeah. That's helpful. Just a little more on that. I'm curious, was that not similar to what you had contemplated for the original registration-enabling trial, that it would line up after ADCs? Or are you now sort of considering a smaller cohort study that would exclusively look at post-ADC, like patients that had failed hormonal therapy and ADCs? Tom HeinemanChief Medical Officer at Oncolytics Biotech00:24:18Yeah. We had anticipated that before. The reality of the matter is that at that time, it was more hypothetical because the ADCs had not yet been approved as the first-line therapy immediately following failure on hormonal therapy, right? Now, with that approval—I do not remember when that was—but first quarter of this year, with that approval now on the books, that opens up a slightly different population and leads us to expect that the ADCs are going to be used even earlier in the treatment path than had been obvious before, right? That provides us with some additional opportunity and motivation to further solidify pela's efficacy in that population. You see what I am saying? Michael FreemanEquity Research Analyst at Raymond James00:25:17Yes. Tom HeinemanChief Medical Officer at Oncolytics Biotech00:25:17If we were to go down that path, we certainly would do it in a smaller study. We would not do it in a tiny study. We would definitely want to make sure that the data that were generated there are robust enough to really move the program forward as rapidly and with as little risk as possible. Michael FreemanEquity Research Analyst at Raymond James00:25:38Okay. All right. Great. I appreciate you guys being dynamic to the landscape. Now, I have a question for Kirk. On the share purchase agreement, congratulations on finding that access to capital. I wonder if you could describe just the basic structure of this agreement, any terms, conditions, benefits to Alumni Capital, and just the flexibility that it offers you. Kirk LookCFO at Oncolytics Biotech00:26:07Yeah. For sure, Michael. I think essentially this share purchase agreement does provide us with access to capital at our discretion. Importantly, the minimum purchase notice is set at $750,000. Often, what we see are smaller purchase notices moving forward. We felt that that was important. The structure in terms of commitment fees, there was an upfront commitment fee that was granted. There is an additional fee that is attached on a pro-rata basis as well in an effort to reduce the cost of capital, which we were pleased with. Kirk LookCFO at Oncolytics Biotech00:26:59It really allows us to, based on kind of the market dynamics of the time, allows us a source of capital that we can, at our discretion, take advantage of and allows us to move the programs forward, get us through our milestones, especially around the GOBLET study that's coming up here, and get through this CEO transition, and importantly, move the runway forward. Michael FreemanEquity Research Analyst at Raymond James00:27:37Okay. All right. That's helpful. Yeah. Have you tapped that since announcing it? Kirk LookCFO at Oncolytics Biotech00:27:48Yes. We've tapped it a little bit. Again, we're just making sure that it works as described, and we're doing it in a strategic manner. Michael FreemanEquity Research Analyst at Raymond James00:28:04Okay. Thank you. That's all for me. Congratulations. Operator00:28:10Thank you. There are no further questions at this time. I would now hand the call back to Mr. Kirk Look for any closing remarks. Kirk LookCFO at Oncolytics Biotech00:28:19Thanks, operator. Once again, I would like to thank everyone for taking the time to hear about our recent progress and plans for the future. We continue to be excited about 2025 and how pela is positioned to positively impact the lives of cancer patients. Wishing everyone a great day. Thanks very much. Operator00:28:36This concludes today's call. Thank you for participating. You may all disconnect.Read moreParticipantsExecutivesWayne PisanoInterim CEOKirk LookCFOJon PattonDirector of Investor Relations and CommunicationChristophe DegoisVP of Business DevelopmentTom HeinemanChief Medical OfficerAnalystsPatrick TrucchioAnalyst at H.C. WainwrightMichael FreemanEquity Research Analyst at Raymond JamesPowered by