Sangamo Therapeutics Q1 2026 Earnings Report

Sangamo Therapeutics EPS Results

• Actual EPS: N/A
• Consensus EPS: $0.01
• Beat/Miss: N/A
• One Year Ago EPS: N/A

Sangamo Therapeutics Revenue Results

• Actual Revenue: N/A
• Expected Revenue: $33.73 million
• Beat/Miss: N/A
• YoY Revenue Growth: N/A

Sangamo Therapeutics Announcement Details

• Quarter: Q1 2026
• Date: 5/14/2026
• Time: After Market Closes
• Conference Call Date: Thursday, May 14, 2026
• Conference Call Time: 4:30PM ET

Sangamo Therapeutics (NASDAQ:SGMO) is a clinical-stage biotechnology company headquartered in Brisbane, California, that specializes in the development of genomic therapies based on its proprietary zinc finger nuclease (ZFN) technology. Founded in 1995, Sangamo pioneered ZFN-based genome editing to precisely alter DNA sequences for the treatment of serious genetic and rare diseases. The company’s platform encompasses in vivo genome editing, ex vivo cell therapy, and genome regulation approaches, with a focus on durable therapeutic effects through permanent genetic modification or sustained gene expression control.

Through its genome editing programs, Sangamo is advancing multiple product candidates into clinical trials for conditions such as hemophilia A and B, mucopolysaccharidosis types I and II, and lysosomal storage disorders. The company’s ex vivo programs leverage ZFN technology to engineer patient-derived cells for applications in immuno-oncology and regenerative medicine. Sangamo also develops gene regulation therapeutics using zinc finger transcription factors designed to upregulate or silence disease-related genes without altering the underlying DNA sequence.

Over the years, Sangamo has formed strategic partnerships with leading pharmaceutical and biotechnology firms to expand its research capabilities and accelerate the development of its pipeline. Collaborators have included major global players in hemophilia, metabolic disorders, and neuroscience, supporting clinical development, manufacturing scale-up, and regulatory filings. Sangamo maintains research operations and manufacturing facilities in the San Francisco Bay Area and collaborates with academic and industry partners worldwide.

Sangamo is led by President and Chief Executive Officer Sandy Macrae, under whose guidance the company has continued to innovate in genome engineering and advance its most promising candidates through regulatory milestones and clinical proof-of-concept studies. With a commitment to addressing unmet medical needs, Sangamo Therapeutics leverages its ZFN platform to develop next-generation therapies aimed at transforming the treatment landscape for patients with genetic and rare diseases.

Sangamo Therapeutics Q1 2026 Earnings Call Transcript

Key Takeaways

• Neutral Sentiment: Sangamo said the rolling BLA submission for ST-920 in Fabry disease is progressing, with the first two modules already filed and the company aiming to complete the submission as early as this summer, subject to funding.
• Positive Sentiment: The company said the FDA reaffirmed the accelerated approval pathway for ST-920 and confirmed that a separate confirmatory study will not be required, with 104-week data potentially supporting traditional approval later.
• Positive Sentiment: Sangamo emphasized durability and tolerability in ST-920 follow-up data, saying patients are being seen out to five years with stable benefit and that several patients remain off enzyme replacement therapy for more than three years.
• Neutral Sentiment: In neurology, Sangamo said six sites are activated for the phase I/II STAND study of ST-503 in small fiber neuropathy, and it also highlighted a published preclinical safety/pharmacology paper in Science Translational Medicine.
• Negative Sentiment: The company disclosed it lost Nasdaq compliance and moved its shares to the OTCQB Venture Market, while also continuing to seek additional capital and evaluate strategic alternatives to strengthen its financial position.

Presentation

[Operator]

Good afternoon, and welcome to Sangamo Therapeutics' first quarter 2026 teleconference call. Please be advised that today's conference is being recorded. I would now like to turn the conference over to your speaker today, Louise Wilkie, head of investor relations and corporate communications. Ma'am, please go ahead.

[Louise Wilkie, Head of Investor Relations and Corporate Communications at Sangamo Therapeutics]

Thank you. Good afternoon, everyone. Thank you for joining us on the call today. On this call are several members of the Sangamo executive leadership team, including Sandy Macrae, Chief Executive Officer, Nathalie Dubois-Stringfellow, Chief Development Officer, and Nikunj Jain, Interim Chief Financial Officer. Slides from our corporate presentation can be found on our website, sangamo.com, under the Presentations page of the Investors and Media section. This call includes forward-looking statements regarding Sangamo's current expectations.

[Louise Wilkie, Head of Investor Relations and Corporate Communications at Sangamo Therapeutics]

These statements include, but are not limited to, statements relating to Sangamo's cash runway, Sangamo's plans to obtain additional capital and its ability to continue to operate as a going concern, the therapeutic and commercial potential and value of Sangamo's product candidates and technologies, Sangamo's ability to establish and maintain collaborations and strategic partnerships, including for its Fabry disease program, the anticipated plans of Sangamo and its collaborators for clinical trials, regulatory submissions, and regulatory approvals, and other statements that are not historical fact. Actual results may differ materially from what we discuss today.

[Louise Wilkie, Head of Investor Relations and Corporate Communications at Sangamo Therapeutics]

These statements are subject to certain risks and uncertainties that are discussed in our filings with the SEC, specifically in our annual report on Form 10-K for the fiscal year ended December 31, 2025, and the quarterly report on Form 10-Q for the fiscal quarter ended March 31, 2026, and subsequent filings and reports that Sangamo makes from time to time with the SEC. The forward-looking statements stated today are made as of today, and we undertake no duty to update such information except as required by law. Please note that all forward-looking statements about our future plans and expectations are subject to our ability to secure adequate additional funding. Now, I'll turn the call over to our CEO, Sandy Macrae.

[Sandy Macrae, CEO at Sangamo Therapeutics]

Thank you, Louise, and good afternoon to everyone joining the call today. In the short time since our fourth quarter earnings call, we have continued to advance the rolling submission of the BLA for ST-920 in Fabry disease and made progress across our differentiated neurology pipeline. Nathalie will provide a detailed update on our development pipeline shortly. This quarter, Sangamo's common stock transitioned to trading on the OTCQB Venture Market following the receipt of a delisting determination from Nasdaq Capital Market due to non-compliance with Nasdaq's minimum bid requirements. We intend to appeal the determination at a hearing before Nasdaq in June. Our stock began trading on the OTCQB Venture Market earlier this month under the same ticker symbol SGMO.

[Sandy Macrae, CEO at Sangamo Therapeutics]

While we are disappointed by the Nasdaq delisting determination, the transition to the OTCQB market will allow Sangamo to maintain access to the public markets while we seek to advance our promising development pipeline. We remain focused on pursuing a number of opportunities to raise additional capital, including evaluating all strategic options to maximize the value of Sangamo's assets. Throughout this process, we have been and continue to be supported by a global investment bank. We continue to engage in business development discussions for a potential Fabry commercialization agreement and will share more information as appropriate. Before I hand over to Nathalie, I'd like to share an update from Boston, where I've just returned, where we had three abstracts accepted to this year's American Society of Gene and Cell Therapy annual meeting.

[Sandy Macrae, CEO at Sangamo Therapeutics]

ASGCT is an important forum for showcasing innovation in gene and cell therapy, and I was proud to see our talented scientists present our most recent advances in zinc finger epigenetic regulation, specifically for Nav1.7 and prion disease, alongside a platform presentation on our Modular Integrase technology. We have now achieved impressive levels of targeted integration in a variety of different cell types, moving us one step closer to our aspiration of achieving large-scale genome engineering to integrate large sequences of DNA into the genome. I'd like now to hand over to Nathalie. Nathalie.

[Nathalie Dubois-Stringfellow, Chief Development Officer at Sangamo Therapeutics]

Thank you, Sandy. Thank you, Sandy. First, I am pleased to share updates from our registrational Phase I/II STAAR study evaluating isaralgagene civaparvovec, or ST-920, our investigational gene therapy for the treatment of adults with Fabry disease. As outlined during our recent fourth quarter earnings call, the rolling submission of a BLA to the U.S. FDA seeking approval of ST-920 under an accelerated approval pathway is in progress, with the first two modules submitted. The team is actively advancing the activity required for the CMC module and we anticipate completing the BLA submission as early as this summer, subject to our ability to secure adequate additional funding. As a reminder, ST-920 has a clear pathway to accelerated approval agreed with the FDA using mean annualized eGFR slope at 52 weeks across all 32 dosed patients in the study.

[Nathalie Dubois-Stringfellow, Chief Development Officer at Sangamo Therapeutics]

The FDA also affirmed to us in a very recent interaction that an additional confirmatory study will not be required and that we may submit 104-week data across all those patients when seeking traditional approval. In February, we also presented detailed clinical data via four platform and poster presentations at the 22nd Annual WORLDSymposium that took place in San Diego, California. We continue to believe that the data support the potential of ST-920 as a one-time, well-tolerated, and durable treatment to provide meaningful multi-organ clinical benefit that could fundamentally shift the Fabry disease treatment paradigm.

[Nathalie Dubois-Stringfellow, Chief Development Officer at Sangamo Therapeutics]

All four presentations are available on the Sangamo website. Moving to our neurology pipeline, we have six clinical sites activated for the phase I/II STAND study evaluating ST-503, our investigational epigenetic regulator for patients with intractable pain due to small fiber neuropathy, or SFN. These sites are working to identify patients.

[Nathalie Dubois-Stringfellow, Chief Development Officer at Sangamo Therapeutics]

This quarter, we were also pleased to have a manuscript published in Science Translational Medicine detailing the preclinical safety and pharmacology of ST-503 in human neurons, mice, and non-human primates. Finally moving to ST-506, our epigenetic regulator for the treatment of prion disease, this quarter we continue to advance clinical trial application, or CTA-enabling activities. The good laboratory practice, or GLP, toxicology study has been completed, and analysis is ongoing. We held a further productive interaction with the U.K.'s Medicines and Healthcare Products Regulatory Agency, or MHRA, including alignment on diagnostic testing, analytical validation, and non-clinical safety matters. I would like now to hand back to Sandy for closing remarks. Sandy?

[Sandy Macrae, CEO at Sangamo Therapeutics]

Thank you, Nathalie. In closing, we've made good progress this quarter. The rolling BLA submission for ST-920 remains in progress, with the first two modules submitted and with real clarity on the regulatory pathway reaffirmed very recently by the FDA. Six sites have been activated in the Phase I/II STAND study evaluating ST-503 for patients with chronic neuropathic pain. We held a productive meeting with the MHRA, including further alignment on key matters for the prion program. We showcase continual progress across our pipeline and platforms at ASGCT, including a platform presentation showing impressive advances in our MINT integrase technology.

[Sandy Macrae, CEO at Sangamo Therapeutics]

This remains an important period for Sangamo as we continue to advance our pipeline while actively pursuing strategic opportunities to strengthen our financial position and maximize the value of our assets. We will continue to provide relevant updates when we are able to. Operator, please open the line for questions.

[Operator]

Thank you. To ask a question, please press star one one on your telephone and wait for your name to be announced. To withdraw your question, please press star one one again. One moment for our first question. Our first question comes from the line of Maury Raycroft with Jefferies. Your line is open. Please go ahead.

[James Stamos, Equity Research Associate at Jefferies]

Hi. This is James on for Maury. Thanks for taking our question. Congrats on getting the reaffirmation from the FDA on the 104-week endpoint. Given that the last patient reached the two-year time point around April, can you walk us through the gating factors for analyzing that data set and disclosing the data set? Would you wait to present the 104-week data at a medical conference such as WORLDSymposium next year, or could it be disclosed earlier after you file the BLA?

[Sandy Macrae, CEO at Sangamo Therapeutics]

As you know, we're I'm gonna say three-fifths the way through the rolling submission, and the clinical module with the one-year data is already submitted. We have a series of cleaning processes to gather the full two-year data, and we'll work out once we have that when the best place to submit it. We can reassure you, Nathalie, that we're now seeing patients out to five years' worth of experience, and it's looking very stable.

[Nathalie Dubois-Stringfellow, Chief Development Officer at Sangamo Therapeutics]

Yes, we absolutely show durability in the benefit for the patient at five years and beyond. We have now four patients that are beyond five years and with a supraphysiological level of alpha-Gal. You know, safety of the products also remains remarkable.

[Sandy Macrae, CEO at Sangamo Therapeutics]

The 17 patients that are off ERT—some of them are over three years off ERT now?

[Nathalie Dubois-Stringfellow, Chief Development Officer at Sangamo Therapeutics]

Yes, absolutely. Yeah.

[James Stamos, Equity Research Associate at Jefferies]

Great. Thank you for taking my question. I'll hop back in the queue.

[Operator]

Thank you. One moment for our next question. Our next question comes from the line of Yanan Zhu with Wells Fargo. Your line is open. Please go ahead.

[Kwan Ang, Equity Research Associate at Wells Fargo]

Hi. Thanks for taking our question. This is Kwan for Yanan. With FDA's recent affirmation that two-year eGFR data can serve as a confirmatory evidence, can you talk about how that'll affect your BD discussions and any updates on the BD discussion around the Fabry program that you can share with us? Thank you.

[Sandy Macrae, CEO at Sangamo Therapeutics]

I hope you can understand that we can't talk about those conversations. I am certain that the people who have been looking at this asset are pleased by the recent affirmation from the agency. Most importantly is to get accelerated approval as quickly as possible, that's with the one-year data. Equally important is the agency signaling that a second study will not be necessary because that would be expensive and delay the process. As we now gather the two-year data, not just for the eGFR but for all the other benefits to the patients, we will plan when we can submit it. I can assure you that the data is looking good. It's showing durability, we look forward to sharing this at the appropriate time.

[Kwan Ang, Equity Research Associate at Wells Fargo]

All right. That's helpful. Thank you.

[Operator]

Thank you. I would now like to hand the conference back over to Louise Wilkie for closing remarks.

[Louise Wilkie, Head of Investor Relations and Corporate Communications at Sangamo Therapeutics]

Thank you once again for joining us today and for your questions. As a reminder, you can access our presentation on the investor relations section of the Sangamo website. We look forward to keeping you updated on our future developments.

[Operator]

This concludes today's conference call. Thank you for participating, and you may now disconnect. Everyone, have a great day.

Participants

Executives

• Louise Wilkie, Head of Investor Relations and Corporate Communications
• Nathalie Dubois-Stringfellow, Chief Development Officer
• Sandy Macrae, CEO

Analysts

• James Stamos, Equity Research Associate at Jefferies
• Kwan Ang, Equity Research Associate at Wells Fargo