Alector (ALEC) Stock Price, News & Analysis

Company Overview

Alector is a clinical-stage biotechnology company headquartered in South San Francisco, California. Founded in 2013, the company is focused on discovering and developing immuno-neurology therapies that target the innate immune system to treat a range of neurodegenerative disorders. Alector’s approach aims to harness the body’s natural defense mechanisms to clear pathological proteins and restore neuronal function in conditions such as Alzheimer’s disease and frontotemporal dementia.

The company’s pipeline includes multiple product candidates in both preclinical and clinical stages, with lead programs AL001 and AL002 advancing in frontotemporal dementia and Alzheimer’s disease studies. Alector designs its molecules to engage key immune receptors in the brain, seeking to slow or halt disease progression rather than simply address symptoms. Research and development activities are supported by state-of-the-art laboratories in North America and collaborations with academic and industry partners in Europe.

Since completing its initial public offering in 2019, Alector has expanded its clinical footprint through strategic alliances and investigator-initiated trials. The company maintains global development programs aimed at bringing the first approved immuno-neurology therapies to patients worldwide.

Alector is led by co-founder and Chief Executive Officer Dr. Arnon Rosenthal, a neuroscientist with over two decades of experience in immunology and drug discovery. The management team brings extensive backgrounds in clinical development, regulatory affairs, and commercialization, supporting Alector’s mission to transform the treatment landscape for neurodegenerative diseases.

Key Stats

• Today's Range: $2.71 to $2.85
• 50-Day Range: $1.43 to $3.01
• 52-Week Range: $0.87 to $6.37
• Volume: 318,572 shs
• Average Volume: 882,218 shs
• Market Capitalization: $280.86 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $4.17
• Consensus Rating: Hold

Alector Stock Analysis - MarketRank™

Alector scored higher than 78% of companies evaluated by MarketBeat, and ranked 242nd out of 954 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.3 / 5
• Analyst Rating: Hold

Consensus Rating

Alector has received a consensus rating of Hold. The company's average rating score is 2.29, and is based on 4 buy ratings, 1 hold rating, and 2 sell ratings.

Upside Potential

Alector has a consensus price target of $4.17, representing about 50.2% upside from its current price of $2.78.

Amount of Analyst Coverage

Alector has only been the subject of 1 research reports in the past 90 days.

Earnings and Valuation

• Score: 0.0 / 5
• Proj. Earnings Growth: Decreasing

Earnings Growth

Earnings for Alector are expected to decrease in the coming year, from ($1.88) to ($1.98) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Alector is -2.39, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Alector is -2.39, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Alector has a P/B Ratio of 2.15. P/B Ratios below 3 indicates that a company is reasonably valued with respect to its assets and liabilities.

Short Interest

• Score: 2.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

7.11% of the float of Alector has been sold short.

Short Interest Ratio / Days to Cover

Alector has a short interest ratio ("days to cover") of 5.8.

Change versus previous month

Short interest in Alector has recently decreased by 0.91%, indicating that investor sentiment is improving.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Alector does not currently pay a dividend.

Dividend Growth

Alector does not have a long track record of dividend growth.

Sustainability and ESG

• Score: 4.5 / 5
• Environmental Score: -0.92

Percentage of Shares Shorted

7.11% of the float of Alector has been sold short.

Short Interest Ratio / Days to Cover

Alector has a short interest ratio ("days to cover") of 5.8.

Change versus previous month

Short interest in Alector has recently decreased by 0.91%, indicating that investor sentiment is improving.

News and Social Media

• Score: 3.4 / 5
• News Sentiment: 1.15

News Sentiment

Alector has a news sentiment score of 1.15. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a higher news sentiment than the 0.94 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 5 news articles for Alector this week, compared to 2 articles on an average week.

Search Interest

11 people have searched for ALEC on MarketBeat in the last 30 days. This is an increase of 38% compared to the previous 30 days.

Company Ownership

• Score: 2.5 / 5
• Insider Trading: Selling Shares

Insider Buying vs. Insider Selling

In the past three months, Alector insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $49,255.00 in company stock.

Percentage Held by Insiders

Only 9.70% of the stock of Alector is held by insiders.

Percentage Held by Institutions

85.83% of the stock of Alector is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

ALEC Stock Analysis - Frequently Asked Questions

How have ALEC shares performed this year?

Alector's stock was trading at $1.89 on January 1st, 2025. Since then, ALEC shares have increased by 46.8% and is now trading at $2.7750.

How were Alector's earnings last quarter?

Alector, Inc. (NASDAQ:ALEC) issued its earnings results on Thursday, August, 7th. The company reported ($0.30) earnings per share for the quarter, beating analysts' consensus estimates of ($0.45) by $0.15. The company earned $7.87 million during the quarter, compared to the consensus estimate of $2.76 million. Alector had a negative net margin of 142.10% and a negative trailing twelve-month return on equity of 112.06%.
Read the conference call transcript.

Does Alector have any subsidiaries?

Alector subsidiaries include Alector LLC.

When did Alector IPO?

Alector (ALEC) raised $177 million in an initial public offering (IPO) on Thursday, February 7th 2019. The company issued 9,300,000 shares at $18.00-$20.00 per share. Morgan Stanley, BofA Merrill Lynch, Cowen and Barclays acted as the underwriters for the IPO.

Who are Alector's major shareholders?

Top institutional investors of Alector include Acadian Asset Management LLC (2.17%), Geode Capital Management LLC (1.98%), Sio Capital Management LLC (0.84%) and TD Asset Management Inc (0.65%). Insiders that own company stock include Polaris Venture Management Co, Arnon Rosenthal, Sara Kenkare-Mitra, Marc Grasso, Gary Romano, Grace Wong-Sarad, Kristine Yaffe and Paula Hammond.
View institutional ownership trends.

How do I buy shares of Alector?

Shares of ALEC stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Alector own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Alector investors own include NVIDIA (NVDA), Advanced Micro Devices (AMD), Enovix (ENVX), Meta Platforms (META), Rambus (RMBS), Saia (SAIA) and Tesla (TSLA).

Company Calendar

• Last Earnings: 8/07/2025
• Today: 9/15/2025
• Next Earnings (Estimated): 11/05/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:ALEC
• CIK: 1653087
• Web: www.alector.com
• Phone: (415) 231-5660
• Fax: N/A
• Employees: 270
• Year Founded: 2013

Price Target and Rating

• Average Price Target for Alector: $4.17
• High Price Target: $10.00
• Low Price Target: $1.00
• Potential Upside/Downside: +51.5%
• Consensus Rating: Hold
• Rating Score (0-4): 2.29
• Research Coverage: 7 Analysts

Profitability

• EPS (Trailing Twelve Months): ($1.16)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$119.05 million
• Net Margins: -142.10%
• Pretax Margin: -142.04%
• Return on Equity: -112.06%
• Return on Assets: -26.37%

Debt

• Debt-to-Equity Ratio: 0.13
• Current Ratio: 3.78
• Quick Ratio: 3.78

Sales & Book Value

• Annual Sales: $100.56 million
• Price / Sales: 2.77
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $1.29 per share
• Price / Book: 2.13

Miscellaneous

• Outstanding Shares: 101,210,000
• Free Float: 91,394,000
• Market Cap: $278.33 million
• Optionable: Optionable
• Beta: 0.99