DAVENPORT & Co LLC cut its stake in Ionis Pharmaceuticals, Inc. (NASDAQ:IONS - Free Report) by 10.1% during the 1st quarter, according to its most recent Form 13F filing with the SEC. The fund owned 56,393 shares of the company's stock after selling 6,347 shares during the period. DAVENPORT & Co LLC's holdings in Ionis Pharmaceuticals were worth $1,701,000 as of its most recent SEC filing.
Several other institutional investors and hedge funds have also recently bought and sold shares of IONS. GAMMA Investing LLC increased its position in shares of Ionis Pharmaceuticals by 3,786.5% in the first quarter. GAMMA Investing LLC now owns 28,993 shares of the company's stock worth $961,000 after acquiring an additional 28,247 shares in the last quarter. Commonwealth Equity Services LLC increased its holdings in Ionis Pharmaceuticals by 1.7% in the 4th quarter. Commonwealth Equity Services LLC now owns 21,826 shares of the company's stock valued at $763,000 after purchasing an additional 373 shares in the last quarter. PNC Financial Services Group Inc. increased its holdings in Ionis Pharmaceuticals by 11.1% in the 4th quarter. PNC Financial Services Group Inc. now owns 10,994 shares of the company's stock valued at $384,000 after purchasing an additional 1,101 shares in the last quarter. Proficio Capital Partners LLC purchased a new position in Ionis Pharmaceuticals in the fourth quarter valued at about $829,000. Finally, Fifth Third Bancorp lifted its stake in shares of Ionis Pharmaceuticals by 4.8% during the first quarter. Fifth Third Bancorp now owns 9,989 shares of the company's stock worth $301,000 after purchasing an additional 458 shares in the last quarter. Institutional investors and hedge funds own 93.86% of the company's stock.
Insider Buying and Selling at Ionis Pharmaceuticals
In related news, Director Michael R. Hayden acquired 15,000 shares of the stock in a transaction that occurred on Thursday, May 1st. The shares were acquired at an average price of $31.86 per share, for a total transaction of $477,900.00. Following the completion of the purchase, the director directly owned 50,219 shares of the company's stock, valued at $1,599,977.34. The trade was a 42.59% increase in their ownership of the stock. The purchase was disclosed in a legal filing with the SEC, which is available through the SEC website. Corporate insiders own 2.71% of the company's stock.
Analyst Upgrades and Downgrades
IONS has been the topic of several analyst reports. Barclays upgraded Ionis Pharmaceuticals from an "equal weight" rating to an "overweight" rating and raised their target price for the company from $51.00 to $57.00 in a report on Tuesday, July 1st. JPMorgan Chase & Co. lifted their price objective on shares of Ionis Pharmaceuticals from $45.00 to $48.00 and gave the company a "neutral" rating in a research note on Thursday, June 12th. HC Wainwright restated a "buy" rating and issued a $50.00 target price on shares of Ionis Pharmaceuticals in a research note on Thursday, June 26th. Redburn Atlantic assumed coverage on shares of Ionis Pharmaceuticals in a research note on Monday, March 31st. They set a "neutral" rating and a $39.00 price target on the stock. Finally, Guggenheim cut their price objective on shares of Ionis Pharmaceuticals from $65.00 to $64.00 and set a "buy" rating on the stock in a report on Thursday, May 1st. Two analysts have rated the stock with a sell rating, three have issued a hold rating, thirteen have assigned a buy rating and one has assigned a strong buy rating to the stock. According to data from MarketBeat, the stock currently has an average rating of "Moderate Buy" and an average target price of $58.25.
Read Our Latest Analysis on Ionis Pharmaceuticals
Ionis Pharmaceuticals Stock Performance
IONS traded down $1.22 during trading hours on Monday, hitting $41.78. The company's stock had a trading volume of 2,239,880 shares, compared to its average volume of 1,607,462. The company has a 50-day simple moving average of $35.24 and a 200 day simple moving average of $33.10. The company has a current ratio of 9.66, a quick ratio of 9.62 and a debt-to-equity ratio of 2.63. The firm has a market capitalization of $6.65 billion, a PE ratio of -13.97 and a beta of 0.23. Ionis Pharmaceuticals, Inc. has a fifty-two week low of $23.95 and a fifty-two week high of $52.34.
Ionis Pharmaceuticals (NASDAQ:IONS - Get Free Report) last issued its quarterly earnings data on Wednesday, April 30th. The company reported ($0.93) earnings per share for the quarter, beating analysts' consensus estimates of ($1.07) by $0.14. The business had revenue of $132.00 million for the quarter, compared to analysts' expectations of $144.31 million. Ionis Pharmaceuticals had a negative net margin of 63.65% and a negative return on equity of 91.85%. The company's revenue was up 10.9% on a year-over-year basis. During the same period in the previous year, the business earned ($0.98) earnings per share. As a group, sell-side analysts expect that Ionis Pharmaceuticals, Inc. will post -3.5 EPS for the current year.
Ionis Pharmaceuticals Company Profile
(
Free Report)
Ionis Pharmaceuticals, Inc discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an antisense injection for the treatment of polyneuropathy caused by hereditary transthyretin amyloidosis in adults; and WAYLIVRA, an antisense medicine for treatment for familial chylomicronemia syndrome (FCS) and familial partial lipodystrophy.
Recommended Stories

Before you consider Ionis Pharmaceuticals, you'll want to hear this.
MarketBeat keeps track of Wall Street's top-rated and best performing research analysts and the stocks they recommend to their clients on a daily basis. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the broader market catches on... and Ionis Pharmaceuticals wasn't on the list.
While Ionis Pharmaceuticals currently has a Moderate Buy rating among analysts, top-rated analysts believe these five stocks are better buys.
View The Five Stocks Here
MarketBeat's analysts have just released their top five short plays for July 2025. Learn which stocks have the most short interest and how to trade them. Enter your email address to see which companies made the list.
Get This Free Report
Like this article? Share it with a colleague.
Link copied to clipboard.