Pictet Asset Management Holding SA Has $28.90 Million Position in Soleno Therapeutics, Inc. $SLNO

Key Points

• Pictet Asset Management increased its stake in Soleno to 624,128 shares (a 13.3% rise) valued at about $28.9 million, joining other large institutions (Avoro, JPMorgan, Capital World Investors) in a stock that is now roughly 97.42% institutionally owned.
• Soleno faces heightened legal risk from multiple class-action notices tied to its DCCR program, with a lead-plaintiff application deadline of May 5, 2026, increasing near-term litigation exposure and investor attention.
• Analysts have been cutting ratings and targets—SLNO carries a consensus rating of "Hold" (consensus target $76.67) after several downgrades and target cuts (e.g., TD Cowen to $53), despite a recent quarterly beat (EPS $0.80 vs. $0.64) and a market cap near $2.73 billion.

Pictet Asset Management Holding SA boosted its holdings in shares of Soleno Therapeutics, Inc. (NASDAQ:SLNO - Free Report) by 13.3% during the fourth quarter, according to its most recent Form 13F filing with the Securities and Exchange Commission (SEC). The institutional investor owned 624,128 shares of the company's stock after buying an additional 73,504 shares during the period. Pictet Asset Management Holding SA owned about 1.16% of Soleno Therapeutics worth $28,897,000 as of its most recent SEC filing.

A number of other institutional investors have also recently bought and sold shares of SLNO. JPMorgan Chase & Co. raised its position in Soleno Therapeutics by 52.8% in the 3rd quarter. JPMorgan Chase & Co. now owns 407,444 shares of the company's stock valued at $27,543,000 after buying an additional 140,779 shares during the last quarter. Avoro Capital Advisors LLC boosted its position in Soleno Therapeutics by 25.7% during the 3rd quarter. Avoro Capital Advisors LLC now owns 2,577,777 shares of the company's stock worth $174,258,000 after acquiring an additional 527,777 shares during the last quarter. Schroder Investment Management Group boosted its position in Soleno Therapeutics by 1,554.9% during the 3rd quarter. Schroder Investment Management Group now owns 280,296 shares of the company's stock worth $19,105,000 after acquiring an additional 263,359 shares during the last quarter. Kingdon Capital Management L.L.C. bought a new position in shares of Soleno Therapeutics during the 3rd quarter worth approximately $20,348,000. Finally, Capital World Investors grew its stake in shares of Soleno Therapeutics by 34.1% during the 3rd quarter. Capital World Investors now owns 824,514 shares of the company's stock worth $55,737,000 after acquiring an additional 209,681 shares in the last quarter. Institutional investors and hedge funds own 97.42% of the company's stock.

Soleno Therapeutics Price Performance

NASDAQ:SLNO opened at $52.82 on Friday. The stock has a market capitalization of $2.73 billion, a PE ratio of 229.66 and a beta of -2.81. Soleno Therapeutics, Inc. has a 1-year low of $29.43 and a 1-year high of $90.32. The firm has a fifty day simple moving average of $42.46 and a 200 day simple moving average of $46.89. The company has a current ratio of 5.80, a quick ratio of 5.55 and a debt-to-equity ratio of 0.11.

Soleno Therapeutics (NASDAQ:SLNO - Get Free Report) last posted its quarterly earnings results on Wednesday, February 25th. The company reported $0.80 earnings per share (EPS) for the quarter, topping the consensus estimate of $0.64 by $0.16. The firm had revenue of $91.73 million for the quarter, compared to the consensus estimate of $88.55 million. On average, research analysts expect that Soleno Therapeutics, Inc. will post 3.67 EPS for the current fiscal year.

Analyst Upgrades and Downgrades

SLNO has been the subject of several recent research reports. Piper Sandler cut shares of Soleno Therapeutics from a "strong-buy" rating to a "hold" rating in a report on Tuesday, April 7th. Robert W. Baird lowered shares of Soleno Therapeutics from a "strong-buy" rating to a "hold" rating in a research note on Monday, April 6th. Zacks Research downgraded shares of Soleno Therapeutics from a "strong-buy" rating to a "hold" rating in a research note on Tuesday, February 3rd. Wall Street Zen cut Soleno Therapeutics from a "buy" rating to a "hold" rating in a report on Sunday, March 22nd. Finally, TD Cowen downgraded Soleno Therapeutics from a "buy" rating to a "hold" rating and lowered their target price for the company from $85.00 to $53.00 in a research report on Tuesday, April 7th. Three equities research analysts have rated the stock with a Buy rating, nine have issued a Hold rating and one has assigned a Sell rating to the company. According to MarketBeat, the stock presently has a consensus rating of "Hold" and a consensus target price of $76.67.

Key Headlines Impacting Soleno Therapeutics

Here are the key news stories impacting Soleno Therapeutics this week:

• Neutral Sentiment: Lead-plaintiff application deadline (May 5, 2026) approaching — numerous law firms are notifying purchasers of SLNO shares (class period: March 26, 2025–Nov 4, 2025) to submit lead-plaintiff applications. This is a procedural development that increases near-term legal activity and investor attention. Soleno Therapeutics Shareholder Alert: ClaimsFiler Reminds Investors With Losses In Excess Of $100,000 Of Lead Plaintiff Deadline In Class Action Lawsuit Against Soleno Therapeutics, Inc. - SLNO
• Negative Sentiment: Multiple class-action notices and filings allege misconduct tied to Soleno’s DCCR program — firms reference alleged misrepresentations about safety timelines, clinical-trial integrity and launch disruptions. Broad solicitor activity (Rosen, Hagens Berman, Faruqi, Bronstein, Levi & Korsinsky, Schall, etc.) signals elevated litigation risk and potential monetary exposure or distraction for management. SLNO 6-DAY DEADLINE ALERT: Hagens Berman Alerts Soleno Therapeutics (SLNO) Investors to Securities Class Action Alleging Hyperphagia Drug Launch Disruptions - Hagens Berman
• Negative Sentiment: An analyst cut SLNO’s price target by ~15.6% to $57.53 — analyst downgrades/target cuts can prompt selling and indicate reduced near-term expectations for revenue/profit or higher risk premium. Soleno Therapeutics (SLNO) price target decreased by 15.57% to 57.53

Soleno Therapeutics Profile

Soleno Therapeutics, Inc is a clinical‐stage biopharmaceutical company focused on the development and commercialization of therapies for rare and orphan diseases. Headquartered in Redwood City, California, Soleno leverages a precision medicine approach to identify and advance small‐molecule treatments that address underlying genetic and metabolic dysfunctions. The company's scientific strategy centers on repurposing and reformulating existing compounds to maximize therapeutic benefit in underserved patient populations.

The company's lead candidate, diazoxide choline controlled release (DCCR), is being investigated for the treatment of Prader-Willi syndrome (PWS), a complex neurodevelopmental disorder characterized by insatiable appetite, hormonal imbalances and behavioral challenges.

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