Vanguard Group Inc. Lowers Position in Catalyst Pharmaceuticals, Inc. $CPRX

Key Points

• Vanguard Group Inc. reduced its Catalyst Pharmaceuticals stake by 3.2% in the fourth quarter, selling 281,273 shares and leaving it with 8.43 million shares valued at about $196.8 million. Despite the trim, Vanguard still owned 6.86% of the company.
• Angelini Pharma agreed to buy Catalyst Pharmaceuticals for about $4.1 billion, or $31.50 per share in cash. The deal is expected to close in the third quarter of 2026.
• Catalyst also settled its FIRDAPSE patent dispute with Hetero Labs, delaying potential generic competition until January 2035 and removing a major legal overhang for the business.

Vanguard Group Inc. cut its stake in Catalyst Pharmaceuticals, Inc. (NASDAQ:CPRX - Free Report) by 3.2% in the 4th quarter, according to the company in its most recent disclosure with the Securities & Exchange Commission. The fund owned 8,432,247 shares of the biopharmaceutical company's stock after selling 281,273 shares during the quarter. Vanguard Group Inc. owned 6.86% of Catalyst Pharmaceuticals worth $196,809,000 as of its most recent filing with the Securities & Exchange Commission.

Several other institutional investors and hedge funds have also recently modified their holdings of the stock. Universal Beteiligungs und Servicegesellschaft mbH raised its stake in shares of Catalyst Pharmaceuticals by 30.0% in the fourth quarter. Universal Beteiligungs und Servicegesellschaft mbH now owns 167,763 shares of the biopharmaceutical company's stock worth $3,913,000 after purchasing an additional 38,695 shares during the last quarter. Round Rock Advisors LLC raised its stake in shares of Catalyst Pharmaceuticals by 28.9% in the fourth quarter. Round Rock Advisors LLC now owns 32,357 shares of the biopharmaceutical company's stock worth $755,000 after purchasing an additional 7,247 shares during the last quarter. Zurcher Kantonalbank Zurich Cantonalbank raised its stake in shares of Catalyst Pharmaceuticals by 28.4% in the fourth quarter. Zurcher Kantonalbank Zurich Cantonalbank now owns 48,643 shares of the biopharmaceutical company's stock worth $1,135,000 after purchasing an additional 10,749 shares during the last quarter. First Horizon Corp purchased a new stake in shares of Catalyst Pharmaceuticals in the fourth quarter worth approximately $52,000. Finally, Asset Management One Co. Ltd. purchased a new stake in shares of Catalyst Pharmaceuticals in the fourth quarter worth approximately $111,000. 79.22% of the stock is owned by hedge funds and other institutional investors.

Trending Headlines about Catalyst Pharmaceuticals

Here are the key news stories impacting Catalyst Pharmaceuticals this week:

• Positive Sentiment: Angelini Pharma agreed to acquire Catalyst Pharmaceuticals for about $4.1 billion, or $31.50 per share in cash, which is above where the stock had been trading and typically supports a takeover premium. Closing is expected in the third quarter of 2026. Italy's Angelini Pharma to buy Catalyst Pharmaceuticals for $4.1 billion
• Positive Sentiment: Catalyst also announced a settlement of its FIRDAPSE patent litigation with Hetero Labs, pushing any potential generic competition to January 2035 and resolving all pending FIRDAPSE patent disputes. That reduces legal overhang for the business. Catalyst Pharmaceuticals Announces Settlement of FIRDAPSE Patent Litigation with Hetero Labs Ltd.
• Neutral Sentiment: The company canceled its first-quarter 2026 conference call and webcast, which may have drawn attention but does not appear to be a major fundamental development on its own. Catalyst Pharmaceuticals Cancels First Quarter 2026 Conference Call and Webcast
• Negative Sentiment: Stephens downgraded Catalyst to Equal Weight from Overweight, which can weigh on sentiment even though the downgrade may be overshadowed by the acquisition bid. Stephens & Co. downgrades Catalyst Pharmaceuticals (CPRX)
• Negative Sentiment: Law firms announced shareholder investigations into whether Catalyst is receiving a fair price in the Angelini transaction, creating a small litigation-related overhang. Shareholder Alert: Ademi LLP investigates whether Catalyst Pharmaceuticals Inc. is obtaining a Fair Price for Public Shareholders

Analyst Upgrades and Downgrades

Several research firms have recently issued reports on CPRX. Truist Financial raised Catalyst Pharmaceuticals to a "strong-buy" rating in a report on Wednesday, March 25th. Robert W. Baird lowered Catalyst Pharmaceuticals from a "strong-buy" rating to a "hold" rating in a report on Thursday. Cantor Fitzgerald raised Catalyst Pharmaceuticals to a "strong-buy" rating in a report on Friday, March 27th. Stephens set a $32.00 target price on Catalyst Pharmaceuticals in a report on Thursday. Finally, Weiss Ratings reaffirmed a "buy (b-)" rating on shares of Catalyst Pharmaceuticals in a report on Friday, March 27th. Three investment analysts have rated the stock with a Strong Buy rating, one has issued a Buy rating and four have assigned a Hold rating to the company. According to data from MarketBeat, the stock presently has an average rating of "Moderate Buy" and a consensus price target of $32.17.

Catalyst Pharmaceuticals Stock Down 0.1%

CPRX stock opened at $31.15 on Friday. The firm has a market cap of $3.81 billion, a PE ratio of 18.43, a P/E/G ratio of 1.01 and a beta of 0.72. The business has a 50 day moving average of $25.31 and a 200-day moving average of $23.93. Catalyst Pharmaceuticals, Inc. has a 12-month low of $19.05 and a 12-month high of $32.56.

About Catalyst Pharmaceuticals

Catalyst Pharmaceuticals, Inc is a biopharmaceutical company focused on the development and commercialization of therapies for patients living with rare neuromuscular, neurological and metabolic diseases. The company's mission centers on delivering safe and effective treatments that address unmet medical needs in small patient populations.

The company's lead product is Firdapse® (amifampridine phosphate), a treatment approved by the U.S. Food and Drug Administration for adults with Lambert-Eaton Myasthenic Syndrome (LEMS).

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