VYNE Therapeutics (VYNE) Stock Price, News & Analysis

Company Overview

VYNE Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery and development of small-molecule therapies for vascular, inflammatory and fibrotic diseases. The company is advancing a pipeline of selective oral inhibitors that modulate key pathways implicated in chronic tissue damage and immune dysregulation. Headquartered in the San Francisco Bay Area, VYNE Therapeutics seeks to address high-unmet-need conditions by leveraging proprietary chemical and biological insights to create differentiated drug candidates.

The company’s lead program, VTX-002, targets the colony-stimulating factor-1 receptor (CSF-1R) pathway, which plays a central role in macrophage proliferation and activation. VTX-002 is in IND-enabling studies for indications such as pulmonary fibrosis and other fibrotic disorders. A second discovery program is focused on a novel mechanism of complement modulation, intended to dampen excessive inflammatory responses in vascular and autoimmune diseases. In addition to these core assets, VYNE maintains a discovery engine aimed at identifying new small molecules with optimized drug-like properties for indications in cardiometabolic and fibrotic pathology.

Since its founding, VYNE Therapeutics has built a leadership team comprised of seasoned executives and scientific founders with prior experience at leading biotechnology and pharmaceutical companies. The company collaborates with academic institutions and contract research organizations to accelerate preclinical and clinical activities. VYNE’s research and development efforts are designed to serve patient populations across North America and Europe, with strategic plans to expand into additional regions through partnerships and licensing agreements.

Key Stats

• Today's Range: $0.30 to $0.34
• 50-Day Range: $0.29 to $1.46
• 52-Week Range: $0.28 to $4.30
• Volume: 3.71 million shs
• Average Volume: 1.76 million shs
• Market Capitalization: $8.51 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $6.25
• Consensus Rating: Hold

VYNE Therapeutics Stock Analysis - MarketRank™

VYNE Therapeutics scored higher than 42% of companies evaluated by MarketBeat. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.6 / 5
• Analyst Rating: Hold

Consensus Rating

VYNE Therapeutics has received a consensus rating of Hold. The company's average rating score is 2.00, and is based on no buy ratings, 3 hold ratings, and no sell ratings.

Upside Potential

VYNE Therapeutics has a consensus price target of $6.25, representing about 1,769.6% upside from its current price of $0.33.

Amount of Analyst Coverage

VYNE Therapeutics has only been the subject of 3 research reports in the past 90 days.

Earnings and Valuation

• Score: 0.6 / 5
• Proj. Earnings Growth: Decreasing

Earnings Growth

Earnings for VYNE Therapeutics are expected to decrease in the coming year, from ($0.97) to ($1.05) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of VYNE Therapeutics is -0.37, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of VYNE Therapeutics is -0.37, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

VYNE Therapeutics has a P/B Ratio of 0.09. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities.

Short Interest

• Score: 4.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

6.44% of the float of VYNE Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

VYNE Therapeutics has a short interest ratio ("days to cover") of 0.6, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in VYNE Therapeutics has recently decreased by 36.79%, indicating that investor sentiment is improving significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

VYNE Therapeutics does not currently pay a dividend.

Dividend Growth

VYNE Therapeutics does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

6.44% of the float of VYNE Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

VYNE Therapeutics has a short interest ratio ("days to cover") of 0.6, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in VYNE Therapeutics has recently decreased by 36.79%, indicating that investor sentiment is improving significantly.

News and Social Media

• Score: 0.0 / 5
• News Sentiment: N/A

Search Interest

Only 1 people have searched for VYNE on MarketBeat in the last 30 days. This is a decrease of -75% compared to the previous 30 days.

Company Ownership

• Score: 1.7 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, VYNE Therapeutics insiders have not sold or bought any company stock.

Percentage Held by Insiders

Only 4.80% of the stock of VYNE Therapeutics is held by insiders.

Percentage Held by Institutions

83.78% of the stock of VYNE Therapeutics is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

VYNE Stock Analysis - Frequently Asked Questions

How have VYNE shares performed this year?

VYNE Therapeutics' stock was trading at $3.35 at the beginning of the year. Since then, VYNE shares have decreased by 90.0% and is now trading at $0.3343.

How were VYNE Therapeutics' earnings last quarter?

VYNE Therapeutics Inc. (NASDAQ:VYNE) issued its earnings results on Thursday, August, 14th. The company reported ($0.13) earnings per share for the quarter, topping the consensus estimate of ($0.23) by $0.10. The business earned $0.07 million during the quarter, compared to analyst estimates of $0.15 million. VYNE Therapeutics had a negative trailing twelve-month return on equity of 77.57% and a negative net margin of 8,097.69%.

When did VYNE Therapeutics' stock split?

VYNE Therapeutics shares reverse split on Monday, February 13th 2023.The 1-18 reverse split was announced on Monday, February 13th 2023. The number of shares owned by shareholders was adjusted after the market closes on Monday, February 13th 2023. An investor that had 100 shares of stock prior to the reverse split would have 6 shares after the split.

Who are VYNE Therapeutics' major shareholders?

VYNE Therapeutics' top institutional shareholders include Acorn Capital Advisors LLC (4.84%), Adage Capital Partners GP L.L.C. (4.23%), Kennedy Capital Management LLC (3.75%) and Patient Square Capital LP (2.08%). Insiders that own company stock include Patrick G Lepore and Mutya Harsch.
View institutional ownership trends.

How do I buy shares of VYNE Therapeutics?

Shares of VYNE stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of VYNE Therapeutics own?

Based on aggregate information from My MarketBeat watchlists, some other companies that VYNE Therapeutics investors own include NIO (NIO), Tesla (TSLA), Sorrento Therapeutics (SRNE), Advanced Micro Devices (AMD), Meta Platforms (META), Allena Pharmaceuticals (ALNA) and NVIDIA (NVDA).

Company Calendar

• Last Earnings: 8/14/2025
• Today: 9/23/2025
• Next Earnings (Estimated): 11/06/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - DRUGS
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:VYNE
• CIK: 1566044
• Web: vynetherapeutics.com
• Phone: (800) 755-7936
• Fax: N/A
• Employees: 30
• Year Founded: N/A

Price Target and Rating

• Average Price Target for VYNE Therapeutics: $6.25
• High Price Target: $8.00
• Low Price Target: $4.50
• Potential Upside/Downside: +1,769.6%
• Consensus Rating: Hold
• Rating Score (0-4): 2.00
• Research Coverage: 3 Analysts

Profitability

• EPS (Trailing Twelve Months): ($0.90)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$39.83 million
• Net Margins: -8,097.69%
• Pretax Margin: -8,091.81%
• Return on Equity: -77.57%
• Return on Assets: -63.09%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 7.60
• Quick Ratio: 7.60

Sales & Book Value

• Annual Sales: $500 thousand
• Price / Sales: 17.03
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $3.53 per share
• Price / Book: 0.09

Miscellaneous

• Outstanding Shares: 25,470,000
• Free Float: 24,249,000
• Market Cap: $8.51 million
• Optionable: Not Optionable
• Beta: 1.80