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Here’s Why Viking Therapeutics Rose Over 50% on Obesity Drug Data

Viking Therapeutics stock price

Key Points

  • Viking Therapeutics reports positive Phase 1 data on its obesity candidate VK2735.
  • During the study, participants lost up to 7.9% of their body weight from their baseline.
  • Phase 2 is planned for mid-2023
  • Viking has five more novel compounds in various stages of clinical trials, which can move the needle on share prices.
  • 5 stocks we like better than Viking Therapeutics

Clinical-stage biotechnology company Viking Therapeutics, Inc. NASDAQ: VKTX stock jumped more than 50% on positive Phase 1 data on its novel dual GLP-1/GLP agonist compound VK2735 for the treatment of obesity. Viking Therapeutics develops novel therapies for metabolic and endocrine disorders. Metabolic disorders hurt the body's ability to break down and synthesize nutrients from food, putting the balance of the biochemical process in disarray. This can result in diabetes mellitus since the body can't regulate blood sugar levels.

Endocrine Disorders

Obesity is considered both a metabolic and endocrine disorder. Endocrine disorders affect the glands that create and distribute thyroid hormones into the bloodstream from overproducing or underproducing. Hyperthyroidism is an endocrine disorder where the body doesn't produce enough thyroid hormones, which leads to slower metabolism and weight gain. Other contributing factors include diet, medications, and genetics. Viking has many competitors, including Altimmune Inc. NASDAQ: ALT, Eli Lilly & Co. NYSE: LLY, Pfizer NYSE: PFE, and Amgen Inc. NYSE: AMGN in the weight loss space.

Positive VK2735 Obesity Phase 1 Data

The Phase 1 randomized, double-blind, and placebo-controlled clinical trial involved patients undergoing a single ascending dose (SAD) and multiple ascending doses (MAD) of VK2735. The SAD single shot of VK2735 had a half-life of 170 to 250 hours with a time to reach maximum plasma (Tmax) between 75 and 90 hours. The MAD portion was a 28-day study administered weekly.

Safety and Efficacy

Both doses were well tolerated and showed positive clinical signs. All participants experienced weight loss of up to 7.8% from baseline. They also experienced mean body weight reduction of up to 6% versus placebo. The weight loss was maintained or improved compared to the placebo 21 days after the last dose. Safety was proven as 98% of participants reported only mild or moderate. In addition to obesity, the drug always targets NASH and diabetes.

Upbeat CEO

Viking Therapeutics CEO Brian Lian, Ph.D., commented, "These Phase 1 data highlight VK2735's attractive early profile, encouraging safety, tolerability, and positive effects on body weight. The initial data suggest excellent clinical characteristics, with good tolerability and up to approximately 18 pounds of mean weight loss from baseline. Though subjects in this study were only exposed to higher doses for a limited time, no signs of plateau were observed. We look forward to exploring higher doses over a longer treatment window in the Phase 2 trial."

Five More in the Pipeline

Viking has six compounds in various clinical stages in its portfolio pipeline. Its lead compound is VK2809, an oral therapeutic for the treatment of non-alcoholic steatohepatitis (NASH) and hypercholesterolemia. It targets liver fat reduction. NASH is a liver condition of inflammation and fat accumulation that can lead to liver cirrhosis, fibrosis, and failure. The NASH market is estimated to grow to $35 billion in the coming years. It will report the results of its Phase 2B VOYAGE study in the first half of 2023. Its other therapeutics include VK0214 in Phase 1b for X-ALD, VK5211 for treating hip fracture surgery, VK0612 for type 2 diabetes, and VK1430 for hypertriglyceridemia and NASH. Clinical trial data for each of these can produce significant gaps up or down, as evidenced by the move on VK2735.

Daily Rectangle Breakout

The daily candlestick chart on VKTX illustrates the large gap and go price action stemming from its Phase 1 study results for VK2735. The stock had a daily rectangle on Feb. 9, 2023, as shares formed a flat-top resistance upper trendline at $11.99 and flat-bottom support lower trendlines at $8.68. Shares looked like they were going to break down just before the announcement. The gap has now caused the daily stochastic to cross back up through the oversold 20-band on over 40 million shares daily trading volume.

Shares gapped to $12.31 on the announcement on March 28, 2023, from a close of $9.12 the previous day. Shares barely pulled back, hitting a low of $12.22 before rocketing up through $14.50. The gap triggered the daily market structure low (MSL) above $11.29.

The daily 20-period exponential moving average (EMA) support is rising at $10.69, followed by the 15-period MA support at $10.25. Pullback support levels are $12.50, $11.99 daily rectangle upper trendline, $11.29 daily MSL trigger, $10.09, and $ 9.62. 

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Companies Mentioned in This Article

CompanyMarketRank™Current PricePrice ChangeDividend YieldP/E RatioConsensus RatingConsensus Price Target
Viking Therapeutics (VKTX)
4.5397 of 5 stars
Amgen (AMGN)
4.5839 of 5 stars
$296.80-1.1%3.03%42.40Moderate Buy$305.65
Eli Lilly and Company (LLY)
4.7056 of 5 stars
$808.90+0.1%0.64%119.13Moderate Buy$769.53
Endo International (ENDP)
0 of 5 stars
Pfizer (PFE)
4.8359 of 5 stars
Altimmune (ALT)
0.9369 of 5 stars
$6.95-0.3%N/A-4.37Moderate Buy$17.25
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Jea Yu

About Jea Yu


Contributing Author

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Jea Yu has been a contributing writer for MarketBeat since 2018.

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Equities, options, ETFs and futures; fundamental, qualitative, quantitative and technical analysis and pattern identification; active and swing trading; trading systems and methodology development


Bachelor of Arts, University of Maryland, College Park

Past Experience

U.S. equity markets trader, writer and analyst for over 25 years. Published four books by publishers McGraw-Hill, John Wiley & Sons, Marketplace Books and Bloomberg Press. Speaker at various expos and seminars and has been quoted and featured in USA Today, The Wall Street Journal, Traders Magazine, The Financial Times and various trade publications, including Stocks & Commodities, Active Trader and Online Investor.

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