S&P 500   4,967.23
DOW   37,986.40
QQQ   414.65
How major US stock indexes fared Friday, 4/19/2024
American Express profits jump 34%, helped by jump in new customers, higher spending
American Express, Fifth Third rise; Netflix, PPG Industries fall, Friday, 4/19/2024
Intuitive Surgical Stock Can Trend Much Higher This Year 
3 Magnificent Seven Stocks Outperforming the Rest
Bargain Hunting: 3 Stocks With RSIs That Scream Oversold
Closing prices for crude oil, gold and other commodities
S&P 500   4,967.23
DOW   37,986.40
QQQ   414.65
How major US stock indexes fared Friday, 4/19/2024
American Express profits jump 34%, helped by jump in new customers, higher spending
American Express, Fifth Third rise; Netflix, PPG Industries fall, Friday, 4/19/2024
Intuitive Surgical Stock Can Trend Much Higher This Year 
3 Magnificent Seven Stocks Outperforming the Rest
Bargain Hunting: 3 Stocks With RSIs That Scream Oversold
Closing prices for crude oil, gold and other commodities
S&P 500   4,967.23
DOW   37,986.40
QQQ   414.65
How major US stock indexes fared Friday, 4/19/2024
American Express profits jump 34%, helped by jump in new customers, higher spending
American Express, Fifth Third rise; Netflix, PPG Industries fall, Friday, 4/19/2024
Intuitive Surgical Stock Can Trend Much Higher This Year 
3 Magnificent Seven Stocks Outperforming the Rest
Bargain Hunting: 3 Stocks With RSIs That Scream Oversold
Closing prices for crude oil, gold and other commodities
S&P 500   4,967.23
DOW   37,986.40
QQQ   414.65
How major US stock indexes fared Friday, 4/19/2024
American Express profits jump 34%, helped by jump in new customers, higher spending
American Express, Fifth Third rise; Netflix, PPG Industries fall, Friday, 4/19/2024
Intuitive Surgical Stock Can Trend Much Higher This Year 
3 Magnificent Seven Stocks Outperforming the Rest
Bargain Hunting: 3 Stocks With RSIs That Scream Oversold
Closing prices for crude oil, gold and other commodities

Three Small-Cap Biotech Stocks to Consider Now

Three Small-Cap Biotech Stocks to Consider Now

Key Points

  • Biotech stocks offer investors a clear risk/reward proposition. 
  • Investors should look at the company’s clinical focus and its pipeline.  
  • This clinical-stage immuno-oncology company’s stock is up over 135% after announcing updated interim data in a Phase 1 trial for its leading therapeutic. 
  • This pre-clinical company is surging as investors are beginning to speculate on the sector.  
  • This company’s stock is up more than 400% in 2022 as it is waiting for results in a Phase 3 clinical trial. 
  • 5 stocks we like better than Harpoon Therapeutics

Small-cap biotech stocks are among the riskiest of stocks for investors to own. One reason is that many of these companies are not only unprofitable but are still in the pre-revenue stage of their business.  

It all comes down to the pipeline. These companies are typically working on therapeutics and pharmaceutical products for chronic diseases and conditions that have no current treatment or one for which the standard of care needs improving. 

If just one of their candidates makes it into production, it could bring billions in revenue to the companies. And that means that the stock price could jump significantly. 

That’s the long-term case. Along the way, however, there are many years of clinical trials. These can create short-term opportunities for traders. This article looks at three small-cap biotech companies with stock prices that are making significant moves and have a bright outlook for 2023.

Harpoon Therapeutics, Inc. NYSE: HARP - Harpoon Therapeutics is a clinical-stage immuno-oncology company that is attempting to harness the killing power of T cells in a pipeline of wholly-owned immunotherapies for patients with hard to treat tumors.  

HARP stock is up nearly 135% on December 12. This was one day after the company presented updated interim data from its Phase 1 clinical trial for its single-agent HPN217 candidate. The drug is being developed to treat relapsed/refractory multiple myeloma (RRMM). The company presented its results at the American Society of Hematology Annual Meeting and Expositon in New Orleans. 

This is one of three such therapies that Harpoon has in Phase 1 trials. That means the company is years away from commercial production. But, analysts tracked by MarketBeat give the stock a consensus price target of $8.75. The recent price action has moved HARP stock into overbought territory, but risk-tolerant investors may want to keep an eye on this for an advantageous entry point.  

HTG Molecular Diagnostics, Inc. (NASDAQ: HTGM) - HTGM stock is following a similar path as Harpoon Therapeutics. This could be a case of two stocks that are riding each other’s coattails. Although there’s no direct news explaining the move in HTGM stock, the company does present investors with a strong long-term case.  


HTG Molecular Diagnostics is in the pre-clinical phase of developing therapeutic treatments “focused on RNA-Modifying Proteins and other targets” in areas like oncology, autoimmune and neurodegnerative disorders, and rare diseases. According to BIS Research, the global market for molecular oncology diagnostics is expected to exceed $12 billion in 10 years.  

Being in the pre-clinical phase means that HTG Molecular Diagnostics is years away from having a commercially available product. Still speculative investors could phase into a position as the company moves through the clinical trial phase. Analysts tracked by MarketBeat have a $2.83 price target on the stock.  

Abeona Therapeutics, Inc. NASDAQ: ABEO - Continuing with a theme with small-cap biotech companies, Abeona Therapeutics is still in the clinical trial stage. However, of the three companies on this list, Abeona is the closest to having a therapeutic brought to market.  

Abeona is attempting to develop gene and cell therapies for life-threatening rare genetic diseases. The company’s EB-101 candidate is an “autologous, engineered cell therapy for RDEB.” This is a rare connective tissue disorder that does not have an approved treatment. The company had $26 million in cash as of June 2022 and believes it is funded through the second quarter of 2023.  

Analysts are confident that EB-101 will be greenlighted in its Phase 3 trial as they are giving the stock a $22 price target which is a gain of over 1,000% from its current price. 

 

Should you invest $1,000 in Harpoon Therapeutics right now?

Before you consider Harpoon Therapeutics, you'll want to hear this.

MarketBeat keeps track of Wall Street's top-rated and best performing research analysts and the stocks they recommend to their clients on a daily basis. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the broader market catches on... and Harpoon Therapeutics wasn't on the list.

While Harpoon Therapeutics currently has a "Hold" rating among analysts, top-rated analysts believe these five stocks are better buys.

View The Five Stocks Here

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Companies Mentioned in This Article

CompanyMarketRank™Current PricePrice ChangeDividend YieldP/E RatioConsensus RatingConsensus Price Target
Harpoon Therapeutics (HARP)
1.5421 of 5 stars
$23.01flatN/A-2.63Hold$27.25
HTG Molecular Diagnostics (HTGM)
0 of 5 stars
$0.00-100.0%N/AN/AN/A
Abeona Therapeutics (ABEO)
3.7672 of 5 stars
$7.57+0.5%N/A-2.93Buy$38.00
Compare These Stocks  Add These Stocks to My Watchlist 

Chris Markoch

About Chris Markoch

  • CTMarkoch@msn.com

Editor & Contributing Author

Retirement, Individual Investing

Experience

Chris Markoch has been an editor & contributing writer for MarketBeat since 2018.

Areas of Expertise

Value investing, retirement stocks, dividend stocks

Education

Bachelor of Arts, The University of Akron

Past Experience

InvestorPlace


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