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3 Mid-Cap Medical Stocks Outperforming the Market

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Key Points

  • Several mid-cap medical stocks, such as ADMA, PEN, and TMDX, are outperforming in 2025, showing resilience despite broader market weakness. 
  • Penumbra, TransMedics, and ADMA Biologics have each posted substantial YTD gains (23%–48%), driven by earnings beats, bullish analyst sentiment, and sector momentum.
  • Growth potential remains strong, with all three companies showing favorable forward P/E ratios and technical strength.
  • Five stocks we like better than TransMedics Group.

While major market indexes like the S&P 500 have struggled to gain traction in 2025 and remain in the red YTD, certain pockets of the market are showing impressive strength. Several medical and biotechnology sector mid-cap stocks have stood out for their resilience and outperformance. Investors looking beyond large-cap names may find compelling opportunities in mid-cap stocks that deliver strong growth and defy broader market weakness.

Here are three mid-cap medical stocks that have significantly outperformed the broader market so far this year. Each shows strong momentum, bullish analyst sentiment, and potential for continued upside.

Penumbra: A High-Growth Medical Devices Company Outperforming the Market

Penumbra Today

Penumbra, Inc. stock logo
PENPEN 90-day performance
Penumbra
$292.21 -0.92 (-0.31%)
As of 03:59 PM Eastern
This is a fair market value price provided by Polygon.io. Learn more.
52-Week Range
$148.00
$310.00
P/E Ratio
859.43
Price Target
$302.40

Penumbra, Inc. NYSE: PEN designs, develops, manufactures, and markets innovative medical devices used in neuro and vascular interventions. With a market capitalization of $11.3 billion, the company has emerged as a standout performer in the medical device space. While recession concerns and geopolitical uncertainty have weighed on equities broadly, Penumbra’s stock is up an impressive 23% year-to-date and 43% over the past 12 months.

The company reported strong first-quarter earnings on April 23, posting earnings per share of $0.83, beating consensus estimates by $0.17. Revenue climbed 16.3% year-over-year to $324.1 million, exceeding expectations of $315.7 million. Despite market volatility in April, Penumbra held its uptrend and trades just 5% below its 52-week high, indicating continued investor confidence.

Valuation remains elevated, with a trailing P/E ratio of 274, though its forward P/E of 58 better reflects its growth trajectory. Analysts remain bullish. Of the 17 analysts covering the stock, the consensus rating is a Moderate Buy, with a price target that points to further potential upside.

TransMedics Group: Momentum and Growth in Organ Transplant Technology

TransMedics Group Today

TransMedics Group, Inc. stock logo
TMDXTMDX 90-day performance
TransMedics Group
$93.38 +1.17 (+1.27%)
As of 04:00 PM Eastern
52-Week Range
$55.00
$177.37
P/E Ratio
99.34
Price Target
$124.20

TransMedics Group NASDAQ: TMDX is a commercial-stage medical technology company revolutionizing organ transplant procedures. The firm’s flagship product, the Organ Care System (OCS), preserves donor organs in near-physiological conditions, significantly extending the window for transplantation. The company also offers the National OCS Program, a turnkey solution for organ retrieval and logistics.

The stock began to rally in April after breaking out above key resistance around $80. Since then, shares have gained substantial momentum and are now up nearly 48% year-to-date. The stock’s high P/E ratio of 91 may give some investors pause, but its forward P/E of 41 suggests strong earnings growth ahead.

Analysts are optimistic about the company’s outlook. Eleven analysts cover the stock, all contributing to a Moderate Buy consensus rating. The consensus price target implies up to 35% upside from current levels.

One catalyst and factor contributing to the stock's surge and momentum is its high short interest. As of April 15, short interest stood at 28% of the float, about 8.8 million shares. While down 7.3% from the prior month, the elevated level may contribute to a short squeeze dynamic, fueling the rally.

ADMA Biologics: Biotech Strength With Room to Run

ADMA Biologics Today

ADMA Biologics, Inc. stock logo
ADMAADMA 90-day performance
ADMA Biologics
$23.15 -0.56 (-2.37%)
As of 03:59 PM Eastern
This is a fair market value price provided by Polygon.io. Learn more.
52-Week Range
$6.72
$25.67
P/E Ratio
82.67
Price Target
$22.50

ADMA Biologics NASDAQ: ADMA is a biopharmaceutical company that develops, manufactures, and markets plasma-derived biologics for treating immune deficiencies and infectious diseases. With a market cap of $5.6 billion, it’s one of the most impressive biotech performers of 2025, with shares up 38% year-to-date.

The stock is trading just 7% below its all-time high, which was reached in late April. Investors will be watching closely as the company is scheduled to report earnings on May 7. ADMA trades at a P/E of 29 and a forward P/E of 23, supported by projected EPS growth of 45% in 2025.

Despite limited analyst coverage, only four analysts cover the stock, all of them rate it as a Buy, reinforcing the stock’s strong growth profile and favorable risk-reward balance.

Should You Invest $1,000 in TransMedics Group Right Now?

Before you consider TransMedics Group, you'll want to hear this.

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While TransMedics Group currently has a Moderate Buy rating among analysts, top-rated analysts believe these five stocks are better buys.

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Ryan Hasson
About The Author

Ryan Hasson

Contributing Author

Technical Analysis, Momentum Trading, Risk Management

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Companies Mentioned in This Article

CompanyMarketRank™Current PricePrice ChangeDividend YieldP/E RatioConsensus RatingConsensus Price Target
Penumbra (PEN)
4.1698 of 5 stars
$292.21-0.3%N/A859.43Moderate Buy$302.40
ADMA Biologics (ADMA)
1.3597 of 5 stars
$23.15-2.4%N/A82.67Buy$22.50
TransMedics Group (TMDX)
3.4385 of 5 stars
$93.38+1.3%N/A99.34Moderate Buy$124.20
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