| 5/21/2025 | Acadian Asset Management LLC | 2,939,856 | $668K | 0.0% | +31.0% | 3.253% | |
| 5/15/2025 | Redmile Group LLC | 856,615 | $195K | 0.0% | -71.6% | 0.948% | |
| 5/14/2025 | Affinity Asset Advisors LLC | 250,000 | $57K | 0.0% | N/A | 0.277% | |
| 5/14/2025 | DLD Asset Management LP | 435,668 | $99K | 0.0% | N/A | 0.482% | |
| 5/12/2025 | Vivo Capital LLC | 765,500 | $174K | 0.0% | -74.1% | 0.847% | |
| 5/8/2025 | Deuterium Capital Management LLC | 473,439 | $108K | 0.2% | N/A | 0.524% | |
| 4/22/2025 | Deltec Asset Management LLC | 257,127 | $59K | 0.0% | N/A | 0.285% | |
| 4/17/2025 | FNY Investment Advisers LLC | 175,000 | $39K | 0.0% | N/A | 0.194% | |
| 2/17/2025 | Tang Capital Management LLC | 378,552 | $458K | 0.0% | +736.4% | 0.424% | |
| 2/17/2025 | Redmile Group LLC | 3,015,097 | $3.65M | 0.3% | -2.0% | 3.375% | |
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| 2/17/2025 | Point72 Asset Management L.P. | 3,594,576 | $4.35M | 0.0% | +105.4% | 4.023% | |
| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 936,797 | $1.13M | 0.1% | +20.5% | 1.049% | |
| 2/17/2025 | Millennium Management LLC | 543,784 | $658K | 0.0% | -45.8% | 0.609% | |
| 2/17/2025 | Deutsche Bank AG | 629,159 | $761K | 0.0% | -31.1% | 0.704% | |
| 2/17/2025 | Deep Track Capital LP | 5,704,282 | $6.90M | 0.3% | +14.1% | 6.385% | |
| 2/17/2025 | Bridgeway Capital Management LLC | 209,900 | $254K | 0.0% | +25.4% | 0.235% | |
| 2/17/2025 | Bank of America Corp DE | 74,301 | $90K | 0.0% | -69.5% | 0.083% | |
| 2/14/2025 | RA Capital Management L.P. | 1,129,931 | $1.37M | 0.0% | N/A | 1.265% | |
| 2/14/2025 | Jane Street Group LLC | 101,097 | $122K | 0.0% | +92.6% | 0.113% | |
| 2/14/2025 | Lynx1 Capital Management LP | 3,628,144 | $4.39M | 1.6% | N/A | 4.061% | |
| 2/14/2025 | RBF Capital LLC | 360,731 | $436K | 0.0% | -29.3% | 0.404% | |
| 2/14/2025 | Rock Springs Capital Management LP | 1,100,409 | $1.33M | 0.1% | -8.3% | 1.232% | |
| 2/13/2025 | Barclays PLC | 754,980 | $914K | 0.0% | -13.2% | 0.845% | |
| 2/13/2025 | Renaissance Technologies LLC | 844,233 | $1.02M | 0.0% | +16.3% | 0.945% | |
| 2/13/2025 | ADAR1 Capital Management LLC | 62,264 | $75K | 0.0% | N/A | 0.070% | |
| 2/11/2025 | Platinum Investment Management Ltd. | 815,956 | $987K | 0.1% | -23.0% | 0.913% | |
| 2/5/2025 | Alta Partners Management Company L.P. | 2,546,147 | $3.08M | 4.9% | N/A | 2.850% | |
| 11/19/2024 | Barclays PLC | 869,969 | $568K | 0.0% | -23.3% | 0.974% | |
| 11/16/2024 | Geode Capital Management LLC | 988,171 | $646K | 0.0% | +8.9% | 1.106% | |
| 11/15/2024 | Barclays PLC | 869,969 | $568K | 0.0% | -23.3% | 0.974% | |
| 11/15/2024 | Jane Street Group LLC | 52,495 | $34K | 0.0% | -71.1% | 0.059% | |
| 11/15/2024 | RBF Capital LLC | 510,529 | $333K | 0.0% | +45.9% | 0.571% | |
| 11/15/2024 | Point72 Asset Management L.P. | 1,750,000 | $1.14M | 0.0% | N/A | 1.959% | |
| 11/15/2024 | Point72 Asia Singapore Pte. Ltd. | 53,324 | $35K | 0.0% | -52.3% | 0.060% | |
| 11/14/2024 | Walleye Capital LLC | 216,392 | $141K | 0.0% | -62.4% | 0.242% | |
| 11/13/2024 | BNP Paribas Financial Markets | 153,624 | $100K | 0.0% | -40.3% | 0.172% | |
| 11/13/2024 | FMR LLC | 5,370,247 | $3.51M | 0.0% | +14.6% | 6.011% | |
| 11/5/2024 | GSA Capital Partners LLP | 794,896 | $519K | 0.0% | +11.9% | 0.895% | |
| 9/16/2024 | Point72 DIFC Ltd | 25,289 | $25K | 0.0% | N/A | 0.028% | |
| 9/16/2024 | Cubist Systematic Strategies LLC | 55,486 | $55K | 0.0% | N/A | 0.062% | |
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| 9/16/2024 | Point72 Asia Singapore Pte. Ltd. | 111,716 | $112K | 0.0% | N/A | 0.126% | |
| 8/15/2024 | Susquehanna Portfolio Strategies LLC | 86,431 | $86K | 0.0% | -46.3% | 0.098% | |
| 8/15/2024 | Point72 Asia Singapore Pte. Ltd. | 111,716 | $112K | 0.0% | N/A | 0.126% | |
| 8/14/2024 | Cubist Systematic Strategies LLC | 55,486 | $55K | 0.0% | N/A | 0.063% | |
| 8/14/2024 | Point72 DIFC Ltd | 25,289 | $25K | 0.0% | N/A | 0.029% | |
| 8/9/2024 | Renaissance Technologies LLC | 562,411 | $562K | 0.0% | -34.3% | 0.635% | |
| 8/6/2024 | Acadian Asset Management LLC | 1,762,814 | $1.76M | 0.0% | +32.4% | 1.991% | |
| 8/1/2024 | Rhumbline Advisers | 38,096 | $38K | 0.0% | -63.2% | 0.043% | |
| 5/29/2024 | Opaleye Management Inc. | 2,435,000 | $3.07M | 0.7% | N/A | 2.750% | |
| 5/17/2024 | Ikarian Capital LLC | 932,675 | $1.18M | 0.1% | +293.4% | 1.053% | |
| 5/16/2024 | BVF Inc. IL | 16,552,417 | $20.86M | 0.6% | +93.5% | 18.695% | |
| 5/16/2024 | Redmile Group LLC | 3,451,076 | $4.35M | 0.2% | -6.0% | 3.898% | |
| 5/15/2024 | Price T Rowe Associates Inc. MD | 638,102 | $805K | 0.0% | -91.9% | 0.721% | |
| 5/14/2024 | Platinum Investment Management Ltd. | 1,172,061 | $1.48M | 0.1% | +84.6% | 1.324% | |
| 5/10/2024 | Acadian Asset Management LLC | 1,331,639 | $1.68M | 0.0% | +1,753.1% | 1.504% | |
| 5/10/2024 | Vanguard Group Inc. | 3,794,729 | $4.78M | 0.0% | +16.6% | 4.286% | |
| 5/7/2024 | Susquehanna Portfolio Strategies LLC | 161,077 | $203K | 0.0% | -45.2% | 0.182% | |
| 5/7/2024 | SG Americas Securities LLC | 30,789 | $39K | 0.0% | -27.0% | 0.035% | |
| 5/3/2024 | GSA Capital Partners LLP | 737,323 | $929K | 0.1% | N/A | 0.833% | |
| 5/1/2024 | BNP Paribas Financial Markets | 205,663 | $259K | 0.0% | +1,041.1% | 0.232% | |
| 2/14/2024 | Pennant Investors LP | 186,100 | $508K | 0.1% | N/A | 0.213% | |
| 2/14/2024 | Sectoral Asset Management Inc. | 752,381 | $2.05M | 0.9% | -2.3% | 0.860% | |
| 2/13/2024 | Aristides Capital LLC | 55,900 | $153K | 0.1% | N/A | 0.064% | |
| 1/30/2024 | Vontobel Holding Ltd. | 752,381 | $2.05M | 0.0% | -2.3% | 0.860% | |
| 12/6/2023 | Citigroup Inc. | 449,615 | $1.02M | 0.0% | -17.2% | 0.514% | |
| 11/15/2023 | Redmile Group LLC | 4,135,061 | $9.39M | 0.4% | +81.1% | 4.757% | |
| 11/15/2023 | Sectoral Asset Management Inc. | 770,132 | $1.75M | 0.3% | +77.3% | 0.886% | |
| 11/14/2023 | Blackstone Inc. | 4,096,652 | $9.30M | 0.0% | +104.2% | 4.713% | |
| 11/13/2023 | Algert Global LLC | 87,200 | $198K | 0.0% | -85.2% | 0.100% | |
| 11/13/2023 | Acadian Asset Management LLC | 83,310 | $189K | 0.0% | -85.7% | 0.096% | |
| 11/9/2023 | Citigroup Inc. | 449,615 | $1.02M | 0.0% | -17.2% | 0.517% | |
| 11/7/2023 | Barclays PLC | 408,966 | $928K | 0.0% | -19.1% | 0.471% | |
| 11/7/2023 | abrdn plc | 131,347 | $298K | 0.0% | N/A | 0.151% | |
| 11/2/2023 | Industry Ventures L.L.C. | 205,652 | $467K | 0.6% | N/A | 0.237% | |
| 10/30/2023 | RiverVest Venture Management LLC | 4,987,522 | $11.32M | 28.0% | +2.0% | 5.738% | |
| 10/27/2023 | Allspring Global Investments Holdings LLC | 22,214 | $50K | 0.0% | -40.0% | 0.026% | |
| 10/27/2023 | TD Asset Management Inc | 163,204 | $370K | 0.0% | +36.1% | 0.188% | |
| 10/24/2023 | Bank of New York Mellon Corp | 203,066 | $461K | 0.0% | -15.0% | 0.234% | |
| 10/13/2023 | SG Americas Securities LLC | 41,876 | $95K | 0.0% | N/A | 0.048% | |
| 10/11/2023 | Vontobel Holding Ltd. | 770,132 | $1.75M | 0.0% | +77.3% | 0.886% | |
| 9/21/2023 | Barclays PLC | 505,246 | $2.20M | 0.0% | +9.8% | 0.581% | |
| 8/15/2023 | Silverarc Capital Management LLC | 200,000 | $872K | 0.3% | -5.2% | 0.230% | |
| 8/15/2023 | BVF Inc. IL | 8,652,417 | $37.73M | 1.1% | +42.8% | 9.954% | |
| 8/15/2023 | Caxton Corp | 17,733 | $77K | 0.2% | -79.5% | 0.020% | |
| 8/14/2023 | Deep Track Capital LP | 228,277 | $995K | 0.0% | -93.6% | 0.263% | |
| 8/14/2023 | Prelude Capital Management LLC | 25,000 | $109K | 0.0% | -23.8% | 0.029% | |
| 8/11/2023 | Sectoral Asset Management Inc. | 434,310 | $1.89M | 0.3% | N/A | 0.502% | |
| 8/11/2023 | Landscape Capital Management L.L.C. | 24,943 | $109K | 0.0% | -53.9% | 0.029% | |
| 8/11/2023 | Inceptionr LLC | 11,272 | $49K | 0.0% | N/A | 0.013% | |
| 8/11/2023 | E Fund Management Co. Ltd. | 18,996 | $83K | 0.0% | -11.4% | 0.022% | |
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| 8/10/2023 | Profund Advisors LLC | 64,054 | $279K | 0.0% | -6.7% | 0.074% | |
| 8/10/2023 | Citigroup Inc. | 542,688 | $2.37M | 0.0% | -35.0% | 0.627% | |
| 8/9/2023 | TD Asset Management Inc | 119,900 | $523K | 0.0% | +46.4% | 0.139% | |
| 8/7/2023 | Acadian Asset Management LLC | 581,100 | $2.53M | 0.0% | +166.3% | 0.671% | |
| 8/4/2023 | American International Group Inc. | 31,997 | $140K | 0.0% | N/A | 0.037% | |
| 8/3/2023 | Barclays PLC | 505,246 | $2.20M | 0.0% | +9.8% | 0.584% | |
| 8/2/2023 | Bank of Montreal Can | 19,006 | $92K | 0.0% | N/A | 0.022% | |
| 7/24/2023 | Allspring Global Investments Holdings LLC | 37,048 | $162K | 0.0% | N/A | 0.043% | |
| 7/24/2023 | Vontobel Holding Ltd. | 434,310 | $1.89M | 0.0% | N/A | 0.502% | |
| 7/18/2023 | Allspring Global Investments Holdings LLC | 37,048 | $162K | 0.0% | N/A | 0.043% | |
