| 5/20/2026 | Vivo Capital LLC | 3,184,713 | $6.39M | 0.5% | N/A | 2.367% | |
| 5/19/2026 | Bank of America Corp DE | 577,783 | $1.16M | 0.0% | +8.6% | 0.429% | |
| 5/18/2026 | Redmile Group LLC | 7,964,188 | $15.97M | 1.1% | +143.9% | 5.919% | |
| 5/16/2026 | venBio Partners LLC | 12,884,638 | $25.83M | 9.2% | +32.8% | 9.575% | |
| 5/16/2026 | Orbimed Advisors LLC | 2,866,256 | $5.75M | 0.1% | N/A | 2.130% | |
| 5/15/2026 | OMERS ADMINISTRATION Corp | 75,000 | $150K | 0.0% | N/A | 0.056% | |
| 5/14/2026 | Renaissance Technologies LLC | 732,599 | $1.47M | 0.0% | +73.2% | 0.544% | |
| 2/26/2026 | Seven Fleet Capital Management LP | 117,817 | $133K | 0.1% | N/A | 0.217% | |
| 2/18/2026 | Bridgeway Capital Management LLC | 76,072 | $86K | 0.0% | +111.3% | 0.140% | |
| 2/13/2026 | Marshall Wace LLP | 26,376 | $30K | 0.0% | -33.4% | 0.049% | |
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| 2/13/2026 | State Street Corp | 124,228 | $140K | 0.0% | +11.0% | 0.229% | |
| 2/12/2026 | Renaissance Technologies LLC | 423,099 | $478K | 0.0% | +157.2% | 0.780% | |
| 1/1/2026 | JPMorgan Chase & Co. | 61,899 | $113K | 0.0% | -29.9% | 0.114% | |
| 11/17/2025 | Qube Research & Technologies Ltd | 16,946 | $31K | 0.0% | -61.6% | 0.031% | |
| 11/17/2025 | Bank of America Corp DE | 530,828 | $971K | 0.0% | -48.7% | 0.979% | |
| 11/17/2025 | Ameriprise Financial Inc. | 652,897 | $1.20M | 0.0% | N/A | 1.204% | |
| 11/14/2025 | Two Sigma Investments LP | 606,671 | $1.11M | 0.0% | +26.9% | 1.119% | |
| 11/14/2025 | Bridgeway Capital Management LLC | 36,000 | $66K | 0.0% | N/A | 0.066% | |
| 11/7/2025 | Vanguard Group Inc. | 1,528,619 | $2.80M | 0.0% | -4.5% | 2.855% | |
| 11/7/2025 | JPMorgan Chase & Co. | 61,899 | $113K | 0.0% | -29.9% | 0.116% | |
| 8/15/2025 | Bank of America Corp DE | 1,035,127 | $430K | 0.0% | -28.7% | 1.933% | |
| 8/14/2025 | Jane Street Group LLC | 203,266 | $84K | 0.0% | N/A | 0.381% | |
| 8/14/2025 | Redmile Group LLC | 3,391,455 | $1.41M | 0.1% | -6.8% | 6.352% | |
| 8/13/2025 | Marshall Wace LLP | 106,280 | $45K | 0.0% | -60.8% | 0.199% | |
| 8/12/2025 | XTX Topco Ltd | 74,770 | $31K | 0.0% | -19.0% | 0.140% | |
| 8/12/2025 | JPMorgan Chase & Co. | 88,352 | $37K | 0.0% | -75.3% | 0.165% | |
| 8/8/2025 | Geode Capital Management LLC | 315,421 | $131K | 0.0% | -59.1% | 0.591% | |
| 6/27/2025 | Goldman Sachs Group Inc. | 373,214 | $233K | 0.0% | -34.4% | 0.699% | |
| 5/21/2025 | Acadian Asset Management LLC | 1,296,331 | $806K | 0.0% | +16.8% | 2.428% | |
| 5/16/2025 | Goldman Sachs Group Inc. | 373,214 | $233K | 0.0% | -34.4% | 0.699% | |
| 5/16/2025 | AQR Capital Management LLC | 119,050 | $74K | 0.0% | +183.6% | 0.223% | |
| 5/16/2025 | Almitas Capital LLC | 1,353,141 | $843K | 0.3% | +10.6% | 2.534% | |
| 5/15/2025 | Redmile Group LLC | 3,640,834 | $2.27M | 0.2% | -1.3% | 6.819% | |
| 5/15/2025 | MPM Bioimpact LLC | 550,000 | $343K | 0.1% | -60.5% | 1.030% | |
| 5/12/2025 | Nuveen LLC | 164,790 | $103K | 0.0% | N/A | 0.309% | |
| 5/12/2025 | Invesco Ltd. | 73,836 | $46K | 0.0% | N/A | 0.138% | |
| 5/8/2025 | XTX Topco Ltd | 92,259 | $57K | 0.0% | -65.0% | 0.173% | |
| 2/17/2025 | Two Sigma Investments LP | 704,131 | $1.18M | 0.0% | +6.7% | 1.335% | |
| 2/17/2025 | Two Sigma Advisers LP | 823,900 | $1.38M | 0.0% | +64.6% | 1.562% | |
| 2/17/2025 | Tang Capital Management LLC | 3,296,883 | $5.51M | 0.4% | -21.6% | 6.251% | |
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| 2/17/2025 | Redmile Group LLC | 3,689,611 | $6.16M | 0.4% | -3.8% | 6.996% | |
| 2/17/2025 | MPM Bioimpact LLC | 1,391,434 | $2.32M | 0.3% | -42.3% | 2.638% | |
| 2/17/2025 | Nuveen Asset Management LLC | 164,790 | $275K | 0.0% | +55.6% | 0.312% | |
| 2/17/2025 | Deutsche Bank AG | 101,113 | $169K | 0.0% | +521.0% | 0.192% | |
| 2/17/2025 | D. E. Shaw & Co. Inc. | 255,878 | $427K | 0.0% | -11.9% | 0.485% | |
| 2/17/2025 | Cubist Systematic Strategies LLC | 32,021 | $53K | 0.0% | -91.7% | 0.061% | |
| 2/17/2025 | Bridgeway Capital Management LLC | 75,000 | $125K | 0.0% | N/A | 0.142% | |
| 2/17/2025 | Bank of America Corp DE | 1,035,326 | $1.73M | 0.0% | +492.9% | 1.963% | |
| 2/17/2025 | Almitas Capital LLC | 1,222,945 | $2.04M | 0.4% | N/A | 2.319% | |
| 2/14/2025 | Northern Trust Corp | 343,066 | $573K | 0.0% | +7.3% | 0.650% | |
| 2/14/2025 | Dimensional Fund Advisors LP | 26,233 | $44K | 0.0% | -30.3% | 0.050% | |
| 2/13/2025 | XTX Topco Ltd | 263,856 | $441K | 0.0% | -16.8% | 0.500% | |
| 2/13/2025 | Bank of Nova Scotia | 105,306 | $176K | 0.0% | N/A | 0.200% | |
| 2/13/2025 | Bank of Montreal Can | 826,582 | $1.38M | 0.0% | N/A | 1.567% | |
| 2/12/2025 | Geode Capital Management LLC | 740,106 | $1.24M | 0.0% | +5.6% | 1.403% | |
| 2/12/2025 | JPMorgan Chase & Co. | 236,046 | $394K | 0.0% | +476.7% | 0.448% | |
| 2/11/2025 | Sei Investments Co. | 60,795 | $102K | 0.0% | N/A | 0.115% | |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 216,707 | $362K | 0.0% | -3.8% | 0.411% | |
| 2/4/2025 | Los Angeles Capital Management LLC | 301,419 | $503K | 0.0% | +16.9% | 0.572% | |
| 2/4/2025 | Bank of New York Mellon Corp | 90,003 | $150K | 0.0% | +12.0% | 0.171% | |
| 1/29/2025 | JSF Financial LLC | 17,500 | $29K | 0.0% | N/A | 0.033% | |
| 11/19/2024 | Barclays PLC | 59,502 | $107K | 0.0% | +243.6% | 0.113% | |
| 11/15/2024 | Barclays PLC | 59,502 | $107K | 0.0% | +243.6% | 0.113% | |
| 11/15/2024 | XTX Topco Ltd | 317,322 | $578K | 0.0% | N/A | 0.602% | |
| 11/15/2024 | Jane Street Group LLC | 27,918 | $51K | 0.0% | -64.3% | 0.053% | |
| 11/15/2024 | Wellington Management Group LLP | 167,831 | $305K | 0.0% | +15.2% | 0.318% | |
| 11/15/2024 | State Street Corp | 671,376 | $1.22M | 0.0% | -4.8% | 1.273% | |
| 11/15/2024 | Redmile Group LLC | 3,836,576 | $6.98M | 0.4% | -5.0% | 7.274% | |
| 11/14/2024 | Verition Fund Management LLC | 133,025 | $242K | 0.0% | +308.4% | 0.252% | |
| 11/14/2024 | Walleye Capital LLC | 230,875 | $420K | 0.0% | +110.3% | 0.438% | |
| 11/13/2024 | FMR LLC | 5,865,106 | $10.67M | 0.0% | -25.0% | 11.121% | |
| 11/12/2024 | Charles Schwab Investment Management Inc. | 225,302 | $410K | 0.0% | -4.5% | 0.428% | |
| 11/8/2024 | Connor Clark & Lunn Investment Management Ltd. | 83,042 | $151K | 0.0% | +207.4% | 0.158% | |
| 11/5/2024 | GSA Capital Partners LLP | 48,204 | $88K | 0.0% | N/A | 0.092% | |
| 11/4/2024 | Los Angeles Capital Management LLC | 257,779 | $469K | 0.0% | N/A | 0.489% | |
| 11/2/2024 | Privium Fund Management B.V. | 509,059 | $926K | 0.2% | +28.2% | 0.967% | |
| 10/3/2024 | SG Americas Securities LLC | 27,394 | $50K | 0.0% | +33.6% | 0.053% | |
| 8/19/2024 | Point72 Asset Management L.P. | 304,100 | $1.83M | 0.0% | N/A | 0.584% | |
| 8/16/2024 | Algert Global LLC | 41,215 | $249K | 0.0% | N/A | 0.079% | |
| 8/15/2024 | Susquehanna Portfolio Strategies LLC | 73,468 | $443K | 0.0% | -19.2% | 0.141% | |
| 8/15/2024 | The Manufacturers Life Insurance Company | 13,662 | $82K | 0.0% | -77.3% | 0.026% | |
| 8/15/2024 | AQR Capital Management LLC | 18,079 | $109K | 0.0% | +50.7% | 0.035% | |
| 8/14/2024 | Cubist Systematic Strategies LLC | 199,441 | $1.20M | 0.0% | N/A | 0.383% | |
| 8/14/2024 | Marshall Wace LLP | 635,679 | $3.83M | 0.0% | +423.0% | 1.220% | |
| 8/12/2024 | Inspire Investing LLC | 58,707 | $354K | 0.0% | +77.1% | 0.113% | |
| 8/12/2024 | Hsbc Holdings PLC | 10,780 | $63K | 0.0% | N/A | 0.021% | |
| 8/9/2024 | Renaissance Technologies LLC | 438,200 | $2.64M | 0.0% | +87.2% | 0.841% | |
| 8/9/2024 | Dimensional Fund Advisors LP | 34,543 | $208K | 0.0% | -31.4% | 0.066% | |
| 8/8/2024 | American Century Companies Inc. | 23,685 | $143K | 0.0% | -20.2% | 0.045% | |
| 8/6/2024 | Quest Partners LLC | 20,781 | $125K | 0.0% | -17.0% | 0.040% | |
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| 8/1/2024 | Rhumbline Advisers | 55,220 | $333K | 0.0% | +10.8% | 0.106% | |
| 8/1/2024 | Privium Fund Management B.V. | 396,966 | $2.27M | 0.6% | N/A | 0.762% | |
| 7/29/2024 | Zurcher Kantonalbank Zurich Cantonalbank | 6,517 | $39K | 0.0% | +394.8% | 0.013% | |
| 7/26/2024 | Bank of New York Mellon Corp | 104,966 | $633K | 0.0% | +31.6% | 0.201% | |
| 7/12/2024 | SG Americas Securities LLC | 20,506 | $124K | 0.0% | -14.2% | 0.039% | |
| 5/16/2024 | California State Teachers Retirement System | 22,797 | $254K | 0.0% | +413.8% | 0.044% | |
| 5/16/2024 | Redmile Group LLC | 4,326,509 | $48.24M | 1.8% | +18.2% | 8.304% | |
| 5/15/2024 | Price T Rowe Associates Inc. MD | 232,769 | $2.60M | 0.0% | -57.2% | 0.447% | |
| 5/14/2024 | EntryPoint Capital LLC | 2,847 | $32K | 0.0% | N/A | 0.005% | |
| 5/14/2024 | CANADA LIFE ASSURANCE Co | 2,379 | $27K | 0.0% | N/A | 0.005% | |