Orbimed Advisors LLC Top Holdings and 13F Report (2026) About Orbimed Advisors LLCInvestment ActivityOrbimed Advisors LLC has $5.05 billion in total holdings as of March 31, 2026.Orbimed Advisors LLC owns shares of 111 different stocks, but just 38 companies or ETFs make up 80% of its holdings.Approximately 26.21% of the portfolio was purchased this quarter.About 21.70% of the portfolio was sold this quarter.This quarter, Orbimed Advisors LLC has purchased 106 new stocks and bought additional shares in 25 stocks.Orbimed Advisors LLC sold shares of 35 stocks and completely divested from 21 stocks this quarter.Largest Holdings Edgewise Therapeutics $488,832,498Enliven Therapeutics $312,013,890MDXHEALTH SA $285,903,800Eli Lilly and Company $217,801,536Avita Medical $196,958,309 Largest New Holdings this Quarter B5950S113 - MDXHEALTH SA $285,903,800 Holding05380C102 - Avita Medical $196,958,309 HoldingG0593M107 - AstraZeneca $132,176,844 Holding62855J104 - Myriad Genetics $122,875,000 Holding58933Y105 - Merck & Co., Inc. $79,800,386 Holding Largest Purchases this Quarter MDXHEALTH SA 124,306,000 shares (about $285.90M)Avita Medical 82,010,995 shares (about $196.96M)AstraZeneca 670,200 shares (about $132.18M)Myriad Genetics 125,000,000 shares (about $122.88M)Merck & Co., Inc. 663,400 shares (about $79.80M) Largest Sales this Quarter Edwards Lifesciences 762,300 shares (about $61.04M)Eli Lilly and Company 64,400 shares (about $59.23M)Alnylam Pharmaceuticals 169,800 shares (about $56.18M)Stryker 142,500 shares (about $46.82M)CG ONCOLOGY INC 568,283 shares (about $38.46M) Sector Allocation Over TimeMap of 500 Largest Holdings ofOrbimed Advisors LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorEWTXEdgewise Therapeutics$488,832,4980.0%15,518,4929.7%MedicalELVNEnliven Therapeutics$312,013,8900.0%7,959,5386.2%MedicalMDXHEALTH SA$285,903,800$285,903,800 â–²New Holding124,306,0005.7%SHS NEWLLYEli Lilly and Company$217,801,536$59,233,188 â–¼-21.4%236,8004.3%MedicalRCELAvita Medical$196,958,309$196,958,309 â–²New Holding82,010,9953.9%MedicalSVASinovac Biotech$184,466,1700.0%2,718,7353.7%MedicalBSXBoston Scientific$149,476,775$2,334,300 â–¼-1.5%2,382,1003.0%MedicalSIONNA THERAPEUTICS INC$141,545,843$1,240,906 â–¼-0.9%3,530,7022.8%COMAZNCFAstraZeneca$132,176,844$132,176,844 â–²New Holding670,2002.6%MedicalMYGNMyriad Genetics$122,875,000$122,875,000 â–²New Holding125,000,0002.4%MedicalMBX BIOSCIENCES INC$108,590,927$8,874,883 â–¼-7.6%3,637,8872.2%COMCRVSCorvus Pharmaceuticals$104,824,0380.0%7,165,0062.1%MedicalARGXargenex$99,971,225$6,645,275 â–¼-6.2%136,9002.0%MedicalEWEdwards Lifesciences$98,546,448$61,044,984 â–¼-38.3%1,230,6002.0%MedicalISRGIntuitive Surgical$96,208,613$25,216,153 â–¼-20.8%208,7001.9%MedicalCMPXCompass Therapeutics$80,513,7680.0%15,219,9941.6%MedicalMRKMerck & Co., Inc.$79,800,386$79,800,386 â–²New Holding663,4001.6%MedicalGPCRStructure Therapeutics$71,114,425$15,115,520 â–²27.0%1,475,4031.4%MedicalARRIVENT BIOPHARMA INC$69,840,4570.0%3,027,3281.4%COMIRONDisc Medicine$68,259,1470.0%1,067,5501.4%MedicalSPRYARS Pharmaceuticals$66,556,7350.0%8,288,5101.3%MedicalCG ONCOLOGY INC$64,178,711$38,461,394 â–¼-37.5%948,2671.3%COMXENEXenon Pharmaceuticals$61,637,314$35,632,634 â–²137.0%1,059,9711.2%MedicalSYKStryker$59,967,675$46,824,075 â–¼-43.8%182,5001.2%MedicalBMYBristol Myers Squibb$56,101,250$9,097,500 â–²19.4%925,0001.1%MedicalMLYSMineralys Therapeutics$55,613,061$29,054,025 â–²109.4%2,052,9001.1%MedicalPRAXIS PRECISION MEDICINES I$55,577,775$25,130,820 â–²82.5%172,5001.1%COM NEWPFEPfizer$54,657,720$8,244,288 â–²17.8%1,946,5001.1%MedicalDYNE THERAPEUTICS INC$52,901,237$12,975,641 â–²32.5%2,917,8841.0%COMNTRANatera$52,397,380$20,758,962 â–¼-28.4%262,0001.0%MedicalABIVAX SA$51,855,695$10,890,030 â–²26.6%465,7001.0%SPONSORED ADSUPSTREAM BIO INC$51,242,3010.0%5,693,5891.0%COMDHRDanaher$50,395,680$6,446,400 â–¼-11.3%265,8001.0%MedicalCARIS LIFE SCIENCES INC$50,185,781$5,528,496 â–¼-9.9%2,806,8111.0%COMASNDAscendis Pharma A/S$41,623,599$2,287,300 â–²5.8%181,9770.8%MedicalSTTKShattuck Labs$40,548,3970.0%6,306,1270.8%MedicalGHGuardant Health$40,199,424$40,199,424 â–²New Holding435,2000.8%MedicalALNYAlnylam Pharmaceuticals$39,373,530$56,181,726 â–¼-58.8%119,0000.8%MedicalPRLDPrelude Therapeutics$37,309,6560.0%10,909,2560.7%MedicalCRNXCrinetics Pharmaceuticals$36,283,6800.0%999,0000.7%MedicalAXSMAxsome Therapeutics$36,156,927$6,625,584 â–¼-15.5%213,9210.7%MedicalQUREuniQure$34,926,036$22,869,546 â–²189.7%2,136,1490.7%MedicalORICOric Pharmaceuticals$34,132,080$12,008,968 â–¼-26.0%2,693,9290.7%MedicalELVElevance Health$33,578,425$4,566,900 â–²15.7%114,7000.7%MedicalRLMDRelmada Therapeutics$32,822,413$14,652,637 â–²80.6%4,715,8640.7%MedicalFORTE BIOSCIENCES INC$31,001,1350.0%1,196,9550.6%COM NEWTRVITrevi Therapeutics$29,280,992$8,784,059 â–¼-23.1%2,454,4000.6%MedicalESPREsperion Therapeutics$28,962,622$12,617,157 â–²77.2%10,570,3000.6%MedicalNPCENeuroPace$27,569,330$4,073,975 â–¼-12.9%2,096,5270.5%MedicalRYTMRhythm Pharmaceuticals$27,317,277$6,461,871 â–²31.0%314,1000.5%MedicalPALVELLA THERAPEUTICS INC NE$23,010,390$23,010,390 â–²New Holding184,6000.5%COMTMOThermo Fisher Scientific$22,856,1450.0%46,5000.5%MedicalSNDXSyndax Pharmaceuticals$22,479,328$22,479,328 â–²New Holding962,3000.4%MedicalBRIGHTSPRING HEALTH SVCS INC$21,211,258$396,273 â–²1.9%497,8000.4%COMLEXEO THERAPEUTICS INC$20,678,063$8,480,563 â–²69.5%3,602,4500.4%COMSUTRO BIOPHARMA INC$19,956,497$19,956,497 â–²New Holding801,1440.4%COM SHSNEKTAR THERAPEUTICS$19,786,250$19,786,250 â–²New Holding275,0000.4%COM NEWPRELUDE THERAPEUTICS INC$19,426,236$17,611,198 â–²970.3%5,680,1860.4%NONVOTINGCYBIN INC$18,397,646$36,754 â–¼-0.2%3,832,8430.4%COM NEWKRYSKrystal Biotech$17,849,912$13,096,824 â–¼-42.3%69,1000.4%MedicalCRBPCorbus Pharmaceuticals$16,313,125$1,314,600 â–²8.8%1,737,2870.3%MedicalURGNUrogen Pharma$15,741,2560.0%875,4870.3%MedicalDEFINIUM THERAPEUTICS INC$15,195,600$15,195,600 â–²New Holding804,0000.3%COM SHSVERAVera Therapeutics$14,868,847$647,542 â–²4.6%369,5960.3%MedicalQ32 BIO INC$14,464,1770.0%2,252,9870.3%COMAADIAadi Bioscience$14,372,7000.0%4,166,0000.3%MedicalAMGNAmgen$14,038,815$14,038,815 â–²New Holding39,9000.3%MedicalALHCAlignment Healthcare$13,937,420$13,937,420 â–²New Holding791,0000.3%MedicalEYPTEyepoint Pharmaceuticals$13,781,305$18,035,263 â–¼-56.7%1,069,1470.3%MedicalJANXJanux Therapeutics$13,672,040$13,494,481 â–¼-49.7%983,6000.3%MedicalBCRXBioCryst Pharmaceuticals$13,567,904$3,014,032 â–¼-18.2%1,425,2000.3%MedicalBICARA THERAPEUTICS INC$13,272,597$9,113,598 â–²219.1%667,3000.3%COMBIOAGE LABS INC$12,449,574$1,383,284 â–¼-10.0%711,8110.2%COMCOGTCogent Biosciences$12,397,629$1,882,161 â–¼-13.2%322,1000.2%MedicalALUMIS INC$12,076,031$12,217,111 â–¼-50.3%548,1630.2%COMREGNRegeneron Pharmaceuticals$11,357,808$11,357,808 â–²New Holding14,7000.2%MedicalCARLSMED INC$11,336,0300.0%1,252,6000.2%COMBIIBBiogen$11,293,128$11,293,128 â–²New Holding61,6000.2%MedicalQIAGEN NV$10,010,000$10,010,000 â–²New Holding250,0000.2%ORD SHARESKINIKSA PHARMACEUTICALS INTL$8,695,842$317,790 â–¼-3.5%180,5990.2%ORD SHS CL AKROSKeros Therapeutics$8,381,071$497,429 â–¼-5.6%759,1550.2%MedicalGILDGilead Sciences$8,306,452$8,306,452 â–²New Holding59,6000.2%MedicalHRTXHeron Therapeutics$7,854,534$7,854,534 â–²New Holding9,816,9400.2%MedicalAVALO THERAPEUTICS INC$7,094,213$10,632,175 â–¼-60.0%475,1650.1%COM NEWTECTONIC THERAPEUTIC INC$7,004,206$10,756,680 â–¼-60.6%226,6000.1%COMADICET BIO INC$7,000,2990.0%1,027,9440.1%COM NEWCMPSCompass Pathways$6,363,072$6,363,072 â–²New Holding1,150,6460.1%MedicalPHVSPharvaris$5,802,5500.0%205,4000.1%MedicalALXOALX Oncology$5,746,843$5,746,843 â–²New Holding2,866,2560.1%MedicalAORTArtivion$5,529,620$5,529,620 â–²New Holding151,0000.1%MedicalNSPRInspireMD$5,107,4500.0%3,133,4050.1%MedicalRVMDRevolution Medicines$5,057,000$2,538,225 â–²100.8%52,0000.1%MedicalADCTADC Therapeutics$4,942,598$16,893,107 â–¼-77.4%1,318,0260.1%MedicalPTGXProtagonist Therapeutics$4,437,340$2,150,160 â–²94.0%42,1000.1%MedicalPALISADE BIO INC$4,082,750$807,765 â–²24.7%2,333,0000.1%COMALTO NEUROSCIENCE INC$3,765,400$955,400 â–²34.0%167,5000.1%COM SHSSVRASavara$3,467,100$3,467,100 â–²New Holding635,0000.1%MedicalCGEMCullinan Therapeutics$3,453,115$383,670 â–¼-10.0%243,0060.1%MedicalSLNOSoleno Therapeutics$3,348,000$3,348,000 â–²New Holding100,0000.1%MedicalPTCTPTC Therapeutics$3,345,183$1,764,567 â–²111.6%49,1000.1%MedicalShowing largest 100 holdings. 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