Orbimed Advisors LLC Top Holdings and 13F Report (2024)

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About Orbimed Advisors LLC

Investment Activity

Orbimed Advisors LLC has $5.46 billion in total holdings as of March 31, 2024.
Orbimed Advisors LLC owns shares of 113 different stocks, but just 41 companies or ETFs make up 80% of its holdings.
Approximately 12.53% of the portfolio was purchased this quarter.
About 17.88% of the portfolio was sold this quarter.
This quarter, Orbimed Advisors LLC has purchased 111 new stocks and bought additional shares in 22 stocks.
Orbimed Advisors LLC sold shares of 30 stocks and completely divested from 18 stocks this quarter.

Largest Holdings

Sinovac Biotech: $340,000,000
Eli Lilly and Company: $280,687,968
Edgewise Therapeutics: $273,996,191
Boston Scientific: $224,167,770
Intuitive Surgical: $196,791,279

Largest New Holdings this Quarter

ARRIVENT BIOPHARMA INC: $54,068,078 Holding
Cytokinetics: $47,864,097 Holding
Q32 BIO INC: $38,390,898 Holding
Esperion Therapeutics: $36,739,399 Holding
PRAXIS PRECISION MEDICINES I: $28,100,442 Holding

Largest Purchases this Quarter

ARRIVENT BIOPHARMA INC: 3,027,328 shares (about $54.07M)
Cytokinetics: 682,700 shares (about $47.86M)
Geron: 12,408,611 shares (about $40.95M)
Q32 BIO INC: 2,252,987 shares (about $38.39M)
Esperion Therapeutics: 13,708,731 shares (about $36.74M)

Largest Sales this Quarter

SpringWorks Therapeutics: 1,512,028 shares (about $74.42M)
APOGEE THERAPEUTICS INC: 559,000 shares (about $37.15M)
Vera Therapeutics: 842,243 shares (about $36.32M)
BioMarin Pharmaceutical: 292,910 shares (about $25.58M)
Vertex Pharmaceuticals: 52,500 shares (about $21.95M)

Sector Allocation Over Time

Selling

Neutral

Buying

Latest 13F Holdings and Changes Since Previous Quarterly Filing

Issuer Name	Holdings Value	Approximate Purchase/Sale	Change in Shares	Shares Held	% of Portfolio	Sector
SVA Sinovac Biotech	$340,000,000		0.0%	2,718,735	6.2%	Medical
LLY Eli Lilly and Company	$280,687,968	$3,578,616 ▼	-1.3%	360,800	5.1%	Medical
EWTX Edgewise Therapeutics	$273,996,191	$8,290,901 ▲	3.1%	15,021,721	5.0%	Medical
BSX Boston Scientific	$224,167,770	$2,314,962 ▼	-1.0%	3,273,000	4.1%	Medical
ISRG Intuitive Surgical	$196,791,279	$2,354,631 ▼	-1.2%	493,100	3.6%	Medical
BIIB Biogen	$194,261,067	$15,805,679 ▲	8.9%	900,900	3.6%	Medical
MRK Merck & Co., Inc.	$173,646,200	$34,438,950 ▲	24.7%	1,316,000	3.2%	Medical
JANX Janux Therapeutics	$160,974,570	$36,054,619 ▲	28.9%	4,275,553	2.9%	Medical
ELVN Enliven Therapeutics	$158,280,765		0.0%	8,998,338	2.9%	Medical
THC Tenet Healthcare	$123,325,563	$5,371,121 ▼	-4.2%	1,173,300	2.3%	Medical
BMRN BioMarin Pharmaceutical	$111,664,190	$25,582,759 ▼	-18.6%	1,278,500	2.0%	Medical
ALPN Alpine Immune Sciences	$106,254,861	$5,757,750 ▲	5.7%	2,680,496	1.9%	Medical
IRON Disc Medicine	$105,981,276		0.0%	1,702,237	1.9%	Medical
SYK Stryker	$96,267,030		0.0%	269,000	1.8%	Medical
SPRY ARS Pharmaceuticals	$94,441,865		0.0%	9,240,887	1.7%	Medical
SRPT Sarepta Therapeutics	$90,298,350		0.0%	697,500	1.7%	Medical
IONS Ionis Pharmaceuticals	$87,264,981	$2,243,969 ▼	-2.5%	2,013,033	1.6%	Medical
ELV Elevance Health	$87,166,574	$13,793,164 ▲	18.8%	168,100	1.6%	Medical
XTNT Xtant Medical	$85,544,073		0.0%	73,114,592	1.6%	Medical
EVH Evolent Health	$85,438,116	$4,620,668 ▼	-5.1%	2,605,615	1.6%	Computer and Technology
APLS Apellis Pharmaceuticals	$85,101,684	$30,894,768 ▲	57.0%	1,447,800	1.6%	Medical
SWTX SpringWorks Therapeutics	$84,034,832	$74,422,018 ▼	-47.0%	1,707,331	1.5%	Medical
KROS Keros Therapeutics	$83,990,191		0.0%	1,268,734	1.5%	Medical
NTRA Natera	$82,261,959	$5,034,873 ▼	-5.8%	899,431	1.5%	Medical
TMO Thermo Fisher Scientific	$76,719,720	$6,858,278 ▼	-8.2%	132,000	1.4%	Medical
PCVX Vaxcyte	$72,827,409	$5,940,238 ▼	-7.5%	1,066,131	1.3%	Medical
CRNX Crinetics Pharmaceuticals	$64,831,850	$13,217,272 ▼	-16.9%	1,385,000	1.2%	Medical
SRRK Scholar Rock	$63,485,464	$11,905,736 ▼	-15.8%	3,574,632	1.2%	Medical
ARGX argenx	$59,687,952	$26,379,240 ▲	79.2%	151,600	1.1%	Medical
ICLR ICON Public	$58,488,895	$14,076,305 ▲	31.7%	174,100	1.1%	Medical
NBIX Neurocrine Biosciences	$58,353,952	$13,265,008 ▼	-18.5%	423,100	1.1%	Medical
SIBN SI-BONE	$56,059,409	$18,530,676 ▲	49.4%	3,424,521	1.0%	Medical
VRNA Verona Pharma	$54,674,898	$6,109,550 ▼	-10.1%	3,398,067	1.0%	Medical
THRD TF Financial	$54,554,430		0.0%	5,779,071	1.0%	Medical
ARRIVENT BIOPHARMA INC	$54,068,078	$54,068,078 ▲	New Holding	3,027,328	1.0%	COM
NPCE NeuroPace	$52,852,364		0.0%	4,003,967	1.0%	Medical
PRLD Prelude Therapeutics	$51,709,873		0.0%	10,909,256	0.9%	Medical
VRTX Vertex Pharmaceuticals	$51,289,827	$21,945,525 ▼	-30.0%	122,700	0.9%	Medical
TERN Terns Pharmaceuticals	$49,981,526		0.0%	7,619,135	0.9%	Medical
CYTK Cytokinetics	$47,864,097	$47,864,097 ▲	New Holding	682,700	0.9%	Medical
APOGEE THERAPEUTICS INC	$47,770,971	$37,145,550 ▼	-43.7%	718,901	0.9%	COM
CMPX Compass Therapeutics	$44,278,443		0.0%	22,362,850	0.8%	Medical
GERN Geron	$42,548,916	$40,948,416 ▲	2,558.5%	12,893,611	0.8%	Medical
SNDX Syndax Pharmaceuticals	$41,626,200		0.0%	1,749,000	0.8%	Medical
Q32 BIO INC	$38,390,898	$38,390,898 ▲	New Holding	2,252,987	0.7%	COM
ESPR Esperion Therapeutics	$36,739,399	$36,739,399 ▲	New Holding	13,708,731	0.7%	Medical
UNH UnitedHealth Group	$34,629,000		0.0%	70,000	0.6%	Medical
RYTM Rhythm Pharmaceuticals	$30,540,804	$7,288,106 ▲	31.3%	704,842	0.6%	Medical
ALXO ALX Oncology	$30,305,366	$4,203,885 ▼	-12.2%	2,717,970	0.6%	Medical
VERA Vera Therapeutics	$29,143,601	$36,317,519 ▼	-55.5%	675,872	0.5%	Medical
PRAXIS PRECISION MEDICINES I	$28,100,442	$28,100,442 ▲	New Holding	460,512	0.5%	COM NEW
HRTX Heron Therapeutics	$28,008,994	$11,586,797 ▲	70.6%	10,111,550	0.5%	Medical
SCPH scPharmaceuticals	$27,908,831		0.0%	5,559,528	0.5%	Medical
SLRN Acelyrin	$27,011,549		0.0%	4,001,711	0.5%	Medical
PRELUDE THERAPEUTICS INC	$26,924,082	$3,263,021 ▼	-10.8%	5,680,186	0.5%	NONVOTING
ACET Adicet Bio	$26,900,779	$7,343,750 ▲	37.6%	11,447,140	0.5%	Medical
MLYS Mineralys Therapeutics	$26,096,584	$26,096,584 ▲	New Holding	2,021,424	0.5%	Medical
RNA Avidity Biosciences	$25,369,432	$25,369,432 ▲	New Holding	994,100	0.5%	Medical
XENE Xenon Pharmaceuticals	$23,677,500		0.0%	550,000	0.4%	Medical
REGN Regeneron Pharmaceuticals	$21,944,772	$8,951,157 ▲	68.9%	22,800	0.4%	Medical
KNTE Kinnate Biopharma	$21,305,879		0.0%	8,009,729	0.4%	Medical
ARWR Arrowhead Pharmaceuticals	$21,154,019	$12,012,000 ▲	131.4%	739,651	0.4%	Medical
NEUMORA THERAPEUTICS INC.	$20,625,000		0.0%	1,500,000	0.4%	COM
DYNE THERAPEUTICS INC	$20,111,476	$20,111,476 ▲	New Holding	708,400	0.4%	COM
MORF Morphic	$19,659,200	$10,035,520 ▲	104.3%	558,500	0.4%	Medical
DXCM DexCom	$19,459,610	$9,306,770 ▲	91.7%	140,300	0.4%	Medical
ABCL AbCellera Biologics	$18,938,879		0.0%	4,180,768	0.3%	Medical
IMTX Immatics	$18,599,631	$2,378,423 ▲	14.7%	1,769,708	0.3%	Medical
VSTM Verastem	$18,043,557		0.0%	1,529,115	0.3%	Medical
AMGN Amgen	$18,025,888	$18,168,048 ▼	-50.2%	63,400	0.3%	Medical
AVTE Aerovate Therapeutics	$16,718,109	$5,664,311 ▼	-25.3%	565,374	0.3%	Medical
TELA TELA Bio	$16,077,523		0.0%	2,835,542	0.3%	Medical
RPTX Repare Therapeutics	$15,648,918		0.0%	3,322,488	0.3%	Medical
PASG Passage Bio	$13,668,178		0.0%	10,124,576	0.3%	Medical
TYRA Tyra Biosciences	$12,605,663	$12,605,663 ▲	New Holding	768,638	0.2%	Medical
CRVS Corvus Pharmaceuticals	$12,359,704		0.0%	6,943,654	0.2%	Medical
IVVD Invivyd	$11,944,932	$6,381,457 ▼	-34.8%	2,690,300	0.2%	Medical
PMVP PMV Pharmaceuticals	$11,007,995		0.0%	6,475,291	0.2%	Medical
VTYX Ventyx Biosciences	$10,287,508	$10,287,508 ▲	New Holding	1,870,456	0.2%	Medical
FATE Fate Therapeutics	$9,948,284	$6,072,177 ▲	156.7%	1,355,352	0.2%	Medical
XFOR X4 Pharmaceuticals	$9,915,586		0.0%	7,133,515	0.2%	Medical
EXAS Exact Sciences	$9,696,024	$9,696,024 ▲	New Holding	140,400	0.2%	Medical
IKENA ONCOLOGY INC	$9,043,394		0.0%	6,368,587	0.2%	NONVOTING
CGEM Cullinan Therapeutics	$8,820,006	$464,204 ▼	-5.0%	517,606	0.2%	Medical
NKTX Nkarta	$8,648,000	$8,648,000 ▲	New Holding	800,000	0.2%	Medical
LXRX Lexicon Pharmaceuticals	$8,500,800	$8,500,800 ▲	New Holding	3,542,000	0.2%	Medical
TXG 10x Genomics	$8,451,756	$6,958,062 ▲	465.8%	225,200	0.2%	Medical
TURNSTONE BIOLOGICS CORP	$8,120,074		0.0%	3,099,265	0.1%	COM
PERSPECTIVE THERAPEUTICS INC	$7,741,902	$7,741,902 ▲	New Holding	6,505,800	0.1%	COM
CTMX CytomX Therapeutics	$7,727,180	$7,727,180 ▲	New Holding	3,544,578	0.1%	Medical
FOLD Amicus Therapeutics	$6,718,134	$2,776,546 ▼	-29.2%	570,300	0.1%	Medical
KRYS Krystal Biotech	$6,612,946	$11,838,394 ▼	-64.2%	37,166	0.1%	Medical
VIR Vir Biotechnology	$6,483,200	$5,460,070 ▲	533.7%	640,000	0.1%	Medical
APLM Apollomics	$6,424,092		0.0%	8,565,456	0.1%	Medical
NSPR InspireMD	$5,056,383		0.0%	2,133,405	0.1%	Medical
IKNA Ikena Oncology	$5,025,888		0.0%	3,539,358	0.1%	Medical
ELEV Elevation Oncology	$4,828,741	$2,866,259 ▼	-37.2%	941,275	0.1%	Medical
PGNY Progyny	$4,322,395	$4,322,395 ▲	New Holding	113,300	0.1%	Medical
ORIC ORIC Pharmaceuticals	$3,947,625	$3,243,185 ▼	-45.1%	287,100	0.1%	Medical
MIST Milestone Pharmaceuticals	$3,580,000	$3,580,000 ▲	New Holding	2,000,000	0.1%	Medical