Assembly Biosciences (ASMB) Stock Price, News & Analysis

Company Overview

Assembly Biosciences, Inc. (NASDAQ: ASMB) is a clinical-stage biotechnology company dedicated to the discovery, development and commercialization of novel therapies for hepatitis B virus (HBV) and hepatitis D virus (HDV) infections. The company’s core expertise lies in small-molecule modulation of viral proteins and host-targeted pathways to achieve sustained viral suppression and potential functional cure. Assembly’s research model integrates medicinal chemistry, structural biology and translational virology to advance its pipeline from early discovery through clinical development.

The company’s lead programs include core protein allosteric modulators (CpAMs) designed to disrupt the HBV lifecycle by interfering with capsid assembly and viral DNA replication, as well as prenylation inhibitors targeting the HDV lifecycle. Vebicorvir (ABI-H0731), a next-generation CpAM, is being studied in combination regimens to assess its ability to reduce surface antigen levels and achieve durable viral control. Assembly is also advancing ABI-H2158, an oral antiviral with broad potential to enhance host immune response and further suppress viral replication in chronic HBV patients.

Assembly conducts multi-center clinical trials across North America, Europe and Asia, collaborating with academic centers and global research networks to evaluate its candidates in diverse patient populations. The company operates its headquarters in Boulder, Colorado, with additional research activities in Cambridge, Massachusetts. Its management team brings extensive experience in antiviral drug development, leveraging prior success in hepatitis and oncology therapeutic programs.

Since its inception in 2015, Assembly has grown through strategic partnerships and in-licensing agreements, establishing a robust intellectual property portfolio around core modulation and prenylation inhibition. The company continues to engage regulatory authorities worldwide with the goal of delivering new, safe and effective treatment options for patients living with chronic HBV and HDV infections.

Key Stats

• Today's Range: $27.39 to $28.75
• 50-Day Range: $20.55 to $30.79
• 52-Week Range: $7.75 to $31.11
• Volume: 36,827 shs
• Average Volume: 148,773 shs
• Market Capitalization: $210.98 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $41.25
• Consensus Rating: Moderate Buy

Assembly Biosciences Stock Analysis - MarketRank™

Assembly Biosciences scored higher than 70% of companies evaluated by MarketBeat, and ranked 275th out of 932 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 4.3 / 5
• Analyst Rating: Moderate Buy

Consensus Rating

Assembly Biosciences has received a consensus rating of Moderate Buy. The company's average rating score is 2.57, and is based on 5 buy ratings, 1 hold rating, and 1 sell rating.

Upside Potential

Assembly Biosciences has a consensus price target of $41.25, representing about 50.0% upside from its current price of $27.50.

Amount of Analyst Coverage

Assembly Biosciences has been the subject of 7 research reports in the past 90 days, demonstrating strong analyst interest in this stock.

Earnings and Valuation

• Score: 0.0 / 5
• Proj. Earnings Growth: Decreasing

Earnings Growth

Earnings for Assembly Biosciences are expected to decrease in the coming year, from ($6.87) to ($7.64) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Assembly Biosciences is -4.93, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Assembly Biosciences is -4.93, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Assembly Biosciences has a P/B Ratio of 5.24. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.

Short Interest

• Score: 0.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

12.93% of the float of Assembly Biosciences has been sold short.

Short Interest Ratio / Days to Cover

Assembly Biosciences has a short interest ratio ("days to cover") of 11.1, which indicates bearish sentiment.

Change versus previous month

Short interest in Assembly Biosciences has recently increased by 26.17%, indicating that investor sentiment is decreasing significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Assembly Biosciences does not currently pay a dividend.

Dividend Growth

Assembly Biosciences does not have a long track record of dividend growth.

Sustainability and ESG

• Score: 4.7 / 5
• Environmental Score: -0.71

Percentage of Shares Shorted

12.93% of the float of Assembly Biosciences has been sold short.

Short Interest Ratio / Days to Cover

Assembly Biosciences has a short interest ratio ("days to cover") of 11.1, which indicates bearish sentiment.

Change versus previous month

Short interest in Assembly Biosciences has recently increased by 26.17%, indicating that investor sentiment is decreasing significantly.

News and Social Media

• Score: 2.6 / 5
• News Sentiment: 0.67

News Sentiment

Assembly Biosciences has a news sentiment score of 0.67. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This news sentiment score is similar to the average news sentiment of Medical companies.

News Coverage This Week

MarketBeat has tracked 3 news articles for Assembly Biosciences this week, compared to 4 articles on an average week.

Search Interest

3 people have searched for ASMB on MarketBeat in the last 30 days. This is an increase of 200% compared to the previous 30 days.

MarketBeat Follows

2 people have added Assembly Biosciences to their MarketBeat watchlist in the last 30 days.

Company Ownership

• Score: 0.0 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Assembly Biosciences insiders have not sold or bought any company stock.

Percentage Held by Insiders

Only 5.30% of the stock of Assembly Biosciences is held by insiders.

Percentage Held by Institutions

Only 19.92% of the stock of Assembly Biosciences is held by institutions.

ASMB Stock Analysis - Frequently Asked Questions

How have ASMB shares performed this year?

Assembly Biosciences' stock was trading at $15.78 at the start of the year. Since then, ASMB stock has increased by 74.3% and is now trading at $27.50.

How were Assembly Biosciences' earnings last quarter?

Assembly Biosciences, Inc. (NASDAQ:ASMB) issued its quarterly earnings results on Wednesday, August, 6th. The biopharmaceutical company reported ($1.33) EPS for the quarter, beating the consensus estimate of ($1.73) by $0.40. The biopharmaceutical company earned $9.63 million during the quarter, compared to the consensus estimate of $5.30 million. Assembly Biosciences had a negative net margin of 117.20% and a negative trailing twelve-month return on equity of 149.01%.

When did Assembly Biosciences' stock split?

Assembly Biosciences's stock reverse split before market open on Monday, February 12th 2024.The 1-12 reverse split was announced on Monday, February 12th 2024. The number of shares owned by shareholders was adjusted after the market closes on Monday, February 12th 2024. An investor that had 100 shares of stock prior to the reverse split would have 8 shares after the split.

Who are Assembly Biosciences' major shareholders?

Assembly Biosciences' top institutional investors include Ellsworth Advisors LLC (0.39%). Insiders that own company stock include Alexander Schornstein, John G Mchutchison, Jason A Okazaki, Nicole S White, Jeanette M Bjorkquist and Michael Houghton.
View institutional ownership trends.

How do I buy shares of Assembly Biosciences?

Shares of ASMB stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Assembly Biosciences own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Assembly Biosciences investors own include Waste Connections (WCN), Voyager Therapeutics (VYGR), DiamondRock Hospitality (DRH), AUO (AUOTY), American Water Works (AWK), The RMR Group (RMR) and iShares Micro-Cap ETF (IWC).

Company Calendar

• Last Earnings: 8/06/2025
• Today: 10/24/2025
• Next Earnings (Estimated): 11/06/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - GENERIC DRG
• Sub-Industry: Pharmaceuticals
• Current Symbol: NASDAQ:ASMB
• CIK: 1426800
• Web: www.assemblybio.com
• Phone: (833) 509-4583
• Fax: 646-706-5101
• Employees: 100
• Year Founded: 2005

Price Target and Rating

• Average Price Target for Assembly Biosciences: $41.25
• High Price Target: $50.00
• Low Price Target: $38.00
• Potential Upside/Downside: +50.0%
• Consensus Rating: Moderate Buy
• Rating Score (0-4): 2.57
• Research Coverage: 7 Analysts

Profitability

• EPS (Trailing Twelve Months): ($5.58)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$40.18 million
• Net Margins: -117.20%
• Pretax Margin: -117.42%
• Return on Equity: -149.01%
• Return on Assets: -39.04%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 1.64
• Quick Ratio: 1.64

Sales & Book Value

• Annual Sales: $33.25 million
• Price / Sales: 6.35
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $5.25 per share
• Price / Book: 5.24

Miscellaneous

• Outstanding Shares: 7,672,000
• Free Float: 7,265,000
• Market Cap: $210.98 million
• Optionable: Optionable
• Beta: 0.60