Can-Fite BioPharma Ltd. (NYSE: CANF) is an Israel-based biopharmaceutical company focused on the development of small-molecule therapeutic candidates that target inflammation, cancer, and liver disease. Founded in 1996 and headquartered in Petach Tikva, Can-Fite leverages its proprietary technology platform to discover and advance novel adenosine receptor modulators, which act on the body’s immune and inflammatory pathways.
The company’s lead clinical programs include Piclidenoson (CF101), an oral A3 adenosine receptor agonist in late-stage development for the treatment of moderate to severe plaque psoriasis, and Namodenoson (CF102), aimed at patients with advanced hepatocellular carcinoma and nonalcoholic steatohepatitis (NASH). Can-Fite has reported positive safety and efficacy data in multiple phase II and III studies, underscoring the potential of its pipeline to address significant unmet medical needs.
Can-Fite maintains research and development facilities in Israel and operates a U.S. administrative office in North Carolina to support clinical collaborations and investigator-initiated trials. The company has forged strategic partnerships with academic institutions, contract research organizations, and specialty pharmaceutical firms to accelerate development and broaden geographic reach, including markets in North America, Europe, and Asia.
Under the leadership of President and CEO Pnina Fishman, Can-Fite’s management team combines deep expertise in clinical development, regulatory affairs, and commercial strategy. Driven by a commitment to innovation and patient-centered outcomes, Can-Fite continues to build a diversified pipeline of oral small molecules designed to deliver new therapeutic options for global patient populations.
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